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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 08 Dec 2016.

Myotrophin

V-I, pantetheinase, GPI-80, Vanin-1, IGKV, L-12
The transcript produced from this gene is bi-cistronic and can encode both myotrophin and leucine zipper protein 6. The myotrophin protein is associated with cardiac hypertrophy, where it is involved in the conversion of NFkappa B p50-p65 heterodimers to p50-p50 and p65-p65 homodimers. This protein also has a potential function in cerebellar morphogenesis, and it may be involved in the differentiation of cerebellar neurons, particularly of granule cells. A cryptic ORF at the 3' end of this transcript uses a novel internal ribosome entry site and a non-AUG translation initiation codon to produce leucine zipper protein 6, a 6.4 kDa tumor antigen that is associated with myeloproliferative disease. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: ACID, CAN, HAD, CD11b, POLYMERASE
Papers using V-I antibodies
eNOS gene transfer inhibits smooth muscle cell migration and MMP-2 and MMP-9 activity.
Supplier
Kirchmair Rudolf, In PLoS ONE, 1998
... Antibodies against β-actin and Vanin-1 were from Cell Signaling (Boston, MA) and Santa ...
Papers on V-I
Early urinary biomarkers for renal tubular damage in spontaneously hypertensive rats on a high salt intake.
New
Fujimura et al., Tochigi, Japan. In Hypertens Res, Jan 2016
Although albuminuria was detected in salt-loaded SHR at 14 weeks of age, urinary excretion of vanin-1 and neutrophil gelatinase-associated lipocalin (NGAL) was elevated in these animals from 10-17 weeks of age.
Study of antibody repertoires to the CD4 binding site of gp120 of a Chinese HIV-1-infected elite neutralizer, using 454 sequencing and single-cell sorting.
New
Shao et al., Changping, China. In Arch Virol, Jan 2016
We first performed 454 pyrosequencing to capture the IGHV1, IGKV, and IGLV germline gene families.
Equine immunoglobulins and organization of immunoglobulin genes.
Review
New
Czerny et al., Göttingen, Germany. In Dev Comp Immunol, Dec 2015
The kappa light chain contains 60 IGKV, 5 IGKJ and 1 IGKC, whereas there are 144 IGLV, 7 IGLJ, and 7 IGLC for the lambda light chain, which is expressed predominantly in horses.
Thermodynamic and fibril formation studies of full length immunoglobulin light chain AL-09 and its germline protein using scan rate dependent thermal unfolding.
New
Ramirez-Alvarado et al., United States. In Biophys Chem, Dec 2015
In this report, we compare the stabilities and amyloidogenic properties of two light chains, an amyloid-associated protein AL-09 FL, and its germline protein κ I O18/O8 FL (IGKV 1-33).
IGK with conserved IGΚV/IGΚJ repertoire is expressed in acute myeloid leukemia and promotes leukemic cell migration.
New
Yin et al., Beijing, China. In Oncotarget, Dec 2015
Interestingly, myeloblasts and mature monocytes/neutrophils shared several restricted IGKV and IGKJ gene usages but with different expression frequency.
Serum Pantetheinase/Vanin Levels Regulate Erythrocyte Homeostasis and Severity of Malaria.
New
Naquet et al., Marseille, France. In Am J Pathol, Nov 2015
Tissue pantetheinase, encoded by the VNN1 gene, regulates response to stress, and previous studies have shown that VNN genes contribute to the susceptibility to malaria.
Molecular Characterization of Murine Monoclonal Antibody Variable Regions Specific for Hepatitis B Surface Antigen.
New
Shokri et al., Tehrān, Iran. In Viral Immunol, Oct 2015
Concerning the IGKV gene, 26% and 22% of clones used KV4 and KV10 gene families, while the rest of the clones used KV8, KV6, KV1, KV12, and KV14 gene families.
In search of human hematopoietic stem cell identity.
