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Ubiquitin specific peptidase 48

USP48, ubiquitin specific protease 31, USP31
This gene encodes a protein containing domains that associate it with the peptidase family C19, also known as family 2 of ubiquitin carboxyl-terminal hydrolases. Family members function as deubiquitinating enzymes, recognizing and hydrolyzing the peptide bond at the C-terminal glycine of ubiquitin. Enzymes in peptidase family C19 are involved in the processing of poly-ubiquitin precursors as well as that of ubiquitinated proteins. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: Ubiquitin, p65, OGT, CAN, Ku80
Papers on USP48
New Salting Out Stability-Indicating and Kinetic Thin Layer Chromatographic Method for Determination of Glimepiride and Metformin HCl Binary Mixture.
Ahmed et al., Asyūţ, Egypt. In J Chromatogr Sci, Oct 2015
The proposed method was validated according to ICH guidelines and complied with USP31-NF26 validation guidelines.
Immunohistochemical detection of FLAG-tagged endogenous proteins in knock-in mice.
French et al., San Francisco, United States. In J Histochem Cytochem, Apr 2015
Focusing on two 3 × FLAG-tagged proteins for which specific antibodies were available, USP48 and RIPK3, we were able to validate our anti-DDDDK assay by comparing the IHC directed against the actual proteins to the anti-DDDDK IHC assay, which recognizes the FLAG epitope.
CSN-associated USP48 confers stability to nuclear NF-κB/RelA by trimming K48-linked Ub-chains.
Naumann et al., Magdeburg, Germany. In Biochim Biophys Acta, Feb 2015
In this study we observed that USP48, a DUB of hitherto ill-defined function identified through a siRNA screen, associates with the CSN and RelA in the nucleus.
Dopamine D3 receptor inhibits the ubiquitin-specific peptidase 48 to promote NHE3 degradation.
Jose et al., Baltimore, United States. In Faseb J, 2014
We now offer and describe a novel mechanism by which D3R decreases sodium transport in the long term by inhibiting the deubiquitinylating activity of ubiquitin-specific peptidase 48 (USP48), thereby promoting Na(+)-H(+) exchanger (NHE)-3 degradation.
Variation in genes related to cochlear biology is strongly associated with adult-onset deafness in border collies.
Neff et al., San Francisco, United States. In Plos Genet, 2012
Through additional validation based on targeted genotyping of additional cases (n = 23 total) and controls (n = 101 total) and an independent replication cohort of 16 cases and 265 controls, we identified variants in USP31 that were strongly associated with adult-onset deafness in Border Collies, suggesting the involvement of the NF-κB pathway.
A novel injection-molded capsular device for oral pulsatile delivery based on swellable/erodible polymers.
Zema et al., Milano, Italy. In Aaps Pharmscitech, 2011
The performance of capsular devices filled with a tracer drug powder was studied by means of a modified USP31 disintegration apparatus.
Mononuclear cell transcriptome response after sustained virgin olive oil consumption in humans: an exploratory nutrigenomics study.
de la Torre et al., Barcelona, Spain. In Omics, 2009
The response to VOO consumption was confirmed for individual samples (n = 10) by qPCR for 10 upregulated genes (ADAM17, ALDH1A1, BIRC1, ERCC5, LIAS, OGT, PPARBP, TNFSF10, USP48, and XRCC5).
Characterization of human gene expression changes after olive oil ingestion: an exploratory approach.
Covas et al., Barcelona, Spain. In Folia Biol (praha), 2008
USP48 by 2.16; OGT by 1.68-fold change) and associated processes such as inflammation (e.g.
Human ubiquitin specific protease 31 is a deubiquitinating enzyme implicated in activation of nuclear factor-kappaB.
Hatzivassiliou et al., Thessaloníki, Greece. In Cell Signal, 2006
A yeast two-hybrid screen of a human cDNA library identified a ubiquitin specific protease homologue (USP31) as a TRAF2-interacting protein.
Identification of the human ubiquitin specific protease 31 (USP31) gene: structure, sequence and expression analysis.
Farrer et al., Jacksonville, United States. In Dna Seq, 2004
Here we report the identification and characterization of a novel human deubiquitylating gene (USP31), which maps to the critical PARK6 region.
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