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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 08 Dec 2016.

Ubiquitin specific peptidase 20

VDU2, USP20, pVHL-interacting deubiquitinating enzyme-2
Top mentioned proteins: Ubiquitin, VDU1, CAN, VHL, Thioredoxin
Papers on VDU2
Regulation of pyruvate kinase isozyme M2 is mediated by the ubiquitin-specific protease 20.
New
Baek et al., South Korea. In Int J Oncol, May 2015
USP20, one of deubiquitinating enzymes (DUBs) belonging to the subfamily of ubiquitin-specific protease (USP), regulates ubiquitin-mediated protein degradation.
Phosphorylation of the deubiquitinase USP20 by protein kinase A regulates post-endocytic trafficking of β2 adrenergic receptors to autophagosomes during physiological stress.
New
Shenoy et al., Durham, United States. In J Biol Chem, May 2015
Ubiquitination by the E3 ligase Nedd4 and deubiquitination by the deubiquitinases USP20 and USP33 have been shown to regulate the lysosomal trafficking and recycling of agonist-activated β2 adrenergic receptors (β2ARs).
HERC2-USP20 axis regulates DNA damage checkpoint through Claspin.
Lou et al., Shanghai, China. In Nucleic Acids Res, 2015
Here, we identified the deubiquitination enzyme (DUB) USP20 as a pivotal regulator of ATR-related DDR pathway.
HERC2/USP20 coordinates CHK1 activation by modulating CLASPIN stability.
Xu et al., Beijing, China. In Nucleic Acids Res, 2015
Under unperturbed conditions, the E3 ubiquitin ligase HERC2 regulates the stability of the deubiquitinating enzyme USP20 by promoting ubiquitination-mediated proteasomal degradation.
Regulation of neuronal morphogenesis and positioning by ubiquitin-specific proteases in the cerebellum.
Bonni et al., Saint Louis, United States. In Plos One, 2014
In RNAi screens of the 32 neuronally expressed USPs, we uncover novel functions for USP1, USP4, and USP20 in the morphogenesis of granule neuron dendrites and axons and we identify a requirement for USP30 and USP33 in granule neuron migration in the rodent cerebellar cortex in vivo.
Ubiquitin-specific peptidase 20 regulates Rad17 stability, checkpoint kinase 1 phosphorylation and DNA repair by homologous recombination.
Shaheen et al., Albuquerque, United States. In J Biol Chem, 2014
We have identified a deubiquitylase, USP20 that is required for Rad17 protein stability in the steady-state and post DNA damage.
Role of the type 2 iodothyronine deiodinase (D2) in the control of thyroid hormone signaling.
Review
Bianco et al., Miami, United States. In Biochim Biophys Acta, 2013
Ubiquitinated D2 can be either targeted to proteasomal degradation or reactivated by deubiquitination, a process that is mediated by the deubiquitinases USP20/33 and is important in adaptive thermogenesis.
Polyclonal and monoclonal antibodies specific for ubiquitin-specific protease 20.
Baek et al., South Korea. In Monoclon Antib Immunodiagn Immunother, 2013
USP20, also known as VDU2, belongs to ubiquitin-specific protease (USP) subfamily of DUBs and has several important roles in cells as shown with other DUBs.
MARCH2 promotes endocytosis and lysosomal sorting of carvedilol-bound β(2)-adrenergic receptors.
Shenoy et al., Durham, United States. In J Cell Biol, 2012
Carvedilol prevented β(2)AR recycling, blocked recruitment of Nedd4 E3 ligase, and promoted the dissociation of the deubiquitinases USP20 and USP33.
Analysis of indel variations in the human disease-associated genes CDKN2AIP, WDR66, USP20 and OR7C2 in a Korean population.
GeneRIF
Park et al., Taejŏn, South Korea. In J Genet, 2011
Analysis of indel variations in the human disease-associated genes CDKN2AIP, WDR66, USP20 and OR7C2 in a Korean population.
Type 2 deiodinase at the crossroads of thyroid hormone action.
Review
Bianco et al., Miami, United States. In Int J Biochem Cell Biol, 2011
Inactivation involves disruption of the D2:D2 dimer and can be reversed via two ubiquitin-specific proteases, USP20 and USP33, rescuing catalytic activity and T3 production.
Ubiquitin-specific peptidase 20 targets TRAF6 and human T cell leukemia virus type 1 tax to negatively regulate NF-kappaB signaling.
GeneRIF
Jeang et al., Bethesda, United States. In J Virol, 2011
Our results point to USP20 as a key negative regulator of HTLV-1 Tax-induced NF-kappaB signaling.
Combined interphase fluorescence in situ hybridization elucidates the genetic heterogeneity of T-cell acute lymphoblastic leukemia in adults.
Mecucci et al., Perugia, Italy. In Haematologica, 2010
In two cases with cryptic del(9)(q34), fluorescence in situ hybridization and reverse transcriptase polymerase chain reaction detected the TAF_INUP214 fusion and gene expression profiling identified a signature characterized by HOXA and NUP214 upregulation and TAF_I, FNBP1, C9orf78, and USP20 down-regulation.
The deubiquitinases USP33 and USP20 coordinate beta2 adrenergic receptor recycling and resensitization.
GeneRIF
Shenoy et al., Durham, United States. In Embo J, 2009
USPs 20 and 33 serve as novel regulators that dictate both post-endocytic sorting as well as the intensity and extent of beta(2)AR signalling from the cell surface.
Cellular and structural biology of the deiodinases.
Review
Larsen et al., Boston, United States. In Thyroid, 2005
This is because D2 interacts with and is a substrate of the pVHL-interacting deubiquitinating enzymes (VDU1 and VDU2), and thus the ubiquitination-deubiquitination cycles regulates the supply of active thyroid hormone in D2-expressing cells.
VHL protein-interacting deubiquitinating enzyme 2 deubiquitinates and stabilizes HIF-1alpha.
GeneRIF
Wu et al., Rochester, United States. In Embo Rep, 2005
von Hippel-Lindau protein-interacting deubiquitinating enzyme 2 (VDU2) deubiquitinates and stabilizes HIF-1alpha.
Triplets! Unexpected structural similarity among the three enzymes that catalyze initiation and termination of thyroid hormone effects.
Review
Bianco, Boston, United States. In Arq Bras Endocrinol Metabol, 2004
In addition, D2 interacts with and is a substrate of the pVHL-interacting deubiquitinating enzymes (VDU1 and VDU2); thus deubiquitination regulates the supply of active thyroid hormone in D2-expressing cells.
Deubiquitination of type 2 iodothyronine deiodinase by von Hippel-Lindau protein-interacting deubiquitinating enzymes regulates thyroid hormone activation.
GeneRIF
Bianco et al., Boston, United States. In J Clin Invest, 2003
identification and description of VDU2 in human cells
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