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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Arginine vasopressin receptor 1B

V1bR, Avpr1b, vasopressin V1b receptor
The protein encoded by this gene acts as receptor for arginine vasopressin. This receptor belongs to the subfamily of G-protein coupled receptors which includes AVPR1A, V2R and OXT receptors. Its activity is mediated by G proteins which stimulate a phosphatidylinositol-calcium second messenger system. The receptor is primarily located in the anterior pituitary, where it stimulates ACTH release. It is expressed at high levels in ACTH-secreting pituitary adenomas as well as in bronchial carcinoids responsible for the ectopic ACTH syndrome. A spliced antisense transcript of this gene has been reported but its function is not known. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: V1a, Arginine Vasopressin, Oxytocin, CAN, CRF1
Papers on V1bR
Carbetocin is a functional selective Gq agonist that does not promote oxytocin receptor recycling after inducing β-arrestin-independent internalisation.
New
Busnelli et al., Rozzano, Italy. In J Neuroendocrinol, Feb 2016
Using Bioluminescence Resonance Energy Transfer (BRET) biosensors, we characterised the effects of carbetocin on the three human oxytocin/vasopressin receptors expressed in the nervous system: the oxytocin receptor (OXTR) and the vasopressin V1a (V1aR) and V1b (V1bR) receptors.
Targeted activation of the hippocampal CA2 area strongly enhances social memory.
New
Young et al., Bethesda, United States. In Mol Psychiatry, Feb 2016
The CA2 area of the hippocampus, particularly the vasopressin 1b receptor (Avpr1b) expressed there, is necessary for memory formation.
Genetic vasopressin 1b receptor variance in overweight and diabetes mellitus.
New
Melander et al., Malmö, Sweden. In Eur J Endocrinol, Jan 2016
Here, we aim to investigate if the genetic variation of the human AVP receptor 1b gene (AVPR1B) is associated with measures of obesity and DM.
Antagonism of V1b receptors promotes maternrencesal motivation to retrieve pups in the MPOA and impairs pup-directed behavior duringren maternal defense in the mpBNST of lactating rats.
New
Bosch et al., Regensburg, Germany. In Horm Behav, Jan 2016
UNASSIGNED: Recent studies using V1b receptor (V1bR) knockout mice or central pharmacological manipulations in lactating rats highlighted the influence of this receptor for maternal behavior.
Arginine Vasopressin and Arginine Vasopressin Receptor 1b Involved in Electroacupuncture-Attenuated Hypothalamic-Pituitary-Adrenal Axis Hyperactivity in Hepatectomy Rats.
New
Tian et al., Shanghai, China. In Neuromodulation, Dec 2015
The expression of AVP, arginine vasopressin receptor 1a (AVPR1a), arginine vasopressin receptor 1b (AVPR1b), and glucocorticoid receptor (GR) was detected by Western blot after surgery.
The arginine vasopressin V1b receptor gene and prosociality: Mediation role of emotional empathy.
New
Su et al., Beijing, China. In Psych J, Sep 2015
The vasopressin V1b receptor (AVPR1B) gene has been shown to be closely associated with bipolar disorder and depression.
Vasopressin V1a and V1b receptor modulators: a patent review (2012 - 2014).
Review
New
Ślusarz, Gdańsk, Poland. In Expert Opin Ther Pat, Jun 2015
Among the V1bR antagonists published in the last years, the oxindole derivatives appear to be the most promising drug candidates.
Age-specific and individual features of vasopressinergic regulation of the hypothalamic-pituitary-adrenal system in primates.
New
Vengerin et al., Sochi, Russia. In Bull Exp Biol Med, Apr 2015
Preinjection of vasopressin V1b receptor antagonist to a female with high anxiety sharply reduced ACTH secretion in response to insulin-induced hypoglycemia in comparison with ACTH secretion under the same conditions without antagonist injection.
AVP modulation of the vestibular nucleus via V1b receptors potentially contributes to the development of motion sickness in rat.
Jiang et al., Nantong, China. In Mol Brain, 2014
However, there was not any difference between these two groups in the SNP of the reported 38 sites of V1bR gene.
