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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 08 Dec 2016.

Utrophin

Utrophin, Drp1
This gene shares both structural and functional similarities with the dystrophin gene. It contains an actin-binding N-terminus, a triple coiled-coil repeat central region, and a C-terminus that consists of protein-protein interaction motifs which interact with dystroglycan protein components. The protein encoded by this gene is located at the neuromuscular synapse and myotendinous junctions, where it participates in post-synaptic membrane maintenance and acetylcholine receptor clustering. Mouse studies suggest that this gene may serve as a functional substitute for the dystrophin gene and therefore, may serve as a potential therapeutic alternative to muscular dystrophy which is caused by mutations in the dystrophin gene. Alternative splicing of the utrophin gene has been described; however, the full-length nature of these variants has not yet been determined. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: Dynamin I, OPA1, HSG, CAN, V1a
Papers using Utrophin antibodies
A guided tour into subcellular colocalization analysis in light microscopy.
Supplier
Green Douglas R., In PLoS Biology, 2005
... Drp1 (Ser616, Cell Signaling), rabbit ...
Mutations in the mitochondrial GTPase mitofusin 2 cause Charcot-Marie-Tooth neuropathy type 2A
Supplier
Sesaki Hiromi et al., In The Journal of Cell Biology, 2003
... To create the null Drp1 allele, we crossed Flox-neo mice to a transgenic strain that expresses Cre ...
Bax/Bak promote sumoylation of DRP1 and its stable association with mitochondria during apoptotic cell death
Supplier
McBride Heidi M. et al., In The Journal of Cell Biology, 2003
... Antibodies were obtained from the following providers: α-DRP1 (BD Biosciences), α-Hsp60 (Sigma-Aldrich), α–SUMO-1 (Zymed ...
Caspase cleavage product of BAP31 induces mitochondrial fission through endoplasmic reticulum calcium signals, enhancing cytochrome c release to the cytosol
Supplier
Shore Gordon C. et al., In The Journal of Cell Biology, 1995
... selection; and mouse mAbs to pigeon cyt.c (BD Biosciences), chicken α-tubulin (clone DM1A; Sigma-Aldrich), rodent Drp1 (BD Biosciences), and HA (clone 16B12; ...
Papers on Utrophin
Disturbed mitochondrial and peroxisomal dynamics due to loss of MFF causes Leigh-like encephalopathy, optic atrophy and peripheral neuropathy.
New
Haack et al., Salzburg, Austria. In J Med Genet, Feb 2016
Components of the fission machinery are partly shared between mitochondria and peroxisomes, and inherited defects in two such components (dynamin-related protein (DRP1) and ganglioside-induced differentiation-associated protein 1 (GDAP1)) have been associated with human disease.
Liraglutide ameliorate non-alcohol fatty liver disease by enhancing mitochondrial architecture and promoting autophagy through SIRT1/SIRT3-FOXO3a pathway.
New
Tian et al., Shanghai, China. In Hepatol Res, Jan 2016
After liraglutide administration, the up-regulated mRNA and protein levels of mitochondrial fission and fusion related DRP1, OPA1 and respiratory chain related COMPLEX1, UCP2 demonstrated the enhancement of mitochondrial architecture which may attenuate the generation of ROS, while the diminished mRNA and protein level of P62 and increased levels of Beclin1, LC3II/I ratioindicated the promoting autophagy, which probably contribute to the ROS elimination.
Physical exercise mitigates doxorubicin-induced brain cortex and cerebellum mitochondrial alterations and cellular quality control signaling.
New
Ascensão et al., Porto, Portugal. In Mitochondrion, Jan 2016
Mitochondrial dynamics (Mfn1, Mfn2, OPA1 and DRP1) and auto(mito)phagy (LC3II, Beclin1, Pink1, Parkin and p62)-related proteins were measured by semi-quantitative Western blotting.
Mitophagy is required for mitochondrial biogenesis and myogenic differentiation of C2C12 myoblasts.
New
Gottlieb et al., San Diego, United States. In Autophagy, Dec 2015
During early myogenic differentiation, autophagy is robustly upregulated and this coincides with DNM1L/DRP1 (dynamin 1-like)-mediated fragmentation and subsequent removal of mitochondria via SQSTM1 (sequestosome 1)-mediated mitophagy.
RCAN1 overexpression promotes age-dependent mitochondrial dysregulation related to neurodegeneration in Alzheimer's disease.
New
Hoeffer et al., New York City, United States. In Acta Neuropathol, Nov 2015
isoform in mice promotes early age-dependent memory and synaptic plasticity deficits, tau pathology, and dysregulation of dynamin-related protein 1 (DRP1) activity associated with mitochondrial dysfunction and oxidative stress, reproducing key AD features.
The RIP1-RIP3 complex initiates mitochondrial fission to fuel NLRP3.
