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Ubiquitin specific peptidase 2

USP2, UBP41
This gene encodes a member of the family of de-ubiquitinating enzymes, which belongs to the peptidase C19 superfamily. The encoded protein is a ubiquitin-specific protease which is required for TNF-alpha (tumor necrosis factor alpha) -induced NF-kB (nuclear factor kB) signaling. This protein deubiquitinates polyubiquitinated target proteins such as fatty acid synthase, murine double minute 2 (MDM2), MDM4/MDMX and cyclin D1. MDM2 and MDM4 are negative regulators of the p53 tumor suppressor and cyclin D1 is required for cell cycle G1/S transition. Multiple alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Aug 2011] (from NCBI)
Top mentioned proteins: Ubiquitin, CAN, HAD, ACID, CLOCK
Papers on USP2
An in vitro-in vivo correlation study for nifedipine immediate release capsules administered with water, alcoholic and non-alcoholic beverages: Impact of in vitro dissolution media and hydrodynamics.
New
Fotaki et al., Graz, Austria. In Int J Pharm, Jan 2016
UNASSIGNED: The impact of hydrodynamics and media composition on nifedipine dissolution profile from IR (immediate release) soft capsules was investigated using dissolution apparatus USP1, USP2, USP3 and USP4 (United State Pharmacopoeia).
Deubiquitylase USP2 Regulates the LDLR Pathway by Counteracting the E3-Ubiquitin Ligase IDOL.
New
Zelcer et al., Liverpool, United Kingdom. In Circ Res, Jan 2016
METHODS AND RESULTS: Using a genetic screening approach we identify the ubiquitin-specific protease 2 (USP2) as a post-transcriptional regulator of IDOL-mediated LDLR degradation.
PTH-Induced Osteoblast Proliferation Requires Upregulation of the Ubiquitin-Specific Peptidase 2 (Usp2) Expression.
New
Ezura et al., Tokyo, Japan. In Calcif Tissue Int, Jan 2016
Therefore, in this study, we investigated the effects of PTH on gene expression in the cultured osteoblastic MC3T3-E1 cells, and found that the ubiquitin-specific peptidase 2 (Usp2) may be one of the direct target genes of PTHR signaling.
USP2-45 Is a Circadian Clock Output Effector Regulating Calcium Absorption at the Post-Translational Level.
New
Staub et al., Lausanne, Switzerland. In Plos One, Dec 2015
One of them is Ubiquitin-Specific Protease 2 (Usp2), whose status remains controversial, as it may be a cogwheel regulating the stability or activity of core cogwheels or an output effector.
Increased acid ceramidase expression depends on upregulation of androgen-dependent deubiquitinases, USP2, in a human prostate cancer cell line, LNCaP.
New
Murate et al., Kakamigahara, Japan. In J Biochem, Oct 2015
Reportedly, USP2, a deubiquitinase, plays an important role in LNCaP cells.
Ubiquitin specific protease 2 acts as a key modulator for the regulation of cell cycle by adiponectin and leptin in cancer cells.
New
Park et al., South Korea. In Mol Cell Endocrinol, Oct 2015
Ubiquitin specific protease-2 (USP-2), a deubiquitinating enzyme, is known to impair proteasome-induced degradation of cyclin D1, a critical cell cycle regulator.
Ubiquitin-specific protease USP2-45 acts as a molecular switch to promote α2δ-1-induced downregulation of Cav1.2 channels.
New
Viard et al., London, United Kingdom. In Pflugers Arch, Sep 2015
Using whole-cell current recordings and surface biotinylation assays, we show that USP2-45 specifically decreases both the amplitude of Cav currents and the amount of Cav1.2 subunits inserted at the plasma membrane.
USP2 promotes cell migration and invasion in triple negative breast cancer cell lines.
New
Shen et al., Shanghai, China. In Tumour Biol, Jul 2015
Ubiquitin-specific protease 2 (USP2) was identified as an upregulated gene in the metastatic group, and its expression was analyzed by immunohistochemistry in 121 primary breast cancers, 13 paired normal tissues, and 13 paired metastatic lesions.
