Vav2 is required for cell spreading
In The Journal of Cell Biology, 1994
... Mutations in the DH and PH domains were generated in T7 epitope–tagged Vav2 in pCMV5 using the Transformer site–directed mutagenesis kit (CLONTECH Laboratories, Inc.) ...
Identification of melanoma biomarkers based on network modules by integrating the human signaling network with microarrays.
Shanghai, China. In J Cancer Res Ther, 2014
Finally, we acquired six significant molecular biomarkers, namely, module 10 (CALM3, Ca 2+ , PKC, PDGFRA, phospholipase-g, PIB5PA, and phosphatidylinositol-3-kinase), module 14 (SRC, Src homology 2 domain-containing [SHC], SAM68, GIT1, transcription factor-4, CBLB, GRB2, VAV2, LCK, YES, PTCH2, downstream of tyrosine kinase [DOK], and KIT), module 16 (ELK3, p85beta, SHC, ZFYVE9, TGFBR1, TGFBR2, CITED1, SH3KBP1, HCK, DOK, and KIT), module 45 (RB, CCND3, CCNA2, CDK4, and CDK6), module 75 (PCNA, CDK4, and CCND1), and module 114 (PSD93, NMDAR, and FYN).
Molecular genetic analysis of primary open-angle glaucoma, normal tension glaucoma, and developmental glaucoma for the VAV2 and VAV3 gene variants in Japanese subjects.
Shenyang, China. In Biochem Biophys Res Commun, 2013
We studied 168 unrelated Japanese patients with primary open-angle glaucoma (POAG), 163 unrelated Japanese patients with normal tension glaucoma (NTG), 45 unrelated Japanese patients with developmental glaucoma (DG), and 180 ethnically matched normal controls, to determine whether variants in the vav 2 guanine nucleotide exchange factor (VAV2) and vav 3 guanine nucleotide exchange factor (VAV3) genes are associated with POAG, NTG, or DG in the Japanese.
Structure and function of vav.
Paris, France. In Cell Signal, 1996
However, recently an homologue of vav, which is widely expressed (vav2) has been identified.