Impact
Miao et al., Chapel Hill, United States. In Nat Immunol, 2014
Vesicular stomatitis virus, a single-stranded RNA virus, triggers activation of the serine-threonine kinases RIP1 and RIP3, which damages mitochondria by activating the GTPase DRP1.
RNA viruses promote activation of the NLRP3 inflammasome through a RIP1-RIP3-DRP1 signaling pathway.
Impact
Zhou et al., Hefei, China. In Nat Immunol, 2014
Infection with an RNA virus initiated assembly of the RIP1-RIP3 complex, which promoted activation of the GTPase DRP1 and its translocation to mitochondria to drive mitochondrial damage and activation of the NLRP3 inflammasome.
Mitochondrial dynamics and the cell cycle.
Review
Kianian et al., Saint Paul, United States. In Front Plant Sci, 2013
In animals disruption of the drp1 gene, a homolog to the plant drp3A and drp3B, delays mitochondrial division.
Dynamin-related proteins in plant post-Golgi traffic.
Review
Tsutsumi et al., Tokyo, Japan. In Front Plant Sci, 2013
Numerous in vivo and in vitro studies indicate that animal dynamins, which are members of DRP family, assemble into ring- or helix-shaped structures at the neck of a bud site on the donor membrane, where they constrict and sever the neck membrane in a GTP hydrolysis-dependent manner.
Physiological and pathological significance of dynamin-related protein 1 (drp1)-dependent mitochondrial fission in the nervous system.
Review
Sun et al., Seoul, South Korea. In Exp Neurobiol, 2013
Several regulatory proteins such as dynamin-related protein 1 (Drp1) are required to maintain mitochondrial morphology via a balance between continuous fusion and fission.
Why size matters - balancing mitochondrial dynamics in Alzheimer's disease.
Review
Götz et al., Boston, United States. In Trends Neurosci, 2013
In this process, the GTPase DRP1 has emerged as a key target of both Aβ and TAU.
Dominant optic atrophy, OPA1, and mitochondrial quality control: understanding mitochondrial network dynamics.
Review
Fuhrmann et al., San Francisco, United States. In Mol Neurodegener, 2012
Mitochondrial fission is facilitated by DRP1, while MFN1 and MFN2 on the mitochondrial outer membrane and OPA1 on the mitochondrial inner membrane are essential for mitochondrial fusion.
Caveolae and non-caveolae lipid raft microdomains of human umbilical vein endothelial cells contain utrophin-associated protein complexes.
GeneRIF
Coral-Vázquez et al., Mexico. In Biochimie, 2012
UAPC located in caveolae and non-caveolae lipid raft domains of HUVECs may have a mechanosensory function that could participate in the control of eNOS activity
Modulation of dynamin-related protein 1 (DRP1) function by increased O-linked-β-N-acetylglucosamine modification (O-GlcNAc) in cardiac myocytes.
GeneRIF
Dillmann et al., San Diego, United States. In J Biol Chem, 2012
O-GlcNAcylation modulates DRP1 functionality in cardiac muscle cells.
Mitochondrial chaperone DnaJA3 induces Drp1-dependent mitochondrial fragmentation.
GeneRIF
Kim et al., Calgary, Canada. In Int J Biochem Cell Biol, 2012
Data show that elevated DnaJA3 induces dynamin-related protein 1 (Drp1)-depedendent mitochondrial fragmentation and decreased cell viability.
Sarcospan-dependent Akt activation is required for utrophin expression and muscle regeneration.
GeneRIF
Crosbie-Watson et al., Los Angeles, United States. In J Cell Biol, 2012
Sarcospan improved cell surface expression of utrophin by increasing transportation of utrophin and dystroglycan from endoplasmic reticulum/Golgi membranes
DRP1-dependent mitochondrial fission initiates follicle cell differentiation during Drosophila oogenesis.
GeneRIF
Lippincott-Schwartz et al., Bethesda, United States. In J Cell Biol, 2012
Thus, DRP1-dependent mitochondrial fission activity is a novel regulator of the onset of follicle cell differentiation during Drosophila
Coupling mitochondrial and cell division.
Impact
Youle et al., In Nat Cell Biol, 2011
Two mitotic kinases, the cyclin B-CDK1 complex and Aurora A, are now shown to cooperate with the small G protein RALA and its effector RALBP1 to promote DRP1 phosphorylation and mitochondrial fission.
RALA and RALBP1 regulate mitochondrial fission at mitosis.
Impact
Counter et al., Durham, United States. In Nat Cell Biol, 2011
Mitotic mitochondrial fission depends on both the relocalization of the large GTPase DRP1 to the outer mitochondrial membrane and phosphorylation of Ser 616 on DRP1 by the mitotic kinase cyclin B-CDK1 (ref.
Mitochondria unite to survive.
Impact
Chang et al., In Nat Cell Biol, 2011
This is now shown to result from inhibition of mitochondrial fission through PKA-mediated phosphorylation of the GTPase DRP1.
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