GoPubMed Proteins lists recent and important papers and reviews for
proteins. Page last changed on 19 Dec 2016.
ATPase, H transporting, lysosomal V1 subunit B2
V-ATPase
subunit of vacuolar H(+)-ATPase [RGD, Feb 2006] (from
NCBI)
Sponsored links
Top mentioned proteins:
ATPase, ACID, V1a, CAN, HAD
Papers using
V-ATPase
antibodies
Surfactant release in excised rat lung is stimulated by air inflation.
Supplier
In PLoS ONE, 1980
... was from BD Biosciences (San Jose, CA), polyclonal rabbit anti-V-ATPase a1 (H-140) and monoclonal mouse anti-V-ATPase B1/2 were from Santa Cruz Biotechnology (Santa Cruz, CA) ...
Papers on
V-ATPase
Rag GTPase in amino acid signaling.
Review
New
Seoul, South Korea. In Amino Acids, Feb 2016
In this review, we provide a current understanding on the amino acid-regulated cell growth control via Rag-mTORC1 with recently identified key players, including Ragulator, v-ATPase, and GATOR complexes.
Drosophila Mitf regulates the V-ATPase and the lysosomal-autophagic pathway.
New
Houston, United States. In Autophagy, Feb 2016
We show that Mitf regulates the expression of genes encoding V-ATPase subunits as well as many additional genes involved in the lysosomal-autophagy pathway.
Nitrogen use efficiency is mediated by vacuolar nitrate sequestration capacity in roots of Brassica napus.
New
Pensacola, United States. In Plant Physiol, Feb 2016
We found that activities of V-ATPase and V-PPase, the two tonoplast proton-pumps, were significantly lower in roots of the high-NUE genotype (Xiangyou15) than in the low-NUE genotype (814); and consequently, less vacuolar NO3- was retained in roots of Xiangyou15.
Eriodictyol Inhibits RANKL-Induced Osteoclast Formation and Function via Inhibition of NFATc1 Activity.
New
Nanning, China. In J Cell Physiol, Feb 2016
Eriodictyol also strongly inhibited RANKL-induction of c-Fos levels (a critical component of AP-1 transcription factor required by osteoclasts) and subsequent activation of NFATc1, concomitant with reduced expression of osteoclast specific genes including cathepsin K (Ctsk), V-ATPase-d2 subunit, and tartrate resistant acid phosphatase (TRAcP/Acp5).
Phosphatidylinositol 3-Kinase Promotes V-ATPase Activation and Vacuolar Acidification and Delays Methyl Jasmonate-induced Leaf Senescence.
New
Guangzhou, China. In Plant Physiol, Feb 2016
Yeast two-hybrid analyses indicated that PI3K bound to the V-ATPase B subunit (VHA-B).
Vacuolar compartmentalization as indispensable component of heavy metal detoxification in plants.
Review
New
Shimla, India. In Plant Cell Environ, Feb 2016
It depends on two vacuolar pumps (V-ATPase and V-PPase) and a set of tonoplast transporters which are directly driven by proton motive force, and primary ATP-dependent pumps.
Recurrent mTORC1-activating RRAGC mutations in follicular lymphoma.
New
Impact
Cambridge, United States. In Nat Genet, Jan 2016
More than half of the mutations preferentially co-occurred with mutations in ATP6V1B2 and ATP6AP1, which encode components of the vacuolar H(+)-ATP ATPase (V-ATPase) known to be necessary for amino acid-induced activation of mTORC1.
Overexpression of ThVHAc1 and its potential upstream regulator, ThWRKY7, improved plant tolerance of Cadmium stress.
New
Harbin, China. In Sci Rep, Dec 2015
We previously reported that overexpression of the Tamarix hispida V-ATPase c subunit (ThVHAc1) improved the Cd tolerance of Saccharomyces cerevisiae.
Proton Transport and pH Control in Fungi.
Review
New
Syracuse, United States. In Adv Exp Med Biol, Dec 2015
The activities of Pma1 and the V-ATPase are coordinated under some conditions, suggesting that pH in the cytosol and organelles is not controlled independently.
Recent Insights into the Structure, Regulation, and Function of the V-ATPases.
