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Vascular cell adhesion molecule 1

Vascular Cell Adhesion Molecule-1, VCAM-1
This gene is a member of the Ig superfamily and encodes a cell surface sialoglycoprotein expressed by cytokine-activated endothelium. This type I membrane protein mediates leukocyte-endothelial cell adhesion and signal transduction, and may play a role in the development of artherosclerosis and rheumatoid arthritis. Three alternatively spliced transcripts encoding different isoforms have been described for this gene. [provided by RefSeq, Dec 2010] (from NCBI)
Top mentioned proteins: Intercellular Adhesion Molecule-1, E-selectin, CAN, Interleukin-6, V1a
Papers using Vascular Cell Adhesion Molecule-1 antibodies
Srt1720, srt2183, srt1460, and resveratrol are not direct activators of sirt1
Supplier
Matter Christian M. et al., In Aging (Albany NY), 2009
... rabbit anti-von Willebrand Factor (Dako), rat anti-CD31, rat anti-VCAM-1 (BD Biosciences), rat anti-ICAM-1 (Serotec).
Superparamagnetic iron oxide nanoparticle-embedded encapsulated microbubbles as dual contrast agents of magnetic resonance and ultrasound imaging
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Liu Yiyao et al., In International Journal of Nanomedicine, 2008
... Biotinylated anti-VCAM-1 monoclonal antibody, streptavidin, and phycoerythrin-labeled streptavidin (PE-streptavidin) were obtained from BioLegend (San Diego, CA) ...
Targeting the tetraspanin CD81 blocks monocyte transmigration and ameliorates EAE
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Hordijk Peter L. et al., In Journal of Biomedicine and Biotechnology, 2007
... (84H10); ICAM-1-FITC; VCAM-1 (1G11) from R&D systems (Minneapolis, MN, USA); pAb against ICAM-1 (H-108) and VCAM-1 (C-19) from Santa Cruz Biotechnology (Heerhugowaard, The Netherlands); mAb ...
Measuring circulating cell-derived microparticles
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Madden Leigh A et al., In Oxidative Medicine and Cellular Longevity, 2003
... either Isotype matched IgG negative control FITC conjugate (4 µL, AbD Serotec, UK) or IgG VCAM-1 specific FITC conjugate (4 µL, AbD Serotec, UK) for 30 min ...
Activation of the hexosamine pathway leads to deterioration of pancreatic beta-cell function through the induction of oxidative stress
Supplier
Yang Zhihong et al., In Oxidative Medicine and Cellular Longevity, 2000
... hydrochloride and chemicals for immunoblotting were purchased from Sigma (Buchs, Switzerland); antibodies against ICAM-1 and VCAM-1 were from Santa Cruz Biotechnology (Munningen, Switzerland); IRDye 800-conjugated ...
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Papers on Vascular Cell Adhesion Molecule-1
Rosiglitazone attenuates indoxyl sulfate-induced endothelial dysfunction.
New
Lee et al., Kao-hsiung, Taiwan. In Clin Exp Pharmacol Physiol, 06 Jan 2015
Our results revealed that indoxyl sulfate up-regulated intracellular cell adhesion molecule-1 (ICAM-1), vascular cell adhesion molecule-1 (VCAM-1), and monocyte chemotactic protein-1 (MCP-1).
Differential and Opposing Effects of Imatinib on LPS- and Ventilator-Induced Lung Injury.
New
Dudek et al., Chicago, United States. In Am J Physiol Lung Cell Mol Physiol, 05 Jan 2015
Down-regulation of c-Abl expression with siRNA attenuates LPS-induced VCAM-1 expression, while specific reduction of Arg reduces VE-cadherin expression in 18% CS-challenged ECs to mimic the imatinib effects.
Obesity superimposed on aging magnifies inflammation and delays the resolving response following myocardial infarction.
New
Halade et al., Birmingham, United States. In Am J Physiol Heart Circ Physiol, 05 Jan 2015
Despite similar infarct areas post-MI, plasma proteomic profiling revealed higher vascular cell adhesion molecule-1 in PUFA aging compared to LC young and LC aging, leading to increased neutrophil infiltration in the PUFA aging group (p<0.05).
