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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Vasodilator-stimulated phosphoprotein

Vasodilator-stimulated phosphoprotein (VASP) is a member of the Ena-VASP protein family. Ena-VASP family members contain an EHV1 N-terminal domain that binds proteins containing E/DFPPPPXD/E motifs and targets Ena-VASP proteins to focal adhesions. In the mid-region of the protein, family members have a proline-rich domain that binds SH3 and WW domain-containing proteins. Their C-terminal EVH2 domain mediates tetramerization and binds both G and F actin. VASP is associated with filamentous actin formation and likely plays a widespread role in cell adhesion and motility. VASP may also be involved in the intracellular signaling pathways that regulate integrin-extracellular matrix interactions. VASP is regulated by the cyclic nucleotide-dependent kinases PKA and PKG. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: Actin, V1a, CAN, HAD, P2Y12
Papers using VASP antibodies
Soluble guanylyl cyclase activation by HMR-1766 (ataciguat) in cells exposed to oxidative stress
Behm David J. et al., In Frontiers in Pharmacology, 2007
... ) VASP, rabbit polyclonal Ab, Cell Signaling Technology, Danvers, MA, USA] ...
Neuronal AKAP150 coordinates PKA and Epac mediated PKB/Akt phosphorylation
Schmidt Martina et al., In Respiratory Research, 2007
... The anti-phospho-ERK1/2 (P-ERK1/2) (9101), anti-ERK1/2 (9102) and anti-VASP which also binds to phospho-VASP (P-VASP) (3112) were from Cell Signaling Technology (Beverly, MA) ...
Absorption, metabolism, and excretion of
Schulz Christian, In PLoS ONE, 2006
... and PAC-1-FITC antibodies were obtained from Becton Dickenson (Vienna, Austria), CD41 antibody from Invitrogen and VASP (pSer 157)-FITC from Acris Antibodies (Herford, Germany) ...
Rac1 is crucial for hair follicle integrity but is not essential for maintenance of the epidermis
Arkowitz Robert Alan, In PLoS ONE, 2005
... monoclonal anti-IQGAP2 (Clone BB9), Upstate, MA, USA; polyclonal anti-MRCK alpha, Santa Cruz Biotechnology, CA, USA; anti-VASP, rhodamin-phalloidin; peroxidase-conjugated goat anti-mouse IgG and goat anti-rabbit IgG, Rockland, PA, USA; polyclonal Sra-1 ...
Rapid actin transport during cell protrusion
Parsons Maddy et al., In The Journal of Cell Biology, 2002
... UK); rabbit anti-FN (2413; Abcam); control IgG (Dako); glyceraldehyde 3-phosphate dehydrogenase (GAPDH; Sigma-Aldrich); rabbit anti-S157(P) VASP (3111; Cell Signaling Technology); rabbit anti-VASP (2010) ...
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Papers on VASP
HEK293 cells exposed to microcystin-LR show reduced protein phosphatase 2A activity and more stable cytoskeletal structure when overexpressing α4 protein.
Xu et al., Hangzhou, China. In Environ Toxicol, Feb 2016
However, the assembly of actin filament and microtubules remained unchanged and the expression and phosphorylation of the cytoskeleton-related proteins HSP27 and VASP did not increase significantly.
Mechanistic insights into the phosphatidylinositol binding properties of the pleckstrin homology domain of lamellipodin.
Manna et al., Guwāhāti, India. In Mol Biosyst, Feb 2016
Lpd promotes actin polymerization with the help of members of the Ena/VASP family of actin regulators and tethering them to actin filaments.
Resveratrol Protects and Restores Endothelium-Dependent Relaxation in Hypercholesterolemic Rabbit Corpus Cavernosum.
Esen et al., İzmir, Turkey. In J Sex Med, Jan 2016
In order to elucidate the possible molecular mechanisms, we measured endothelial NO synthase (eNOS) and phosphovasodilator-stimulated phosphoprotein (VASP) expressions and activations, NADPH oxidase, superoxide dismutase (SOD), and catalase (CAT) and glutathione peroxidase (GPx) activity in cavernosal tissues obtained at the end of the study.
The E3 Ubiquitin Ligase TRIM9 Is a Filopodia Off Switch Required for Netrin-Dependent Axon Guidance.
Gupton et al., Chapel Hill, United States. In Dev Cell, Jan 2016
Here, we demonstrate that TRIM9, an E3 ubiquitin ligase that localizes to filopodia tips and binds the netrin receptor DCC, interacts with and ubiquitinates the barbed-end polymerase VASP to modulate filopodial stability during netrin-dependent axon guidance.
Vasorelaxant Effect of a New Hydrogen Sulfide-Nitric Oxide Conjugated Donor in Isolated Rat Aortic Rings through cGMP Pathway.
Zhu et al., Shanghai, China. In Oxid Med Cell Longev, Dec 2015
ZYZ-803 increased cGMP level and the activity of vasodilator stimulated phosphoprotein (VASP) in aortic rings, and those effects could be suppressed by the inhibitory generation of H2S and NO.
Definition of a consensus integrin adhesome and its dynamics during adhesion complex assembly and disassembly.
Humphries et al., Manchester, United Kingdom. In Nat Cell Biol, Dec 2015
The consensus adhesome is likely to represent a core cell adhesion machinery, centred around four axes comprising ILK-PINCH-kindlin, FAK-paxillin, talin-vinculin and α-actinin-zyxin-VASP, and includes underappreciated IAC components such as Rsu-1 and caldesmon.
Bleeding and stent thrombosis on P2Y12-inhibitors: collaborative analysis on the role of platelet reactivity for risk stratification after percutaneous coronary intervention.
