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Undifferentiated embryonic cell transcription factor 1

UTF1, undifferentiated embryonic cell transcription factor 1
Top mentioned proteins: Sox2, CAN, Nanog, Rex-1, OCT
Papers on UTF1
Comparison of enzymatic digestion and mechanical dissociation of human testicular tissues.
New
Neuhaus et al., Münster, Germany. In Fertil Steril, Aug 2015
MAIN OUTCOME MEASURE(S): The composition of testicular cell suspensions was assessed performing quantitative real-time polymerase chain reaction (qPCR) analyses for germ cell-specific (FGFR3, SALL4, UTF1, MAGE-A4) and somatic marker genes (ACTA2 and VIM).
Quantitative phosphoproteome analysis of embryonic stem cell differentiation toward blood.
New
Whetton et al., Bologna, Italy. In Oncotarget, Jun 2015
Among the proteins differentially phosphorylated toward mesoderm differentiation were: the epigenetic regulator Dnmt3b, the protein kinase GSK3b, the chromatin remodeling factor Smarcc1, the transcription factor Utf1; as well as protein specifically related to stem cell differentiation, as Eomes, Hmga2, Ints1 and Rif1.
Induced overexpression of Oct4A in human dental pulp cells enhances pluripotency and multilineage differentiation capability.
New
Ling et al., Guangzhou, China. In Stem Cells Dev, May 2015
Cell proliferation, multilineage differentiation, and the expression of Oct4B1, Sox2, Nanog, Klf4, c-Myc, and Utf1 in DPCs after Oct4A transfection were detected by cell counting kit-8, Alizarin red/Oil red O staining, immunofluorescent staining, alkaline phosphatase analysis, and real-time PCR.
DDX3Y gene rescue of a Y chromosome AZFa deletion restores germ cell formation and transcriptional programs.
Reijo Pera et al., Stanford, United States. In Sci Rep, 2014
Moreover, expression of UTF1, a prospermatogonial protein, was restored in cells complemented by introduction of DDX3Y on the AZFa background.
PTEN signaling is required for the maintenance of spermatogonial stem cells in mouse, by regulating the expressions of PLZF and UTF1.
Yu et al., Shanghai, China. In Cell Biosci, 2014
RESULTS: We report that promyelocytic leukaemia zinc finger (PLZF) and undifferentiated embryonic cell transcription factor 1 (UTF1), both of which are germ cell-specific transcriptional factors, are regulated by Pten.
Mesenchymal stem cells derived from human induced pluripotent stem cells retain adequate osteogenicity and chondrogenicity but less adipogenicity.
Luo et al., Århus, Denmark. In Stem Cell Res Ther, 2014
The iPSC-MSCs and the tri-lineage differentiated cells (osteoblasts, chondrocytes, adipocytes) all lack expression of "stemness" genes: OCT4, SOX2, GDF3, CRIPTO, UTF1, DPPA4, DNMT3B, LIN28a, and SAL4.
Reprogramming barriers and enhancers: strategies to enhance the efficiency and kinetics of induced pluripotency.
Ebrahimi, Yazd, Iran. In Cell Regen (lond), 2014
Different strategies have been applied for enhancing reprogramming efficiency, including depletion/inhibition of barriers (p53, p21, p57, p16(Ink4a)/p19(Arf), Mbd3, etc.), overexpression of enhancing genes (e.g., FOXH1, C/EBP alpha, UTF1, and GLIS1), and administration of certain cytokines and small molecules.
Transcriptional coactivator undifferentiated embryonic cell transcription factor 1 expressed in spermatogonial stem cells: a putative marker of boar spermatogonia.
Song et al., South Korea. In Anim Reprod Sci, 2014
The objective of this study was to characterize the expression of undifferentiated embryonic cell transcription factor 1 (UTF1) gene as a potential marker for spermatogonia and SSCs in the boar testis.
Functional expression and regulation of hyperpolarization-activated cyclic nucleotide-gated channels (HCN) in mouse iPS cell-derived cardiomyocytes after UTF1 -neo selection.
