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Variable charge, X-linked 3A

This gene belongs to the VCX/Y gene family, which has multiple members on both X and Y chromosomes, and all are expressed exclusively in male germ cells. The X-linked members are clustered on chromosome Xp22 and Y-linked members are two identical copies of the gene within a palindromic region on Yq11. The family members share a high degree of sequence identity, with the exception that a 30-bp unit is tandemly repeated in X-linked members but occurs only once in Y-linked members. The VCX gene cluster is polymorphic in terms of copy number; different individuals may have a different number of VCX genes. VCX/Y genes encode small and highly charged proteins of unknown function. The presence of a putative bipartite nuclear localization signal suggests that VCX/Y members are nuclear proteins. This gene contains 8 repeats of the 30-bp unit. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: HAD, CAN, sulfatase, Kms, p22
Papers on VCX-A
A search for novel cancer/testis antigens in lung cancer identifies VCX/Y genes, expanding the repertoire of potential immunotherapeutic targets.
Hanash et al., Vancouver, Canada. In Cancer Res, 2014
VCX3A, a member of the VCX/Y gene family, was expressed at the protein level in approximately 20% of lung adenocarcinomas and 35% of squamous cell carcinomas, but not expressed in normal lung tissues.
Decreased expression of genes associated with memory and x-linked mental retardation in boys with non-syndromic cryptorchidism and high infertility risk.
Oakeley et al., Basel, Switzerland. In Mol Syndromol, 2014
However, boys in the HIR group had low or no expression of EGR4, FMR2 (AFF2) and VCX3A.
Xp22.3 interstitial deletion: a recognizable chromosomal abnormality encompassing VCX3A and STS genes in a patient with X-linked ichthyosis and mental retardation.
Mougou-Zerelli et al., Sousse, Tunisia. In Gene, 2013
In fact, VCX3A gene, a member of the VCX (variable charge, X chromosome) gene family, was previously proposed as the candidate gene for X-linked non-specific mental retardation in patients with X-linked ichthyosis.
Array-CGH characterization of a de novo t(X;Y)(p22;q11) in a female with short stature and mental retardation.
Mohn et al., Chieti, Italy. In Gene, 2012
The structure of the derivative X chromosome was studied using BAC array-CGH which disclosed the Xp22 breakpoint between the STS and the VCX3A gene and the presence of the Yq11.1qter
Intellectual disabilities, neuronal posttranscriptional RNA metabolism, and RNA-binding proteins: three actors for a complex scenario.
Melko et al., Antibes, France. In Prog Brain Res, 2011
Functional absence of some RNA-binding proteins--namely, FMRP, FMR2P, PQBP1, UFP3B, VCX-A--causes different forms of ID.
Modulation of neuritogenesis by a protein implicated in X-linked mental retardation.
Kiledjian et al., United States. In J Neurosci, 2009
We demonstrate that VCX-A can specifically bind a subset of mRNAs involved in neuritogenesis and is also capable of promoting translational silencing.
Atypical X-linked ichthyosis in a patient with a large deletion involving the steroid sulfatase (STS) gene.
Cuevas-Covarrubias et al., Mexico. In Int J Dermatol, 2009
PCR analysis showed deletion of the STS gene, markers DXS1139 and DXF22S1and the 5' end of the VCX3A gene.
Analysis of the VCX3A, VCX2 and VCX3B genes shows that VCX3A gene deletion is not sufficient to result in mental retardation in X-linked ichthyosis.
González-Huerta et al., Mexico. In Br J Dermatol, 2008
two different deletion patterns were observed: the first group included 62 patients with deletion of VCX3A & VCX genes. The second group included 18 patients with breakpoints at several regions on either side of the STS gene not including the VCX3A gene.
First reported case of intrachromosomal cryptic inv dup del Xp in a boy with developmental retardation.
Dupont et al., Paris, France. In Am J Med Genet A, 2007
(13.7 Mb) region including the STS, VCX-A and KAL1 genes, associated with a terminal Xp deletion Xp22.33-Xpter (3.6 Mb) encompassing the SHOX and ARSE genes.
Deletions of VCX-A and NLGN4: a variable phenotype including normal intellect.
Meiner et al., Jerusalem, Israel. In J Intellect Disabil Res, 2007
Previously, VCX-A (variably charged protein X-A), located at Xp22.3, was introduced as a gene for ID and its presence was suggested to be sufficient to maintain normal mental development.
Deletion of distal promoter of VCXA in a patient with X-linked ichthyosis associated with borderline mental retardation.
Ishii et al., Kashihara, Japan. In J Dermatol Sci, 2007
Recently, VCXA, which is located approximately 0.7Mb telomeric to the STS gene, was reported as a candidate gene for mental retardation (MR) in patients with XLI.
Identification of an mRNA-decapping regulator implicated in X-linked mental retardation.
Kiledjian et al., United States. In Mol Cell, 2007
Our data demonstrate that VCX-A can regulate mRNA stability and that it is an example of a tissue-specific decapping regulator.
Molecular cytogenetic analysis of a familial interstitial deletion Xp22.2-22.3 with a highly variable phenotype in female carriers.
Kehrer-Sawatzki et al., Ulm, Germany. In Am J Med Genet A, 2006
The deletion also includes all four VCX genes (VCX-A, VCX-B1, VCX-B, and VCX-C) and the neuroligin 4 (NLGN4) gene.
FG syndrome: linkage analysis in two families supporting a new gene localization at Xp22.3 [FGS3].
Briault et al., Tours, France. In Am J Med Genet, 2002
In this region, two potential candidate genes, VCX-A and PRKX, were excluded by sequence analysis of the coding region in patients of the two reported FG families.
Genes responsible for nonspecific mental retardation.
Milà et al., Barcelona, Spain. In Mol Genet Metab, 2001
Eight genes involved in nonspecific X-linked MR have been identified so far, including FMR2, OPHN1, GDI1, PAK3, IL1RAPL, TM4SF2, VCX-A, and ARHGEF6.
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