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proteins. Page last changed on 14 Mar 2013.
Vascular endothelial growth factor A
vascular endothelial growth factor, VEGF, Vascular Endothelial Growth Factor A
This gene is a member of the PDGF/VEGF growth factor family and encodes a protein that is often found as a disulfide linked homodimer. This protein is a glycosylated mitogen that specifically acts on endothelial cells and has various effects, including mediating increased vascular permeability, inducing angiogenesis, vasculogenesis and endothelial cell growth, promoting cell migration, and inhibiting apoptosis. Elevated levels of this protein is linked to POEMS syndrome, also known as Crow-Fukase syndrome. Mutations in this gene have been associated with proliferative and nonproliferative diabetic retinopathy. Alternatively spliced transcript variants, encoding either freely secreted or cell-associated isoforms, have been characterized. There is also evidence for the use of non-AUG (CUG) translation initiation sites upstream of, and in-frame with the first AUG, leading to additional isoforms. [provided by RefSeq, Jul 2008] (from
NCBI)
Papers using
vascular endothelial growth factor
antibodies
Overexpression of von Hippel–Lindau protein synergizes with doxorubicin to suppress hepatocellular carcinoma in mice
Supplier
In PLoS ONE, 2010
... Antibody against VEGF was acquired from Abcam Inc ...
Magnetic/silica nanocomposites as dual-mode contrast agents for combined magnetic resonance imaging and ultrasonography
Supplier
In International Journal of Nanomedicine, 2010
... To bind the anti-VEGF Abs (sc507; Santa Cruz Biotechnology, Santa Cruz, CA) to ...
Podocyte vascular endothelial growth factor (Vegf164) overexpression causes severe nodular glomerulosclerosis in a mouse model of type I diabetes.
Supplier
In PLoS ONE, 2010
... A shRNA targeting the first exon of mouse VEGF (Acc# M95200.1) was selected using siRNA Designer algorithm (Clontech).
A thrombospondin-mimetic peptide, ABT-898, suppresses angiogenesis and promotes follicular atresia in pre- and early-antral follicles in vivo.
Supplier
In PLoS ONE, 2009
Sunitinib malate for gastrointestinal stromal tumour in imatinib mesylate-resistant patients: recommendations and evidence
more suppliersSupplier
In Frontiers in Endocrinology, 2009
... Primary antibodies were VEGF-R2 monoclonal mouse antibody (Flk-1), used in a dilution of 1:250 and VEGF antibody A-20 in a dilution of 1:100 (both antibodies from Santa Cruz Biotechnology, Heidelberg, Germany) ...
Papers on
vascular endothelial growth factor
RNAi-mediated gene silencing of vascular endothelial growth factor-C inhibits tumor lymphangiogenesis and growth of gastric cancer in vivo in mice.
New
China. In Tumour Biol, 10 Apr 2013
Overexpression of vascular endothelial growth factor-C (VEGF-C) has been implicated as a critical molecular signal in tumor development by promoting intratumoral lymphangiogenesis.
Growth inhibition of pancreatic cancer cells by Histone Deacetylase inhibitor belinostat through suppression of multiple pathways including HIF, NFkB, and mTOR signaling in vitro and in vivo.
New
Singapore, Singapore. In Mol Carcinog, 08 Apr 2013
Surprisingly, belinostat profoundly blocked hypoxia signaling including the suppression of hypoxia response element reporter activity; as well as an approximately 10-fold decreased transcriptional expression of VEGF, adrenomedullin, and HIF1α at 1% compared to 20% O2 .
Soluble vascular endothelial growth factor receptor-3 is essential for corneal alymphaticity.
New
Salt Lake City, United States. In Blood, 08 Apr 2013
Key points Endogenous soluble VEGF receptor-3 is expressed by cornea that binds and sequesters VEGF-C and it is critical for corneal alymphaticitySoluble VEGFR-3 over-expression enhances murine corneal graft transplant survival 5-fold by blocking lymphangiogenesis and hemangiogenesis.
