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Vascular endothelial growth factor A

vascular endothelial growth factor, VEGF, Vascular Endothelial Growth Factor A
This gene is a member of the PDGF/VEGF growth factor family and encodes a protein that is often found as a disulfide linked homodimer. This protein is a glycosylated mitogen that specifically acts on endothelial cells and has various effects, including mediating increased vascular permeability, inducing angiogenesis, vasculogenesis and endothelial cell growth, promoting cell migration, and inhibiting apoptosis. Elevated levels of this protein is linked to POEMS syndrome, also known as Crow-Fukase syndrome. Mutations in this gene have been associated with proliferative and nonproliferative diabetic retinopathy. Alternatively spliced transcript variants, encoding either freely secreted or cell-associated isoforms, have been characterized. There is also evidence for the use of non-AUG (CUG) translation initiation sites upstream of, and in-frame with the first AUG, leading to additional isoforms. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: CAN, HAD, KDR, V1a, AGE
Papers using vascular endothelial growth factor antibodies
Podocyte vascular endothelial growth factor (Vegf164) overexpression causes severe nodular glomerulosclerosis in a mouse model of type I diabetes.
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Chatziantoniou Christos, In PLoS ONE, 2010
... A shRNA targeting the first exon of mouse VEGF (Acc# M95200.1) was selected using siRNA Designer algorithm (Clontech).
Overexpression of von Hippel–Lindau protein synergizes with doxorubicin to suppress hepatocellular carcinoma in mice
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El-Rifai Wael, In PLoS ONE, 2010
... Antibody against VEGF was acquired from Abcam Inc ...
Magnetic/silica nanocomposites as dual-mode contrast agents for combined magnetic resonance imaging and ultrasonography
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Chen Yuh-Lien et al., In International Journal of Nanomedicine, 2010
... To bind the anti-VEGF Abs (sc507; Santa Cruz Biotechnology, Santa Cruz, CA) to ...
A thrombospondin-mimetic peptide, ABT-898, suppresses angiogenesis and promotes follicular atresia in pre- and early-antral follicles in vivo.
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Addison Christina Lynn, In PLoS ONE, 2009
... Mouse anti-VEGF receptor 2 antibody was from Cell Signaling Technology ...
Sunitinib malate for gastrointestinal stromal tumour in imatinib mesylate-resistant patients: recommendations and evidence
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Fassnacht Martin et al., In Frontiers in Endocrinology, 2009
... Primary antibodies were VEGF-R2 monoclonal mouse antibody (Flk-1), used in a dilution of 1:250 and VEGF antibody A-20 in a dilution of 1:100 (both antibodies from Santa Cruz Biotechnology, Heidelberg, Germany) ...
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Papers on vascular endothelial growth factor
Functional Restoration of Amyotrophic Lateral Sclerosis Patient-Derived Mesenchymal Stromal Cells Through Inhibition of DNA Methyltransferase.
New
Cho et al., Kwangju, South Korea. In Cell Mol Neurobiol, 26 Aug 2015
RG108-treated ALS-MSCs exhibit increased expression of the anti-senescence genes TERT, VEGF, and ANG, and decreased expression of the senescence-related genes ATM and p21.
Delivery of miR-155 to retinal pigment epithelial cells mediated by Burkitt's lymphoma exosomes.
New
Kim et al., Pusan, South Korea. In Tumour Biol, 26 Aug 2015
Isolated Raji exosomes increased transcriptional and translational levels of VEGF-A in ARPE-19 cells, which was reversely correlated with von Hippel-Lindau expression.
Minocycline ameliorates hypoxia-induced blood-brain barrier damage by inhibition of HIF-1α through SIRT-3 / PHD-2 degradation pathway.
New
Huang et al., Chongqing, China. In Neuroscience, 23 Aug 2015
Minocycline administration significantly reduced HIF-1α expression, protein and mRNA expression of MMP-2, MMP-9 and VEGF (P<0.05), and increased TJs (ZO-1, claudin-5 and occluding) (P<0.05) in HBMECs after hypoxia.
BEST: A Randomized Phase II Study of Vascular Endothelial Growth Factor, RAF Kinase, and Mammalian Target of Rapamycin Combination Targeted Therapy With Bevacizumab, Sorafenib, and Temsirolimus in Advanced Renal Cell Carcinoma-A Trial of the ECOG-ACRIN Cancer Research Group (E2804).
