Ureases as multifunctional toxic proteins: A review.
Porto Alegre, Brazil. In Toxicon, Feb 2016
Since our first description of the neurotoxic properties of canatoxin, an isoform of the jack bean urease, which appeared in Toxicon in 1981, about one hundred articles have been published on "new" properties of plant and microbial ureases.
Dihydropyrimidine based hydrazine dihydrochloride derivatives as potent urease inhibitors.
Karāchi, Pakistan. In Bioorg Chem, Jan 2016
UNASSIGNED: Four series of heterocyclic compounds 4-dihydropyrimidine-2-thiones 7-12 (series A), N,S-dimethyl-dihydropyrimidines 13-18 (series B), hydrazine derivatives of dihydropyrimidine 19-24 (series C), and tetrazolo dihydropyrimidine derivatives 25-30 (series D), were synthesized and evaluated for in vitro urease inhibitory activity.
Oral Microbiome Metabolism: From "Who Are They?" to "What Are They Doing?".
Sendai, Japan. In J Dent Res, Dec 2015
Saccharolytic bacteria-including Streptococcus, Actinomyces, and Lactobacillus species-degrade carbohydrates into organic acids via the Embden-Meyerhof-Parnas pathway and several of its branch pathways, resulting in dental caries, while alkalization and acid neutralization via the arginine deiminase system, urease, and so on, counteract acidification.
Treatment of the Infected Stone.
Nashville, United States. In Urol Clin North Am, Nov 2015
Infected kidney stones refer to stones that form because of urinary tract infections with urease-producing bacteria, secondarily infected stones of any composition, or stones obstructing the urinary tract leading to pyelonephritis.
Self-powered enzyme micropumps.
United States. In Nat Chem, 2014
In the four cases studied (catalase, lipase, urease and glucose oxidase), the flow is driven by a gradient in fluid density generated by the enzymatic reaction.
Binuclear metallohydrolases: complex mechanistic strategies for a simple chemical reaction.
Brisbane, Australia. In Acc Chem Res, 2012
Other members of this family are urease, which contains a di-Ni(2+) center and catalyzes the breakdown of urea, arginase, which contains a di-Mn(2+) center and catalyzes the final step in the urea cycle, and the metallo-β-lactamases, which contain a di-Zn(2+) center and are virulence factors contributing to the spread of antibiotic-resistant pathogens.