Endocytosis regulates VEGF signalling during angiogenesis.
New
Impact
Uppsala, Sweden. In Nat Cell Biol, 01 Apr 2013
New work reinforces the importance of endocytosis for VEGF receptor signalling and angiogenesis in the developing eye, and describes a mechanism for its differential regulation in angiogenic versus quiescent endothelial cells.
Targeting placental growth factor/neuropilin 1 pathway inhibits growth and spread of medulloblastoma.
New
Impact
Boston, United States. In Cell, 28 Mar 2013
We reveal that PlGF is produced in the cerebellar stroma via tumor-derived Sonic hedgehog (Shh) and show that PlGF acts through Nrp1-and not vascular endothelial growth factor receptor 1-to promote tumor cell survival.
Markers of Response for the Antiangiogenic Agent Bevacizumab.
New
Impact
Leuven, Belgium. In J Clin Oncol, 11 Mar 2013
In particular, these studies suggest that circulating levels of short vascular endothelial growth factor A (VEGF-A) isoforms, expression of neuropilin-1 and VEGF receptor 1 in tumors or plasma, and genetic variants in VEGFA or its receptors are strong biomarker candidates.
Which drug, and when, for patients with BRAF-mutant melanoma?
New
Impact
Washington, D.C., United States. In Lancet Oncol, 28 Feb 2013
Multiple resistance mechanisms have been identified, including those that lead to reactivation of the MAPK pathway and other pathways, such as the PI3K-AKT-mTOR and VEGF pathways.
Spatial regulation of VEGF receptor endocytosis in angiogenesis.
New
Impact
Münster, Germany. In Nat Cell Biol, 27 Feb 2013
Here, we show that sprouting endothelial cells in the retina have high rates of VEGF uptake, VEGF receptor endocytosis and turnover.
Molecular basis of physiological heart growth: fundamental concepts and new players.
Review
New
Impact
Cincinnati, United States. In Nat Rev Mol Cell Biol, Jan 2013
Physiological hypertrophy is initiated by finite signals, which include growth hormones (such as thyroid hormone, insulin, insulin-like growth factor 1 and vascular endothelial growth factor) and mechanical forces that converge on a limited number of intracellular signalling pathways (such as PI3K, AKT, AMP-activated protein kinase and mTOR) to affect gene transcription, protein translation and metabolism.
Surgical implantation of steroids with antiangiogenic characteristics for treating neovascular age-related macular degeneration.
Review
New
Providence, United States. In Cochrane Database Syst Rev, Dec 2012
With the emergence of anti-vascular endothelial growth factor modalities, based on evidence summarized in this review, it is unclear what role steroids have in treating patients with neovascular AMD.
Anti-vascular endothelial growth factor for macular oedema secondary to branch retinal vein occlusion.
Review
New
London, United Kingdom. In Cochrane Database Syst Rev, Dec 2012
Recently, antiangiogenic therapy with anti-vascular endothelial growth factor (anti-VEGF) has been used successfully to treat MO resulting from a variety of causes.
Vitexicarpin acts as a novel angiogenesis inhibitor and its target network.
New
Beijing, China. In Evid Based Complement Alternat Med, Dec 2012
Firstly, VIT can exert good antiangiogenic effects by inhibiting vascular-endothelial-growth-factor- (VEGF-) induced endothelial cell proliferation, migration, and capillary-like tube formation on matrigel in a dose-dependent manner.
Rapamycin Inhibits ALDH Activity, Resistance to Oxidative Stress, and Metastatic Potential in Murine Osteosarcoma Cells.
New
Pittsburgh, United States. In Sarcoma, Dec 2012
Furthermore, rapamycin treatment reduces bone morphogenetic protein-2 (BMP2) and vascular endothelial growth factor (VEGF) gene expression and inhibits K7M2 proliferation, migration, and invasion .
[Is the vascular-endothelial growth factor responsible for the malignancy of lung cancer?].