Cigarette smoking reduces DNA methylation levels at multiple genomic loci but the effect is partially reversible upon cessation.
Deloukas et al., Cambridge, United Kingdom. In Epigenetics, 2014
In addition, we found 6 new loci at PRSS23, AVPR1B, PSEN2, LINC00299, RPS6KA2, and KIAA0087.
[Arginine-vasopressin receptor gene (AVPR1A, AVPR1B) polymorphisms and their relation to personality traits].
Khusnutdinova et al., In Genetika, 2014
The association of AVPR1B G*A-haplotype (rs28632197 and rs33911258, respectively) and decreased Self-transcendence (TCI-125) (P(FDR) = 0.040) was demonstrated in the total sample and in Udmurts.
Neuroendocrine regulation of stress in birds with an emphasis on vasotocin receptors (VTRs).
Review
Jurkevich et al., Fayetteville, United States. In Gen Comp Endocrinol, 2013
The neuroendocrine stress response of vertebrates, particularly mammals, comprises at least two types of neuropeptide containing neurons, corticotropin-releasing hormone (CRH) and vasopressin (VP) neurons, and four receptors [CRH receptor one (CRH-R1) and two (CRH-R2) and VP receptor 1a (V1aR) and 1b (V1bR)].
Association between functional polymorphism of the AVPR1b gene and polymorphism rs1293651 of the CRHR1 gene and bipolar disorder with psychotic features.
GeneRIF
Hauser et al., Poznań, Poland. In J Affect Disord, 2012
polymorphism rs28536160 genotype TT of the AVPR1b gene may increase susceptibility for obtaining psychotic features in the course of bipolar disorder I.
The vasopressin 1b receptor and the neural regulation of social behavior.
Review
GeneRIF
Caldwell et al., Kent, United States. In Horm Behav, 2012
we focus on the genetic and pharmacological studies that have implicated the Avpr1b in the neural regulation of social behaviors, including social forms of aggressive behavior, social memory, and social motivation--REVIEW
The contributions of oxytocin and vasopressin pathway genes to human behavior.
Review
Lai et al., Singapore, Singapore. In Horm Behav, 2012
The current review examines in detail the behavioral genetics of the first level of human AVP-OXT pathway genes including arginine vasopressin 1a receptor (AVPR1a), oxytocin receptor (OXTR), AVP (AVP-neurophysin II [NPII]) and OXT (OXT neurophysin I [NPI]), oxytocinase/vasopressinase (LNPEP), ADP-ribosyl cyclase (CD38) and arginine vasopressin 1b receptor (AVPR1b).
Effect of vasopressin V1b receptor antagonist, SSR149415, on anxiety-like behavior and Lewis lung carcinoma metastasis in mice.
GeneRIF
Popova et al., Novosibirsk, Russia. In Exp Oncol, 2011
vasopressin V1b receptor is involved in the mediation of anxious behavior of animals but is not involved in the mechanism underlying the influence of negative psychoemotional state on Lewis lung carcinoma metastasis
The vasopressin Avpr1b receptor: molecular and pharmacological studies.
Review
GeneRIF
Lolait et al., Bristol, United Kingdom. In Stress, 2011
distribution and functional studies of the Avpr1b have established its major role in the pituitary where it plays a pivotal part in the regulation of the HPA response to stress, and in particular to acute stress[review]
Oxytocin and vasopressin involved in restraint water-immersion stress mediated by oxytocin receptor and vasopressin 1b receptor in rat brain.
GeneRIF
Ai et al., China. In Plos One, 2010
Data indicate that RWIS activates both oxytocinergic and vasopressinergic neurons in the PVN and SON, which may project to the NTS or DMV mediating the activity of the neurons by OTR and V(1b)R.
Bench-to-bedside review: Vasopressin in the management of septic shock.
Review
Russell, Vancouver, Canada. In Crit Care, 2010
Vasopressin, a key stress hormone in response to hypotension, stimulates a family of receptors: AVPR1a, AVPR1b, AVPR2, oxytocin receptors and purinergic receptors.
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