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Vascular endothelial growth factor A

vascular endothelial growth factor, VEGF, Vascular Endothelial Growth Factor A
This gene is a member of the PDGF/VEGF growth factor family and encodes a protein that is often found as a disulfide linked homodimer. This protein is a glycosylated mitogen that specifically acts on endothelial cells and has various effects, including mediating increased vascular permeability, inducing angiogenesis, vasculogenesis and endothelial cell growth, promoting cell migration, and inhibiting apoptosis. Elevated levels of this protein is linked to POEMS syndrome, also known as Crow-Fukase syndrome. Mutations in this gene have been associated with proliferative and nonproliferative diabetic retinopathy. Alternatively spliced transcript variants, encoding either freely secreted or cell-associated isoforms, have been characterized. There is also evidence for the use of non-AUG (CUG) translation initiation sites upstream of, and in-frame with the first AUG, leading to additional isoforms. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: CAN, HAD, V1a, KDR, AGE
Papers using vascular endothelial growth factor antibodies
Podocyte vascular endothelial growth factor (Vegf164) overexpression causes severe nodular glomerulosclerosis in a mouse model of type I diabetes.
Chatziantoniou Christos, In PLoS ONE, 2010
... A shRNA targeting the first exon of mouse VEGF (Acc# M95200.1) was selected using siRNA Designer algorithm (Clontech).
Overexpression of von Hippel–Lindau protein synergizes with doxorubicin to suppress hepatocellular carcinoma in mice
El-Rifai Wael, In PLoS ONE, 2010
... Antibody against VEGF was acquired from Abcam Inc ...
Magnetic/silica nanocomposites as dual-mode contrast agents for combined magnetic resonance imaging and ultrasonography
Chen Yuh-Lien et al., In International Journal of Nanomedicine, 2010
... To bind the anti-VEGF Abs (sc507; Santa Cruz Biotechnology, Santa Cruz, CA) to ...
A thrombospondin-mimetic peptide, ABT-898, suppresses angiogenesis and promotes follicular atresia in pre- and early-antral follicles in vivo.
Addison Christina Lynn, In PLoS ONE, 2009
... Mouse anti-VEGF receptor 2 antibody was from Cell Signaling Technology ...
Sunitinib malate for gastrointestinal stromal tumour in imatinib mesylate-resistant patients: recommendations and evidence
Fassnacht Martin et al., In Frontiers in Endocrinology, 2009
... Primary antibodies were VEGF-R2 monoclonal mouse antibody (Flk-1), used in a dilution of 1:250 and VEGF antibody A-20 in a dilution of 1:100 (both antibodies from Santa Cruz Biotechnology, Heidelberg, Germany) ...
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Papers on vascular endothelial growth factor
Prevention of Venous Neointimal Hyperplasia by a Multitarget Receptor Tyrosine Kinase Inhibitor.
Cheung et al., Salt Lake City, United States. In J Vasc Res, Feb 2016
RESULTS: In an in vivo porcine model, PDGF, VEGF and their receptors PDGFR-α and VEGFR-2 were upregulated at the venous anastomosis within 2 weeks after AVG placement, with NH development by 4 weeks.
Coffee induces vascular endothelial growth factor (VEGF) expression in human neuroblastama SH-SY5Y cells.
Tamura et al., In Nutr Neurosci, Feb 2016
UNASSIGNED: Recent evidence indicates that hypoxia-inducible vascular endothelial growth factor (VEGF) has neurotrophic and neuroprotective effects on neuronal and glial cells.
Enhanced healing of surgical periodontal defects in rats following application of a self-assembling peptide nanofiber hydrogel.
Saito et al., Tokyo, Japan. In J Clin Periodontol, Feb 2016
Expression levels of PCNA-positive cells, vascular endothelial growth factor and osteopontin in the RADA16 group were significantly greater than those in other groups.
Targeting of the pulmonary capillary vascular niche promotes lung alveolar repair and ameliorates fibrosis.
Ding et al., New York City, United States. In Nat Med, Feb 2016
Whereas the chemokine receptor CXCR7, expressed on PCECs, acts to prevent epithelial damage and ameliorate fibrosis after a single round of treatment with bleomycin or hydrochloric acid, repeated injury leads to suppression of CXCR7 expression and recruitment of vascular endothelial growth factor receptor 1 (VEGFR1)-expressing perivascular macrophages.
