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Ubiquitin specific peptidase 24

USP24, ubiquitin specific peptidase 24
Modification of cellular proteins by ubiquitin is an essential regulatory mechanism controlled by the coordinated action of multiple ubiquitin-conjugating and deubiquitinating enzymes. USP24 belongs to a large family of cysteine proteases that function as deubiquitinating enzymes (Quesada et al., 2004 [PubMed 14715245]).[supplied by OMIM, Mar 2008] (from NCBI)
Top mentioned proteins: Ubiquitin, AGE, CAN, EIF2B3, SET
Papers on USP24
Variants of ubiquitin-specific peptidase 24 play a crucial role in lung cancer malignancy.
Hung et al., Tainan City, Taiwan. In Oncogene, Dec 2015
Here we found that ubiquitin-specific peptidase 24 (USP24) is highly expressed in cell lines with enhanced malignancy and in late-stage lung cancer clinical samples.
The deubiquitinating enzyme USP24 is a regulator of the UV damage response.
Gong et al., Miami, United States. In Cell Rep, Feb 2015
In this study, we demonstrate that USP24 deubiquitinates p53 in human cells.
Transcriptional regulation of human USP24 gene expression by NF-kappa B.
Song et al., Vancouver, Canada. In J Neurochem, 2014
Genetic linkage studies indicated that the region of the human ubiquitin-specific protease 24 (USP24) gene is significantly correlated with Parkinson's disease.
Association mapping of the PARK10 region for Parkinson's disease susceptibility genes.
Zabetian et al., Seattle, United States. In Parkinsonism Relat Disord, 2014
BACKGROUND: Previous studies indicate that as many as six genes within the PARK10 region (RNF11, UQCRH, HIVEP3, EIF2B3, USP24, ELAVL4) might modify susceptibility or age at onset in Parkinson's disease (PD).
Validated method for the determination of piroxicam by capillary zone electrophoresis and its application to tablets.
Do─črukol-Ak et al., Eski┼čehir, Turkey. In J Anal Methods Chem, 2013
The method described here was applied to tablet dosage forms and the content of a tablet was found in the limits of USP-24 suggestions.
The deubiquitinating protein USP24 interacts with DDB2 and regulates DDB2 stability.
Gong et al., Miami, United States. In Cell Cycle, 2013
We identified a deubiquitinating enzyme, USP24, as a likely DDB2-interacting partner.
Association analysis of single-nucleotide polymorphisms of USP24 and USP40 with Parkinson's disease in the Han Chinese population.
Shang et al., Chengdu, China. In Eur Neurol, 2011
Numerous single-nucleotide polymorphisms (SNPs) in both USP24 and USP40 genes have been linked to increased risks of late-onset PD, but the association has not been confirmed in the residents of mainland China, especially the Han population.
Ubiquitin specific proteases USP24 and USP40 and ubiquitin thiolesterase UCHL1 polymorphisms have synergic effect on the risk of Parkinson's disease among Taiwanese.
Lee-Chen et al., Taipei, Taiwan. In Clin Chim Acta, 2010
USP24 alone plays a role in PD susceptibility among Taiwanese people >or=60 years of age, or acting synergistically with USP40 and UCHL1 in the total subjects.
Fine-mapping and candidate gene investigation within the PARK10 locus.
Farrer et al., Jacksonville, United States. In Eur J Hum Genet, 2009
After correction for multiple testing, markers within ubiquitin specific peptidase 24 (USP24) are significantly associated with PD within Norwegian, Irish, and US series combined (rs13312: odds ratio (OR) 0.78, P<0.001; rs487230: OR 0.80, P=0.001).
Comparative in vivo bioequivalence and in vitro dissolution of two cyclosporin A soft gelatin capsule formulations.
Domb et al., Jerusalem, Israel. In Int J Clin Pharmacol Ther, 2007
In addition, the comparative drug release rate was assessed using a dissolution apparatus test according to the USP-24 method.
Genetic evidence for ubiquitin-specific proteases USP24 and USP40 as candidate genes for late-onset Parkinson disease.
Grupe et al., Alameda, United States. In Hum Mutat, 2006
Data suggest that genetic variants in USP24 affect the risk for late-onset Parkinson disease (PD), which is consistent with the predicted role of the ubiquitination pathway in PD etiology.
International harmonization of generic drugs: in vitro dissolution tests for Japanese and American generic tablets.
Jorgenson et al., Musashino, Japan. In Biomed Mater Eng, 2005
Ibuprofen tablets on the market in Japan and the USA were compared by manual- and automatic-dissolution tests according to USP24 criteria.
Identification of risk and age-at-onset genes on chromosome 1p in Parkinson disease.
Vance et al., Durham, United States. In Am J Hum Genet, 2005
Using the overall data set of 267 multiplex families, we identified six associated genes in the region, but further screening of a subset of 83 families linked to the chromosome 1 locus identified only two genes significantly associated with AAO in PD: the gamma subunit of the translation initiation factor EIF2B gene (EIF2B3), which was more significant in the linked subset and the ubiquitin-specific protease 24 gene (USP24).
Drug formulations intended for the global market should be tested for stability under tropical climatic conditions.
Remon et al., Dar es Salaam, Tanzania. In Eur J Clin Pharmacol, 2003
RESULTS: Drug content and drug release from all tested ciprofloxacin formulations were within USP-24 requirements and remained stable during storage at simulated tropical conditions.
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