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Vascular cell adhesion molecule 1

Vascular Cell Adhesion Molecule-1, VCAM-1
This gene is a member of the Ig superfamily and encodes a cell surface sialoglycoprotein expressed by cytokine-activated endothelium. This type I membrane protein mediates leukocyte-endothelial cell adhesion and signal transduction, and may play a role in the development of artherosclerosis and rheumatoid arthritis. Three alternatively spliced transcripts encoding different isoforms have been described for this gene. [provided by RefSeq, Dec 2010] (from NCBI)
Top mentioned proteins: Intercellular Adhesion Molecule-1, E-selectin, CAN, V1a, Interleukin-6
Papers using Vascular Cell Adhesion Molecule-1 antibodies
Srt1720, srt2183, srt1460, and resveratrol are not direct activators of sirt1
Supplier
Matter Christian M. et al., In Aging (Albany NY), 2009
... rabbit anti-von Willebrand Factor (Dako), rat anti-CD31, rat anti-VCAM-1 (BD Biosciences), rat anti-ICAM-1 (Serotec).
Superparamagnetic iron oxide nanoparticle-embedded encapsulated microbubbles as dual contrast agents of magnetic resonance and ultrasound imaging
Supplier
Liu Yiyao et al., In International Journal of Nanomedicine, 2008
... Biotinylated anti-VCAM-1 monoclonal antibody, streptavidin, and phycoerythrin-labeled streptavidin (PE-streptavidin) were obtained from BioLegend (San Diego, CA) ...
Targeting the tetraspanin CD81 blocks monocyte transmigration and ameliorates EAE
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Hordijk Peter L. et al., In Journal of Biomedicine and Biotechnology, 2007
... (84H10); ICAM-1-FITC; VCAM-1 (1G11) from R&D systems (Minneapolis, MN, USA); pAb against ICAM-1 (H-108) and VCAM-1 (C-19) from Santa Cruz Biotechnology (Heerhugowaard, The Netherlands); mAb ...
Measuring circulating cell-derived microparticles
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Madden Leigh A et al., In Oxidative Medicine and Cellular Longevity, 2003
... either Isotype matched IgG negative control FITC conjugate (4 µL, AbD Serotec, UK) or IgG VCAM-1 specific FITC conjugate (4 µL, AbD Serotec, UK) for 30 min ...
Activation of the hexosamine pathway leads to deterioration of pancreatic beta-cell function through the induction of oxidative stress
Supplier
Yang Zhihong et al., In Oxidative Medicine and Cellular Longevity, 2000
... hydrochloride and chemicals for immunoblotting were purchased from Sigma (Buchs, Switzerland); antibodies against ICAM-1 and VCAM-1 were from Santa Cruz Biotechnology (Munningen, Switzerland); IRDye 800-conjugated ...
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Papers on Vascular Cell Adhesion Molecule-1
Evaluation of the effects of Eserine and JWH-133 on brain dysfunction associated with experimental endotoxemia.
New
Sharawy et al., Cairo, Egypt. In J Neuroimmunol, 15 May 2015
We observed that the use of Eserine, JWH-133 or Eserine+JWH-133 reverted the increases in the inflammatory markers [interleukin 6 (IL6), vascular cell adhesion molecule 1(VCAM-1) and Eselectin] and oxidative-nitrous stress MDM, and that the anti-inflammatory, antioxidant properties of both JWH-133 and Eserine successfully improve the LPS induced brain dysfunction.
Increased size and cellularity of advanced atherosclerotic lesions in mice with endothelial overexpression of the human TRPC3 channel.
New
Vazquez et al., Toledo, United States. In Proc Natl Acad Sci U S A, 13 May 2015
UNASSIGNED: In previous in vitro studies, we showed that Transient Receptor Potential Canonical 3 (TRPC3), a calcium-permeable, nonselective cation channel endowed with high constitutive function, is an obligatory component of the inflammatory signaling that controls expression of the vascular cell adhesion molecule-1 (VCAM-1) and monocyte adhesion to coronary artery endothelial cells.
New indole-thiazolidine attenuates atherosclerosis in LDLr(-/-) mice.
New
Abdalla et al., São Paulo, Brazil. In Vascul Pharmacol, 10 May 2015
LYSO-7 shows low cytotoxicity in RAW 264.7 cells and at 2.5 μmol/L induces PPARα and PPARγ transactivation as well as inhibits LPS-induced nitrite production and the mRNA gene expression levels of inducible nitric oxide synthase (iNOS), cyclooxygenase-2 (COX-2), vascular cell adhesion molecule-1 (VCAM-1) and monocyte chemoattractant protein-1 (MCP-1).
