Uracil-DNA Glycosylase UNG Promotes Tet-mediated DNA Demethylation.
Shanghai, China. In J Biol Chem, Feb 2016
UNG2, one of the glycosylases known to excise uracil residues from DNA, was found to reduce DNA methylation, thus activating transcription of a methylation-silenced reporter gene when co-transfected with Tet2 into HEK293T cells.
Base excision repair.
Trondheim, Norway. In Cold Spring Harb Perspect Biol, 2013
More recently, an important role of uracil-DNA glycosylase UNG2 in adaptive immunity was revealed.
Mechanism and regulation of class switch recombination.
Worcester, United States. In Annu Rev Immunol, 2007
AID activity converts several dC bases to dU bases in each S region, and the dU bases are then excised by the uracil DNA glycosylase UNG; the resulting abasic sites are nicked by apurinic/apyrimidinic endonuclease (APE).