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Vav 3 oncogene

This gene is a member of the VAV gene family. The VAV proteins are guanine nucleotide exchange factors (GEFs) for Rho family GTPases that activate pathways leading to actin cytoskeletal rearrangements and transcriptional alterations. This gene product acts as a GEF preferentially for RhoG, RhoA, and to a lesser extent, RAC1, and it associates maximally with the nucleotide-free states of these GTPases. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: NBS1, HAD, Akt, CAN, Vav2
Papers on Vav3
Rac1/p21-activated kinase pathway controls retinoblastoma protein phosphorylation and E2F transcription factor activation in B lymphocytes.
Zugaza et al., Spain. In Febs J, Jan 2016
In this study, using immortalized chicken DT40 B cell lines to investigate the role of the Vav/Rac signalling cascade on B cell proliferation, it is shown that the proliferative response triggered by B cell receptor activation is dramatically reduced in the absence of Vav3 expression.
MicroRNA-31 is a positive modulator of endothelial-mesenchymal transition and associated secretory phenotype induced by TGF-β.
Miyazono et al., Tokyo, Japan. In Genes Cells, Jan 2016
We identified VAV3, a regulator of actin remodeling and MRTF-A activity, as a miR-31 target.
Age-related obesity and type 2 diabetes dysregulate neuronal associated genes and proteins in humans.
Rezaee et al., Groningen, Netherlands. In Oncotarget, Nov 2015
BAG3 up-regulated, VAV3 and APOA1 down-regulated) highly differentially expressed genes with neuronal functions as compared to control tissues.
VAV3 Overexpressed in Cancer Stem Cells Is a Poor Prognostic Indicator in Ovarian Cancer Patients.
An et al., South Korea. In Stem Cells Dev, Aug 2015
GSC (4.26-fold), VAV3 (7.05-fold), FOXA2 (12.06-fold),
Differential Gene Expression of the Proto-oncogene VAV3 and the Transcript Variant VAV3.1 in Oral Squamous Cell Carcinoma.
Sieg et al., Lübeck, Germany. In Anticancer Res, May 2015
The VAV proteins VAV1, VAV2 and VAV3 have been identified as important molecules in tumorigenesis, tumor growth and cell migration.
Establishment of a DNA methylation marker to evaluate cancer cell fraction in gastric cancer.
Ushijima et al., Tokyo, Japan. In Gastric Cancer, Mar 2015
RESULTS: Genome-wide DNA methylation analysis of 12 GC cell lines, 30 GCs, six normal gastric mucosae, one sample of peripheral leukocytes, and four noncancerous gastric mucosae identified OSR2, PPFIA3, and VAV3 as barely methylated in normal cells and highly methylated in cancer cells.
Identification of a Hashimoto thyroiditis susceptibility locus via a genome-wide comparison with Graves' disease.
Sasazuki et al., Fukuoka, Japan. In J Clin Endocrinol Metab, Feb 2015
RESULTS: A genome-wide direct comparison between HT and GD revealed an SNP at the VAV3 locus with genome-wide significant association signals (rs7537605: P(combined) = 3.90 × 10(-8); odds ratio(combined) = 1.77; 95% confidence interval = 1.44-2.17).
Immunohistochemical analysis of the natural killer cell cytotoxicity pathway in human abdominal aortic aneurysms.
Kuivaniemi et al., Berlin, Germany. In Int J Mol Sci, 2014
We followed up the microarray studies by immunohistochemical analyses using antibodies against nine members of the NK pathway (VAV1, VAV3, PLCG1, PLCG2, HCST, TYROBP, PTK2B, TNFA, and GZMB) and aortic tissue samples from AAA repair operations (n = 6) and control aortae (n = 8) from age-, sex- and ethnicity-matched donors from autopsies.
Genome Wide Association Analysis Reveals New Production Trait Genes in a Male Duroc Population.
Li et al., Beijing, China. In Plos One, 2014
The Gene ontology analysis identified 14 candidate genes close to significant single nucleotide polymorphisms, with growth-related functions: six for days to 100 KG (WT1, FBXO3, DOCK7, PPP3CA, AGPAT9, and NKX6-1), seven for food conversion ratio (MAP2, TBX15, IVL, ARL15, CPS1, VWC2L, and VAV3), and one for average daily gain (COL27A1).
