Ureases as multifunctional toxic proteins: A review.
Porto Alegre, Brazil. In Toxicon, Feb 2016
Since our first description of the neurotoxic properties of canatoxin, an isoform of the jack bean urease, which appeared in Toxicon in 1981, about one hundred articles have been published on "new" properties of plant and microbial ureases.
Dihydropyrimidine based hydrazine dihydrochloride derivatives as potent urease inhibitors.
Karāchi, Pakistan. In Bioorg Chem, Jan 2016
UNASSIGNED: Four series of heterocyclic compounds 4-dihydropyrimidine-2-thiones 7-12 (series A), N,S-dimethyl-dihydropyrimidines 13-18 (series B), hydrazine derivatives of dihydropyrimidine 19-24 (series C), and tetrazolo dihydropyrimidine derivatives 25-30 (series D), were synthesized and evaluated for in vitro urease inhibitory activity.
Proteus mirabilis and Urinary Tract Infections.
In Microbiol Spectr, Oct 2015
P. mirabilis uses a diverse set of virulence factors to access and colonize the host urinary tract, including urease and stone formation, fimbriae and other adhesins, iron and zinc acquisition, proteases and toxins, biofilm formation, and regulation of pathogenesis.
Self-powered enzyme micropumps.
United States. In Nat Chem, 2014
In the four cases studied (catalase, lipase, urease and glucose oxidase), the flow is driven by a gradient in fluid density generated by the enzymatic reaction.
Binuclear metallohydrolases: complex mechanistic strategies for a simple chemical reaction.
Brisbane, Australia. In Acc Chem Res, 2012
Other members of this family are urease, which contains a di-Ni(2+) center and catalyzes the breakdown of urea, arginase, which contains a di-Mn(2+) center and catalyzes the final step in the urea cycle, and the metallo-β-lactamases, which contain a di-Zn(2+) center and are virulence factors contributing to the spread of antibiotic-resistant pathogens.