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Vascular endothelial growth factor A

vascular endothelial growth factor, VEGF, Vascular Endothelial Growth Factor A
This gene is a member of the PDGF/VEGF growth factor family and encodes a protein that is often found as a disulfide linked homodimer. This protein is a glycosylated mitogen that specifically acts on endothelial cells and has various effects, including mediating increased vascular permeability, inducing angiogenesis, vasculogenesis and endothelial cell growth, promoting cell migration, and inhibiting apoptosis. Elevated levels of this protein is linked to POEMS syndrome, also known as Crow-Fukase syndrome. Mutations in this gene have been associated with proliferative and nonproliferative diabetic retinopathy. Alternatively spliced transcript variants, encoding either freely secreted or cell-associated isoforms, have been characterized. There is also evidence for the use of non-AUG (CUG) translation initiation sites upstream of, and in-frame with the first AUG, leading to additional isoforms. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: CAN, HAD, V1a, KDR, AGE
Papers using vascular endothelial growth factor antibodies
Podocyte vascular endothelial growth factor (Vegf164) overexpression causes severe nodular glomerulosclerosis in a mouse model of type I diabetes.
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Chatziantoniou Christos, In PLoS ONE, 2010
... A shRNA targeting the first exon of mouse VEGF (Acc# M95200.1) was selected using siRNA Designer algorithm (Clontech).
Overexpression of von Hippel–Lindau protein synergizes with doxorubicin to suppress hepatocellular carcinoma in mice
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El-Rifai Wael, In PLoS ONE, 2010
... Antibody against VEGF was acquired from Abcam Inc ...
Magnetic/silica nanocomposites as dual-mode contrast agents for combined magnetic resonance imaging and ultrasonography
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Chen Yuh-Lien et al., In International Journal of Nanomedicine, 2010
... To bind the anti-VEGF Abs (sc507; Santa Cruz Biotechnology, Santa Cruz, CA) to ...
A thrombospondin-mimetic peptide, ABT-898, suppresses angiogenesis and promotes follicular atresia in pre- and early-antral follicles in vivo.
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Addison Christina Lynn, In PLoS ONE, 2009
... Mouse anti-VEGF receptor 2 antibody was from Cell Signaling Technology ...
Sunitinib malate for gastrointestinal stromal tumour in imatinib mesylate-resistant patients: recommendations and evidence
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Fassnacht Martin et al., In Frontiers in Endocrinology, 2009
... Primary antibodies were VEGF-R2 monoclonal mouse antibody (Flk-1), used in a dilution of 1:250 and VEGF antibody A-20 in a dilution of 1:100 (both antibodies from Santa Cruz Biotechnology, Heidelberg, Germany) ...
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Papers on vascular endothelial growth factor
Compound A Inhibits Bladder Cancer Growth Predominantly via Glucocorticoid Receptor Transrepression.
New
Miyamoto et al., Hangzhou, China. In Mol Endocrinol, 01 Oct 2015
Correspondingly, the expression of NF-κB-related molecules, MMP-2, MMP-9, IL-6, and VEGF, was significantly down-regulated by CpdA in control lines, but not in GR-silencing cells.
Lack of EC-SOD worsens alveolar and vascular development in a neonatal mouse model of bleomycin-induced bronchopulmonary dysplasia and pulmonary hypertension.
New
Nozik-Grayck et al., Dallas, United States. In Pediatr Res, 01 Oct 2015
Disruption in the VEGF and nitric oxide signaling pathways contributes to BPD.
Nasopharyngeal carcinoma.
New
Impact
Chan et al., Singapore, Singapore. In Lancet, 27 Sep 2015
Among the exciting developments in nasopharyngeal carcinoma, vascular endothelial growth factor inhibition and novel immunotherapies targeted at immune checkpoint and EBV-specific tumour antigens offer promising alternatives to patients with metastatic disease.
Adipose tissue-derived stem cells as a therapeutic tool for cardiovascular disease.
New
Nishimatsu et al., Kawasaki, Japan. In World J Cardiol, 26 Sep 2015
ADSCs also produce a variety of paracrine factors such as vascular endothelial growth factor, hepatocyte growth factor, and insulin-like growth factor-1 that have proangiogenic and/or antiapoptotic activities.