Infliximab improves endothelial dysfunction in a mouse model of antiphospholipid syndrome: role of reduced oxidative stress.
New
Richard et al., Rouen, France. In Vascul Pharmacol, 10 May 2015
Seven days after Anti-β2GPI-IgG injection, we observed an increase in plasma sVCAM-1 and sE-selectin levels and in aortic mRNA expression of VCAM-1 and E-selectin.
Membrane lipid rafts, master regulators of hematopoietic stem cell retention in bone marrow, and their trafficking.
Review
New
Adamiak et al., Louisville, United States. In Leukemia, 09 Apr 2015
These structures play an important role in assembling signaling molecules (e.g., Rac-1, RhoH, and Lyn) together with surface receptors, such as the CXCR4 receptor for α-chemokine stromal-derived factor 1 (SDF-1), the α1β4 integrin receptor (VLA-4) for vascular cell adhesion molecule-1 (VCAM-1), and the c-kit receptor for stem cell factor (SCF), which together regulate several aspects of hematopoietic stem/progenitor cell (HSPC) biology.
[The morphology of vocal fold polyps and mucosa in Reinke's edema].
New
In Arkh Patol, Jan 2015
SUBJECTS AND METHODS: Polyps of the vocal folds and their mucosal tissue samples in Reinke's edema mucosa, which had been obtained after microsurgical treatment of 31 patients (13 men and 18 women) aged 23 to 75 years, were studied using a wide panel of peroxidase-labeled monoclonal and polyclonal antibodies (DAB chromogen), including T and B cell differentiation markers, Toll-like receptors (TLR2, TLR4, and TLR9), the costimulatory molecule CD80 (B7- 1), and markers for angiogenesis (CD34), vascular and tissue permeability (matrix metalloproteinases (MMP-1 and MMP-9)), and vascular cell adhesion molecule-1 (VCAM-1).
Iron metabolism in obesity: How interaction between homoeostatic mechanisms can interfere with their original purpose. Part I: Underlying homoeostatic mechanisms of energy storage and iron metabolisms and their interaction.
Review
New
Schümann et al., Freising, Germany. In J Trace Elem Med Biol, Dec 2014
This process is regulated by a complex interaction of cytokines (TNF-α, IL-6), adipokines (adiponectin, apelin, liptin), adhesion molecules (ICAM-1, VCAM-1, E-selectin) and transcription factors (NF-κB, HIF-1α).
Role of mast cells in atherosclerosis: a classical inflammatory disease.
Review
New
Conti et al., Cagliari, Italy. In Int J Immunopathol Pharmacol, Oct 2014
Mast cells can be activated by pro-inflammatory stimuli, including cytokines, hypercholesterolemia, and hyperglycemia, and trigger the endothelial expression of adhesion molecules such as P-selection, vascular cell adhesion molecule-1 (VCAM-1) and chemokines which mediate the recruitment and adhesion of leukocytes.
Meta-analysis and meta-regression analysis of biomarkers for abdominal aortic aneurysm.
Review
New
Bown et al., Leicester, United Kingdom. In Br J Surg, Oct 2014
Although meta-analysis was not possible for MMP-2 in aortic tissue, tumour necrosis factor α, osteoprotegerin, osteopontin, interferon γ, intercellular cell adhesion molecule 1 and vascular cell adhesion molecule 1, systematic review suggested an increase in these biomarkers in patients with AAA.
Molecular magnetic resonance imaging of brain-immune interactions.
Review
Vivien et al., Caen, France. In Front Cell Neurosci, 2013
Thus, molecular magnetic resonance imaging (MRI) of inflammatory processes is a central theme of research in several neurological disorders focusing on a set of molecules expressed by endothelial cells, such as adhesion molecules (VCAM-1, ICAM-1, P-selectin, E-selectin, …), which emerge as therapeutic targets and biomarkers for neurological diseases.
Recruitment of beneficial M2 macrophages to injured spinal cord is orchestrated by remote brain choroid plexus.
Impact
Schwartz et al., Israel. In Immunity, 2013
The resolving M2 macrophages (Ly6c(lo)CX3CR1(hi)) derived from monocytes trafficked through a remote blood-cerebrospinal-fluid (CSF) barrier, the brain-ventricular choroid plexus (CP), via VCAM-1-VLA-4 adhesion molecules and epithelial CD73 enzyme for extravasation and epithelial transmigration.
