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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 22 May 2015.

Vascular endothelial growth factor A

vascular endothelial growth factor, VEGF, Vascular Endothelial Growth Factor A
This gene is a member of the PDGF/VEGF growth factor family and encodes a protein that is often found as a disulfide linked homodimer. This protein is a glycosylated mitogen that specifically acts on endothelial cells and has various effects, including mediating increased vascular permeability, inducing angiogenesis, vasculogenesis and endothelial cell growth, promoting cell migration, and inhibiting apoptosis. Elevated levels of this protein is linked to POEMS syndrome, also known as Crow-Fukase syndrome. Mutations in this gene have been associated with proliferative and nonproliferative diabetic retinopathy. Alternatively spliced transcript variants, encoding either freely secreted or cell-associated isoforms, have been characterized. There is also evidence for the use of non-AUG (CUG) translation initiation sites upstream of, and in-frame with the first AUG, leading to additional isoforms. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: CAN, V1a, KDR, HAD, AGE
Papers using vascular endothelial growth factor antibodies
Podocyte vascular endothelial growth factor (Vegf164) overexpression causes severe nodular glomerulosclerosis in a mouse model of type I diabetes.
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Chatziantoniou Christos, In PLoS ONE, 2010
... A shRNA targeting the first exon of mouse VEGF (Acc# M95200.1) was selected using siRNA Designer algorithm (Clontech).
Overexpression of von Hippel–Lindau protein synergizes with doxorubicin to suppress hepatocellular carcinoma in mice
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El-Rifai Wael, In PLoS ONE, 2010
... Antibody against VEGF was acquired from Abcam Inc ...
Magnetic/silica nanocomposites as dual-mode contrast agents for combined magnetic resonance imaging and ultrasonography
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Chen Yuh-Lien et al., In International Journal of Nanomedicine, 2010
... To bind the anti-VEGF Abs (sc507; Santa Cruz Biotechnology, Santa Cruz, CA) to ...
A thrombospondin-mimetic peptide, ABT-898, suppresses angiogenesis and promotes follicular atresia in pre- and early-antral follicles in vivo.
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Addison Christina Lynn, In PLoS ONE, 2009
... Mouse anti-VEGF receptor 2 antibody was from Cell Signaling Technology ...
Sunitinib malate for gastrointestinal stromal tumour in imatinib mesylate-resistant patients: recommendations and evidence
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Fassnacht Martin et al., In Frontiers in Endocrinology, 2009
... Primary antibodies were VEGF-R2 monoclonal mouse antibody (Flk-1), used in a dilution of 1:250 and VEGF antibody A-20 in a dilution of 1:100 (both antibodies from Santa Cruz Biotechnology, Heidelberg, Germany) ...
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Papers on vascular endothelial growth factor
Endothelium-derived essential signals involved in pancreas organogenesis.
Review
New
Dafoe et al., Los Angeles, United States. In World J Exp Med, 20 Jun 2015
By the end of the gestation and close to birth, these islets contain immature beta cells with the capacity to express vascular endothelial growth factor and therefore to recruit ECs from the surrounding microenvironment.
Angiogenesis in Glaucoma Filtration Surgery and Neovascular Glaucoma-A Review.
Review
New
Ying et al., Chicago, United States. In Surv Ophthalmol, 14 Jun 2015
Up regulation of vascular endothelial growth factor (VEGF), a key mediator of angiogenesis, occurs in eyes that have undergone glaucoma filtration surgery, as well as those with NVG.
Second-line dovitinib (TKI258) in patients with FGFR2-mutated or FGFR2-non-mutated advanced or metastatic endometrial cancer: a non-randomised, open-label, two-group, two-stage, phase 2 study.
New
Impact
Kristeleit et al., Los Angeles, United States. In Lancet Oncol, 13 Jun 2015
We assessed the safety and activity of dovitinib, a potent tyrosine-kinase inhibitor of fibroblast growth factor receptors, VEGF receptors, PDGFR-β, and c-KIT, as second-line therapy both in patients with FGFR2-mutated (FGFR2(mut)) endometrial cancer and in those with FGFR2-non-mutated (FGFR2(non-mut)) endometrial cancer.
Is the imbalance between pro-angiogenic and anti-angiogenic factors associated with preeclampsia?
