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Vascular cell adhesion molecule 1

Vascular Cell Adhesion Molecule-1, VCAM-1
This gene is a member of the Ig superfamily and encodes a cell surface sialoglycoprotein expressed by cytokine-activated endothelium. This type I membrane protein mediates leukocyte-endothelial cell adhesion and signal transduction, and may play a role in the development of artherosclerosis and rheumatoid arthritis. Three alternatively spliced transcripts encoding different isoforms have been described for this gene. [provided by RefSeq, Dec 2010] (from NCBI)
Top mentioned proteins: Intercellular Adhesion Molecule-1, E-selectin, CAN, V1a, Interleukin-6
Papers using Vascular Cell Adhesion Molecule-1 antibodies
Srt1720, srt2183, srt1460, and resveratrol are not direct activators of sirt1
Supplier
Matter Christian M. et al., In Aging (Albany NY), 2009
... rabbit anti-von Willebrand Factor (Dako), rat anti-CD31, rat anti-VCAM-1 (BD Biosciences), rat anti-ICAM-1 (Serotec).
Superparamagnetic iron oxide nanoparticle-embedded encapsulated microbubbles as dual contrast agents of magnetic resonance and ultrasound imaging
Supplier
Liu Yiyao et al., In International Journal of Nanomedicine, 2008
... Biotinylated anti-VCAM-1 monoclonal antibody, streptavidin, and phycoerythrin-labeled streptavidin (PE-streptavidin) were obtained from BioLegend (San Diego, CA) ...
Targeting the tetraspanin CD81 blocks monocyte transmigration and ameliorates EAE
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Hordijk Peter L. et al., In Journal of Biomedicine and Biotechnology, 2007
... (84H10); ICAM-1-FITC; VCAM-1 (1G11) from R&D systems (Minneapolis, MN, USA); pAb against ICAM-1 (H-108) and VCAM-1 (C-19) from Santa Cruz Biotechnology (Heerhugowaard, The Netherlands); mAb ...
Measuring circulating cell-derived microparticles
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Madden Leigh A et al., In Oxidative Medicine and Cellular Longevity, 2003
... either Isotype matched IgG negative control FITC conjugate (4 µL, AbD Serotec, UK) or IgG VCAM-1 specific FITC conjugate (4 µL, AbD Serotec, UK) for 30 min ...
Activation of the hexosamine pathway leads to deterioration of pancreatic beta-cell function through the induction of oxidative stress
Supplier
Yang Zhihong et al., In Oxidative Medicine and Cellular Longevity, 2000
... hydrochloride and chemicals for immunoblotting were purchased from Sigma (Buchs, Switzerland); antibodies against ICAM-1 and VCAM-1 were from Santa Cruz Biotechnology (Munningen, Switzerland); IRDye 800-conjugated ...
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Papers on Vascular Cell Adhesion Molecule-1
Microvascular Abnormalities in Adjuvant-Induced Arthritis: Relationship with Macrovascular Endothelial Function and Markers of Endothelial Activation.
New
Demougeot et al., Mongolia. In Arthritis Rheumatol, 23 Mar 2015
Macrovascular function was studied on aortic rings and blood pressure, plasma levels of C-reactive protein (CRP), intercellular adhesion molecule 1 (ICAM-1) and vascular cell adhesion molecule 1 (VCAM-1) were measured at each time.
Effects of Acute and Antecedent Hypoglycemia on Endothelial Function and Markers of Atherothrombotic Balance in Healthy Man.
New
Davis et al., Baltimore, United States. In Diabetes, 18 Mar 2015
Two D Doppler ultrasound was used to determine brachial arterial endothelial function.PAI-1, VCAM-1, ICAM-1, E-selectin, P-selectin, TAT (thrombin/anti-thrombin complex), TNF-α and IL-6 responses were increased (p<0.05) during single or repeated hypoglycemia as compared to euglycemia.
Diverging trajectory patterns of systemic versus vascular inflammation over age in healthy Caucasians and African-Americans.
