Excess of rare variants in genes that are key epigenetic regulators of spermatogenesis in the patients with non-obstructive azoospermia.
Shenzhen, China. In Sci Rep, 2014
We found a significant excess of rare, non-silent variants in genes that are key epigenetic regulators of spermatogenesis, such as BRWD1, DNMT1, DNMT3B, RNF17, UBR2, USP1 and USP26, in NOA patients (P = 5.5 × 10(-7)), corresponding to a carrier frequency of 22.5% of patients and 13.7% of controls (P = 1.4 × 10(-5)).
[Sex chromosomes and male infertility].
Nanjing, China. In Zhonghua Nan Ke Xue, 2010
The importance of the X chromosome in mammalian spermatogenesis is suggested by its enrichment of germ cell-specific genes expressed in spermatogenesis, such as AR, USP26, TAF7L, TEX11, KAL1, AKAP4, and NXF2.
[Genetics and male infertility].
Brussels, Belgium. In Verh K Acad Geneeskd Belg, 2008
The genes NXF2, USP26 and TAF7L were investigated for the presence of mutations.