New
Impact
DiPaola et al., Philadelphia, United States. In J Clin Oncol, 20 Aug 2015
PURPOSE: On the basis of evidence that resistance to vascular endothelial growth factor (VEGF) receptor inhibition is caused by hypoxia-driven residual VEGF and other proangiogenic factors, combinations of agents from these classes were hypothesized to improve treatment outcomes relative to single-agent VEGF pathway blockade.
Circulating biomarkers of hepatocellular carcinoma response after locoregional treatments: New insights.
Review
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Koskinas et al., Athens, Greece. In World J Hepatol, 18 Aug 2015
The aim of this review is to analyze the existing data considering the prognostic significance of changes of serum diagnostic markers such as alpha-fetoprotein, des-gamma-carboxy prothrombin, alpha-fetoprotein-L3, angiogenetic factors (vascular endothelial growth factor, hypoxia inducible factor-1a) and immune parameters before and after radiofrequency ablation or transarterial chemoembolization.
Analysis of circulating DNA and protein biomarkers to predict the clinical activity of regorafenib and assess prognosis in patients with metastatic colorectal cancer: a retrospective, exploratory analysis of the CORRECT trial.
New
Impact
Van Cutsem et al., Barcelona, Spain. In Lancet Oncol, 13 Aug 2015
We also measured the concentration of 15 proteins of interest-angiopoietin 2, interleukin 6, interleukin 8, placental growth factor, soluble TIE-1, soluble VEGFR1, VEGF-A, VEGF-C, VEGF-D, VEGF-A isoform 121, bone morphogenetic protein 7, macrophage colony-stimulating factor, stromal cell-derived factor-1, tissue inhibitor of metalloproteinase 2, and von Willebrand factor-in plasma samples from 611 patients.
Cholangiocytes derived from human induced pluripotent stem cells for disease modeling and drug validation.
New
Impact
Vallier et al., Cambridge, United Kingdom. In Nat Biotechnol, 13 Aug 2015
CLCs show functional characteristics of cholangiocytes, including bile acids transfer, alkaline phosphatase activity, γ-glutamyl-transpeptidase activity and physiological responses to secretin, somatostatin and vascular endothelial growth factor.
Cediranib or placebo in combination with cisplatin and gemcitabine chemotherapy for patients with advanced biliary tract cancer (ABC-03): a randomised phase 2 trial.
New
Impact
Bridgewater et al., Manchester, United Kingdom. In Lancet Oncol, 10 Aug 2015
BACKGROUND: Cisplatin and gemcitabine is the standard first-line chemotherapy regimen for patients with advanced biliary tract cancer; expression of VEGF and its receptors is associated with adverse outcomes.
Peripheral vascular endothelial growth factor as a novel depression biomarker: A meta-analysis.
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Berk et al., Fortaleza, Brazil. In Psychoneuroendocrinology, 08 Aug 2015
Nevertheless, emerging evidence has implicated the multi-competent angiogenic and neurogenic molecule - vascular endothelial growth factor (VEGF) - in hippocampal neurogenesis and depression pathophysiology.
Protective Effects of Physical Exercise in Alzheimer's Disease and Parkinson's Disease: A Narrative Review.
Review
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de Souto Barreto et al., Tarbes, France. In J Clin Neurol, 31 Jul 2015
Research has shown that the neuroprotective mechanisms induced by PE are linked to an increased production of superoxide dismutase, endothelial nitric oxide synthase, brain-derived neurotrophic factor, nerve growth factor, insulin-like growth factor, and vascular endothelial growth factor, and a reduction in the production of free radicals in brain areas such as the hippocampus, which is particularly involved in memory.
Ramucirumab versus placebo as second-line treatment in patients with advanced hepatocellular carcinoma following first-line therapy with sorafenib (REACH): a randomised, double-blind, multicentre, phase 3 trial.
New
Impact
REACH Trial Investigators et al., Boston, United States. In Lancet Oncol, 31 Jul 2015
BACKGROUND: VEGF and VEGF receptor-2-mediated angiogenesis contribute to hepatocellular carcinoma pathogenesis.
Selective use of vandetanib in the treatment of thyroid cancer.
Review
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Antonelli et al., Pisa, Italy. In Drug Des Devel Ther, Dec 2014
Vandetanib is a once-daily orally available tyrosine kinase inhibitor that works by blocking RET (REarranged during Transfection), vascular endothelial growth factor receptor (VEGFR-2, VEGFR-3), and epidermal growth factor receptor and to a lesser extent VEGFR-1, which are important targets in thyroid cancer (TC).
Immunotherapy in Metastatic Renal Cell Carcinoma: A Comprehensive Review.