Tumor necrosis factor-α enhanced fusions between oral squamous cell carcinoma cells and endothelial cells via VCAM-1/VLA-4 pathway.
GeneRIF
Shang et al., Wuhan, China. In Exp Cell Res, 2012
Expression of VCAM-1, a ligand for VLA-4, was evident on vascular endothelium of oral squamous cell carcinoma.
VCAM1 is essential to maintain the structure of the SVZ niche and acts as an environmental sensor to regulate SVZ lineage progression.
Impact
Temple et al., San Antonio, United States. In Cell Stem Cell, 2012
Here we show that the apical endfeet express high levels of the adhesion and signaling molecule vascular cell adhesion molecule-1 (VCAM1).
The NF-κB target genes ICAM-1 and VCAM-1 are differentially regulated during spontaneous differentiation of Caco-2 cells.
GeneRIF
Banerjee et al., Ankara, Turkey. In Febs J, 2012
we have shown here that the two cell adhesion molecules ICAM-1 and VCAM-1, although best known as inflammatory NF-kappaB target genes, are regulated differentially during Caco-2 differentiation
Primitive erythropoiesis is regulated by miR-126 via nonhematopoietic Vcam-1+ cells.
GeneRIF
Keller et al., Toronto, Canada. In Dev Cell, 2012
Vcam-1 expressed by a mesenchymal cell population is a relevant target of miR-126.
Nuclear-localized focal adhesion kinase regulates inflammatory VCAM-1 expression.
GeneRIF
Schlaepfer et al., San Diego, United States. In J Cell Biol, 2012
studies reveal new developmental and anti-inflammatory roles for kinase-inhibited FAK in limiting VCAM-1 production via nuclear localization and promotion of GATA4 turnover
Pre-diagnostic levels of adiponectin and soluble vascular cell adhesion molecule-1 are associated with colorectal cancer risk.
GeneRIF
Czernichow et al., Bobigny, France. In World J Gastroenterol, 2012
Pre-diagnostic plasma VCAM-1 levels are associated with increased colorectal cancer risk.
Metastatic cells will take any help they can get.
Impact
Hynes, Cambridge, United States. In Cancer Cell, 2012
Two recent papers in Cancer Cell (Lu et al., this issue of Cancer Cell, and Kang et al.) illustrate means whereby acquisition of VCAM-1 by tumor cells can promote metastasis.
VCAM-1 promotes osteolytic expansion of indolent bone micrometastasis of breast cancer by engaging α4β1-positive osteoclast progenitors.
Impact
GeneRIF
Kang et al., Princeton, United States. In Cancer Cell, 2012
VCAM-1 promotes osteolytic expansion of indolent bone micrometastasis of breast cancer by engaging integrin alpha4beta1-positive osteoclast progenitors
Macrophage binding to receptor VCAM-1 transmits survival signals in breast cancer cells that invade the lungs.
Impact
GeneRIF
Massagué et al., New York City, United States. In Cancer Cell, 2011
Cancer cells expressing VCAM-1 can thrive in leukocyte-rich microenvironments through juxtacrine activation of a VCAM-1-Ezrin-PI3K/Akt survival pathway.
More papers using Vascular Cell Adhesion Molecule-1 antibodies
Determination of trans-resveratrol in human plasma by high-performance liquid chromatography
Supplier
Kang Young-Hee et al., In Nutrition Research and Practice, 1998
... Antibodies against human VCAM-1, human β-actin and human VCAM-1 were purchased from Santa Cruz Biotechnology (Santa Cruz, CA) ...
Human T-cell leukemia virus type 1 Tax induction of NF-κB involves activation of the IκB kinase α (IKKα) and IKKβ cellular kinases.
Supplier
Chatziantoniou Christos, In PLoS ONE, 1997
... secondary antibodies were from Calbiochem (Merck, Darmstadt, Germany) and the fluorescent antibodies recognizing E-selectin and VCAM-1 used for FACS analyses were from BD Biosciences (Pharmigen, Germany) ...
Tumor necrosis factor-alpha in sera of obese patients: fall with weight loss
Supplier
Goalstone Marc L et al., In Journal of Inflammation (London, England), 1997
... Primary antibodies to VCAM-1 proteins were from Cell Signaling Technology (Boston, MA) and ...
Intercellular adhesion molecule-1-deficient mice have antibody responses but impaired leukocyte recruitment
Supplier
Wagner Norbert et al., In The Journal of Experimental Medicine, 1996
... VCAM-1 gene 35 and Mx-cre transgenic mice ...
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