Acinetobacter baumannii universal stress protein A plays a pivotal role in stress response and is essential for pneumonia and sepsis pathogenesis.
Attia et al., Cairo, Egypt. In Int J Med Microbiol, 2015
This distinguishes A. baumannii UspA from its closely related homolog, the Staphylococcus aureus Usp2, as well as from the less similar Burkholderia glumae Usps.
Peroxisomal Import Reduces the Proapoptotic Activity of Deubiquitinating Enzyme USP2.
Erdmann et al., Bochum, Germany. In Plos One, 2014
The human deubiquitinating enzyme ubiquitin-specific protease 2 (USP2) regulates multiple cellular pathways, including cell proliferation and apoptosis.
USP2 regulates the intracellular localization of PER1 and circadian gene expression.
Wing et al., Montréal, Canada. In J Biol Rhythms, 2014
Recently, we showed that the deubiquitinating enzyme ubiquitin-specific peptidase 2 (USP2) associates with clock proteins and deubiquitinates PERIOD1 (PER1) but does not affect its overall stability.
Deubiquitinases in skeletal muscle atrophy.
Review
Wing, Canada. In Int J Biochem Cell Biol, 2013
USP19, USP2 and A20 are also implicated in myogenesis.
USP2a protein deubiquitinates and stabilizes the circadian protein CRY1 in response to inflammatory signals.
GeneRIF
Yin et al., Ann Arbor, United States. In J Biol Chem, 2012
USP2a potentially mediates circadian disruption by suppressing the CRY1 degradation during inflammation.
De-ubiquitinating protease USP2a targets RIP1 and TRAF2 to mediate cell death by TNF.
GeneRIF
Grimm et al., London, United Kingdom. In Cell Death Differ, 2012
De-ubiquitinating protease USP2a targets RIP1 and TRAF2 to mediate cell death by TNF.
Ubiquitin-specific protease 2 regulates hepatic gluconeogenesis and diurnal glucose metabolism through 11β-hydroxysteroid dehydrogenase 1.
GeneRIF
Lin et al., Ann Arbor, United States. In Diabetes, 2012
These studies delineate a novel pathway that links hormonal and circadian signals to gluconeogenesis and glucose homeostasis.
The ubiquitin-specific protease USP2a enhances tumor progression by targeting cyclin A1 in bladder cancer.
GeneRIF
Freeman et al., Los Angeles, United States. In Cell Cycle, 2012
USP2a loss attenuates proliferation and migration in T24 human bladder cancer cells.
Castration of dromedary camel through prescrotal midline incision.
Taleb et al., Abu Dhabi, United Arab Emirates. In Open Vet J, 2011
The incision was closed with one interrupted, horizontal mattress suture using USP-2 chromic catgut.
The de-ubiquitinylating enzyme, USP2, is associated with the circadian clockwork and regulates its sensitivity to light.
GeneRIF
Besharse et al., Milwaukee, United States. In Plos One, 2010
Rhythmic expression of USP2 in the SCN and other tissues offers a new level of control of the clock machinery through de-ubiqutinylation and suggests a role for USP2 during circadian adaptation to environmental day length changes
Early transcriptional control of ENaC (de)ubiquitylation by aldosterone.
Review
Staub et al., Zürich, Switzerland. In Kidney Int, 2008
Among a series of new early aldosterone-induced gene products recently identified in kidney target tubules, an additional regulator of ENaC ubiquitylation, the deubiquitylating enzyme Usp2-45, was identified.
Insights into the molecular basis of the hormonal control of molting and metamorphosis from Manduca sexta and Drosophila melanogaster.
Review
Nelson et al., Seattle, United States. In Insect Biochem Mol Biol, 2003
We show new evidence that EcR-A/USP-2 and E75A contribute to the down-regulation of MHR3 after the peak of ecdysteroid.
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