New
Berglund et al., Davis, United States. In Atherosclerosis, 16 Mar 2015
Systemic inflammation was assessed by C-reactive protein (CRP), serum amyloid A (SAA), fibrinogen, haptoglobin and α-acid glycoprotein, and vascular inflammation was assessed by pentraxin-3 (PTX-3), soluble intercellular adhesion molecule-1 (sICAM-1) and soluble vascular cell adhesion molecule-1 (sVCAM).
The Fucosylation Inhibitor, 2-Fluorofucose, Inhibits Vaso-Occlusion, Leukocyte-Endothelium Interactions and NF-ĸB Activation in Transgenic Sickle Mice.
New
Vercellotti et al., Bothell, United States. In Plos One, Dec 2014
NF-ĸB activation and VCAM-1 and E-selectin expression were inhibited in the livers of SCD mice consistent with an overall decrease in vascular inflammation and ischemia-reperfusion physiology.
Recruitment of the adaptor protein Nck to PECAM-1 couples oxidative stress to canonical NF-κB signaling and inflammation.
New
Orr et al., Shreveport, United States. In Sci Signal, Dec 2014
Depletion of Nck prevented oxidative stress induced by exogenous hydrogen peroxide or hypoxia/reoxygenation injury from activating NF-κB in endothelial cells, increasing the abundance of the proinflammatory molecules ICAM-1 (intracellular adhesion molecule-1) and VCAM-1 (vascular cell adhesion molecule-1) and recruiting leukocytes.
Iron metabolism in obesity: How interaction between homoeostatic mechanisms can interfere with their original purpose. Part I: Underlying homoeostatic mechanisms of energy storage and iron metabolisms and their interaction.
Review
New
Schümann et al., Freising, Germany. In J Trace Elem Med Biol, Dec 2014
This process is regulated by a complex interaction of cytokines (TNF-α, IL-6), adipokines (adiponectin, apelin, liptin), adhesion molecules (ICAM-1, VCAM-1, E-selectin) and transcription factors (NF-κB, HIF-1α).
The Renin-Angiotensin-aldosterone system in vascular inflammation and remodeling.
Review
Ndebele et al., Jackson, United States. In Int J Inflam, 2013
Inflammatory factors such as ICAM-1, VCAM-1, TNFα, IL-6, and CRP have key roles in mediating vascular inflammation and blocking RAAS negatively modulates the levels of these inflammatory molecules.
Remodeling and fibrosis in chronic eosinophil inflammation.
Review
Aceves, San Diego, United States. In Dig Dis, 2013
A number of profibrotic and proangiogenic factors are elevated in EoE, including TGF-β1, CCL-18, FGF-9, VEGF, and VCAM-1.
Soluble adhesion molecules as markers for sepsis and the potential pathophysiological discrepancy in neonates, children and adults.
Review
Carman et al., In Crit Care, 2013
Five soluble adhesion molecules are associated with sepsis, specifically, E-selectin, L-selectin and P-selectin, intercellular adhesion molecule-1 and vascular cell adhesion molecule-1.
Molecular magnetic resonance imaging of brain-immune interactions.
Review
Vivien et al., Caen, France. In Front Cell Neurosci, 2013
Thus, molecular magnetic resonance imaging (MRI) of inflammatory processes is a central theme of research in several neurological disorders focusing on a set of molecules expressed by endothelial cells, such as adhesion molecules (VCAM-1, ICAM-1, P-selectin, E-selectin, …), which emerge as therapeutic targets and biomarkers for neurological diseases.
Recruitment of beneficial M2 macrophages to injured spinal cord is orchestrated by remote brain choroid plexus.
Impact
Schwartz et al., Israel. In Immunity, 2013
The resolving M2 macrophages (Ly6c(lo)CX3CR1(hi)) derived from monocytes trafficked through a remote blood-cerebrospinal-fluid (CSF) barrier, the brain-ventricular choroid plexus (CP), via VCAM-1-VLA-4 adhesion molecules and epithelial CD73 enzyme for extravasation and epithelial transmigration.
Tumor necrosis factor-α enhanced fusions between oral squamous cell carcinoma cells and endothelial cells via VCAM-1/VLA-4 pathway.
GeneRIF
Shang et al., Wuhan, China. In Exp Cell Res, 2012
Expression of VCAM-1, a ligand for VLA-4, was evident on vascular endothelium of oral squamous cell carcinoma.