Review
New
Dusse et al., Monte Santo de Minas, Brazil. In Clin Chim Acta, 13 Jun 2015
The inadequate placentation process results in a change in angiogenic factors levels, such as vascular endothelial growth factor (VEGF), placental growth factor (PlGF), soluble form of endoglin (s-Eng) and soluble form of vascular endothelial growth factor receptor type 1 (sFlt-1).
Pazopanib and depot octreotide in advanced, well-differentiated neuroendocrine tumours: a multicentre, single-group, phase 2 study.
New
Impact
Kulke et al., Houston, United States. In Lancet Oncol, 05 Jun 2015
Pazopanib is an orally bioavailable, small molecule, multitargeted kinase inhibitor that inhibits VEGF receptors 1, 2, and 3. We did a study of the efficacy of pazopanib with depot octreotide in patients with advanced NETs.
Slit2 signaling through Robo1 and Robo2 is required for retinal neovascularization.
New
Impact
Chédotal et al., Paris, France. In Nat Med, 31 May 2015
Vascular endothelial growth factor (VEGF) blockade improves vision, but not all individuals respond to anti-VEGF treatment, making additional means to prevent neovascularization necessary.
Targeted Therapy for NSCLC-A Double-edged Sword?
Review
New
Dempke, München, Germany. In Anticancer Res, 31 May 2015
Bevacizumab, a monoclonal antibody which targets vascular endothelium growth factor (VEGF), has been fully developed in NSCLC, and small-molecule tyrosin kinase inhibitors (TKIs) have been approved as first-line therapy for patients with advanced and metastatic NSCLC harbouring EGFR mutations.
Biodegradable silicon nanoneedles delivering nucleic acids intracellularly induce localized in vivo neovascularization.
New
Impact
Tasciotti et al., London, United Kingdom. In Nat Mater, 31 May 2015
Here, we show that a tunable array of biodegradable nanoneedles fabricated by metal-assisted chemical etching of silicon can access the cytosol to co-deliver DNA and siRNA with an efficiency greater than 90%, and that in vivo the nanoneedles transfect the VEGF-165 gene, inducing sustained neovascularization and a localized sixfold increase in blood perfusion in a target region of the muscle.
Ramucirumab versus placebo in combination with second-line FOLFIRI in patients with metastatic colorectal carcinoma that progressed during or after first-line therapy with bevacizumab, oxaliplatin, and a fluoropyrimidine (RAISE): a randomised, double-blind, multicentre, phase 3 study.
New
Impact
RAISE Study Investigators et al., Barcelona, Spain. In Lancet Oncol, 31 May 2015
Ramucirumab is a human IgG-1 monoclonal antibody that targets the extracellular domain of VEGF receptor 2. We assessed the efficacy and safety of ramucirumab versus placebo in combination with second-line FOLFIRI (leucovorin, fluorouracil, and irinotecan) for metastatic colorectal cancer in patients with disease progression during or after first-line therapy with bevacizumab, oxaliplatin, and a fluoropyrimidine.
Combined autologous bone marrow mononuclear cell and gene therapy as the last resort for patients with critical limb ischemia.
New
Garcarek et al., Wrocław, Poland. In Arch Med Sci, 25 May 2015
In the first group, administration of autologous bone marrow MNC and vascular endothelial growth factor (VEGF) plasmid was performed.
Polyunsaturated fatty acids augment tumoricidal action of 5-fluorouracil on gastric cancer cells by their action on vascular endothelial growth factor, tumor necrosis factor-α and lipid metabolism related factors.
New
Das et al., Hangzhou, China. In Arch Med Sci, 25 May 2015
MATERIAL AND METHODS: The human gastric cancer cell line MGC (undifferentiated) and human gastric cancer cell line SGC (semi-differentiated) were either 5-FU alone or a combination of 5-FU + PUFAs and their proliferation, and ability to secrete tumor necrosis factor-α (TNF-α) and vascular endothelial growth factor (VEGF) and lipid metabolism-related factors lipoprotein lipase (LPL), peroxisome proliferator-activated-γ (PPAR-γ), and CCAAT enhancer-binding protein (C/EBP) were investigated and analyzed.
Body protective compound-157 enhances alkali-burn wound healing in vivo and promotes proliferation, migration, and angiogenesis in vitro.
New
Zhang et al., Xi'an, China. In Drug Des Devel Ther, Dec 2014
We also observed that BPC-157 upregulated the expression of VEGF-a and accelerated vascular tube formation in vitro.
The mechanism of CCN1-enhanced retinal neovascularization in oxygen-induced retinopathy through PI3K/Akt-VEGF signaling pathway.