Ten years of anti-vascular endothelial growth factor therapy.
Adamis et al., San Diego, United States. In Nat Rev Drug Discov, Feb 2016
UNASSIGNED: The targeting of vascular endothelial growth factor A (VEGFA), a crucial regulator of both normal and pathological angiogenesis, has revealed innovative therapeutic approaches in oncology and ophthalmology.
Role of Delta-Notch signaling in cerebral cavernous malformations.
Bertalanffy et al., Hannover, Germany. In Neurosurg Rev, Feb 2016
In addition to reviewing the current literatures, this review will also focus on the cross talk between Delta-Notch and vascular endothelial growth factor (VEGF) signaling in angiogenesis and in CCM pathogenesis.
VEGF pathway targeting agents, vessel normalization and tumor drug uptake: from bench to bedside.
de Vries et al., Groningen, Netherlands. In Oncotarget, Feb 2016
UNASSIGNED: Vascular endothelial growth factor (VEGF) pathway targeting agents have been combined with other anticancer drugs, leading to improved efficacy in carcinoma of the cervix, stomach, lung, colon and rectum, ovary, and breast.
Leptin, BMI, and a Metabolic Gene Expression Signature Associated with Clinical Outcome to VEGF Inhibition in Colorectal Cancer.
Barry et al., Macclesfield, United Kingdom. In Cell Metab, Feb 2016
VEGF (vascular endothelial growth factor) signaling inhibitors are widely used in different cancer types; however, patient selection remains a challenge.
Recommendations for the appropriate management of diabetic macular edema: Light on DME survey and consensus document by an expert panel.
Lanzetta et al., Milano, Italy. In Eur J Ophthalmol, Feb 2016
RESULTS: Consensus was reached on several relevant aspects of current DME management, namely the initiation and course of treatment with anti-vascular endothelial growth factor (VEGF) therapy, assessment of the outcomes of anti-VEGF therapy based on both functional and morphologic outcomes, combination of anti-VEGF with laser therapy, and management of nonresponders to anti-VEGFs.
Biomarkers in systemic sclerosis: Their potential to predict clinical courses.
Hasegawa, Fukui, Japan. In J Dermatol, Jan 2016
Other potential serum/plasma biomarkers for fibrosis and vascular involvement of SSc are connective tissue growth factor, interleukin-6, CCL2, CXCL4, intercellular adhesion molecule (ICAM)-1, P-selectin, vascular endothelial growth factor, von Willebrand factor, endostatin, endoglin and endothelin-1.
Bevacizumab for newly diagnosed pleural mesothelioma in the Mesothelioma Avastin Cisplatin Pemetrexed Study (MAPS): a randomised, controlled, open-label, phase 3 trial.
French Cooperative Thoracic Intergroup (IFCT) et al., Caen, France. In Lancet, Jan 2016
Vascular endothelial growth factor is a key mitogen for malignant pleural mesothelioma cells, therefore targeting of vascular endothelial growth factor might prove effective.
Characterization of the expression and clinical features of epidermal growth factor receptor and vascular endothelial growth factor receptor-2 in esophageal carcinoma.
Awut et al., Ürümqi, China. In Oncol Lett, Dec 2015
UNASSIGNED: The present study aimed to understand the expression characteristics of epidermal growth factor receptor (EGFR) and vascular endothelial growth factor receptor-2 (VEGFR-2) in individuals of Uygur, Han and Kazak ethnicity with esophageal carcinoma in Xinjiang (China) and their interrelation analysis, and to investigate the expression differences in these genes between esophageal carcinoma and pericarcinoma tissue samples, and between the three ethnic groups.
Prognostic value of vascular endothelial growth factor-C and podoplanin mRNA expression in esophageal cancer.
Nikliński et al., Białystok, Poland. In Oncol Lett, Dec 2015
UNASSIGNED: Vascular endothelial growth factor-C (VEGF-C), VEGF-D, VEGF receptor-3 (VEGFR-3) and podoplanin (PDPN) are involved in the spread of cancer.
Profile of panitumumab as first-line treatment in patients with wild-type KRAS metastatic colorectal cancer.
