Rag GTPase in amino acid signaling.
Seoul, South Korea. In Amino Acids, Feb 2016
In this review, we provide a current understanding on the amino acid-regulated cell growth control via Rag-mTORC1 with recently identified key players, including Ragulator, v-ATPase, and GATOR complexes.
Recurrent mTORC1-activating RRAGC mutations in follicular lymphoma.
Cambridge, United States. In Nat Genet, Jan 2016
More than half of the mutations preferentially co-occurred with mutations in ATP6V1B2 and ATP6AP1, which encode components of the vacuolar H(+)-ATP ATPase (V-ATPase) known to be necessary for amino acid-induced activation of mTORC1.
Proton Transport and pH Control in Fungi.
Syracuse, United States. In Adv Exp Med Biol, Dec 2015
The activities of Pma1 and the V-ATPase are coordinated under some conditions, suggesting that pH in the cytosol and organelles is not controlled independently.