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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Ubiquitously-expressed, prefoldin-like chaperone

The protein encoded by this gene functions as a cofactor that modulates androgen receptor-dependent transcription, and also plays a critical role in tumor necrosis factor-induced apoptosis. Expression of this gene may play a role in tumorigenesis. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Nov 2011] (from NCBI)
Top mentioned proteins: GAPDH, CAN, ACID, RPS9, Actin
Papers on UXT
UXT, a novel MDMX-binding protein, promotes glycolysis by mitigating p53-mediated restriction of NF-κB activity.
Yuan et al., Changsha, China. In Oncotarget, Aug 2015
We report the identification of a novel p53 inhibitor, UXT, which binds to MDMX and suppresses the basal activity of p53.
Ubiquitously expressed transcript is a novel interacting protein of protein inhibitor of activated signal transducer and activator of transcription 2.
Zheng et al., Yangzhou, China. In Mol Med Report, Apr 2015
The screening identified an interaction between PIAS2 and ubiquitously expressed transcript (UXT).
UXT potentiates angiogenesis by attenuating Notch signaling.
Wang et al., Shanghai, China. In Development, Mar 2015
Here, we identified UXT as an evolutionarily conserved and developmentally expressed protein, indispensable for intersegmental vessel (ISV) formation in zebrafish.
Technical note: Selection of suitable reference genes for studying gene expression in milk somatic cell of yak (Bos grunniens) during the lactation cycle.
Zhao et al., Shenyang, China. In J Dairy Sci, 2014
In the present study, we evaluated the transcriptional stability of 10 candidate reference genes in milk somatic cells of lactating yak, including ACTB, B2M, GAPDH, GTP, MRPL39, PPP1R11, RPS9, RPS15, UXT, and RN18S1.
UXT is a novel regulatory factor of regulatory T cells associated with Foxp3.
Zhang et al., Xi'an, China. In Eur J Immunol, 2014
In the present study, we identified ubiquitously expressed transcript (UXT) to be a novel regulator of human Treg-cell function.
Bovine mammary epithelial cell cultures for the study of mammary gland functions.
Szatkowska et al., Szczecin, Poland. In In Vitro Cell Dev Biol Anim, 2013
Of the reference genes, the UXT and GAPDH genes appeared to be the most stable ones for the mammary gland tissue samples and epithelial cell cultures.
Androgen receptor coactivators that inhibit prostate cancer growth.
Lee et al., New York City, United States. In Am J Clin Exp Urol, 2013
In this review, we discuss the expression and function of several AR coactivators exhibiting growth suppressive function in PCa, including ARA70/ELE1/NCOA4, androgen receptor coactivator p44/MEP50/WDR77, TBLR1, and ART-27.
Identification of suitable housekeeping genes for normalization of quantitative real-time PCR data during different physiological stages of mammary gland in riverine buffaloes (Bubalus bubalis).
Mukesh et al., Karnāl, India. In J Anim Physiol Anim Nutr (berl), 2013
A total of 16 potential HKGs (GAPDH, β-actin, UXT, β2M, A2M, RPl4, RPS9, RPS15A, RPS18, RPS23, HMBS, HPRT1, GTP, EEF1A1, UB1 and RPL22) from different functional classes were evaluated.
Regulation of the transcriptional activation of the androgen receptor by the UXT-binding protein VHL.
Zhou et al., Wuhan, China. In Biochem J, 2013
Using a yeast two-hybrid system, we have identified the AR (androgen receptor) co-activator UXT (ubiquitously expressed transcript), as a VHL-interacting protein.
UXT plays dual opposing roles on SARM-induced apoptosis.
Ding et al., Singapore, Singapore. In Febs Lett, 2013
Ubiquitously expressed transcript (UXT), which exists in two isoforms (V1 and V2), interact with both apoptotic and cellular proteins.
Selection of reference genes for quantitative real-time PCR normalisation in adipose tissue, muscle, liver and mammary gland from ruminants.
Leroux et al., Clermont-Ferrand, France. In Animal, 2013
In this study, eight commonly used reference genes that belong to different functional classes (CLN3, EIF3K, MRPL39, PPIA, RPLP0, TBP, TOP2B and UXT) were analysed using the geNorm procedure to determine the most stable reference genes in bovine and/or caprine tissues.
Epstein-Barr virus BGLF4 kinase downregulates NF-κB transactivation through phosphorylation of coactivator UXT.
Chen et al., Taipei, Taiwan. In J Virol, 2012
In this study, we identify an NF-κB coactivator, UXT, as a substrate of BGLF4.
Selection of suitable reference genes for quantitative gene expression studies in milk somatic cells of lactating cows (Bos indicus).
Batish et al., Karnāl, India. In J Dairy Sci, 2012
Nine candidate reference genes [glyceraldehyde 3-phosphate dehydrogenase (GAPDH), protein phosphatase 1 regulatory subunit 11 (PPP1R11), β-actin (ACTB), β-2 microglobulin (B2M), 40S ribosomal protein S15a (RPS15A), ubiquitously expressed transcript (UXT), mitochondrial GTPase 1 (MTG1), 18S rRNA (RN18S1), and ubiquitin (UBC)] were evaluated.
Androgen receptor co-activators in the regulation of cellular events in prostate cancer.
Santer et al., Innsbruck, Austria. In World J Urol, 2012
Most co-factors are important for the stimulation of cellular proliferation, although in some cases (ART-27), they act as tumor suppressors and are deleted in prostate cancer tissue.
UXT-V1 facilitates the formation of MAVS antiviral signalosome on mitochondria.
Wang et al., Shanghai, China. In J Immunol, 2012
UXT-V1 represents a novel integral component of the MAVS signalosome on mitochondria, mediating the innate antiviral signal transduction.
Alfa-class prefoldin protein UXT is a novel interacting partner of Amyotrophic Lateral Sclerosis 2 (Als2) protein.
Basak et al., İstanbul, Turkey. In Biochem Biophys Res Commun, 2011
these results suggest that Als2 is a binding partner of Uxt and Als2/Uxt interaction could be important for the activation of Nf-kappaB pathway.
Regulation of androgen receptor-mediated transcription by RPB5 binding protein URI/RMP.
Logan et al., New York City, United States. In Mol Cell Biol, 2011
Data show that while Art-27 can bind AR directly, URI is bound to chromatin prior to hormone-dependent recruitment of AR, suggesting a role for URI in modulating AR recruitment to target genes.
UXT-V1 protects cells against TNF-induced apoptosis through modulating complex II formation.
Wang et al., Shanghai, China. In Mol Biol Cell, 2011
Ubiquitously expressed transcript, UXT-V1, is a novel regulator of TNF-induced apoptosis. It protects cells against TNF-induced apoptosis through modulating complex II formation.
High-resolution mapping of the protein interaction network for the human transcription machinery and affinity purification of RNA polymerase II-associated complexes.
Coulombe et al., Montréal, Canada. In Methods, 2009
Is part of an RNA polymerase II-associated complex with possible chaperone activity.
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