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Vascular cell adhesion molecule 1

Vascular Cell Adhesion Molecule-1, VCAM-1
This gene is a member of the Ig superfamily and encodes a cell surface sialoglycoprotein expressed by cytokine-activated endothelium. This type I membrane protein mediates leukocyte-endothelial cell adhesion and signal transduction, and may play a role in the development of artherosclerosis and rheumatoid arthritis. Three alternatively spliced transcripts encoding different isoforms have been described for this gene. [provided by RefSeq, Dec 2010] (from NCBI)
Top mentioned proteins: Intercellular Adhesion Molecule-1, E-selectin, CAN, Interleukin-6, V1a
Papers using Vascular Cell Adhesion Molecule-1 antibodies
Srt1720, srt2183, srt1460, and resveratrol are not direct activators of sirt1
Supplier
Matter Christian M. et al., In Aging (Albany NY), 2009
... rabbit anti-von Willebrand Factor (Dako), rat anti-CD31, rat anti-VCAM-1 (BD Biosciences), rat anti-ICAM-1 (Serotec).
Superparamagnetic iron oxide nanoparticle-embedded encapsulated microbubbles as dual contrast agents of magnetic resonance and ultrasound imaging
Supplier
Liu Yiyao et al., In International Journal of Nanomedicine, 2008
... Biotinylated anti-VCAM-1 monoclonal antibody, streptavidin, and phycoerythrin-labeled streptavidin (PE-streptavidin) were obtained from BioLegend (San Diego, CA) ...
Targeting the tetraspanin CD81 blocks monocyte transmigration and ameliorates EAE
Supplier
Hordijk Peter L. et al., In Journal of Biomedicine and Biotechnology, 2007
... (84H10); ICAM-1-FITC; VCAM-1 (1G11) from R&D systems (Minneapolis, MN, USA); pAb against ICAM-1 (H-108) and VCAM-1 (C-19) from Santa Cruz Biotechnology (Heerhugowaard, The Netherlands); mAb ...
Measuring circulating cell-derived microparticles
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Madden Leigh A et al., In Oxidative Medicine and Cellular Longevity, 2003
... either Isotype matched IgG negative control FITC conjugate (4 µL, AbD Serotec, UK) or IgG VCAM-1 specific FITC conjugate (4 µL, AbD Serotec, UK) for 30 min ...
Activation of the hexosamine pathway leads to deterioration of pancreatic beta-cell function through the induction of oxidative stress
Supplier
Yang Zhihong et al., In Oxidative Medicine and Cellular Longevity, 2000
... hydrochloride and chemicals for immunoblotting were purchased from Sigma (Buchs, Switzerland); antibodies against ICAM-1 and VCAM-1 were from Santa Cruz Biotechnology (Munningen, Switzerland); IRDye 800-conjugated ...
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Papers on Vascular Cell Adhesion Molecule-1
The kinetics of hematopoietic niche cytokines and their influence on mobilization efficacy and timing in patients with hematological malignancies.
New
Wierzbowska et al., Łódź, Poland. In J Clin Apher, 29 Nov 2014
The aim of our study was to evaluate the levels of VCAM-1, VEGF, MMP-9 and SDF during mobilization of CD34+ cells in patients with hematological malignancies.
Complement Inhibition in a Xenogeneic Model of Interactions Between Human Whole Blood and Porcine Endothelium.
New
Chavakis et al., Dresden, Germany. In Horm Metab Res, 28 Nov 2014
Moreover, Cp40 inhibited the activation of PAECs and leukocytes, since the levels of the adhesion molecules E-selectin, ICAM-1, ICAM-2, and VCAM-1 on PAECs and the surface expression of integrin CD11b on neutrophils were significantly decreased.
Immune impairments in multiple myeloma bone marrow mesenchymal stromal cells.
New
Lagneaux et al., Brussels, Belgium. In Cancer Immunol Immunother, 24 Nov 2014
We demonstrated that MM BM-MSCs exhibit abnormal expression of CD40/40L, VCAM1, ICAM-1, LFA-3, HO-1, HLA-DR and HLA-ABC.