Trebananib (AMG 386) in Combination With Sunitinib in Patients With Metastatic Renal Cell Cancer: An Open-Label, Multicenter, Phase II Study.
New
Impact
Ravaud et al., Bordeaux, France. In J Clin Oncol, 24 Sep 2015
This phase II study was conducted to evaluate trebananib plus sunitinib, a vascular endothelial growth factor receptor inhibitor, in patients with metastatic clear cell renal cell carcinoma.
The cellular response to vascular endothelial growth factors requires co-ordinated signal transduction, trafficking and proteolysis.
Review
New
Ponnambalam et al., Leeds, United Kingdom. In Biosci Rep, 18 Sep 2015
Such responses are initiated by VEGF binding to soluble and membrane-bound VEGFRs (VEGF receptor tyrosine kinases) and co-receptors.
Thioredoxin-1 (Trx1) engineered mesenchymal stem cell therapy increased pro-angiogenic factors, reduced fibrosis and improved heart function in the infarcted rat myocardium.
New
Maulik et al., Farmington, United States. In Int J Cardiol, 15 Sep 2015
Western blot analysis, 4days after treatment showed increased vascular endothelial growth factor (VEGF), heme oxygenase-1 (HO-1), and C-X-C chemokine receptor type 4 (CXCR4).
Long-Pentraxin 3 Derivative as a Small-Molecule FGF Trap for Cancer Therapy.
New
Impact
Presta et al., Brescia, Italy. In Cancer Cell, 10 Sep 2015
The fibroblast growth factor (FGF)/FGF receptor (FGFR) system plays a crucial role in cancer by affecting tumor growth, angiogenesis, drug resistance, and escape from anti-angiogenic anti-vascular endothelial growth factor therapy.
VEGF-Mediated Induction of PRD1-BF1/Blimp1 Expression Sensitizes Tumor Vasculature to Oncolytic Virus Infection.
New
Impact
Bell et al., Ottawa, Canada. In Cancer Cell, 10 Sep 2015
We show here that this expanded tropism of oncolytic vaccinia virus to the endothelial compartment is a consequence of VEGF-mediated suppression of the intrinsic antiviral response.
Generation of vascular endothelial and smooth muscle cells from human pluripotent stem cells.
New
Impact
Cowan et al., Basel, Switzerland. In Nat Cell Biol, 31 Aug 2015
We found that GSK3 inhibition and BMP4 treatment rapidly committed pluripotent cells to a mesodermal fate and subsequent exposure to VEGF-A or PDGF-BB resulted in the differentiation of either endothelial or vascular smooth muscle cells, respectively.
Individualized Treatment of Neovascular Age-Related Macular Degeneration: What are Patients Gaining? Or Losing?
Review
New
Stewart, Jacksonville, United States. In J Clin Med, Dec 2014
The widespread use of drugs that bind diffusible vascular endothelial growth factor (VEGF) has revolutionized the treatment of neovascular age-related macular degeneration (AMD).
Polypoidal Choroidal Vasculopathy in Asians.
Review
New
Cheung et al., Singapore, Singapore. In J Clin Med, Dec 2014
While the standard of care for CNV-AMD is anti-vascular endothelial growth factor (VEGF) therapy, photodynamic therapy (PDT) has been the mainstay of treatment for PCV, although long-term visual prognosis remains unsatisfactory.
[Adverse cardiac effects associated with anticancer drugs].
Review
New
Kerkelä et al., In Duodecim, Dec 2014
Treatments targeting VEGF inhibition are frequently associated with significant elevation of blood pressure.
Anti-angiogenesis or pro-angiogenesis for cancer treatment: focus on drug distribution.
Review
New
Mou et al., Hangzhou, China. In Int J Clin Exp Med, Dec 2014
In the past years, the vascular normalization theory has gained widespread acceptance for explaining additional antitumor effects of inhibitors of vascular endothelial growth factor (VEGF) signaling, when combined with chemotherapeutics.
