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Voltage-dependent anion channel 1

VDAC1, Voltage-Dependent Anion Channel 1, VDAC, POR1
This gene encodes a voltage-dependent anion channel protein that is a major component of the outer mitochondrial membrane. The encoded protein facilitates the exchange of metabolites and ions across the outer mitochondrial membrane and may regulate mitochondrial functions. This protein also forms channels in the plasma membrane and may be involved in transmembrane electron transport. Alternate splicing results in multiple transcript variants. Multiple pseudogenes of this gene are found on chromosomes 1, 2 3, 6, 9, 12, X and Y.[provided by RefSeq, Sep 2010] (from NCBI)
Top mentioned proteins: CAN, bcl-2, V1a, ACID, Hexokinase
Papers using VDAC1 antibodies
Mitochondrial and Nuclear Genomic Responses to Loss of LRPPRC Expression*
Mootha Vamsi K. et al., In The Journal of Biological Chemistry, 2008
... Antibodies including CO2, NDUFB8, SDHB, UQCRC2, ATP5A, and VDAC1 were purchased from Mitosciences (Eugene, OR) ...
Bioinformatics enrichment tools: paths toward the comprehensive functional analysis of large gene lists
Martelli Fabio, In PLoS ONE, 2008
... Antibody for VDAC1 (ab15895) (1∶500) was from Abcam.
The mitochondrial permeability transition, release of cytochrome c and cell death. Correlation with the duration of pore openings in situ.
Koch Karl-Wilhelm, In PLoS ONE, 2000
... Sigma; the monoclonal anti-CyP-D antibody was from Calbiochem (San Diego, CA); the rabbit polyclonal anti VDAC1 antibody was from Abcam, (Cambridge, UK); the goat ...
ARL4, an ARF-like Protein That Is Developmentally Regulated and Localized to Nuclei and Nucleoli
Aspenstrom Pontus, In PLoS ONE, 1999
... ATPase, Bax (Santa Cruz Biotechnology, Santa Cruz, CA, USA), VDAC (Cell Signaling Technology, Danvers, MA, USA), ...
Serine phosphorylation of death agonist BAD in response to survival factor results in binding to 14-3-3 not BCL-X(L)
Youle Richard J. et al., In The Journal of Cell Biology, 1995
... Human VDAC-1 (a gift from Michael Forte, Vollum Institute, Oregon Health Sciences University, Portland, OR) was cloned into the DsRed vector (CLONTECH Laboratories, Inc.) ...
Papers on VDAC1
Effects of age and unaccustomed resistance exercise on mitochondrial transcript and protein abundance in skeletal muscle of men.
Tarnopolsky et al., In Am J Physiol Regul Integr Comp Physiol, 18 Mar 2015
Elevated mitophagy could not explain the reduction in mitochondrial proteins and DNA, as there was no increase in ubiquitinated VDAC or its association with Pink1 or Parkin, and elevated p62 content indicated an impairment or reduction in autophagocytic flux.
Local mitochondrial-endolysosomal microfusion cleaves the voltage-dependent anion channel 1 to promote survival in hypoxia.
Mazure et al., Nice, France. In Mol Cell Biol, 17 Mar 2015
We previously demonstrated that the hypoxia-inducible factor-1 mediated hyperfusion of mitochondria, by inducing Bcl-2/adenovirus E1B 19-kDa interacting protein 3, and post-translational truncation of the mitochondrial ATP transporter, the outer-membrane voltage-dependent anion channel 1, in hypoxic cells.
Acetylproteomic analysis reveals functional implications of lysine acetylation in human sperm.
Zhang et al., Shanghai, China. In Mol Cell Proteomics, 13 Mar 2015
Novel acetylation of VDAC channel proteins was also found.
The BH4 domain of anti-apoptotic Bcl-XL, but not that of the related Bcl-2, limits the voltage-dependent anion channel 1 (VDAC1)-mediated transfer of pro-apoptotic Ca2+ signals to mitochondria.
Bultynck et al., Leuven, Belgium. In J Biol Chem, 13 Mar 2015
Bcl-2 and Bcl-XL proteins exert part of their anti-apoptotic function by directly targeting Ca2+-transport systems, like the ER-localized inositol 1,4,5-trisphosphate receptors (IP3Rs) and the voltage-dependent anion channel 1 (VDAC1) at the outer mitochondrial membranes.
Arabidopsis thaliana defense response to the ochratoxin A-producing strain (Aspergillus ochraceus 3.4412).
Xu et al., Beijing, China. In Plant Cell Rep, 10 Mar 2015
Of these, six proteins were involved in basic metabolism and four in defense-related processes, which included glutathione-S-transferase F7, voltage-dependent anion-selective channel protein 3 (VDAC-3), osmotin-like protein OSM34 and blue copper-binding protein.
The mitochondrial voltage-dependent anion channel 1 in tumor cells.