MiR-183 Regulates ITGB1P Expression and Promotes Invasion of Endometrial Stromal Cells.
Shi et al., Nanjing, China. In Biomed Res Int, 2014
Using microarray analysis, we identified 27 differentially expressed genes (19 were upregulated and 8 downregulated), from which we selected 4 downregulated genes (ITGB1, AMIGO2, VAV3, and PSEN2) based on GO databases for functional analysis and significant pathway analysis.
VAV3 oncogene expression in colorectal cancer: clinical aspects and functional characterization.
Lin et al., Tainan City, Taiwan. In Sci Rep, 2014
In this study, we investigated the involvement of the VAV3 oncogene in tumor progression and in the prognosis of human CRC.
Genome-wide association study of susceptibility loci for breast cancer in Sardinian population.
Palmieri et al., Sassari, Italy. In Bmc Cancer, 2014
Only SNP rs345299, located in intron 1 of VAV3, remained suggestively associated (p-value, 1.16 x 10(-5)), but it did not associate with breast cancer risk in pooled data from two large, mixed-population cohorts.
Discovery of new risk loci for IgA nephropathy implicates genes involved in immunity against intestinal pathogens.
Gharavi et al., New York City, United States. In Nat Genet, 2014
We identified six new genome-wide significant associations, four in ITGAM-ITGAX, VAV3 and CARD9 and two new independent signals at HLA-DQB1 and DEFA.
Transcriptome analysis on the inflammatory cell infiltration of nonalcoholic steatohepatitis in bama minipigs induced by a long-term high-fat, high-sucrose diet.
Li et al., Beijing, China. In Plos One, 2013
Moreover, we identified several differentially expressed inflammation-related genes between the two groups, including FOS, JUN, TLR7, MYC, PIK3CD, VAV3, IL2RB and IL4R, that could be potential targets for further investigation.
Functional consequences of somatic mutations in cancer using protein pocket-based prioritization approach.
Zhao et al., Nashville, United States. In Genome Med, 2013
Using a statistical framework, we identified four putative cancer genes (RWDD1, NCF1, PLEK, and VAV3), whose expression profiles were associated with overall poor survival rates in melanoma, lung, or colorectal cancer patients.
Vav3 collaborates with p190-BCR-ABL in lymphoid progenitor leukemogenesis, proliferation, and survival.
Cancelas et al., Cincinnati, United States. In Blood, 2012
Vav3 collaborates with p190-BCR-ABL in lymphoid progenitor leukemogenesis, proliferation, and survival.
Vav3-rac1 signaling regulates prostate cancer metastasis with elevated Vav3 expression correlating with prostate cancer progression and posttreatment recurrence.
Wang et al., Taiwan. In Cancer Res, 2012
Among patients with stage IIB or earlier prostate cancer, higher Vav3 expression correlated with lower cumulative biochemical failure-free survival, suggesting that Vav3 may represent a prognostic marker for posttreatment recurrence of prostate cancer.
Clinical significance of increased guanine nucleotide exchange factor Vav3 expression in human gastric cancer.
Uen et al., Tainan City, Taiwan. In Mol Cancer Res, 2012
Study suggests that overexpression of guanine nucleotide exchange factor Vav3 can be a useful marker for predicting the outcome of patients with gastric cancer and that Vav3 targeting can represent a potential modality for treating gastric cancer.
The β-glucan receptor Dectin-1 activates the integrin Mac-1 in neutrophils via Vav protein signaling to promote Candida albicans clearance.
Mayadas et al., Boston, United States. In Cell Host Microbe, 2012
Dectin-1 activates the integrin Mac-1 in neutrophils via Vav1 and Vav3 signaling to promote Candida albicans clearance.
Novel associations for hypothyroidism include known autoimmune risk loci.
Do et al., Mountain View, United States. In Plos One, 2011
Novel associations for hypothyroidism and autoimmune risk loci include SNPs near the VAV3 gene.
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