New
Chen et al., Shenyang, China. In Drug Des Devel Ther, Dec 2014
The roles of vascular endothelial growth factor (VEGF) in angiogenesis are well described.
Current and emerging treatment options for myopic choroidal neovascularization.
Review
New
Kort et al., Tunisia. In Clin Ophthalmol, Dec 2014
The purpose of this study is to provide an overview of the current treatments for mCNV, including laser, surgical management, verteporfin photodynamic therapy, and mainly anti-vascular endothelial growth factor therapy.
SIRT1 expression is associated with poor prognosis of lung adenocarcinoma.
New
Wu et al., Changzhou, China. In Onco Targets Ther, Dec 2014
In addition, anaplastic lymphoma kinase, epidermal growth factor receptor, vascular endothelial growth factor (VEGF), and Survivin expression were evaluated by fluorescent in situ hybridization or immunohistochemistry, respectively.
Circulating endothelial progenitor cells are reduced in rat oxygen-induced retinopathy despite a retinal SDF-1/CXCR4 and VEGF proangiogenic response.
GeneRIF
Fernández-Durango et al., Madrid, Spain. In Life Sci, 2012
We found increased levels of CXCR4 and VEGF mRNA in OIR retinas, especially during the vascular attenuation stage
Vascular endothelial growth factor-induced osteopontin expression mediates vascular inflammation and neointima formation via Flt-1 in adventitial fibroblasts.
GeneRIF
Gao et al., Shanghai, China. In Arterioscler Thromb Vasc Biol, 2012
VEGF/Flt-1 signaling plays a significant role in vascular inflammation and neointima formation by regulating osteopontin expression in vascular adevntitial fibroblasts.
Intracellular VEGF regulates the balance between osteoblast and adipocyte differentiation.
GeneRIF
Olsen et al., Boston, United States. In J Clin Invest, 2012
VEGF controls differentiation in mesenchymal stem cells by regulating the transcription factors RUNX2 and PPARgamma2 as well as through a reciprocal interaction with nuclear envelope proteins lamin A and C.
Current evidence on VEGF+405G/C polymorphism and malignancy susceptibility: a meta-analysis involving 30 studies.
GeneRIF
Zhang et al., Nanning, China. In Twin Res Hum Genet, 2012
Our meta-analysis indicated a weak association of VEGF+405G/C polymorphism with malignancy susceptibility in Africans, no persuasive evidence of association between the polymorphism and malignancy susceptibility was detected in the pooled analyses.
Quantification of tumour and circulating vascular endothelial growth factor (VEGF) in patients with oesophagogastric cancer: a long-term follow-up study.
GeneRIF
Spence et al., United Kingdom. In Br J Biomed Sci, 2011
analysis of tumour and circulating vascular endothelial growth factor (VEGF) in patients with oesophagogastric cancer
More papers using vascular endothelial growth factor antibodies
Magnetically enhanced high-specificity virus detection using bio-activated magnetic nanoparticles with antibodies as labeling markers
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Yang Hong-Chang et al., In International Journal of Nanomedicine, 2009
... MO), conjugated bilirubin (C-BL) (14370-250MG; Sigma), triglyceride (TG) (T2449-10ML, Sigma), and vascular endothelial growth factor (VEGF) (sc-7269; Santa Cruz Biotechnology, Santa Cruz, CA), were ...
Endothelial precursors in vascular repair
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Wu Zhongshi et al., In International Journal of Nanomedicine, 2009
... Human recombinant VEGF-165 was purchased from Cell Signaling technology (Danvers, MA) ...
Gambogic acid inhibits angiogenesis through suppressing vascular endothelial growth factor-induced tyrosine phosphorylation of KDR/Flk-1
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Chen Baoan et al., In International Journal of Nanomedicine, 2006
... Monoclonal antibodies, including ETS1, cyclin D1, u-PA, and VEGF, were purchased from Santa Cruz Biotechnology (Santa Cruz, CA) ...
Reducible poly(amido ethylenimine) directed to enhance RNA interference
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Zhang Qiang et al., In International Journal of Nanomedicine, 2006
... Human VEGF ELISA Kit was purchased from RayBiotech, Inc (Norcross, GA).
Increased lymphangiogenesis in joints of mice with inflammatory arthritis
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Detmar Michael et al., In The Journal of Experimental Medicine, 2006
... Increased microvascular density and enhanced leukocyte rolling and adhesion in the skin of VEGF transgenic mice ...