Review
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Vaena et al., Iowa City, United States. In Biomed Res Int, Dec 2014
The advent of targeted agents such as vascular endothelial growth factor tyrosine kinase inhibitors VEGF-TKIs and mammalian target of rapamycin (mTOR) inhibitors led to a change in this paradigm due to improved response rates and progression-free survival, a better safety profile, and the convenience of oral administration.
Hypoxia-Inducible Factor-1 in Physiological and Pathophysiological Angiogenesis: Applications and Therapies.
Review
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Kurpisz et al., Poznań, Poland. In Biomed Res Int, Dec 2014
Whether the process is physiological or pathological, HIF-1 seems to participate in vasculature formation by synergistic correlations with other proangiogenic factors such as VEGF (vascular endothelial growth factor), PlGF (placental growth factor), or angiopoietins.
Influence of type 2 diabetes on local production of inflammatory molecules in adults with and without chronic periodontitis: a cross-sectional study.
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Mustafa et al., Bergen, Norway. In Bmc Oral Health, Dec 2014
The DM group had higher levels of IL-10, VEGF, and G-CSF compared to the CP group.
Circulating endothelial progenitor cells are reduced in rat oxygen-induced retinopathy despite a retinal SDF-1/CXCR4 and VEGF proangiogenic response.
GeneRIF
Fernández-Durango et al., Madrid, Spain. In Life Sci, 2012
We found increased levels of CXCR4 and VEGF mRNA in OIR retinas, especially during the vascular attenuation stage
Vascular endothelial growth factor-induced osteopontin expression mediates vascular inflammation and neointima formation via Flt-1 in adventitial fibroblasts.
GeneRIF
Gao et al., Shanghai, China. In Arterioscler Thromb Vasc Biol, 2012
VEGF/Flt-1 signaling plays a significant role in vascular inflammation and neointima formation by regulating osteopontin expression in vascular adevntitial fibroblasts.
Intracellular VEGF regulates the balance between osteoblast and adipocyte differentiation.
GeneRIF
Olsen et al., Boston, United States. In J Clin Invest, 2012
VEGF controls differentiation in mesenchymal stem cells by regulating the transcription factors RUNX2 and PPARgamma2 as well as through a reciprocal interaction with nuclear envelope proteins lamin A and C.
Current evidence on VEGF+405G/C polymorphism and malignancy susceptibility: a meta-analysis involving 30 studies.
GeneRIF
Zhang et al., Nanning, China. In Twin Res Hum Genet, 2012
Our meta-analysis indicated a weak association of VEGF+405G/C polymorphism with malignancy susceptibility in Africans, no persuasive evidence of association between the polymorphism and malignancy susceptibility was detected in the pooled analyses.
Quantification of tumour and circulating vascular endothelial growth factor (VEGF) in patients with oesophagogastric cancer: a long-term follow-up study.
GeneRIF
Spence et al., United Kingdom. In Br J Biomed Sci, 2011
analysis of tumour and circulating vascular endothelial growth factor (VEGF) in patients with oesophagogastric cancer
More papers using vascular endothelial growth factor antibodies
Magnetically enhanced high-specificity virus detection using bio-activated magnetic nanoparticles with antibodies as labeling markers
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Yang Hong-Chang et al., In International Journal of Nanomedicine, 2009
... MO), conjugated bilirubin (C-BL) (14370-250MG; Sigma), triglyceride (TG) (T2449-10ML, Sigma), and vascular endothelial growth factor (VEGF) (sc-7269; Santa Cruz Biotechnology, Santa Cruz, CA), were ...
Endothelial precursors in vascular repair
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Wu Zhongshi et al., In International Journal of Nanomedicine, 2009
... Human recombinant VEGF-165 was purchased from Cell Signaling technology (Danvers, MA) ...
Gambogic acid inhibits angiogenesis through suppressing vascular endothelial growth factor-induced tyrosine phosphorylation of KDR/Flk-1
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Chen Baoan et al., In International Journal of Nanomedicine, 2006
... Monoclonal antibodies, including ETS1, cyclin D1, u-PA, and VEGF, were purchased from Santa Cruz Biotechnology (Santa Cruz, CA) ...
Reducible poly(amido ethylenimine) directed to enhance RNA interference
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Zhang Qiang et al., In International Journal of Nanomedicine, 2006
... Human VEGF ELISA Kit was purchased from RayBiotech, Inc (Norcross, GA).
Increased lymphangiogenesis in joints of mice with inflammatory arthritis
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Detmar Michael et al., In The Journal of Experimental Medicine, 2006
... Increased microvascular density and enhanced leukocyte rolling and adhesion in the skin of VEGF transgenic mice ...
