Splicing factor mutations and cancer.
Kyoto, Japan. In Wiley Interdiscip Rev Rna, 2014
These mutations were heterozygous and mainly affected U2AF1 (U2AF35), SRSF2 (SC35), SF3B1 (SF3B155 or SAP155), and ZRSR2 (URP), which are engaged in the initial steps of RNA splicing, including 3' splice-site recognition, and occur in a large mutually exclusive pattern, suggesting a common impact of these mutations on RNA splicing.
Molecular evolution of GPCRs: Somatostatin/urotensin II receptors.
Uppsala, Sweden. In J Mol Endocrinol, 2014
Following the 2R event, the vertebrate ancestor is deduced to have possessed three SS (SS1, SS2, and SS5) and six SSTR (SSTR1-6) genes, on the one hand, and four UII (UII, URP, URP1, and URP2) and five UTS2R (UTS2R1-5) genes, on the other hand.
Urotensin II, from fish to human.
Mont-Saint-Aignan, France. In Ann N Y Acad Sci, 2010
A UII paralog called urotensin II-related peptide (URP) has been identified in the rat brain.