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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 08 Dec 2016.

Ubiquitin specific peptidase 19

USP19
Top mentioned proteins: Ubiquitin, fibrillin-1, CAN, HAD, Myogenin
Papers on USP19
Inactivation of the ubiquitin-specific protease 19 deubiquitinating enzyme protects against muscle wasting.
New
Wing et al., Montréal, Canada. In Faseb J, Sep 2015
Because ubiquitin-specific protease (USP)19 deubiquitinating enzyme is induced in skeletal muscle in many catabolic conditions, we generated USP19 knockout (KO) mice.
Female-specific regulation of skeletal muscle mass by USP19 in young mice.
New
Yamaji et al., Ōsaka, Japan. In J Endocrinol, Jun 2015
The expression of ubiquitin-specific peptidase 19 (USP19) is upregulated during muscle atrophy and by E₂-activated ERα.
USP19 deubiquitinating enzyme inhibits muscle cell differentiation by suppressing unfolded-protein response signaling.
New
Wing et al., Montréal, Canada. In Mol Biol Cell, Apr 2015
The USP19 deubiquitinating enzyme modulates the expression of myogenin and myofibrillar proteins in L6 muscle cells.
Ubiquitin-specific protease 19 regulates the stability of the E3 ubiquitin ligase MARCH6.
Hirose et al., Yokohama, Japan. In Exp Cell Res, 2014
Here, we show that USP19 interacts with the ERAD-associated E3 ubiquitin ligase MARCH6.
Characterization of the deubiquitinating activity of USP19 and its role in endoplasmic reticulum-associated degradation.
Ye et al., Bethesda, United States. In J Biol Chem, 2014
USP19, the only DUB containing a carboxyl-terminal transmembrane domain, was proposed to function in endoplasmic reticulum-associated degradation (ERAD).
Deubiquitinases in skeletal muscle atrophy.
Review
Wing, Canada. In Int J Biochem Cell Biol, 2013
Instead several deubiquitinases are induced in atrophying muscle, in particular USP19 and USP14.
The preventive effect of β-carotene on denervation-induced soleus muscle atrophy in mice.
Inui et al., Sakai, Japan. In Br J Nutr, 2013
β-Carotene reduced the H2O2-induced increased expression levels of E3 ubiquitin ligases (Atrogin-1 and MuRF1) and deubiquitinating enzymes (USP14 and USP19) (P< 0·05, n 3) and attenuated the H2O2-induced nuclear localisation of FOXO3a.
An N-terminal SIAH-interacting motif regulates the stability of the ubiquitin specific protease (USP)-19.
Lindsten et al., Stockholm, Sweden. In Biochem Biophys Res Commun, 2013
The Ubiquitin Specific Protease-19 (USP19) regulates cell cycle progression and is involved in the cellular response to different types of stress, including the unfolded protein response (UPR), hypoxia and muscle atrophy.
Viral immune modulators perturb the human molecular network by common and unique strategies.
Impact
GeneRIF
Superti-Furga et al., Vienna, Austria. In Nature, 2012
experimentally verified the targets heterogeneous nuclear ribonucleoprotein U, phosphatidylinositol-3-OH kinase, the WNK (with-no-lysine) kinase family and USP19 (ubiquitin-specific peptidase 19) as vulnerable nodes in the host cellular defence system against viruses
Ubiquitin-specific protease 19 (USP19) regulates hypoxia-inducible factor 1α (HIF-1α) during hypoxia.
GeneRIF
Lindsten et al., Stockholm, Sweden. In J Biol Chem, 2012
ubiquitin-specific protease-19 (USP19) interacts with components of the hypoxia pathway including HIF-1alpha and rescues it from degradation independent of its catalytic activity
17β-estradiol represses myogenic differentiation by increasing ubiquitin-specific peptidase 19 through estrogen receptor α.
GeneRIF
Inui et al., Sakai, Japan. In J Biol Chem, 2012
E2 induces USP19 expression through nuclear ERalpha, (ii) increased USP19-mediated deubiquitinating activity represses myogenesis, and (iii) ERbeta inhibits ERalpha-activated USP19 expression.
The USP19 deubiquitinase regulates the stability of c-IAP1 and c-IAP2.
GeneRIF
Yang et al., Philadelphia, United States. In J Biol Chem, 2011
The USP19 deubiquitinase regulates the stability of c-IAP1 and c-IAP2.
Prevention of muscle disuse atrophy by MG132 proteasome inhibitor.
Francaux et al., Louvain-la-Neuve, Belgium. In Muscle Nerve, 2011
HU was also associated with an increased expression of MuRF-1 (P = 0.006), MAFbx (P = 0.001), and USP28 (P = 0.027) mRNA, whereas Nedd4, E3α, USP19, and UBP45 mRNA did not change significantly.
Identification of distinctive patterns of USP19-mediated growth regulation in normal and malignant cells.
GeneRIF
Wing et al., Montréal, Canada. In Plos One, 2010
ability of USP19 to regulate cell proliferation and p27(Kip1) levels; complete loss of USP19 function on cell growth may arise as a result of oncogenic transformation of cells.
USP19-deubiquitinating enzyme regulates levels of major myofibrillar proteins in L6 muscle cells.
GeneRIF
Wing et al., Montréal, Canada. In Am J Physiol Endocrinol Metab, 2009
USP19 modulates transcription of major myofibrillar proteins.
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