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Vascular cell adhesion molecule 1

Vascular Cell Adhesion Molecule-1, VCAM-1
This gene is a member of the Ig superfamily and encodes a cell surface sialoglycoprotein expressed by cytokine-activated endothelium. This type I membrane protein mediates leukocyte-endothelial cell adhesion and signal transduction, and may play a role in the development of artherosclerosis and rheumatoid arthritis. Three alternatively spliced transcripts encoding different isoforms have been described for this gene. [provided by RefSeq, Dec 2010] (from NCBI)
Top mentioned proteins: Intercellular Adhesion Molecule-1, E-selectin, V1a, CAN, Interleukin-6
Papers using Vascular Cell Adhesion Molecule-1 antibodies
Srt1720, srt2183, srt1460, and resveratrol are not direct activators of sirt1
Matter Christian M. et al., In Aging (Albany NY), 2009
... rabbit anti-von Willebrand Factor (Dako), rat anti-CD31, rat anti-VCAM-1 (BD Biosciences), rat anti-ICAM-1 (Serotec).
Superparamagnetic iron oxide nanoparticle-embedded encapsulated microbubbles as dual contrast agents of magnetic resonance and ultrasound imaging
Liu Yiyao et al., In International Journal of Nanomedicine, 2008
... Biotinylated anti-VCAM-1 monoclonal antibody, streptavidin, and phycoerythrin-labeled streptavidin (PE-streptavidin) were obtained from BioLegend (San Diego, CA) ...
Targeting the tetraspanin CD81 blocks monocyte transmigration and ameliorates EAE
Hordijk Peter L. et al., In Journal of Biomedicine and Biotechnology, 2007
... (84H10); ICAM-1-FITC; VCAM-1 (1G11) from R&D systems (Minneapolis, MN, USA); pAb against ICAM-1 (H-108) and VCAM-1 (C-19) from Santa Cruz Biotechnology (Heerhugowaard, The Netherlands); mAb ...
Measuring circulating cell-derived microparticles
Madden Leigh A et al., In Oxidative Medicine and Cellular Longevity, 2003
... either Isotype matched IgG negative control FITC conjugate (4 µL, AbD Serotec, UK) or IgG VCAM-1 specific FITC conjugate (4 µL, AbD Serotec, UK) for 30 min ...
Activation of the hexosamine pathway leads to deterioration of pancreatic beta-cell function through the induction of oxidative stress
Yang Zhihong et al., In Oxidative Medicine and Cellular Longevity, 2000
... hydrochloride and chemicals for immunoblotting were purchased from Sigma (Buchs, Switzerland); antibodies against ICAM-1 and VCAM-1 were from Santa Cruz Biotechnology (Munningen, Switzerland); IRDye 800-conjugated ...
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Papers on Vascular Cell Adhesion Molecule-1
Endothelial hyperpermeability after cardiac surgery with cardiopulmonary bypass as assessed using an in vitro bioassay for endothelial barrier function.
Boer et al., Amsterdam, Netherlands. In Br J Anaesth, Feb 2016
RESULTS: Cardiopulmonary bypass was associated with increased P-selectin, vascular cell adhesion molecule-1, and von Willebrand factor plasma concentrations and an increase in the angiopoietin-2 to angiopoietin-1 ratio, irrespective of the flow profile.
Ginkgolide B protects human umbilical vein endothelial cells against xenobiotic injuries via PXR activation.
Gao et al., Nanning, China. In Acta Pharmacol Sin, Feb 2016
METHODS: Human umbilical vein endothelial cells (HUVECs) were treated with ginkgolide B. The expression of PXR, CYP3A4, MDR1, VCAM-1, E-selectin and caspase-3 were quantified with qRT-PCR and Western blot analysis.
Effect of vitamin B12 and folic acid supplementation on biomarkers of endothelial function and inflammation among elderly individuals with hyperhomocysteinemia.
Smulders et al., Rotterdam, Netherlands. In Vasc Med, Feb 2016
Using an electrochemiluminescence platform, we measured intercellular adhesion molecule 1 (ICAM-1), vascular adhesion molecule 1 (VCAM-1), serum amyloid A (SAA), vascular endothelial growth factor (VEGF) and C-reactive protein (CRP) at baseline and follow-up in a subsample of 522 participants (271 intervention group; 251 placebo).