Long-Term Outcome of Patients With Crohn's Disease who Discontinued Infliximab Therapy Upon Clinical Remission.
New
Ferrante et al., Leuven, Belgium. In Clin Gastroenterol Hepatol, 02 Jan 2015
Among factors evaluated at the time of infliximab discontinuation, infliximab trough concentrations (<6 μg/ml, P=.031), complete mucosal healing (P=.046), and serum positivity for vascular cell adhesion molecule-1 (>0.67 μg/ml, P=.024) were associated with SCR.
Mechanisms of endothelial cell protection by hydroxycinnamic acids.
Review
New
Palomo et al., Talca, Chile. In Vascul Pharmacol, 13 Dec 2014
Therefore, it can be established that due to the hydroxycinnamic acid content (caffeic, chlorogenic, feluric and p-coumaric acids), fruit, vegetables and beverages contribute to endothelial protection (attenuates oxidative stress, improved nitric oxide bioavailability and decreased E-selectin, ICAM-1 and VCAM-1 expression, among others).
Iron metabolism in obesity: How interaction between homoeostatic mechanisms can interfere with their original purpose. Part I: Underlying homoeostatic mechanisms of energy storage and iron metabolisms and their interaction.
Review
New
Schümann et al., Freising, Germany. In J Trace Elem Med Biol, 06 Dec 2014
This process is regulated by a complex interaction of cytokines (TNF-α, IL-6), adipokines (adiponectin, apelin, liptin), adhesion molecules (ICAM-1, VCAM-1, E-selectin) and transcription factors (NF-κB, HIF-1α).
The influence of physical training on endothelial function in patients with stable coronary artery disease.
New
Mazurek et al., Wrocław, Poland. In Adv Clin Exp Med, Sep 2014
Blood for VCAM-1 and ICAM-1 was collected with the subjects remaining for 30 min in supine position, through a venous access inserted in the basilica vein.
The Renin-Angiotensin-aldosterone system in vascular inflammation and remodeling.
Review
New
Ndebele et al., Jackson, United States. In Int J Inflam, Dec 2013
Inflammatory factors such as ICAM-1, VCAM-1, TNFα, IL-6, and CRP have key roles in mediating vascular inflammation and blocking RAAS negatively modulates the levels of these inflammatory molecules.
Remodeling and fibrosis in chronic eosinophil inflammation.
Review
New
Aceves, San Diego, United States. In Dig Dis, Dec 2013
A number of profibrotic and proangiogenic factors are elevated in EoE, including TGF-β1, CCL-18, FGF-9, VEGF, and VCAM-1.
Suppressive effects of cacao polyphenols on the development of atherosclerosis in apolipoprotein E-deficient mice.
Review
New
Baba et al., Odawara, Japan. In Subcell Biochem, Dec 2013
Immunochemical staining in the 0.25 and 0.40 % groups showed that expression of the cell adhesion molecules (VCAM-1 and ICAM-1) and production of oxidative stress markers (4-hydroxynonenal, hexanoyl-lysine, and dityrosine) were reduced in cross-sections of the brachiocephalic trunk.
Recruitment of beneficial M2 macrophages to injured spinal cord is orchestrated by remote brain choroid plexus.
New
Impact
Schwartz et al., Israel. In Immunity, Apr 2013
The resolving M2 macrophages (Ly6c(lo)CX3CR1(hi)) derived from monocytes trafficked through a remote blood-cerebrospinal-fluid (CSF) barrier, the brain-ventricular choroid plexus (CP), via VCAM-1-VLA-4 adhesion molecules and epithelial CD73 enzyme for extravasation and epithelial transmigration.
Tumor necrosis factor-α enhanced fusions between oral squamous cell carcinoma cells and endothelial cells via VCAM-1/VLA-4 pathway.
GeneRIF
Shang et al., Wuhan, China. In Exp Cell Res, 2012
Expression of VCAM-1, a ligand for VLA-4, was evident on vascular endothelium of oral squamous cell carcinoma.
