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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 15 Jul 2015.

Ubiquitin specific peptidase 9, Y-linked

This gene is a member of the peptidase C19 family. It encodes a protein that is similar to ubiquitin-specific proteases, which cleave the ubiquitin moiety from ubiquitin-fused precursors and ubiquitinylated proteins. [provided by RefSeq, Mar 2009] (from NCBI)
Top mentioned proteins: Ubiquitin, MEN, HAD, DAZ, SRY
Papers on USP9Y
Isoform Level Gene Expression Profile of Human Y Chromosome Azoospermia Factor Genes and their X Paralogues in the Testicular Tissue of Non-obstructive Azoospermia Patients.
Salekdeh et al., In J Proteome Res, 10 Aug 2015
We profiled the expression of 41 alternative transcripts encoded by 14 AZFa, AZFb and AZFc region genes (USP9Y, DDX3Y, XKRY, HSFY1, CYORF15A, CYORF15B, KDM5D, EIF1AY, RPS4Y2, RBMY1A1, PRY, BPY2, DAZ1 and CDY1) as well as their X chromosome homologue transcripts and a few autosomal homologues.
DDX3Y, a Male Specific Region of Y Chromosome Gene, may modulate neuronal differentiation.
Salekdeh et al., In J Proteome Res, 05 Aug 2015
Including RBMY1, EIF1AY, DDX3Y1, HSFY1, BPY2, PCDH11Y, UTY, RPS4Y1, USP9Y, SRY, PRY, and ZFY.
TRAF Family Member-associated NF-κB Activator (TANK) Inhibits Genotoxic Nuclear Factor κB Activation by Facilitating Deubiquitinase USP10-dependent Deubiquitination of TRAF6 Ligase.
Wu et al., Nanchang, China. In J Biol Chem, 22 Jun 2015
We found TANK formed a complex with MCPIP1 (also known as ZC3H12A) and a deubiquitinase, USP10, which was essential for the USP10-dependent deubiquitination of TRAF6 and the resolution of genotoxic NF-κB activation upon DNA damage.
Clinical utility of a novel urine-based gene fusion TTTY15-USP9Y in predicting prostate biopsy outcome.
Sun et al., Shanghai, China. In Urol Oncol, 22 Jun 2015
Our previous study has demonstrated the high prevalence of TTTY15-USP9Y in prostate cancer samples from a Chinese population.
Primary Osteomyelofibrosis and an XX-Male Genotype.
Bäsecke et al., Göttingen, Germany. In Eur J Haematol, Apr 2015
This rare coincidence was further accentuated as the USP9Y gene, suspected to be to be involved in sperm cell production was absent but no azoospermia was present.
Beclin1 controls the levels of p53 by regulating the deubiquitination activity of USP10 and USP13.
Yuan et al., Shanghai, China. In Cell, 2011
USP10 mediates the deubiquitination of p53, regulating deubiquitination activity of USP10 and USP13 by Beclin1 provides a mechanism for Beclin1 to control the levels of p53.
Interplay between p53-family, their regulators, and PARPs in DNA repair.
Emami, Saint-Pierre-des-Corps, France. In Clin Res Hepatol Gastroenterol, 2011
We highlight the recent progress in the analysis of protein signals to p53, including PARPs, and ubiquitination cascade proteins MDM2, CRM1, USP10 and 14-3-3σ.
The deubiquitinating enzyme USP10 regulates the endocytic recycling of CFTR in airway epithelial cells.
Stanton et al., United States. In Channels (austin), 2010
a novel function for USP10 in facilitating the deubiquitination of CFTR in early endosomes, thereby enhancing the endocytic recycling and cell surface expression of CFTR.
USP10 regulates p53 localization and stability by deubiquitinating p53.
Lou et al., Rochester, United States. In Cell, 2010
Findings reveal USP10 to be a novel regulator of p53, providing an alternative mechanism of p53 inhibition in cancers with wild-type p53.
USP10: friend and foe.
Shiloh et al., Leiden, Netherlands. In Cell, 2010
In this issue, Yuan et al. (2010) identify the deubiquitinating protease USP10 as a new regulator of p53 in the DNA damage response and tumor development.
The deubiquitinating enzyme USP10 regulates the post-endocytic sorting of cystic fibrosis transmembrane conductance regulator in airway epithelial cells.
Stanton et al., United States. In J Biol Chem, 2009
USP10 has a role in facilitating the deubiquitination of CFTR in early endosomes and thereby enhancing the endocytic recycling of CFTR
Spermatogenesis in a man with complete deletion of USP9Y.
Piomboni et al., Siena, Italy. In N Engl J Med, 2009
Deletions in the azoospermia factor region AZFa on the human Y chromosome and, more specifically, in the region that encompasses the ubiquitin-specific peptidase 9, Y-linked gene USP9Y have been implicated in infertility associated with oligospermia and azoospermia.
An evolutionary perspective on Y-chromosomal variation and male infertility.
Tyler-Smith, Sanger, United States. In Int J Androl, 2008
Comparison with the chimpanzee Y chromosome indicates that USP9Y is dispensable in apes, but that multiple copies of TSPY1 may have an important role.
AZF gene expression analysis in peripheral leukocytes and testicular cells from idiopathic infertility.
Wu et al., Nanjing, China. In Arch Androl, 2007
Frequency of AZF microdeletions in peripheral leukocytes and testicular cells in Chinese men with idiopathic infertility.
[Alteration of spermatogenesis and Y chromosome microdelations. Analysis of the DAZ gene family].
Tessari et al., Padova, Italy. In Minerva Endocrinol, 2002
The genes responsible for the testicular phenotype observed in these subjects are DBY and USP9Y for AZFa, RBMY1 for AZFb, and DAZ for AZFc.
A Y-encoded subunit of the translation initiation factor Eif2 is essential for mouse spermatogenesis.
Burgoyne et al., London, United Kingdom. In Nat Genet, 2001
4,5), Smcy, Uty, Usp9y (also known as Dffry), Eif2s3y (also known as Eif-2gammay) and Dby10; all have closely similar X-encoded homologs.
Y chromosome microdeletions and alterations of spermatogenesis.
Ferlin et al., Padova, Italy. In Endocr Rev, 2001
Deletions in these regions remove one or more of the candidate genes (DAZ, RBMY, USP9Y, and DBY) and cause severe testiculopathy leading to male infertility.
Role of the AZFa candidate genes in male infertility.
Ferlin et al., Padova, Italy. In J Endocrinol Invest, 2000
It contains three genes, USP9Y, DBY and UTY, but only the former two can be at present considered candidate genes for the infertile phenotype associated with deletion of this interval.
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