Suitable in vitro Eimeria arloingi macromeront formation in host endothelial cells and modulation of adhesion molecule, cytokine and chemokine gene transcription.
New
Hermosilla et al., Évora, Portugal. In Parasitol Res, 23 Nov 2014
Gene transcription of adhesion molecules (E-selectin, P-selectin, VCAM-1, ICAM-1) was enhanced in the first hours post-infection (p.i.) in E. arloingi-infected BUVEC.
Rho-GTPase signaling in leukocyte extravasation: An endothelial point of view.
Review
New
van Buul et al., Amsterdam, Netherlands. In Cell Adh Migr, Mar 2014
The adhesion molecules ICAM-1 and VCAM-1 are known as central mediators of TEM.
Suppressive effects of cacao polyphenols on the development of atherosclerosis in apolipoprotein E-deficient mice.
Review
New
Baba et al., Odawara, Japan. In Subcell Biochem, Dec 2013
Immunochemical staining in the 0.25 and 0.40 % groups showed that expression of the cell adhesion molecules (VCAM-1 and ICAM-1) and production of oxidative stress markers (4-hydroxynonenal, hexanoyl-lysine, and dityrosine) were reduced in cross-sections of the brachiocephalic trunk.
The Renin-Angiotensin-aldosterone system in vascular inflammation and remodeling.
Review
New
Ndebele et al., Jackson, United States. In Int J Inflam, Dec 2013
Inflammatory factors such as ICAM-1, VCAM-1, TNFα, IL-6, and CRP have key roles in mediating vascular inflammation and blocking RAAS negatively modulates the levels of these inflammatory molecules.
Immunomodulatory effects of 17-O-acetylacuminolide in RAW264.7 cells and HUVECs: involvement of MAPK and NF-κB pathways.
New
Mustafa et al., Kuala Lumpur, Malaysia. In Drug Des Devel Ther, Dec 2013
In human umbilical vein endothelial cells, AA inhibited the expression of inflammatory proteins including the adhesion molecules intercellular adhesion molecule 1; vascular cell adhesion molecule 1; and E-selectin, as well as the release of the chemokine interleukin-8.
Low shear stress up-regulation of proinflammatory gene expression in human retinal microvascular endothelial cells.
Review
New
Yoshida et al., Asahikawa, Japan. In Exp Eye Res, Nov 2013
HRMECs exposed to 1.5 dyne/cm(2) significantly up-regulated the mRNA expression of intercellular adhesion molecule-1, vascular cell adhesion molecule-1, and E-selectin.
Recruitment of beneficial M2 macrophages to injured spinal cord is orchestrated by remote brain choroid plexus.
New
Impact
Schwartz et al., Israel. In Immunity, Apr 2013
The resolving M2 macrophages (Ly6c(lo)CX3CR1(hi)) derived from monocytes trafficked through a remote blood-cerebrospinal-fluid (CSF) barrier, the brain-ventricular choroid plexus (CP), via VCAM-1-VLA-4 adhesion molecules and epithelial CD73 enzyme for extravasation and epithelial transmigration.
Positron emission tomography imaging of atherosclerosis.
Review
Cai et al., Madison, United States. In Theranostics, 2012
The targets and pathways that have been investigated to date for PET imaging of atherosclerosis include: glycolysis, cell membrane metabolism (phosphatidylcholine synthesis), integrin αvβ3, low density lipoprotein (LDL) receptors (LDLr), natriuretic peptide clearance receptors (NPCRs), fatty acid synthesis, vascular cell adhesion molecule-1 (VCAM-1), macrophages, platelets, etc.
Tumor necrosis factor-α enhanced fusions between oral squamous cell carcinoma cells and endothelial cells via VCAM-1/VLA-4 pathway.
GeneRIF
Shang et al., Wuhan, China. In Exp Cell Res, 2012
Expression of VCAM-1, a ligand for VLA-4, was evident on vascular endothelium of oral squamous cell carcinoma.
VCAM1 is essential to maintain the structure of the SVZ niche and acts as an environmental sensor to regulate SVZ lineage progression.