VCAM1 is essential to maintain the structure of the SVZ niche and acts as an environmental sensor to regulate SVZ lineage progression.
Impact
Temple et al., San Antonio, United States. In Cell Stem Cell, 2012
Here we show that the apical endfeet express high levels of the adhesion and signaling molecule vascular cell adhesion molecule-1 (VCAM1).
The NF-κB target genes ICAM-1 and VCAM-1 are differentially regulated during spontaneous differentiation of Caco-2 cells.
GeneRIF
Banerjee et al., Ankara, Turkey. In Febs J, 2012
we have shown here that the two cell adhesion molecules ICAM-1 and VCAM-1, although best known as inflammatory NF-kappaB target genes, are regulated differentially during Caco-2 differentiation
Primitive erythropoiesis is regulated by miR-126 via nonhematopoietic Vcam-1+ cells.
GeneRIF
Keller et al., Toronto, Canada. In Dev Cell, 2012
Vcam-1 expressed by a mesenchymal cell population is a relevant target of miR-126.
Nuclear-localized focal adhesion kinase regulates inflammatory VCAM-1 expression.
GeneRIF
Schlaepfer et al., San Diego, United States. In J Cell Biol, 2012
studies reveal new developmental and anti-inflammatory roles for kinase-inhibited FAK in limiting VCAM-1 production via nuclear localization and promotion of GATA4 turnover
Pre-diagnostic levels of adiponectin and soluble vascular cell adhesion molecule-1 are associated with colorectal cancer risk.
GeneRIF
Czernichow et al., Bobigny, France. In World J Gastroenterol, 2012
Pre-diagnostic plasma VCAM-1 levels are associated with increased colorectal cancer risk.
Metastatic cells will take any help they can get.
Impact
Hynes, Cambridge, United States. In Cancer Cell, 2012
Two recent papers in Cancer Cell (Lu et al., this issue of Cancer Cell, and Kang et al.) illustrate means whereby acquisition of VCAM-1 by tumor cells can promote metastasis.
VCAM-1 promotes osteolytic expansion of indolent bone micrometastasis of breast cancer by engaging α4β1-positive osteoclast progenitors.
Impact
GeneRIF
Kang et al., Princeton, United States. In Cancer Cell, 2012
VCAM-1 promotes osteolytic expansion of indolent bone micrometastasis of breast cancer by engaging integrin alpha4beta1-positive osteoclast progenitors
Macrophage binding to receptor VCAM-1 transmits survival signals in breast cancer cells that invade the lungs.
Impact
GeneRIF
Massagué et al., New York City, United States. In Cancer Cell, 2011
Cancer cells expressing VCAM-1 can thrive in leukocyte-rich microenvironments through juxtacrine activation of a VCAM-1-Ezrin-PI3K/Akt survival pathway.
More papers using Vascular Cell Adhesion Molecule-1 antibodies
Determination of trans-resveratrol in human plasma by high-performance liquid chromatography
Supplier
Kang Young-Hee et al., In Nutrition Research and Practice, 1998
... Antibodies against human VCAM-1, human β-actin and human VCAM-1 were purchased from Santa Cruz Biotechnology (Santa Cruz, CA) ...
Human T-cell leukemia virus type 1 Tax induction of NF-κB involves activation of the IκB kinase α (IKKα) and IKKβ cellular kinases.
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Chatziantoniou Christos, In PLoS ONE, 1997
... secondary antibodies were from Calbiochem (Merck, Darmstadt, Germany) and the fluorescent antibodies recognizing E-selectin and VCAM-1 used for FACS analyses were from BD Biosciences (Pharmigen, Germany) ...
Tumor necrosis factor-alpha in sera of obese patients: fall with weight loss
Supplier
Goalstone Marc L et al., In Journal of Inflammation (London, England), 1997
... Primary antibodies to VCAM-1 proteins were from Cell Signaling Technology (Boston, MA) and ...
Intercellular adhesion molecule-1-deficient mice have antibody responses but impaired leukocyte recruitment
Supplier
Wagner Norbert et al., In The Journal of Experimental Medicine, 1996
... VCAM-1 gene 35 and Mx-cre transgenic mice ...
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