Circulating endothelial progenitor cells are reduced in rat oxygen-induced retinopathy despite a retinal SDF-1/CXCR4 and VEGF proangiogenic response.
GeneRIF
Fernández-Durango et al., Madrid, Spain. In Life Sci, 2012
We found increased levels of CXCR4 and VEGF mRNA in OIR retinas, especially during the vascular attenuation stage
Vascular endothelial growth factor-induced osteopontin expression mediates vascular inflammation and neointima formation via Flt-1 in adventitial fibroblasts.
GeneRIF
Gao et al., Shanghai, China. In Arterioscler Thromb Vasc Biol, 2012
VEGF/Flt-1 signaling plays a significant role in vascular inflammation and neointima formation by regulating osteopontin expression in vascular adevntitial fibroblasts.
Intracellular VEGF regulates the balance between osteoblast and adipocyte differentiation.
GeneRIF
Olsen et al., Boston, United States. In J Clin Invest, 2012
VEGF controls differentiation in mesenchymal stem cells by regulating the transcription factors RUNX2 and PPARgamma2 as well as through a reciprocal interaction with nuclear envelope proteins lamin A and C.
Current evidence on VEGF+405G/C polymorphism and malignancy susceptibility: a meta-analysis involving 30 studies.
GeneRIF
Zhang et al., Nanning, China. In Twin Res Hum Genet, 2012
Our meta-analysis indicated a weak association of VEGF+405G/C polymorphism with malignancy susceptibility in Africans, no persuasive evidence of association between the polymorphism and malignancy susceptibility was detected in the pooled analyses.
Quantification of tumour and circulating vascular endothelial growth factor (VEGF) in patients with oesophagogastric cancer: a long-term follow-up study.
GeneRIF
Spence et al., United Kingdom. In Br J Biomed Sci, 2011
analysis of tumour and circulating vascular endothelial growth factor (VEGF) in patients with oesophagogastric cancer
Evaluation of Copper, Zinc, Cu/Zn, and VEGF in Patients with AML in Iran.
Biorani et al., Tabrīz, Iran. In Iran J Cancer Prev, 2010
Copper (Cu) has an important role in angiogenesis and acts by increasing Vascular Endothelial Growth Factor (VEGF).
More papers using vascular endothelial growth factor antibodies
Magnetically enhanced high-specificity virus detection using bio-activated magnetic nanoparticles with antibodies as labeling markers
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Yang Hong-Chang et al., In International Journal of Nanomedicine, 2009
... MO), conjugated bilirubin (C-BL) (14370-250MG; Sigma), triglyceride (TG) (T2449-10ML, Sigma), and vascular endothelial growth factor (VEGF) (sc-7269; Santa Cruz Biotechnology, Santa Cruz, CA), were ...
Endothelial precursors in vascular repair
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Wu Zhongshi et al., In International Journal of Nanomedicine, 2009
... Human recombinant VEGF-165 was purchased from Cell Signaling technology (Danvers, MA) ...
Gambogic acid inhibits angiogenesis through suppressing vascular endothelial growth factor-induced tyrosine phosphorylation of KDR/Flk-1
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Chen Baoan et al., In International Journal of Nanomedicine, 2006
... Monoclonal antibodies, including ETS1, cyclin D1, u-PA, and VEGF, were purchased from Santa Cruz Biotechnology (Santa Cruz, CA) ...
Reducible poly(amido ethylenimine) directed to enhance RNA interference
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Zhang Qiang et al., In International Journal of Nanomedicine, 2006
... Human VEGF ELISA Kit was purchased from RayBiotech, Inc (Norcross, GA).
Increased lymphangiogenesis in joints of mice with inflammatory arthritis
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Detmar Michael et al., In The Journal of Experimental Medicine, 2006
... Increased microvascular density and enhanced leukocyte rolling and adhesion in the skin of VEGF transgenic mice ...
The Tol2kit: A multisite gateway-based construction kit for Tol2 transposon transgenesis constructs
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Jin Suk-Won et al., In Nature cell biology, 2006
... Hyperplasia of lymphatic vessels in VEGF-C transgenic mice ...