Impact
Temple et al., San Antonio, United States. In Cell Stem Cell, 2012
Here we show that the apical endfeet express high levels of the adhesion and signaling molecule vascular cell adhesion molecule-1 (VCAM1).
The NF-κB target genes ICAM-1 and VCAM-1 are differentially regulated during spontaneous differentiation of Caco-2 cells.
GeneRIF
Banerjee et al., Ankara, Turkey. In Febs J, 2012
we have shown here that the two cell adhesion molecules ICAM-1 and VCAM-1, although best known as inflammatory NF-kappaB target genes, are regulated differentially during Caco-2 differentiation
Primitive erythropoiesis is regulated by miR-126 via nonhematopoietic Vcam-1+ cells.
GeneRIF
Keller et al., Toronto, Canada. In Dev Cell, 2012
Vcam-1 expressed by a mesenchymal cell population is a relevant target of miR-126.
Nuclear-localized focal adhesion kinase regulates inflammatory VCAM-1 expression.
GeneRIF
Schlaepfer et al., San Diego, United States. In J Cell Biol, 2012
studies reveal new developmental and anti-inflammatory roles for kinase-inhibited FAK in limiting VCAM-1 production via nuclear localization and promotion of GATA4 turnover
Pre-diagnostic levels of adiponectin and soluble vascular cell adhesion molecule-1 are associated with colorectal cancer risk.
GeneRIF
Czernichow et al., Bobigny, France. In World J Gastroenterol, 2012
Pre-diagnostic plasma VCAM-1 levels are associated with increased colorectal cancer risk.
Metastatic cells will take any help they can get.
Impact
Hynes, Cambridge, United States. In Cancer Cell, 2012
Two recent papers in Cancer Cell (Lu et al., this issue of Cancer Cell, and Kang et al.) illustrate means whereby acquisition of VCAM-1 by tumor cells can promote metastasis.
VCAM-1 promotes osteolytic expansion of indolent bone micrometastasis of breast cancer by engaging α4β1-positive osteoclast progenitors.
Impact
GeneRIF
Kang et al., Princeton, United States. In Cancer Cell, 2012
VCAM-1 promotes osteolytic expansion of indolent bone micrometastasis of breast cancer by engaging integrin alpha4beta1-positive osteoclast progenitors
Macrophage binding to receptor VCAM-1 transmits survival signals in breast cancer cells that invade the lungs.
Impact
GeneRIF
Massagué et al., New York City, United States. In Cancer Cell, 2011
Cancer cells expressing VCAM-1 can thrive in leukocyte-rich microenvironments through juxtacrine activation of a VCAM-1-Ezrin-PI3K/Akt survival pathway.
More papers using Vascular Cell Adhesion Molecule-1 antibodies
Determination of trans-resveratrol in human plasma by high-performance liquid chromatography
Supplier
Kang Young-Hee et al., In Nutrition Research and Practice, 1998
... Antibodies against human VCAM-1, human β-actin and human VCAM-1 were purchased from Santa Cruz Biotechnology (Santa Cruz, CA) ...
Human T-cell leukemia virus type 1 Tax induction of NF-κB involves activation of the IκB kinase α (IKKα) and IKKβ cellular kinases.
Supplier
Chatziantoniou Christos, In PLoS ONE, 1997
... secondary antibodies were from Calbiochem (Merck, Darmstadt, Germany) and the fluorescent antibodies recognizing E-selectin and VCAM-1 used for FACS analyses were from BD Biosciences (Pharmigen, Germany) ...
Tumor necrosis factor-alpha in sera of obese patients: fall with weight loss
Supplier
Goalstone Marc L et al., In Journal of Inflammation (London, England), 1997
... Primary antibodies to VCAM-1 proteins were from Cell Signaling Technology (Boston, MA) and ...
Intercellular adhesion molecule-1-deficient mice have antibody responses but impaired leukocyte recruitment
Supplier
Wagner Norbert et al., In The Journal of Experimental Medicine, 1996
... VCAM-1 gene 35 and Mx-cre transgenic mice ...
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