Review
New
Kantharalak, Thailand. In Pol Merkur Lekarski, Oct 2012
The reason of this ability lies in the creation process of blood vessels that is angiogenesis, which main stimulus is the vascular-endothelial growth factor (VEGF).
Expression of pro- and anti-angiogenic isoforms of VEGF in the mouse model of oxygen-induced retinopathy.
GeneRIF
Beijing, China. In Exp Eye Res, 2011
Report expression of pro- and anti-angiogenic isoforms of VEGF in the mouse model of oxygen-induced retinopathy.
Impact of VEGF gene polymorphisms and haplotypes on radiation-induced late toxicity in prostate cancer patients.
GeneRIF
Graz, Austria. In Strahlenther Onkol, 2011
We conclude that genetic variants in the VEGF gene may influence the risk of high-grade late rectal toxicity after definitive radiotherapy for prostate cancer.
Association of vascular endothelial growth factor +936 C/T single-nucleotide polymorphism with pregnancies complicated by small-for-gestational-age babies.
GeneRIF
Adelaide, Australia. In Arch Pediatr Adolesc Med, 2011
(SNPs)in VEGFA (-2578 C/A and +936 C/T) associates with SGA, and the association is stronger for SGA with abnormal uterine or umbilical artery Doppler findings.
Antiangiogenic therapy with anti-vascular endothelial growth factor modalities for diabetic macular oedema.
Review
Florence, Italy. In Cochrane Database Syst Rev, 2011
Antiangiogenic therapy with anti-vascular endothelial growth factor (anti-VEGF) modalities has recently been proposed for improving vision in people with DMO.
[Expression and clinical significance of serum VEGF and bFGF in children with acute leukemia].
GeneRIF
Hechuan, China. In Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi, 2011
vascular endothelial growth factor
Analysis of vascular distribution and growth factors in human gingival tissue associated with periodontal probing depth.
More papers using
vascular endothelial growth factor
antibodies
GeneRIF
Tokyo, Japan. In Okajimas Folia Anat Jpn, 2011
In the early stage of angiogenesis, VEGF-R2 leads to expression of VEGF, and HIF-1 mediates increased VEGF expression in response to hypoxia in swollen tissues or during the expansion of periodontal tissues.
Magnetically enhanced high-specificity virus detection using bio-activated magnetic nanoparticles with antibodies as labeling markers
Supplier
In International Journal of Nanomedicine, 2009
... MO), conjugated bilirubin (C-BL) (14370-250MG; Sigma), triglyceride (TG) (T2449-10ML, Sigma), and vascular endothelial growth factor (VEGF) (sc-7269; Santa Cruz Biotechnology, Santa Cruz, CA), were ...
Aminopeptidase N/CD13 induces angiogenesis through interaction with a pro-angiogenic protein, galectin-3
Supplier
In The Journal of Experimental Medicine, 2006
Reducible poly(amido ethylenimine) directed to enhance RNA interference
Supplier
In International Journal of Nanomedicine, 2006
... Human VEGF ELISA Kit was purchased from RayBiotech, Inc (Norcross, GA).
Gambogic acid inhibits angiogenesis through suppressing vascular endothelial growth factor-induced tyrosine phosphorylation of KDR/Flk-1
Supplier
In International Journal of Nanomedicine, 2006
... Monoclonal antibodies, including ETS1, cyclin D1, u-PA, and VEGF, were purchased from Santa Cruz Biotechnology (Santa Cruz, CA) ...
Increased lymphangiogenesis in joints of mice with inflammatory arthritis
Supplier
In The Journal of Experimental Medicine, 2006
... Increased microvascular density and enhanced leukocyte rolling and adhesion in the skin of VEGF transgenic mice ...
The Tol2kit: A multisite gateway-based construction kit for Tol2 transposon transgenesis constructs
Supplier
In Nature cell biology, 2006
... Hyperplasia of lymphatic vessels in VEGF-C transgenic mice ...
