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Ubiquitin specific peptidase 16

USP16, Ubp-M
This gene encodes a deubiquitinating enzyme that is phosphorylated at the onset of mitosis and then dephosphorylated at the metaphase/anaphase transition. It can deubiquitinate H2A, one of two major ubiquitinated proteins of chromatin, in vitro and a mutant form of the protein was shown to block cell division. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: Histone, H2A, Ubiquitin, Ubiquitin Thiolesterase, CAN
Papers on USP16
Epigenetic Alterations in Fanconi Anaemia: Role in Pathophysiology and Therapeutic Potential.
Almeida et al., Lisbon, Portugal. In Plos One, 2014
Treatment of FA cells with histone deacetylase inhibitor Vorinostat increased the expression of DNM3Tβ and reduced the levels of CIITA and HDAC9, PAK1, USP16, all involved in different aspects of epigenetic and immune regulation.
The histone H2A deubiquitinase USP16 interacts with HERC2 and fine-tunes cellular response to DNA damage.
Wang et al., Shanghai, China. In J Biol Chem, 2014
Here we report that the histone H2A deubiquitinase USP16 interacts with HERC2, fine-tunes the ubiquitin signal during repair, and importantly, is required for terminating the ubiquitination signal after repair.
Transcriptional profile of fibroblasts obtained from the primary site, lymph node and bone marrow of breast cancer patients.
Azevedo Koike Folgueira et al., São Paulo, Brazil. In Genet Mol Biol, 2014
In a biological validation set, NOTCH2 was confirmed to be more expressed in N+ (vs CAF) and ADCY2, HECTD1, HNMT, LOX, MACF1, SLC1A3 and USP16 more expressed in BM (vs CAF).
Ubp-M serine 552 phosphorylation by cyclin-dependent kinase 1 regulates cell cycle progression.
Wang et al., Birmingham, United States. In Cell Cycle, 2013
Here, we report that cyclin-dependent kinase 1 (CDK1) phosphorylates the histone H2A deubiquitinase Ubp-M at serine 552 (S552P), and, importantly, this phosphorylation is required for cell cycle progression.
Usp16 contributes to somatic stem-cell defects in Down's syndrome.
Clarke et al., Stanford, United States. In Nature, 2013
Here we show that in Ts65Dn mice, which are trisomic for 132 genes homologous to genes on human chromosome 21, triplication of Usp16 reduces the self-renewal of haematopoietic stem cells and the expansion of mammary epithelial cells, neural progenitors and fibroblasts.
The aurora B kinase and the polycomb protein ring1B combine to regulate active promoters in quiescent lymphocytes.
Dillon et al., London, United Kingdom. In Mol Cell, 2013
Aurora B phosphorylates histone H3S28 at active promoters in resting B cells as well as inhibiting Ring1B-mediated ubiquitination of histone H2A and enhancing binding and activity of the USP16 deubiquitinase at transcribed genes.
HDAC6 and Ubp-M BUZ domains recognize specific C-terminal sequences of proteins.
Pei et al., Columbus, United States. In Biochemistry, 2011
In this work, the BUZ domains of HDAC6 and Ubp-M were subjected to screening against a one-bead-one-compound (OBOC) peptide library that exhibited random peptide sequences with free C-termini.
ATM-dependent chromatin changes silence transcription in cis to DNA double-strand breaks.
Greenberg et al., Philadelphia, United States. In Cell, 2010
Silencing is partially dependent on E3 ubiquitin ligases RNF8 and RNF168, whereas reversal of silencing relies on the uH2A deubiquitylating enzyme USP16.
Thyroid hormone-related regulation of gene expression in human fatty liver.
Patti et al., Boston, United States. In J Clin Endocrinol Metab, 2009
This gene set included genes related to RNA metabolism (SNRPE, HNRPH3, TIA1, and SFRS2), protein catabolism (PSMA1, PSMD12, USP9X, IBE2B, USP16, and PCMT1), and energy metabolism (ATP5C1, COX7C, UQCRB).
Genome profiling of chronic myelomonocytic leukemia: frequent alterations of RAS and RUNX1 genes.
Chaffanet et al., Marseille, France. In Bmc Cancer, 2007
a new cryptic USP16-RUNX1 fusion in chronic myelomonocytic leukemia
Regulation of cell cycle progression and gene expression by H2A deubiquitination.
Wang et al., Birmingham, United States. In Nature, 2007
knockdown of Ubp-M in HeLa cells results in slow cell growth rates owing to defects in the mitotic phase of the cell cycle
Solution structure of the Ubp-M BUZ domain, a highly specific protein module that recognizes the C-terminal tail of free ubiquitin.
Zhou et al., Durham, United States. In J Mol Biol, 2007
Study reports the solution structure of the BUZ domain of Ubp-M, a ubiquitin-specific protease, and its interaction with ubiquitin; the Ubp-M BUZ domain features three zinc-binding sites consisting of 12 residues.
Distinctive gene expression of human lung adenocarcinomas carrying LKB1 mutations.
Sanchez-Cespedes et al., Madrid, Spain. In Oncogene, 2004
USP16 and UBE2L3).
Caspase-dependent deubiquitination of monoubiquitinated nucleosomal histone H2A induced by diverse apoptogenic stimuli.
Neckers et al., Bethesda, United States. In Cell Death Differ, 2001
Transient transfection of 293 cells with the gene encoding Ubp-M, a human deubiquitinating enzyme, promoted uH2A deubiquitination, while an inactive mutated Ubp-M enzyme did not.
A mutant deubiquitinating enzyme (Ubp-M) associates with mitotic chromosomes and blocks cell division.
Marchesi et al., New Haven, United States. In Proc Natl Acad Sci U S A, 1999
A new ubiquitin-processing protease (Ubp-M) has been identified in mammalian cells that is phosphorylated at the onset of mitosis and dephosphorylated during the metaphase/anaphase transition.
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