Nguemo et al., Köln, Germany. In Cell Physiol Biochem, 2013
METHODS: We differentiated murine iPS cells selected by an undifferentiated transcription factor 1 (UTF1) -promoter-driven G418 resistance to CMs in vitro and characterized them by RT-PCR, immunocytochemistry, and electrophysiology.
UTF1, a putative marker for spermatogonial stem cells in stallions.
Yoon et al., Sangju, South Korea. In Plos One, 2013
Undifferentiated cell transcription factor 1 (UTF1) is a putative marker for undifferentiated spermatogonia in humans and rats.
Expression of undifferentiated embryonic cell transcription factor-1 (UTF1) in breast cancers and their matched normal tissues.
Chen et al., Shaoxing, China. In Cancer Cell Int, 2013
OBJECTIVES: Undifferentiated embryonic cell transcription factor-1 (UTF1) plays a critical role in the developmental timing during embryonic development.
Utf1: Goldilocks for ESC bivalency.
Impact
Knoepfler et al., Sacramento, United States. In Cell Stem Cell, 2013
Recently in Cell, Jia et al. (2012) reported novel Utf1-controlled mechanisms of maintaining pluripotency and self-renewal in embryonic stem cells (ESCs).
Regulation of pluripotency and self- renewal of ESCs through epigenetic-threshold modulation and mRNA pruning.
Impact
Zheng et al., Baltimore, United States. In Cell, 2012
We report that Utf1, a target of Oct4 and Sox2, is a bivalent chromatin component that buffers poised states of bivalent genes.
Single-cell expression analyses during cellular reprogramming reveal an early stochastic and a late hierarchic phase.
Impact
Jaenisch et al., Cambridge, United States. In Cell, 2012
Expression of Esrrb, Utf1, Lin28, and Dppa2 is a better predictor for cells to progress into iPSCs than expression of the previously suggested reprogramming markers Fbxo15, Fgf4, and Oct4.
The H3K27 demethylase Utx regulates somatic and germ cell epigenetic reprogramming.
Impact
Hanna et al., Israel. In Nature, 2012
The latter directly hampers the derepression of potent pluripotency promoting gene modules (including Sall1, Sall4 and Utf1), which can cooperatively substitute for exogenous OSK supplementation in iPSC formation.
UTF1 deficiency promotes retinoic acid-induced neuronal differentiation in P19 embryonal carcinoma cells.
GeneRIF
Chen et al., Taiwan. In Int J Biochem Cell Biol, 2012
Suppression of UTF1 expression in P19 cells by RNA interference enhanced retinoic acid (RA)-induced neuronal differentiation.
Embryonic stem cell factors undifferentiated transcription factor-1 (UFT-1) and reduced expression protein-1 (REX-1) are widely expressed in human skin and may be involved in cutaneous differentiation but not in stem cell fate determination.
GeneRIF
Pammer et al., Vienna, Austria. In Int J Exp Pathol, 2011
role for UTF1 in differentiation of matrix cells of the shaft as well as in suprabasal keratinocytes.
Undifferentiated embryonic cell transcription factor 1 regulates ESC chromatin organization and gene expression.
GeneRIF
Eggen et al., Haren, Netherlands. In Stem Cells, 2010
Data show that UTF1 is a key chromatin component in ES cells, preventing ES cell chromatin decondensation, and aberrant gene expression; both essential for proper initiation of lineage-specific differentiation of ES cells.
Expression of UTF1 in primary and metastatic testicular germ cell tumors.
GeneRIF
Cao et al., Beijing, China. In Am J Clin Pathol, 2010
Strong UTF1 staining can be used for diagnosing embryonal carcinoma and seminoma. UTF1 expression in spermatogonia suggests its possible role in spermatogenesis and renewal of spermatogonia.
Functional characterization of single-nucleotide polymorphisms in the human undifferentiated embryonic-cell transcription factor 1 gene.
GeneRIF
Eggen et al., Haren, Netherlands. In Dna Cell Biol, 2010
Single SNPs did not alter the chromatin association and mobility of hUTF1; however, the double mutant, G73R/L275M, demonstrated a decreased chromatin association, indicating a degree of protein malfunction.
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