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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Uronyl-2-sulfotransferase

UST
Uronyl 2-sulfotransferase transfers sulfate to the 2-position of uronyl residues, such as iduronyl residues in dermatan sulfate and glucuronyl residues in chondroitin sulfate (Kobayashi et al., 1999 [PubMed 10187838]).[supplied by OMIM, Mar 2008] (from NCBI)
Top mentioned proteins: ACID, CAN, 2-O-sulfotransferase, HAD, elastase
Papers on UST
Pharmacological treatment of psoriatic arthritis: a systematic literature review for the 2015 update of the EULAR recommendations for the management of psoriatic arthritis.
Review
New
Gossec et al., Leiden, Netherlands. In Ann Rheum Dis, Jan 2016
The efficacy of tumour necrosis factor inhibitors (including the recently added golimumab and certolizumab pegol) was confirmed and 16 articles/abstracts focused on 3 drugs with new modes of action: ustekinumab (UST), secukinumab (SEC) and apremilast (APR).
Phenotypic and metabolic responses to drought and salinity of four contrasting lentil accessions.
New
Altmann et al., Reggio di Calabria, Italy. In J Exp Bot, Sep 2015
The effects of salinity and drought on germination and early growth of Castelluccio di Norcia (CAST), Pantelleria (PAN), Ustica (UST), and Eston (EST) accessions were evaluated to identify metabolic and phenotypic traits related to drought and/or salinity stress tolerance.
A de novo 0.63 Mb 6q25.1 deletion associated with growth failure, congenital heart defect, underdeveloped cerebellar vermis, abnormal cutaneous elasticity and joint laxity.
New
Briuglia et al., London, United Kingdom. In Am J Med Genet A, Sep 2015
41 of Bisgaard et al., and 23 of Caselli et al.,], including the TAB2 (likely responsible for the girl's congenital heart defect), LATS1 gene, and the UST gene (a regulator of the homeostasis of proteoglycans, which could have played a role in the abnormal dermal and cartilage elasticity).
High-resolution 400K oligonucleotide array comparative genomic hybridization analysis of neurofibromatosis type 1-associated cutaneous neurofibromas.
New
Hosokawa et al., Japan. In Gene, Apr 2015
(56%, NKAIN2), 6q22.33 (67%, ARHGAP18), 6q25.1 (67%, UST), 7q13 (56%, ADCY1), 12q13.13
Uronyl 2-O sulfotransferase potentiates Fgf2-induced cell migration.
New
Seidler et al., In J Cell Sci, Mar 2015
Uronyl 2-O-sulfotransferase (Ust)introduces sulfation at the C2 of IdoUA and GlcUA resulting inover-sulfated units.
Chondroitin / dermatan sulfate modification enzymes in zebrafish development.
Ledin et al., Uppsala, Sweden. In Plos One, 2014
We identify single orthologous genes in the zebrafish genome for the sulfotransferases chst7, chst11, chst13, chst14, chst15 and ust and the epimerase dse.
Ustekinumab : targeting the IL-17 pathway to improve outcomes in psoriatic arthritis.
Review
Ritchlin et al., Rochester, United States. In Expert Opin Biol Ther, 2014
Recently, ustekinumab (UST) an agent that targets the 12 - 23/Th17 pathway was approved by the FDA for the treatment of active PsA.
A decorin-deficient matrix affects skin chondroitin/dermatan sulfate levels and keratinocyte function.
Seidler et al., Münster, Germany. In Matrix Biol, 2014
The total amount of chondroitin/dermatan sulfate (CS/DS) was increased in the Dcn(-/-) skin, but was overall less sulfated with a significant reduction in bisulfated ΔDiS2,X (X=4 or 6) disaccharide units, due to the reduced expression of uronyl 2-O sulfotransferase (Ust).
Ustekinumab in the treatment of psoriatic arthritis: latest findings and clinical potential.
Narang et al., Boston, United States. In Ther Adv Musculoskelet Dis, 2013
Ustekinumab (UST) is a fully human immunoglobulin G1κ (IgG1κ) monoclonal antibody against common sub-unit p40 of interleukin-12 (IL-12) and interleukin-23 (IL-23).