Pigment epithelium-derived factor (PEDF) inhibits advanced glycation end product-induced retinal vascular hyperpermeability by blocking reactive oxygen species-mediated vascular endothelial growth factor (VEGF) expression
Supplier
In Journal of Ocular Biology, Diseases, and Informatics, 2005
... After this blocking step, slides were incubated for 2 h with rabbit polyclonal antibody directed against VEGF (Santa Cruz Biotechnology, Santa Cruz, CA, USA) ...
Augmentation of tumor angiogenesis by a Myc-activated microRNA cluster.
Supplier
In PLoS ONE, 2005
... antibodies for phosphor-H2AX, Ser 139, (γH2AX) (BioLegend, San Diego, CA, USA), vascular endothelial growth factor (VEGF, Santa Cruz Biotechnology), thrombospondin -1 (TSP-1) (Lab ...
A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration
Supplier
In Nature Medicine, 2005
... provided and characterized the VEGF transgenic mice ...
Silibinin upregulates the expression of cyclin-dependent kinase inhibitors and causes cell cycle arrest and apoptosis in human colon carcinoma HT-29 cells.
Supplier
In PLoS ONE, 2002
... VEGF antibody was from abcam (Cambridge, MA, USA) ...
QSAR study on the contribution of log P and Es to the in vitro antiprotozoal activity of glutathione derivatives
Supplier
In BMC Cell Biology, 2000
... from Apollo Cytokine Research, (Cambridge, UK), EGF, VEGFR-1 and -2, FGFR-1 and -2, anti-FGF-2 and anti-VEGF antibodies were obtained from Santa Cruz Biotechnology (Heidelberg, GDR) ...
Bone morphogenetic protein 2 induces pulmonary angiogenesis via Wnt–β-catenin and Wnt–RhoA–Rac1 pathways
Supplier
In The Journal of Cell Biology, 2000
... Anti-VEGF and antisurvivin were obtained from Abcam.
Fibroblast growth factor 2 control of vascular tone
Supplier
In The Journal of Cell Biology, 1997
... (Minneapolis, MN); anti-human VEGF antibody (αVEGF sc507) was purchased from Santa Cruz Biotechnology, Inc. ...
VEGF-A induces tumor and sentinel lymph node lymphangiogenesis and promotes lymphatic metastasis
Supplier
In The Journal of Experimental Medicine, 1997
... Generation of K14/GFP and of K14/GFP/VEGF-A transgenic mice.
New model for the study of angiogenesis and antiangiogenesis in the chick embryo chorioallantoic membrane: the gelatin sponge/chorioallantoic membrane assay.
Supplier
In PLoS ONE, 1996
... (goat polyclonal, Santa Cruz, Santa Cruz, CA, USA), anti-Laminin mAb (Biogenex, San Ramon, CA, USA), anti-VEGF-C mAb (Zymed, San Francisco, CA, USA), or anti- IL6 (rabbit polyclonal, Abcam, Cambridge, UK) ...
Apaf-1, a human protein homologous to C. elegans CED-4, participates in cytochrome c–dependent activation of caspase-3
Supplier
In International Journal of Molecular Sciences, 1996
... antibody was purchased from ProSci Incorporated (Poway, CA, USA), rabbit anti-human vascular endothelial growth factor (VEGF) polyclonal antibody was from Santa Cruz Biotechnology (Santa Cruz, CA, USA), ...
Pharmacology of oleanolic acid and ursolic acid.
Supplier
In PLoS ONE, 1994
... Antibodies against Bax (clone P-19), VEGF (clone C-1) and tubulin (clone b-7) were purchased from Santa Cruz Biotechnology (Santa Cruz, CA, USA) ...
Induction of beta-platelet-derived growth factor receptor in rat hepatic lipocytes during cellular activation in vivo and in culture.
Supplier
In PLoS ONE, 1993
... The responder tet-soluble VEGF-R1 transgenic line encodes a tetracycline-inducible protein ...