Sibbing et al., New York City, United States. In Eur Heart J, Aug 2015
Based on best available evidence for each device (exploratory studies), LPR-OPR-HPR categories were defined as <95, 95-208, and >208 PRU for VerifyNow, <19, 19-46, and >46 U for the Multiplate analyser and <16, 16-50, and >50% for VASP assay.
PDE3A mutations cause autosomal dominant hypertension with brachydactyly.
Bähring et al., Berlin, Germany. In Nat Genet, Jun 2015
Levels of phosphorylated VASP were diminished, and PTHrP levels were dysregulated.
Virulent Burkholderia species mimic host actin polymerases to drive actin-based motility.
Welch et al., Berkeley, United States. In Cell, May 2015
In contrast, B. pseudomallei and B. mallei BimA mimic host Ena/VASP actin polymerases in their ability to nucleate, elongate, and bundle filaments by associating with barbed ends, as well as in their use of WH2 motifs and oligomerization for activity.
The role of actin-binding proteins in the control of endothelial barrier integrity.
Schnoor et al., Mexico. In Thromb Haemost, 2015
Several studies have recently been published highlighting the importance of actin-binding molecules such as cortactin, ezrin/radixin/moesin, Arp2/3, VASP or WASP for the control of vascular permeability by various mechanisms.
VASP, zyxin and TES are tension-dependent members of Focal Adherens Junctions independent of the α-catenin-vinculin module.
de Rooij et al., Utrecht, Netherlands. In Sci Rep, 2014
Here we identify the actin-regulators VASP, zyxin and TES as members of punctate, tensile cadherin-based junctions called Focal Adherens Junctions (FAJ) and show that they display mechanosensitive recruitment similar to that of vinculin.
Generation of contractile actomyosin bundles depends on mechanosensitive actin filament assembly and disassembly.
Lappalainen et al., Helsinki, Finland. In Elife, 2014
Importantly, this myosin II-derived force inhibits vectorial actin polymerization at focal adhesions through AMPK-mediated phosphorylation of VASP, and thereby halts stress fiber elongation and ensures their proper contractility.
Capping protein regulators fine-tune actin assembly dynamics.
Cooper et al., Saint Louis, United States. In Nat Rev Mol Cell Biol, 2014
Filament elongation factors, such as formins and ENA/VASP (enabled/vasodilator-stimulated phosphoprotein), indirectly regulate CP by competing with CP for binding to the barbed end, whereas other molecules, including V-1 and phospholipids, directly bind to CP and sterically block its interaction with the filament.
Steering cell migration: lamellipodium dynamics and the regulation of directional persistence.
Gautreau et al., Gif-sur-Yvette, France. In Nat Rev Mol Cell Biol, 2014
Recently, advances have been made in our understanding of positive and negative ARP2/3 regulators (such as the SCAR/WAVE (SCAR/WASP family verprolin-homologous protein) complex and Arpin, respectively) and of proteins that control actin branch stability (such as glial maturation factor (GMF)) or actin filament elongation (such as ENA/VASP proteins) in lamellipodium dynamics and cell migration.
Superfamily of G-protein coupled receptors (GPCRs)--extraordinary and outstanding success of evolution.
Kochman, Panama. In Postepy Hig Med Dosw (online), 2013
GPCRs can also interact with the Enabled/VASP homology (EVH)-like domain which interacts directly with group 1 mGluR receptors.
A phosphatidylinositol lipids system, lamellipodin, and Ena/VASP regulate dynamic morphology of multipolar migrating cells in the developing cerebral cortex.
Nakajima et al., Tokyo, Japan. In J Neurosci, 2012
The results of this study suggested that that PI(3,4)P2, Lpd, and Ena/VASP are involved in the process movement of multipolar migrating cells.
HIF-1α acts downstream of TNF-α to inhibit vasodilator-stimulated phosphoprotein expression and modulates the adhesion and proliferation of breast cancer cells.
Wei et al., Wuhan, China. In Dna Cell Biol, 2012
a novel TNF-alpha/HIF-1alpha/VASP axis in which HIF-1alpha acts downstream of TNF-alpha to inhibit VASP expression and modulate the adhesion and proliferation of breast cancer cells
Abl-1-bridged tyrosine phosphorylation of VASP by Abelson kinase impairs association of VASP to focal adhesions and regulates leukaemic cell adhesion.
Watanabe et al., Sendai, Japan. In Biochem J, 2012
The phosphorylation and dephosphorylation cycle of VASP by the Abi-1-bridged mechanism regulates association of VASP with focal adhesions, which may regulate adhesion of Bcr-Abl-transformed leukaemic cells.
β2-adrenergic receptor agonists modulate human airway smooth muscle cell migration via vasodilator-stimulated phosphoprotein.
Panettieri et al., Philadelphia, United States. In Am J Respir Cell Mol Biol, 2012
Prolonged treatment with albuterol prevents the agonist-induced phosphorylation of VASP at Ser157.
Phosphorylation of vasodilator-stimulated phosphoprotein (VASP) dampens hepatic ischemia-reperfusion injury.
Rosenberger et al., Tübingen, Germany. In Plos One, 2010
studies identified VASP and VASP phosphorylation as crucial target for future hepatoprotective strategies
More papers using VASP antibodies
A new generation of Ca2+ indicators with greatly improved fluorescence properties
Pintus Gianfranco, In PLoS ONE, 1984
... phospho-AMPK (Thr172), phospho-Akt (Ser473), phospho-ACC (Ser79), phospho-MEK1/2 (Ser217/212), phospho-ERK1/2 (Thr202/Tyr204), AMPK, Akt, ACC, MEK1/2, ERK1/2, phospho-VASP (Ser157), and H-89 were from Cell Signaling Technologies (Beverly, MA) ...
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