Garrido-Laguna et al., Salt Lake City, United States. In Onco Targets Ther, Dec 2015
Targeted therapies against EGFR, vascular endothelial growth factor, and vascular endothelial growth factor receptor have expanded treatment options for patients with metastatic colorectal cancer (mCRC).
Constitutive Activation of mTORC1 in Endothelial Cells Leads to the Development and Progression of Lymphangiosarcoma through VEGF Autocrine Signaling.
Guan et al., Cincinnati, United States. In Cancer Cell, Dec 2015
Increased VEGF expression in tumor cells was seen, and blocking autocrine VEGF signaling abolished vascular tumor development and growth.
Circulating endothelial progenitor cells are reduced in rat oxygen-induced retinopathy despite a retinal SDF-1/CXCR4 and VEGF proangiogenic response.
Fernández-Durango et al., Madrid, Spain. In Life Sci, 2012
We found increased levels of CXCR4 and VEGF mRNA in OIR retinas, especially during the vascular attenuation stage
Vascular endothelial growth factor-induced osteopontin expression mediates vascular inflammation and neointima formation via Flt-1 in adventitial fibroblasts.
Gao et al., Shanghai, China. In Arterioscler Thromb Vasc Biol, 2012
VEGF/Flt-1 signaling plays a significant role in vascular inflammation and neointima formation by regulating osteopontin expression in vascular adevntitial fibroblasts.
Intracellular VEGF regulates the balance between osteoblast and adipocyte differentiation.
Olsen et al., Boston, United States. In J Clin Invest, 2012
VEGF controls differentiation in mesenchymal stem cells by regulating the transcription factors RUNX2 and PPARgamma2 as well as through a reciprocal interaction with nuclear envelope proteins lamin A and C.
Current evidence on VEGF+405G/C polymorphism and malignancy susceptibility: a meta-analysis involving 30 studies.
Zhang et al., Nanning, China. In Twin Res Hum Genet, 2012
Our meta-analysis indicated a weak association of VEGF+405G/C polymorphism with malignancy susceptibility in Africans, no persuasive evidence of association between the polymorphism and malignancy susceptibility was detected in the pooled analyses.
Quantification of tumour and circulating vascular endothelial growth factor (VEGF) in patients with oesophagogastric cancer: a long-term follow-up study.
Spence et al., United Kingdom. In Br J Biomed Sci, 2011
analysis of tumour and circulating vascular endothelial growth factor (VEGF) in patients with oesophagogastric cancer
More papers using vascular endothelial growth factor antibodies
Magnetically enhanced high-specificity virus detection using bio-activated magnetic nanoparticles with antibodies as labeling markers
Yang Hong-Chang et al., In International Journal of Nanomedicine, 2009
... MO), conjugated bilirubin (C-BL) (14370-250MG; Sigma), triglyceride (TG) (T2449-10ML, Sigma), and vascular endothelial growth factor (VEGF) (sc-7269; Santa Cruz Biotechnology, Santa Cruz, CA), were ...
Endothelial precursors in vascular repair
Wu Zhongshi et al., In International Journal of Nanomedicine, 2009
... Human recombinant VEGF-165 was purchased from Cell Signaling technology (Danvers, MA) ...
Gambogic acid inhibits angiogenesis through suppressing vascular endothelial growth factor-induced tyrosine phosphorylation of KDR/Flk-1
Chen Baoan et al., In International Journal of Nanomedicine, 2006
... Monoclonal antibodies, including ETS1, cyclin D1, u-PA, and VEGF, were purchased from Santa Cruz Biotechnology (Santa Cruz, CA) ...
Reducible poly(amido ethylenimine) directed to enhance RNA interference
Zhang Qiang et al., In International Journal of Nanomedicine, 2006
... Human VEGF ELISA Kit was purchased from RayBiotech, Inc (Norcross, GA).
Increased lymphangiogenesis in joints of mice with inflammatory arthritis
Detmar Michael et al., In The Journal of Experimental Medicine, 2006
... Increased microvascular density and enhanced leukocyte rolling and adhesion in the skin of VEGF transgenic mice ...
The Tol2kit: A multisite gateway-based construction kit for Tol2 transposon transgenesis constructs
Jin Suk-Won et al., In Nature cell biology, 2006
... Hyperplasia of lymphatic vessels in VEGF-C transgenic mice ...
