Autophagy and Neurodegeneration: Insights from a Cultured Cell Model of ALS.
Milano, Italy. In Cells, 2014
In this review, we focus on the main molecular features of autophagy to provide a framework for discussion of our recent findings about the role in disease pathogenesis of the ALS-linked form of the VAPB gene product, a mutant protein that drives the generation of unusual cytoplasmic inclusions.
From ER to Eph receptors: new roles for VAP fragments.
Bar Harbor, United States. In Cell, 2008
Dominantly inherited mutations in an endoplasmic reticulum protein called VAPB have been found in a subset of patients with a rare familial form of amyotrophic lateral sclerosis (ALS).