A systematic review of biomarkers in the diagnosis of infective endocarditis.
Honoré et al., Århus, Denmark. In Int J Cardiol, Feb 2016
Based on current research, N-terminal-pro-B-type natriuretic peptide (NT-proBNP) alone or in combination with Cystatin C (Cys C), lipopolysaccharide-binding protein (LBP), troponins, aquaporin-9 (AQP9), S100 calcium binding protein A11 (S100A11), E-selectin (CD62E) and VCAM-1 (CD54) and interleukin-6 (IL-6) are potential biomarkers for future studies.
Association between 25-hydroxyvitamin D and inflammatory biomarker levels in a cross-sectional population-based study, São Paulo, Brazil.
Martini et al., São Paulo, Brazil. In Nutr Res, Jan 2016
Serum 25(OH)D concentration, plasma inflammatory biomarker levels (C-reactive protein, interleukin [IL]-1β, IL-6, IL-8, IL-10, tumor necrosis factor [TNF] α, IL-12p70, adiponectin, monocyte chemoattractant protein-1, soluble intercellular adhesion molecule-1, and soluble vascular cell adhesion molecule-1), and plasma blood lipid parameters were evaluated.
[Relationship between macrophages and erythropoiesis].
Zhu et al., Tianjin, China. In Zhongguo Dang Dai Er Ke Za Zhi, Jan 2016
A recent mouse study has demonstrated that the phenotype of macrophages in erythroblastic islands is CD169(+) VCAM-1(+) ER-HR3(+) CD11b(+) F4/80(+) Ly-6G(+).
The Establishment and Characteristics of Rat Model of Atherosclerosis Induced by Hyperuricemia.
Li et al., Qingdao, China. In Stem Cells Int, Dec 2015
Proliferating cell nuclear antigen, monocyte chemotactic factor-1, intercellular adhesion molecule-1, and vascular cell adhesion molecule-1 mRNA levels were increased in the HFD and HAD groups compared with the ND group.
Interleukin-33 and Mast Cells Bridge Innate and Adaptive Immunity: From the Allergologist's Perspective.
Kim et al., Inch'ŏn, South Korea. In Int Neurourol J, Sep 2015
IL-33 increases the expression of adhesion molecules, such as intracellular adhesion molecule-1 and vascular cell adhesion molecule-1, in endothelial cells, thus enhancing mast cell adhesion to blood vessel walls.
[Advances in studies on pharmacological action of main chemical constituent of Curcuma Zedoary in preventing in-stent restenosis].
Shi et al., In Zhongguo Zhong Yao Za Zhi, Apr 2015
In recent years, studies have showed that certain extracts and chemical components of E'Zhu could mitigate myocardial cell mitochondria injury and protect vascular endothelium by enhancing heme oxygenase-1 activity, inhibit nuclear factor NF-kappaB, target genes interleukin-associated kinase-1 (IRAK-1), tumor necrosis factor receptor-6 (TRAF-6) and vascular cell adhesion molecule-1 (VCAM-1), reduce inflammatory infiltration, and inhibit growth factor-induced smooth muscle cells (SMCs) proliferation and migration by impacting oxidation of cellular phosphatases.
Crossing the Vascular Wall: Common and Unique Mechanisms Exploited by Different Leukocyte Subsets during Extravasation.
van Buul et al., Mexico. In Mediators Inflamm, 2014
The endothelial adhesion molecules ICAM-1 and VCAM-1 are known as the central mediators of leukocyte adhesion to and transmigration across the endothelium.
Recruitment of beneficial M2 macrophages to injured spinal cord is orchestrated by remote brain choroid plexus.
Schwartz et al., Israel. In Immunity, 2013
The resolving M2 macrophages (Ly6c(lo)CX3CR1(hi)) derived from monocytes trafficked through a remote blood-cerebrospinal-fluid (CSF) barrier, the brain-ventricular choroid plexus (CP), via VCAM-1-VLA-4 adhesion molecules and epithelial CD73 enzyme for extravasation and epithelial transmigration.
Tumor necrosis factor-α enhanced fusions between oral squamous cell carcinoma cells and endothelial cells via VCAM-1/VLA-4 pathway.