The Tol2kit: A multisite gateway-based construction kit for Tol2 transposon transgenesis constructs
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Jin Suk-Won et al., In Nature cell biology, 2006
... Hyperplasia of lymphatic vessels in VEGF-C transgenic mice ...
Aminopeptidase N/CD13 induces angiogenesis through interaction with a pro-angiogenic protein, galectin-3
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Panjwani Noorjahan et al., In The Journal of Experimental Medicine, 2006
... Recombinant VEGF-A was obtained from Cell Sciences and R&D Systems ...
Augmentation of tumor angiogenesis by a Myc-activated microRNA cluster.
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Oshima Robert, In PLoS ONE, 2005
... antibodies for phosphor-H2AX, Ser 139, (γH2AX) (BioLegend, San Diego, CA, USA), vascular endothelial growth factor (VEGF, Santa Cruz Biotechnology), thrombospondin -1 (TSP-1) (Lab ...
A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration
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Opal Puneet et al., In Nature Medicine, 2005
... provided and characterized the VEGF transgenic mice ...
Pigment epithelium-derived factor (PEDF) inhibits advanced glycation end product-induced retinal vascular hyperpermeability by blocking reactive oxygen species-mediated vascular endothelial growth factor (VEGF) expression
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Tombran-Tink Joyce et al., In Journal of Ocular Biology, Diseases, and Informatics, 2005
... After this blocking step, slides were incubated for 2 h with rabbit polyclonal antibody directed against VEGF (Santa Cruz Biotechnology, Santa Cruz, CA, USA) ...
Bone morphogenetic protein 2 induces pulmonary angiogenesis via Wnt–β-catenin and Wnt–RhoA–Rac1 pathways
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Rabinovitch Marlene et al., In The Journal of Cell Biology, 2000
... Anti-VEGF and antisurvivin were obtained from Abcam.
QSAR study on the contribution of log P and Es to the in vitro antiprotozoal activity of glutathione derivatives
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Gaffney John et al., In BMC Cell Biology, 2000
... from Apollo Cytokine Research, (Cambridge, UK), EGF, VEGFR-1 and -2, FGFR-1 and -2, anti-FGF-2 and anti-VEGF antibodies were obtained from Santa Cruz Biotechnology (Heidelberg, GDR) ...
Fibroblast growth factor 2 control of vascular tone
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Mignatti Paolo et al., In The Journal of Cell Biology, 1997
... (Minneapolis, MN); anti-human VEGF antibody (αVEGF sc507) was purchased from Santa Cruz Biotechnology, Inc. ...
VEGF-A induces tumor and sentinel lymph node lymphangiogenesis and promotes lymphatic metastasis
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Detmar Michael et al., In The Journal of Experimental Medicine, 1997
... Generation of K14/GFP and of K14/GFP/VEGF-A transgenic mice.
New model for the study of angiogenesis and antiangiogenesis in the chick embryo chorioallantoic membrane: the gelatin sponge/chorioallantoic membrane assay.
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Ng Irene Oi-Lin, In PLoS ONE, 1996
... (goat polyclonal, Santa Cruz, Santa Cruz, CA, USA), anti-Laminin mAb (Biogenex, San Ramon, CA, USA), anti-VEGF-C mAb (Zymed, San Francisco, CA, USA), or anti- IL6 (rabbit polyclonal, Abcam, Cambridge, UK) ...
Apaf-1, a human protein homologous to C. elegans CED-4, participates in cytochrome c–dependent activation of caspase-3
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He Shaoheng et al., In International Journal of Molecular Sciences, 1996
... antibody was purchased from ProSci Incorporated (Poway, CA, USA), rabbit anti-human vascular endothelial growth factor (VEGF) polyclonal antibody was from Santa Cruz Biotechnology (Santa Cruz, CA, USA), ...
Pharmacology of oleanolic acid and ursolic acid.
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Bauer Joseph Alan, In PLoS ONE, 1994
... Antibodies against Bax (clone P-19), VEGF (clone C-1) and tubulin (clone b-7) were purchased from Santa Cruz Biotechnology (Santa Cruz, CA, USA) ...
Induction of beta-platelet-derived growth factor receptor in rat hepatic lipocytes during cellular activation in vivo and in culture.
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Emanueli Costanza, In PLoS ONE, 1993
... The responder tet-soluble VEGF-R1 transgenic line encodes a tetracycline-inducible protein ...
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