Tripathi et al., Beersheba, Israel. In Biochim Biophys Acta, Dec 2014
In addressing the recently solved 3D structures of VDAC1, this review will point to structure-function relationships of VDAC as critical for deciphering how this channel can perform such a variety of roles, all of which are important for cell life and death.
Measurement of mitochondrial Ca2+ transport mediated by three transport proteins: VDAC1, the Na+/Ca2+ exchanger, and the Ca2+ uniporter.
Shoshan-Barmatz et al., Beersheba, Israel. In Cold Spring Harb Protoc, Feb 2014
The first of these is Ca(2+) transport mediated by the outer mitochondrial protein, the voltage-dependent anion-selective channel protein 1 (VDAC1, also known as porin 1), both as a purified protein reconstituted into a planar lipid bilayer (PLB) or into liposomes and as a mitochondrial membrane-embedded protein.
Plasma membrane coenzyme Q: evidence for a role in autism.
Gvozdjáková et al., West Lafayette, United States. In Biologics, 2013
DATA SOURCES: Correlation of porin redox activity and expression of autism is based on extensive literature, especially studies of antibodies, identification of cytosolic nicotinamide adenine dinucleotide reduced (NADH) dehydrogenase activity in the VDAC, and evidence for extreme sensitivity of the dehydrogenase to a mercurial.
Hypoxic VDAC1: a potential mitochondrial marker for cancer therapy.
Mazure et al., Nice, France. In Adv Exp Med Biol, 2013
The mitochondrial voltage-dependent anion channel (VDAC) is a protein at the crossroads of metabolic and survival pathways.
Structural basis for membrane binding specificity of the Bin/Amphiphysin/Rvs (BAR) domain of Arfaptin-2 determined by Arl1 GTPase.
Wakatsuki et al., Tsukuba, Japan. In J Biol Chem, 2012
The Arl1.Arfaptin-2 BAR structure suggests that one of the two Arl1 molecules competes with Rac1, which binds to the concave face of the Arfaptin-2 BAR homodimer and may hinder its membrane association.
Mediation of the antiapoptotic activity of Bcl-xL protein upon interaction with VDAC1 protein.
Shoshan-Barmatz et al., Beersheba, Israel. In J Biol Chem, 2012
Interfering with Bcl-xL binding to the mitochondria by VDAC1-based peptides may serve to induce apoptosis in cancer cells.
Structure-based analysis of VDAC1: N-terminus location, translocation, channel gating and association with anti-apoptotic proteins.
Shoshan-Barmatz et al., Beersheba, Israel. In Biochem J, 2012
A single cysteine-residue-bearing VDAC1 demonstrates that the N-terminal region lies inside the channel pore.
Peripheral benzodiazepine receptor regulates vascular endothelial activations via suppression of the voltage-dependent anion channel-1.
Jeon et al., Taejŏn, South Korea. In Febs Lett, 2012
PBR can inhibit endothelial activation through inhibition of mitochondrial ROS and/or VDAC-1 expression in endothelial cells
Lipid dynamics and protein-lipid interactions in 2D crystals formed with the β-barrel integral membrane protein VDAC1.
Griffin et al., Cambridge, United States. In J Am Chem Soc, 2012
analysis of lipid dynamics and protein-lipid interactions in 2D crystals formed with the beta-barrel integral membrane protein VDAC1
PKCε promotes oncogenic functions of ATF2 in the nucleus while blocking its apoptotic function at mitochondria.
Ronai et al., Los Angeles, United States. In Cell, 2012
Genotoxic stress attenuates PKCε effect on ATF2; enables ATF2 nuclear export and localization at the mitochondria, where it perturbs the HK1-VDAC1 complex; increases mitochondrial permeability; and promotes apoptosis.
PINK1/Parkin-mediated mitophagy is dependent on VDAC1 and p62/SQSTM1.
Springer et al., Tübingen, Germany. In Nat Cell Biol, 2010
Data identified VDAC1 (voltage-dependent anion channel 1) as a target for Parkin-mediated Lys 27 poly-ubiquitylation and mitophagy.
Solution structure of the integral human membrane protein VDAC-1 in detergent micelles.
Wagner et al., Boston, United States. In Science, 2008
study presents NMR solution structure of recombinant VDAC-1 reconstituted in detergent micelles
RAS-RAF-MEK-dependent oxidative cell death involving voltage-dependent anion channels.
Stockwell et al., New York City, United States. In Nature, 2007
RNA-interference-mediated knockdown of VDAC2 or VDAC3 caused resistance to erastin, implicating these two VDAC isoforms in the mechanism of action of erastin.
Voltage-dependent anion channels are dispensable for mitochondrial-dependent cell death.
Molkentin et al., Cincinnati, United States. In Nat Cell Biol, 2007
Vdacs are dispensable for both MPT and Bcl-2 family member-driven cell death.
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