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Ubiquitin specific peptidase 26

USP26, ubiquitin-specific protease 26
This gene encodes a member of the ubiquitin-specific processing (UBP) family of proteases and is a deubiquitinating enzyme (DUB) with His and Cys domains. It is specifically expressed in testis tissue. Mutations in this gene have been associated with Sertoli cell-only syndrome and male infertility. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: Ubiquitin, MEN, CAN, ACID, HAD
Papers on USP26
The de-ubiquitylating enzymes USP26 and USP37 regulate homologous recombination by counteracting RAP80.
New
van Attikum et al., Leiden, Netherlands. In Nucleic Acids Res, Sep 2015
Through genetic screens we identified USP26 and USP37 as key de-ubiquitylating enzymes (DUBs) that limit the repressive impact of RNF8/RNF168 on HR.
Evidence from enzymatic and meta-analyses does not support a direct association between USP26 gene variants and male infertility.
New
Tian et al., Shijiazhuang, China. In Andrology, Mar 2015
Do men who carry mutations in USP26 have an increased risk of infertility?
Excess of rare variants in genes that are key epigenetic regulators of spermatogenesis in the patients with non-obstructive azoospermia.
Gui et al., Shenzhen, China. In Sci Rep, 2014
We found a significant excess of rare, non-silent variants in genes that are key epigenetic regulators of spermatogenesis, such as BRWD1, DNMT1, DNMT3B, RNF17, UBR2, USP1 and USP26, in NOA patients (P = 5.5 × 10(-7)), corresponding to a carrier frequency of 22.5% of patients and 13.7% of controls (P = 1.4 × 10(-5)).
Association of 370-371insACA, 494T>C, and 1423C>T haplotype in ubiquitin-specific protease 26 gene and male infertility: a meta-analysis.
Dai et al., Nanjing, China. In Asian J Androl, 2014
Whether the 370-371insACA, 494T>C, and 1423C>T haplotype in ubiquitin-specific protease 26 (USP26) gene is associated with male infertility is controversial.
Ubiquitin Specific Protease 26 (USP26) expression analysis in human testicular and extragonadal tissues indicates diverse action of USP26 in cell differentiation and tumorigenesis.
Paduch et al., New York City, United States. In Plos One, 2013
Ubiquitin specific protease 26 (USP26), a deubiquitinating enzyme, is highly expressed early during murine spermatogenesis, in round spermatids, and at the blood-testis barrier.
Ubiquitin-specific protease (USP26) gene alterations associated with male infertility and recurrent pregnancy loss (RPL) in Iranian infertile patients.
Mohseni Meybodi et al., Tehrān, Iran. In J Assist Reprod Genet, 2013
Mutations in USP26 gene have been proposed to be associated with male infertility.
[Polymorphism of Usp26 correlates with idiopathic male infertility].
Qiu et al., Dalian, China. In Zhonghua Nan Ke Xue, 2012
OBJECTIVE: To study the correlation of nucleotide polymorphism in the ubiquitin-specific protease 26 (Usp26) gene with idiopathic male infertility and its action mechanism in spermatogenesis.
Localization of ubiquitin specific protease 26 at blood-testis barrier and near Sertoli cell-germ cell interface in mouse testes.
GeneRIF
Yen et al., Taipei, Taiwan. In Int J Androl, 2011
RT-PCR assays detected the expression of Usp26 in germ cells, but not in primary Sertoli cell lines
Association between ubiquitin-specific protease USP26 polymorphism and male infertility in Chinese men.
Huang et al., Nanjing, China. In Clin Chim Acta, 2011
Ubiquitin-specific protease 26 (USP26), which is an X-linked gene, has been studied as a potential infertility gene.
The deubiquitinating enzyme USP26 is a regulator of androgen receptor signaling.
GeneRIF
Bernards et al., Amsterdam, Netherlands. In Mol Cancer Res, 2010
USP26 assembles with androgen receptors (AR)and other cofactors in subnuclear foci and serves to counteract hormone-induced AR ubiquitination, thereby contributing to the regulation of AR transcriptional activity.
[Sex chromosomes and male infertility].
Review
Huang et al., Nanjing, China. In Zhonghua Nan Ke Xue, 2010
The importance of the X chromosome in mammalian spermatogenesis is suggested by its enrichment of germ cell-specific genes expressed in spermatogenesis, such as AR, USP26, TAF7L, TEX11, KAL1, AKAP4, and NXF2.
[Mutation of the USP26 gene in spermatogenesis dysfunction].
Review
Huang et al., Nanjing, China. In Zhonghua Nan Ke Xue, 2010
The ubiquitin specific protease 26 (USP26) gene is located at Xq26.2 and present as a single exon on the X chromosome encoding for a protein of 913 amino acids.
Male infertility and the involvement of the X chromosome.
Review
Lissens et al., Brussels, Belgium. In Hum Reprod Update, 2009
In the second part of the study, the results of mutation analyses of seven genes (AR, SOX3, USP26, NXF2, TAF7L, FATE and AKAP4) are described.
USP26 gene variations in fertile and infertile men.
GeneRIF
Kleiman et al., Tel Aviv-Yafo, Israel. In Hum Reprod, 2009
Mutation within the USP26 gene is associated with risk of inguinal hernia leading to impaired male fertility.
[Genetics and male infertility].
Review
Lissens et al., Brussels, Belgium. In Verh K Acad Geneeskd Belg, 2008
The genes NXF2, USP26 and TAF7L were investigated for the presence of mutations.
Association of USP26 haplotypes in men in Taiwan, China with severe spermatogenic defect.
GeneRIF
Teng et al., Zhengzhou, China. In Asian J Androl, 2008
Some USP26 alleles and haplotypes are associated with spermatogenic defect in the Han nationality in Taiwan
Sequence analysis of the X-linked USP26 gene in severe male factor infertility patients and fertile controls.
GeneRIF
Carrell et al., Salt Lake City, United States. In Fertil Steril, 2008
Mutations of the USP26 gene do not appear to be a common cause of idiopathic azoospermia or severe oligozoospermia.
Gene polymorphisms/mutations relevant to abnormal spermatogenesis.
Review
Krausz et al., Florence, Italy. In Reprod Biomed Online, 2008
Other polymorphisms are awaiting further confirmation, whereas for some (POLG, DAZL, USP26, FSHR) a lack of association with abnormal spermatogenesis has now been ascertained.
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