Aminopeptidase N/CD13 induces angiogenesis through interaction with a pro-angiogenic protein, galectin-3
Panjwani Noorjahan et al., In The Journal of Experimental Medicine, 2006
... Recombinant VEGF-A was obtained from Cell Sciences and R&D Systems ...
Augmentation of tumor angiogenesis by a Myc-activated microRNA cluster.
Oshima Robert, In PLoS ONE, 2005
... antibodies for phosphor-H2AX, Ser 139, (γH2AX) (BioLegend, San Diego, CA, USA), vascular endothelial growth factor (VEGF, Santa Cruz Biotechnology), thrombospondin -1 (TSP-1) (Lab ...
A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration
Opal Puneet et al., In Nature Medicine, 2005
... provided and characterized the VEGF transgenic mice ...
Pigment epithelium-derived factor (PEDF) inhibits advanced glycation end product-induced retinal vascular hyperpermeability by blocking reactive oxygen species-mediated vascular endothelial growth factor (VEGF) expression
Tombran-Tink Joyce et al., In Journal of Ocular Biology, Diseases, and Informatics, 2005
... After this blocking step, slides were incubated for 2 h with rabbit polyclonal antibody directed against VEGF (Santa Cruz Biotechnology, Santa Cruz, CA, USA) ...
Bone morphogenetic protein 2 induces pulmonary angiogenesis via Wnt–β-catenin and Wnt–RhoA–Rac1 pathways
Rabinovitch Marlene et al., In The Journal of Cell Biology, 2000
... Anti-VEGF and antisurvivin were obtained from Abcam.
QSAR study on the contribution of log P and Es to the in vitro antiprotozoal activity of glutathione derivatives
Gaffney John et al., In BMC Cell Biology, 2000
... from Apollo Cytokine Research, (Cambridge, UK), EGF, VEGFR-1 and -2, FGFR-1 and -2, anti-FGF-2 and anti-VEGF antibodies were obtained from Santa Cruz Biotechnology (Heidelberg, GDR) ...
Fibroblast growth factor 2 control of vascular tone
Mignatti Paolo et al., In The Journal of Cell Biology, 1997
... (Minneapolis, MN); anti-human VEGF antibody (αVEGF sc507) was purchased from Santa Cruz Biotechnology, Inc. ...
VEGF-A induces tumor and sentinel lymph node lymphangiogenesis and promotes lymphatic metastasis
Detmar Michael et al., In The Journal of Experimental Medicine, 1997
... Generation of K14/GFP and of K14/GFP/VEGF-A transgenic mice.
New model for the study of angiogenesis and antiangiogenesis in the chick embryo chorioallantoic membrane: the gelatin sponge/chorioallantoic membrane assay.
Ng Irene Oi-Lin, In PLoS ONE, 1996
... (goat polyclonal, Santa Cruz, Santa Cruz, CA, USA), anti-Laminin mAb (Biogenex, San Ramon, CA, USA), anti-VEGF-C mAb (Zymed, San Francisco, CA, USA), or anti- IL6 (rabbit polyclonal, Abcam, Cambridge, UK) ...
Apaf-1, a human protein homologous to C. elegans CED-4, participates in cytochrome c–dependent activation of caspase-3
He Shaoheng et al., In International Journal of Molecular Sciences, 1996
... antibody was purchased from ProSci Incorporated (Poway, CA, USA), rabbit anti-human vascular endothelial growth factor (VEGF) polyclonal antibody was from Santa Cruz Biotechnology (Santa Cruz, CA, USA), ...
Pharmacology of oleanolic acid and ursolic acid.
Bauer Joseph Alan, In PLoS ONE, 1994
... Antibodies against Bax (clone P-19), VEGF (clone C-1) and tubulin (clone b-7) were purchased from Santa Cruz Biotechnology (Santa Cruz, CA, USA) ...
Induction of beta-platelet-derived growth factor receptor in rat hepatic lipocytes during cellular activation in vivo and in culture.
Emanueli Costanza, In PLoS ONE, 1993
... The responder tet-soluble VEGF-R1 transgenic line encodes a tetracycline-inducible protein ...
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