New
Impact
Medvinsky et al., Edinburgh, United Kingdom. In Cell Stem Cell, Feb 2015
In this issue of Cell Stem Cell, Prashad et al. (2014) describe a novel surface marker for human fetal liver HSCs, glycosylphosphatidylinositol-anchored protein GPI-80, that is functionally required for their self-renewal.
GPI-80 defines self-renewal ability in hematopoietic stem cells during human development.
New
Impact
Mikkola et al., Los Angeles, United States. In Cell Stem Cell, Feb 2015
We discovered that the glycophosphatidylinositol-anchored surface protein GPI-80 defines a subpopulation of human fetal liver hematopoietic stem/progenitor cells (HSPCs) with self-renewal ability.
Camelid Ig V genes reveal significant human homology not seen in therapeutic target genes, providing for a powerful therapeutic antibody platform.
Achour et al., Utrecht, Netherlands. In Mabs, 2014
In addition, we amplified IGKV and IGLV genes to uncover the V germline repertoire of Lama glama and sequenced BAC clones covering part of the Lama pacos IGK and IGL loci.
Novel pantothenate derivatives for anti-malarial chemotherapy.
Schalkwijk et al., Nijmegen, Netherlands. In Malar J, 2014
No correlation, however, was found between anti-vanin and anti-malarial activity, nor was pantetheinase activity detected in P. falciparum extracts.
Influence of Vanin-1 and Catalytic Products in Liver During Normal and Oxidative Stress Conditions.
Review
Manautou et al., United States. In Curr Med Chem, 2014
Expression of pantetheinase is controlled by the Vnn1 gene and is upregulated in response to free fatty acids, PPAR activation or oxidative stress.
Role of the Vnn1 pantetheinase in tissue tolerance to stress.
Review
Galland et al., L'Aquila, Italy. In Biochem Soc Trans, 2014
Pantetheinase isoforms are encoded by the Vnn (vanin) genes and Vnn1 is the predominant tissue isoform in mice and humans.
Exploiting the coenzyme A biosynthesis pathway for the identification of new antimalarial agents: the case for pantothenamides.
Review
Spry et al., In Biochem Soc Trans, 2014
These compounds, however, are degraded, and therefore rendered inactive, by the enzyme pantetheinase (vanin), which is present in serum.
The shape of the lymphocyte receptor repertoire: lessons from the B cell receptor.
Review
Collins et al., Sydney, Australia. In Front Immunol, 2012
The process of somatic point mutations has given B cell studies a major focus on variable (IGHV, IGLV, and IGKV) genes.
Epithelial vanin-1 controls inflammation-driven carcinogenesis in the colitis-associated colon cancer model.
GeneRIF
Galland et al., Marseille, France. In Inflamm Bowel Dis, 2010
Epithelial vanin-1 controls inflammation-driven carcinogenesis in the colitis-associated colon cancer model.
miR-375 enhances palmitate-induced lipoapoptosis in insulin-secreting NIT-1 cells by repressing myotrophin (V1) protein expression.
GeneRIF
Fu et al., Guangzhou, China. In Int J Clin Exp Pathol, 2009
miR-375 enhances palmitate-induced lipoapoptosis in insulin-secreting NIT-1 cells (a NOD-derived beta-cell line) by repressing myotrophin (V1) protein expression.
CSIG inhibits PTEN translation in replicative senescence.
GeneRIF
Tong et al., Beijing, China. In Mol Cell Biol, 2008
CSIG acts as a novel regulatory component of replicative senescence, which requires PTEN as a mediator and involves in a translational regulatory mechanism.
Mouse vanin-1 is cytoprotective for islet beta cells and regulates the development of type 1 diabetes.
GeneRIF
Naquet et al., Marseille, France. In Diabetologia, 2008
The vanin-1/cysteamine pathway contributes to the protection of islet beta cells from streptozotocin-induced death in vitro and in vivo
Cystamine restores GSTA3 levels in Vanin-1 null mice.
GeneRIF
Pitari et al., L'Aquila, Italy. In Free Radic Biol Med, 2008
we investigate antioxidant-detoxifying enzymatic activities at the tissue level, comparing Vanin-1 -/- and wild-type mice
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