Genome-wide scan of job-related exhaustion with three replication studies implicate a susceptibility variant at the UST gene locus.
Paunio et al., Helsinki, Finland. In Hum Mol Genet, 2013
A variant located in an intron of UST, uronyl-2-sulfotransferase (rs13219957), gave the strongest statistical evidence in the initial genome-wide study (P = 1.55 × 10(-7)), and was associated with job-related exhaustion in all the replication sets (P < 0.05; P = 6.75 × 10(-7) from the meta-analysis).
Breast density measurements using ultrasound tomography for patients undergoing tamoxifen treatment.
Gierach et al., Toronto, Canada. In Proc Spie, 2013
Ultrasound tomography (UST) is an imaging modality that can create tomographic sound speed images of the breast.
Low-intensity ultrasound enhances the anticancer activity of cetuximab in human head and neck cancer cells.
Hosoi et al., In Exp Ther Med, 2013
Experiments were divided into 4 groups: non-treated (CNTRL), cetuximab-treated (CETU), ultrasound-treated (UST) and the combination of cetuximab and US-treated (COMB).
Analysis of organ-enriched microRNAs in plasma as an approach to development of Universal Screening Test: feasibility study.
Umansky et al., United States. In J Transl Med, 2012
Here we propose a framework of a novel approach - Universal Screening Test (UST) for the detection of pathological processes in a particular organ system, organ, or tissue by RT-qPCR analysis of circulating cell-free miRNAs in plasma.
The Yo-Yo IR2 test: physiological response, reliability, and application to elite soccer.
Moir et al., United States. In J Strength Cond Res, 2012
Nineteen National Collegiate Athletic Association Division II female soccer players were assigned to either an unstable training group (UST: 19.0 ± 0.47 years; 1.69 ± 6.4 m; 67.8 ± 7.7 kg) or a stable training group (ST: 19.6 ± 0.49 years; 1.64 ± 3.2 m; 62.7 ± 6.27 kg).
Pulsed ultrasound therapy accelerates the recovery of skeletal muscle damage induced by Bothrops jararacussu venom.
Melo et al., Rio de Janeiro, Brazil. In Braz J Med Biol Res, 2012
We studied the effect of pulsed ultrasound therapy (UST) and antibothropic polyvalent antivenom (PAV) on the regeneration of mouse extensor digitorum longus muscle following damage by Bothrops jararacussu venom.
Oversulfated chondroitin sulfate plays critical roles in the neuronal migration in the cerebral cortex.
GeneRIF
Maeda et al., Fuchū, Japan. In J Biol Chem, 2008
analysis of the three CS sulfotransferases in the developing neocortex: uronyl 2-O-sulfotransferase (UST), N-acetylgalactosamine 4-sulfate 6-O-sulfotransferase (4,6-ST) and dermatan 4-O-sulfotransferase-1 (D4-ST)
Heparan sulphate proteoglycans in glia and in the normal and injured CNS: expression of sulphotransferases and changes in sulphation.
GeneRIF
Fawcett et al., Cambridge, United Kingdom. In Eur J Neurosci, 2008
The major injury-related change, seen in injured brain and cultured glia, was an increase in 2-O-sulphated HS and increased syndecan-1, suggesting novel approaches to modulating scar formation.
Mutational study of heparan sulfate 2-O-sulfotransferase and chondroitin sulfate 2-O-sulfotransferase.
GeneRIF
Liu et al., Chapel Hill, United States. In J Biol Chem, 2007
analysis of differences and similarities various residues play in the biological roles of the HS-2OST and CS-2OST enzymes
Recognition of sulfation pattern of chondroitin sulfate by uronosyl 2-O-sulfotransferase.
GeneRIF
Habuchi et al., Kariya, Japan. In J Biol Chem, 2005
2OST transfers sulfate preferentially to the GlcA residue located in a unique sequence, -GalNAc(4SO(4))-GlcA-GalNAc(6SO(4))-.
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