The Tol2kit: A multisite gateway-based construction kit for Tol2 transposon transgenesis constructs
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Jin Suk-Won et al., In Nature cell biology, 2006
... Hyperplasia of lymphatic vessels in VEGF-C transgenic mice ...
Aminopeptidase N/CD13 induces angiogenesis through interaction with a pro-angiogenic protein, galectin-3
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Panjwani Noorjahan et al., In The Journal of Experimental Medicine, 2006
... Recombinant VEGF-A was obtained from Cell Sciences and R&D Systems ...
Augmentation of tumor angiogenesis by a Myc-activated microRNA cluster.
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Oshima Robert, In PLoS ONE, 2005
... antibodies for phosphor-H2AX, Ser 139, (γH2AX) (BioLegend, San Diego, CA, USA), vascular endothelial growth factor (VEGF, Santa Cruz Biotechnology), thrombospondin -1 (TSP-1) (Lab ...
A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration
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Opal Puneet et al., In Nature Medicine, 2005
... provided and characterized the VEGF transgenic mice ...
Pigment epithelium-derived factor (PEDF) inhibits advanced glycation end product-induced retinal vascular hyperpermeability by blocking reactive oxygen species-mediated vascular endothelial growth factor (VEGF) expression
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Tombran-Tink Joyce et al., In Journal of Ocular Biology, Diseases, and Informatics, 2005
... After this blocking step, slides were incubated for 2 h with rabbit polyclonal antibody directed against VEGF (Santa Cruz Biotechnology, Santa Cruz, CA, USA) ...
Bone morphogenetic protein 2 induces pulmonary angiogenesis via Wnt–β-catenin and Wnt–RhoA–Rac1 pathways
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Rabinovitch Marlene et al., In The Journal of Cell Biology, 2000
... Anti-VEGF and antisurvivin were obtained from Abcam.
QSAR study on the contribution of log P and Es to the in vitro antiprotozoal activity of glutathione derivatives
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Gaffney John et al., In BMC Cell Biology, 2000
... from Apollo Cytokine Research, (Cambridge, UK), EGF, VEGFR-1 and -2, FGFR-1 and -2, anti-FGF-2 and anti-VEGF antibodies were obtained from Santa Cruz Biotechnology (Heidelberg, GDR) ...
Fibroblast growth factor 2 control of vascular tone
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Mignatti Paolo et al., In The Journal of Cell Biology, 1997
... (Minneapolis, MN); anti-human VEGF antibody (αVEGF sc507) was purchased from Santa Cruz Biotechnology, Inc. ...
VEGF-A induces tumor and sentinel lymph node lymphangiogenesis and promotes lymphatic metastasis
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Detmar Michael et al., In The Journal of Experimental Medicine, 1997
... Generation of K14/GFP and of K14/GFP/VEGF-A transgenic mice.
New model for the study of angiogenesis and antiangiogenesis in the chick embryo chorioallantoic membrane: the gelatin sponge/chorioallantoic membrane assay.
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Ng Irene Oi-Lin, In PLoS ONE, 1996
... (goat polyclonal, Santa Cruz, Santa Cruz, CA, USA), anti-Laminin mAb (Biogenex, San Ramon, CA, USA), anti-VEGF-C mAb (Zymed, San Francisco, CA, USA), or anti- IL6 (rabbit polyclonal, Abcam, Cambridge, UK) ...
Apaf-1, a human protein homologous to C. elegans CED-4, participates in cytochrome c–dependent activation of caspase-3
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He Shaoheng et al., In International Journal of Molecular Sciences, 1996
... antibody was purchased from ProSci Incorporated (Poway, CA, USA), rabbit anti-human vascular endothelial growth factor (VEGF) polyclonal antibody was from Santa Cruz Biotechnology (Santa Cruz, CA, USA), ...
Pharmacology of oleanolic acid and ursolic acid.
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Bauer Joseph Alan, In PLoS ONE, 1994
... Antibodies against Bax (clone P-19), VEGF (clone C-1) and tubulin (clone b-7) were purchased from Santa Cruz Biotechnology (Santa Cruz, CA, USA) ...
Induction of beta-platelet-derived growth factor receptor in rat hepatic lipocytes during cellular activation in vivo and in culture.
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Emanueli Costanza, In PLoS ONE, 1993
... The responder tet-soluble VEGF-R1 transgenic line encodes a tetracycline-inducible protein ...
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