Aminopeptidase N/CD13 induces angiogenesis through interaction with a pro-angiogenic protein, galectin-3
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Panjwani Noorjahan et al., In The Journal of Experimental Medicine, 2006
... Recombinant VEGF-A was obtained from Cell Sciences and R&D Systems ...
Augmentation of tumor angiogenesis by a Myc-activated microRNA cluster.
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Oshima Robert, In PLoS ONE, 2005
... antibodies for phosphor-H2AX, Ser 139, (γH2AX) (BioLegend, San Diego, CA, USA), vascular endothelial growth factor (VEGF, Santa Cruz Biotechnology), thrombospondin -1 (TSP-1) (Lab ...
A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration
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Opal Puneet et al., In Nature Medicine, 2005
... provided and characterized the VEGF transgenic mice ...
Pigment epithelium-derived factor (PEDF) inhibits advanced glycation end product-induced retinal vascular hyperpermeability by blocking reactive oxygen species-mediated vascular endothelial growth factor (VEGF) expression
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Tombran-Tink Joyce et al., In Journal of Ocular Biology, Diseases, and Informatics, 2005
... After this blocking step, slides were incubated for 2 h with rabbit polyclonal antibody directed against VEGF (Santa Cruz Biotechnology, Santa Cruz, CA, USA) ...
Bone morphogenetic protein 2 induces pulmonary angiogenesis via Wnt–β-catenin and Wnt–RhoA–Rac1 pathways
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Rabinovitch Marlene et al., In The Journal of Cell Biology, 2000
... Anti-VEGF and antisurvivin were obtained from Abcam.
QSAR study on the contribution of log P and Es to the in vitro antiprotozoal activity of glutathione derivatives
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Gaffney John et al., In BMC Cell Biology, 2000
... from Apollo Cytokine Research, (Cambridge, UK), EGF, VEGFR-1 and -2, FGFR-1 and -2, anti-FGF-2 and anti-VEGF antibodies were obtained from Santa Cruz Biotechnology (Heidelberg, GDR) ...
Fibroblast growth factor 2 control of vascular tone
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Mignatti Paolo et al., In The Journal of Cell Biology, 1997
... (Minneapolis, MN); anti-human VEGF antibody (αVEGF sc507) was purchased from Santa Cruz Biotechnology, Inc. ...
VEGF-A induces tumor and sentinel lymph node lymphangiogenesis and promotes lymphatic metastasis
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Detmar Michael et al., In The Journal of Experimental Medicine, 1997
... Generation of K14/GFP and of K14/GFP/VEGF-A transgenic mice.
New model for the study of angiogenesis and antiangiogenesis in the chick embryo chorioallantoic membrane: the gelatin sponge/chorioallantoic membrane assay.
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Ng Irene Oi-Lin, In PLoS ONE, 1996
... (goat polyclonal, Santa Cruz, Santa Cruz, CA, USA), anti-Laminin mAb (Biogenex, San Ramon, CA, USA), anti-VEGF-C mAb (Zymed, San Francisco, CA, USA), or anti- IL6 (rabbit polyclonal, Abcam, Cambridge, UK) ...
Apaf-1, a human protein homologous to C. elegans CED-4, participates in cytochrome c–dependent activation of caspase-3
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He Shaoheng et al., In International Journal of Molecular Sciences, 1996
... antibody was purchased from ProSci Incorporated (Poway, CA, USA), rabbit anti-human vascular endothelial growth factor (VEGF) polyclonal antibody was from Santa Cruz Biotechnology (Santa Cruz, CA, USA), ...
Pharmacology of oleanolic acid and ursolic acid.
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Bauer Joseph Alan, In PLoS ONE, 1994
... Antibodies against Bax (clone P-19), VEGF (clone C-1) and tubulin (clone b-7) were purchased from Santa Cruz Biotechnology (Santa Cruz, CA, USA) ...
Induction of beta-platelet-derived growth factor receptor in rat hepatic lipocytes during cellular activation in vivo and in culture.
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Emanueli Costanza, In PLoS ONE, 1993
... The responder tet-soluble VEGF-R1 transgenic line encodes a tetracycline-inducible protein ...
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