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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Urate oxidase

Urate Oxidase, uricase
catalyzes the hydrolysis of uric acid to allantoin in purine degradation [RGD, Feb 2006] (from NCBI)
Top mentioned proteins: ACID, CAN, HAD, catalase, V1a
Papers on Urate Oxidase
Horseradish peroxidase-catalyzed polymerization of l-DOPA for mono-/bi-enzyme immobilization and amperometric biosensing of H2O2 and uric acid.
New
Meng et al., Changsha, China. In Talanta, Apr 2016
dopamine) in the presence of H2O2 (and uricase (UOx)) was exploited to immobilize mono-/bi-enzymes for hydroquinone-mediated amperometric biosensing of H2O2 and uric acid (UA).
An analytical comparison between point-of-care uric acid testing meters.
New
Hughes et al., Mölndal, Sweden. In Expert Rev Mol Diagn, Feb 2016
Cross-validation of meter precision with laboratory-based uricase assay gave good correlations between both methods (R(2) = 0.8061 and 0.7605, respectively).
Uric acid is released in the brain during seizure activity and increases severity of seizures in a mouse model for acute limbic seizures.
New
Boon et al., Gent, Belgium. In Exp Neurol, Feb 2016
Manipulating uric acid levels through administration of allopurinol or knock-out of urate oxidase significantly altered the number of generalized seizures, decreasing and increasing them by a twofold respectively.
Hyperstabilization of Tetrameric Bacillus sp. TB-90 Urate Oxidase by Introducing Disulfide Bonds through Structural Plasticity.
New
Nishiya et al., In Biochemistry, Feb 2016
TB-90 urate oxidase (BTUO) is one of the most thermostable homotetrameric enzymes.
Melamine Nephrotoxicity is Mediated by Hyperuricemia.
New
Liu et al., Beijing, China. In Biomed Environ Sci, Dec 2015
OBJECTIVE: We tested whether melamine nephrotoxicity was exacerbated by urate (a typical component of renal stones in humans) in rats with hyperuricemiainduced by the uricase inhibitor, potassium oxonate (Oxo).
Uric acid as a modulator of glucose and lipid metabolism.
Review
New
Chaves et al., Divinópolis, Brazil. In Biochimie, Sep 2015
Hyperuricaemia reduction in the Pound mouse or fructose-fed rats, as well as hyperuricaemia induction by uricase inhibition in rodents and studies using cell culture have suggested that uric acid plays an important role in the development of metabolic syndrome.
Risk of anaphylaxis with repeated courses of rasburicase: a Research on Adverse Drug Events and Reports (RADAR) project.
Review
New
Trifilio et al., Chicago, United States. In Drug Saf, Feb 2015
BACKGROUND: Rasburicase, a recombinant urate oxidase, is used to rapidly metabolize uric acid in patients with hyperuricaemia.
Rasburicase in the management of tumor lysis: an evidence-based review of its place in therapy.
Review
Bose et al., United States. In Core Evid, 2014
Rasburicase, a recombinant urate oxidase, was approved by the US Food and Drug Administration for children in 2002 and adults in 2009, ushering in a new era in TLS therapy.
A novel enzymatic approach in the production of food with low purine content using Arxula adeninivorans endogenous and recombinant purine degradative enzymes.
Review
Kunze et al., Germany. In Bioengineered, 2014
Many lower organisms, such as the yeast Arxula adeninivorans, possess the enzyme, urate oxidase that converts uric acid to 5-hydroxyisourate, thus preventing uric acid accumulation.
Hyperuricemia, urate deposition and the association with hypertension.
Review
Borghi et al., Milano, Italy. In Curr Med Res Opin, 2014
In experimental models, the inhibition of hepatic uricase induces hyperuricemia, hypertension and mild renal disease.
Efficacy and tolerability of pegloticase for the treatment of chronic gout in patients refractory to conventional treatment: two randomized controlled trials.
Impact
Becker et al., Durham, United States. In Jama, 2011
Pegloticase, monomethoxypoly(ethylene glycol)-conjugated mammalian recombinant uricase, was developed to fulfill this need.
Gout therapeutics: new drugs for an old disease.
Review
Impact
Wortmann et al., United States. In Lancet, 2011
We also review results from studies of pegloticase, a pegylated uricase in development, and we summarise data for several other pipeline drugs for gout, such as the selective uricosuric drug RDEA594 and various interleukin-1 inhibitors.
DNase 2 is the main DNA-degrading enzyme of the stratum corneum.
GeneRIF
Eckhart et al., Vienna, Austria. In Plos One, 2010
These data identify DNase 2 as the predominant DNase on the mammalian skin surface and indicate that its activity is primarily targeted to exogenous DNA.
Self-sufficient control of urate homeostasis in mice by a synthetic circuit.
Impact
Fussenegger et al., In Nat Biotechnol, 2010
This synthetic device consists of a modified Deinococcus radiodurans-derived protein that senses uric acids levels and triggers dose-dependent derepression of a secretion-engineered Aspergillus flavus urate oxidase that eliminates uric acid.
Effect of allopurinol on blood pressure of adolescents with newly diagnosed essential hypertension: a randomized trial.
Impact
Johnson et al., Houston, United States. In Jama, 2008
Experimentally increasing uric acid levels using a uricase inhibitor causes systemic hypertension in animal models.
SLC2A9 is a newly identified urate transporter influencing serum urate concentration, urate excretion and gout.
Impact
Wright et al., Edinburgh, United Kingdom. In Nat Genet, 2008
Uric acid is the end product of purine metabolism in humans and great apes, which have lost hepatic uricase activity, leading to uniquely high serum uric acid concentrations (200-500 microM) compared with other mammals (3-120 microM).
Degradation of nuclear DNA by DNase II-like acid DNase in cortical fiber cells of mouse eye lens.
GeneRIF
Nagata et al., Ōsaka, Japan. In Febs J, 2007
DNase II-like acid DNase is synthesized as a precursor with a signal sequence, and is localized to lysosomes. DNase II-like acid DNase mRNA was found in cortical fiber cells but not epithelial cells
Purification, and properties of a bovine uricase.
GeneRIF
Zia et al., Faisalābād, Pakistan. In Protein Pept Lett, 2005
Activation energy requirement for uric acid hydrolysis by uricase & inactivation of enzyme were 11.6 & 14.5 kJ/M respectively. Both enthalpy & entropy of activation for uricase activity were lower than those reported for some thermostable enzymes.
Nuclear cataract caused by a lack of DNA degradation in the mouse eye lens.
Impact
GeneRIF
Nagata et al., Ōsaka, Japan. In Nature, 2003
The DLAD-/- mice develop cataracts of the nucleus lentis, and their response to light on electroretinograms is severely reduced; these results indicate that DLAD is responsible for the degradation of nuclear DNA during lens cell differentiation
Towards a new T-fold protein?: the coproporphyrinogen III oxidase sequence matches many structural features from urate oxidase.
GeneRIF
Camadro et al., Caen, France. In Febs Lett, 2002
coproporphyrinogen III oxidase sequence matches many structural features from urate oxidase
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