Melamine Nephrotoxicity is Mediated by Hyperuricemia.
Beijing, China. In Biomed Environ Sci, Dec 2015
OBJECTIVE: We tested whether melamine nephrotoxicity was exacerbated by urate (a typical component of renal stones in humans) in rats with hyperuricemiainduced by the uricase inhibitor, potassium oxonate (Oxo).
Uric acid as a modulator of glucose and lipid metabolism.
Divinópolis, Brazil. In Biochimie, Sep 2015
Hyperuricaemia reduction in the Pound mouse or fructose-fed rats, as well as hyperuricaemia induction by uricase inhibition in rodents and studies using cell culture have suggested that uric acid plays an important role in the development of metabolic syndrome.
Gout therapeutics: new drugs for an old disease.
United States. In Lancet, 2011
We also review results from studies of pegloticase, a pegylated uricase in development, and we summarise data for several other pipeline drugs for gout, such as the selective uricosuric drug RDEA594 and various interleukin-1 inhibitors.
Purification, and properties of a bovine uricase.
Faisalābād, Pakistan. In Protein Pept Lett, 2005
Activation energy requirement for uric acid hydrolysis by uricase & inactivation of enzyme were 11.6 & 14.5 kJ/M respectively. Both enthalpy & entropy of activation for uricase activity were lower than those reported for some thermostable enzymes.