VCAM1 is essential to maintain the structure of the SVZ niche and acts as an environmental sensor to regulate SVZ lineage progression.
Impact
Temple et al., San Antonio, United States. In Cell Stem Cell, 2012
Here we show that the apical endfeet express high levels of the adhesion and signaling molecule vascular cell adhesion molecule-1 (VCAM1).
The NF-κB target genes ICAM-1 and VCAM-1 are differentially regulated during spontaneous differentiation of Caco-2 cells.
GeneRIF
Banerjee et al., Ankara, Turkey. In Febs J, 2012
we have shown here that the two cell adhesion molecules ICAM-1 and VCAM-1, although best known as inflammatory NF-kappaB target genes, are regulated differentially during Caco-2 differentiation
Primitive erythropoiesis is regulated by miR-126 via nonhematopoietic Vcam-1+ cells.
GeneRIF
Keller et al., Toronto, Canada. In Dev Cell, 2012
Vcam-1 expressed by a mesenchymal cell population is a relevant target of miR-126.
Nuclear-localized focal adhesion kinase regulates inflammatory VCAM-1 expression.
GeneRIF
Schlaepfer et al., San Diego, United States. In J Cell Biol, 2012
studies reveal new developmental and anti-inflammatory roles for kinase-inhibited FAK in limiting VCAM-1 production via nuclear localization and promotion of GATA4 turnover
Pre-diagnostic levels of adiponectin and soluble vascular cell adhesion molecule-1 are associated with colorectal cancer risk.
GeneRIF
Czernichow et al., Bobigny, France. In World J Gastroenterol, 2012
Pre-diagnostic plasma VCAM-1 levels are associated with increased colorectal cancer risk.
Metastatic cells will take any help they can get.
Impact
Hynes, Cambridge, United States. In Cancer Cell, 2012
Two recent papers in Cancer Cell (Lu et al., this issue of Cancer Cell, and Kang et al.) illustrate means whereby acquisition of VCAM-1 by tumor cells can promote metastasis.
VCAM-1 promotes osteolytic expansion of indolent bone micrometastasis of breast cancer by engaging α4β1-positive osteoclast progenitors.
Impact
GeneRIF
Kang et al., Princeton, United States. In Cancer Cell, 2012
VCAM-1 promotes osteolytic expansion of indolent bone micrometastasis of breast cancer by engaging integrin alpha4beta1-positive osteoclast progenitors
Macrophage binding to receptor VCAM-1 transmits survival signals in breast cancer cells that invade the lungs.
Impact
GeneRIF
Massagué et al., New York City, United States. In Cancer Cell, 2011
Cancer cells expressing VCAM-1 can thrive in leukocyte-rich microenvironments through juxtacrine activation of a VCAM-1-Ezrin-PI3K/Akt survival pathway.
More papers using Vascular Cell Adhesion Molecule-1 antibodies
Determination of trans-resveratrol in human plasma by high-performance liquid chromatography
Supplier
Kang Young-Hee et al., In Nutrition Research and Practice, 1998
... Antibodies against human VCAM-1, human β-actin and human VCAM-1 were purchased from Santa Cruz Biotechnology (Santa Cruz, CA) ...
Human T-cell leukemia virus type 1 Tax induction of NF-κB involves activation of the IκB kinase α (IKKα) and IKKβ cellular kinases.
Supplier
Chatziantoniou Christos, In PLoS ONE, 1997
... secondary antibodies were from Calbiochem (Merck, Darmstadt, Germany) and the fluorescent antibodies recognizing E-selectin and VCAM-1 used for FACS analyses were from BD Biosciences (Pharmigen, Germany) ...
Tumor necrosis factor-alpha in sera of obese patients: fall with weight loss
Supplier
Goalstone Marc L et al., In Journal of Inflammation (London, England), 1997
... Primary antibodies to VCAM-1 proteins were from Cell Signaling Technology (Boston, MA) and ...
Intercellular adhesion molecule-1-deficient mice have antibody responses but impaired leukocyte recruitment
Supplier
Wagner Norbert et al., In The Journal of Experimental Medicine, 1996
... VCAM-1 gene 35 and Mx-cre transgenic mice ...
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