Review
New
Boston, United States. In Trends Biochem Sci, Oct 2015
This review focuses on recent insights into their structure and mechanism, the mechanisms that regulate V-ATPase activity (particularly regulated assembly and trafficking), and the role of V-ATPases in processes such as cell signaling and cancer.
Electron cryomicroscopy observation of rotational states in a eukaryotic V-ATPase.
New
Impact
Toronto, Canada. In Nature, Jun 2015
The eukaryotic V-ATPase is the most complex rotary ATPase: it has three peripheral stalks, a hetero-oligomeric proton-conducting proteolipid ring, several subunits not found in other rotary ATPases, and is regulated by reversible dissociation of its catalytic and proton-conducting regions.
Metabolism. Differential regulation of mTORC1 by leucine and glutamine.
New
Impact
San Diego, United States. In Science, Feb 2015
Amino acids stimulate mTORC1 activation at the lysosome in a manner thought to be dependent on the Rag small guanosine triphosphatases (GTPases), the Ragulator complex, and the vacuolar H(+)-adenosine triphosphatase (v-ATPase).
[Total Synthesis of Biologically Active Natural Products toward Elucidation of the Mode of Action].
Review
In Yakugaku Zasshi, 2014
The stereochemistry of the epoxide was critical for the V-ATPase inhibition; natural product destruxin E exhibited 10-fold more potent V-ATPase inhibition than epi-destruxin E. Next, the scalable synthesis of destruxin E for in vivo study was also performed via solution-phase synthesis.
The histidine transporter SLC15A4 coordinates mTOR-dependent inflammatory responses and pathogenic antibody production.
Impact
Tokyo, Japan. In Immunity, 2014
SLC15A4 loss disturbed the endolysosomal pH regulation and probably the v-ATPase integrity, and these changes were associated with disruption of the mTOR pathway, leading to failure of the IFN regulatory factor 7 (IRF7)-IFN-I regulatory circuit.
The lysosomal v-ATPase-Ragulator complex is a common activator for AMPK and mTORC1, acting as a switch between catabolism and anabolism.
Impact
Xiamen, China. In Cell Metab, 2014
In this study we found, most surprisingly, that the late endosomal/lysosomal protein complex v-ATPase-Ragulator, essential for activation of mTORC1, is also required for AMPK activation.
ATP6v0d2 deficiency increases bone mass, but does not influence ovariectomy-induced bone loss.
GeneRIF
Philadelphia, United States. In Biochem Biophys Res Commun, 2011
these findings suggest that the critical role of ATP6v0d2 may be limited to the control of bone homeostasis under normal development.
Proteomic analysis of osteoclast lipid rafts: the role of the integrity of lipid rafts on V-ATPase activity in osteoclasts.
GeneRIF
Seoul, South Korea. In J Bone Miner Metab, 2010
The data indicate that integrity of lipid rafts regulates the activity of V-ATPase in osteoclasts, suggesting that cholesterol-lowering agents might be useful for inhibiting osteoclast-dependent bone resorption.
Vacuolar ATPase regulates surfactant secretion in rat alveolar type II cells by modulating lamellar body calcium.
GeneRIF
Stillwater, United States. In Plos One, 2009
Data show that silencing of V-ATPase a1 and B2 subunits decreased stimulated surfactant secretion.
Long-term regulation of vacuolar H(+)-ATPase by angiotensin II in proximal tubule cells.
GeneRIF
São Paulo, Brazil. In Pflugers Arch, 2009
Long-term exposure of proximal tubule cells to angiotensin II causes upregulation of H(+)-ATPase activity due to increased B2-subunit cell-surface expression, which is dependent on mechanisms involving tyrosine kinase, p38 MAPK, and PI3K activation.
Myocyte enhancer factor 2 and microphthalmia-associated transcription factor cooperate with NFATc1 to transactivate the V-ATPase d2 promoter during RANKL-induced osteoclastogenesis.
GeneRIF
Australia. In J Biol Chem, 2009
MEF2 and MITF function cooperatively with NFATc1 to transactivate the V-ATPase d2 promoter during RANKL-induced osteoclastogenesis.