Shang et al., Wuhan, China. In Exp Cell Res, 2012
Expression of VCAM-1, a ligand for VLA-4, was evident on vascular endothelium of oral squamous cell carcinoma.
VCAM1 is essential to maintain the structure of the SVZ niche and acts as an environmental sensor to regulate SVZ lineage progression.
Temple et al., San Antonio, United States. In Cell Stem Cell, 2012
Here we show that the apical endfeet express high levels of the adhesion and signaling molecule vascular cell adhesion molecule-1 (VCAM1).
The NF-κB target genes ICAM-1 and VCAM-1 are differentially regulated during spontaneous differentiation of Caco-2 cells.
Banerjee et al., Ankara, Turkey. In Febs J, 2012
we have shown here that the two cell adhesion molecules ICAM-1 and VCAM-1, although best known as inflammatory NF-kappaB target genes, are regulated differentially during Caco-2 differentiation
Primitive erythropoiesis is regulated by miR-126 via nonhematopoietic Vcam-1+ cells.
Keller et al., Toronto, Canada. In Dev Cell, 2012
Vcam-1 expressed by a mesenchymal cell population is a relevant target of miR-126.
Nuclear-localized focal adhesion kinase regulates inflammatory VCAM-1 expression.
Schlaepfer et al., San Diego, United States. In J Cell Biol, 2012
studies reveal new developmental and anti-inflammatory roles for kinase-inhibited FAK in limiting VCAM-1 production via nuclear localization and promotion of GATA4 turnover
Pre-diagnostic levels of adiponectin and soluble vascular cell adhesion molecule-1 are associated with colorectal cancer risk.
Czernichow et al., Bobigny, France. In World J Gastroenterol, 2012
Pre-diagnostic plasma VCAM-1 levels are associated with increased colorectal cancer risk.
Metastatic cells will take any help they can get.
Hynes, Cambridge, United States. In Cancer Cell, 2012
Two recent papers in Cancer Cell (Lu et al., this issue of Cancer Cell, and Kang et al.) illustrate means whereby acquisition of VCAM-1 by tumor cells can promote metastasis.
VCAM-1 promotes osteolytic expansion of indolent bone micrometastasis of breast cancer by engaging α4β1-positive osteoclast progenitors.
Kang et al., Princeton, United States. In Cancer Cell, 2012
VCAM-1 promotes osteolytic expansion of indolent bone micrometastasis of breast cancer by engaging integrin alpha4beta1-positive osteoclast progenitors
Macrophage binding to receptor VCAM-1 transmits survival signals in breast cancer cells that invade the lungs.
Massagué et al., New York City, United States. In Cancer Cell, 2011
Cancer cells expressing VCAM-1 can thrive in leukocyte-rich microenvironments through juxtacrine activation of a VCAM-1-Ezrin-PI3K/Akt survival pathway.
More papers using Vascular Cell Adhesion Molecule-1 antibodies
Determination of trans-resveratrol in human plasma by high-performance liquid chromatography
Kang Young-Hee et al., In Nutrition Research and Practice, 1998
... Antibodies against human VCAM-1, human β-actin and human VCAM-1 were purchased from Santa Cruz Biotechnology (Santa Cruz, CA) ...
Human T-cell leukemia virus type 1 Tax induction of NF-κB involves activation of the IκB kinase α (IKKα) and IKKβ cellular kinases.
Chatziantoniou Christos, In PLoS ONE, 1997
... secondary antibodies were from Calbiochem (Merck, Darmstadt, Germany) and the fluorescent antibodies recognizing E-selectin and VCAM-1 used for FACS analyses were from BD Biosciences (Pharmigen, Germany) ...
Tumor necrosis factor-alpha in sera of obese patients: fall with weight loss
Goalstone Marc L et al., In Journal of Inflammation (London, England), 1997
... Primary antibodies to VCAM-1 proteins were from Cell Signaling Technology (Boston, MA) and ...
Intercellular adhesion molecule-1-deficient mice have antibody responses but impaired leukocyte recruitment
Wagner Norbert et al., In The Journal of Experimental Medicine, 1996
... VCAM-1 gene 35 and Mx-cre transgenic mice ...
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