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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

UQCRC2 ubiquinol-cytochrome c reductase core protein II

UQCRC2, Core protein II, ubiquinol cytochrome c reductase core protein 2, ubiquinol-cytochrome c reductase core protein II
Top mentioned proteins: V1a, AGE, fibrillin-1, OUT, oxidoreductase
Papers on UQCRC2
Mitochondrial DNA depletion in respiratory chain-deficient Parkinson disease neurons.
Turnbull et al., Lübeck, Germany. In Ann Neurol, Dec 2015
METHODS: Multiple-label immunofluorescence was applied to postmortem sections of 10 IPD patients and 10 controls to quantify the abundance of CI-IV subunits (NDUFB8 or NDUFA13, SDHA, UQCRC2 and COXI), and mitochondrial transcription factors (TFAM and TFB2M) relative to mitochondrial mass (Porin and GRP75) in dopaminergic neurons.
In silico analysis of the molecular mechanism of postmenopausal osteoporosis.
Xu et al., Jining, China. In Mol Med Report, Nov 2015
In addition, the five largest modules were identified with TTN, L1G1, ACADM, UQCRC2 and TRIM63 as the hub proteins, and they were associated with the biological processes of muscle contraction, DNA replication initiation, lipid modification, generation of precursor metabolites and energy, and regulation of acetyl‑CoA biosynthetic process, respectively.
The landscape of copy number variations in Finnish families with autism spectrum disorders.
Järvelä et al., Helsinki, Finland. In Autism Res, Jul 2015
Additionally, several novel candidate genes (BDKRB1, BDKRB2, AP2M1, SPTA1, PTH1R, CYP2E1, PLCD3, F2RL1, UQCRC2, LILRB3, RPS9, and COL11A2) were identified through gene prioritization.
Phenotypic variation of TTC19-deficient mitochondrial complex III deficiency: a case report and literature review.
Yu et al., Adelaide, Australia. In Am J Med Genet A, Jun 2015
It has been associated with mutations in MT-CYB, the only mitochondrial DNA encoded subunit, as well as in nine nuclear genes described thus far: BCS1L, TTC19, UQCRB, UQCRQ, UQCRC2, CYC1, UQCC2, LYRM7, and UQCC3.
The α-tocopherol derivative ESeroS-GS induces cell death and inhibits cell motility of breast cancer cells through the regulation of energy metabolism.
Wei et al., Beijing, China. In Eur J Pharmacol, 2015
Further studies indicated that ESeroS-GS down-regulated the expression of hexokinase II, SDH B, UQCRC2 and COX II in MDA-MB-231 cells but not in MCF-10A cells.
Increased male fertility using fertility-related biomarkers.
Pang et al., Ansŏng, South Korea. In Sci Rep, 2014
The results demonstrated that cytochrome b-c1 complex subunit 2 (UQCRC2) was abundantly expressed in high-litter size spermatozoa (>3-fold).
Impact of exposure to low concentrations of nitric oxide on protein profile in murine and human pancreatic islet cells.
Bedoya et al., Sevilla, Spain. In Islets, 2013
These include stress response mitochondrial proteins (UQCRC2, VDAC1, ATP5C1, ATP5A1) in RINm5F cells and stress response endoplasmic reticulum proteins (HSPA5, PDIA6, VCP, GANAB) in HPI.
Mitochondrial complex III deficiency caused by a homozygous UQCRC2 mutation presenting with neonatal-onset recurrent metabolic decompensation.
Matsumoto et al., Yokohama, Japan. In Hum Mutat, 2013
We found a homozygous missense mutation in UQCRC2 that encodes mitochondrial ubiquinol-cytochrome c reductase core protein II by whole-exome sequencing combined with linkage analysis.
Identification of Target Genes Involved in the Antiproliferative Effect of Enzyme-Modified Ginseng Extract in HepG2 Hepatocarcinoma Cell.
Jang et al., Taejŏn, South Korea. In Evid Based Complement Alternat Med, 2012
Using the Agilent PrimeView Human Gene Expression Array, we found that the expression of several genes involved in apoptosis (caspase-4, Annexin A2, HSPA9, AIFM1, UQCRC2, and caspase-7) were increased in HepG2 human hepatocarcinoma cells after their treatment with enzyme-modified ginseng extract (EMGE).
Nutlin-3a decreases male fertility via UQCRC2.
Pang et al., Ansŏng, South Korea. In Plos One, 2012
Ubiquinol-cytochrome-c reductase core protein 2 (UQCRC2) is a component of ubiquinol-cytochrome c reductase complex that is known to correlate with male fertility via spermatogenesis.
Fertility-related proteomic profiling bull spermatozoa separated by percoll.
Pang et al., Ansŏng, South Korea. In J Proteome Res, 2012
Five proteins, enolase 1 (ENO1), ATP synthase H+ transporting mitochondrial F1 complex beta subunit, apoptosis-stimulating of p53 protein 2, alpha-2-HS-glycoprotein, and phospholipid hydroperoxide glutathione peroxide, were more highly represented in high fertility bulls, whereas three proteins, voltage dependent anion channel 2 (VDAC2), ropporin-1, and ubiquinol-cytochrome-c reductase complex core protein 2 (UQCRC2), were more highly represented in low fertility bulls.
Preliminary evidences on mitochondrial injury and impaired oxidative metabolism in breast cancer.
Grammatico et al., Roma, Italy. In Mitochondrion, 2012
Drastic OXPHOS reduction was observed in HMC-1 cells for the succinate-dehydrogenase complex II SDH-B protein, while decreasing was reported for the NADH-ubiquinone oxidoreductase complex I NDUFS3 and the ubiquinol cytochrome c reductase complex III UQCRC2 subunits.
Differential proteomics leads to identification of domain-specific epididymal sperm proteins.
Khole et al., Mumbai, India. In J Androl, 2011
Validation of 3 proteins, namely MMSDH, NDUFS1, and UQCRC2, using antibodies very elegantly demonstrates that the strategy has been very effective.
Mitochondrial dysfunction increases allergic airway inflammation.
Boldogh et al., Galveston, United States. In J Immunol, 2009
Out of these, the ubiquinol-cytochrome c reductase core II protein (UQCRC2) was found to be implicated in mitochondrial ROS generation from respiratory complex III.
Apolipoprotein E4 (1-272) fragment is associated with mitochondrial proteins and affects mitochondrial function in neuronal cells.
Michikawa et al., Ōbu, Japan. In Mol Neurodegener, 2008
Here, we found that apoE4 binds to ubiquinol cytochrome c reductase core protein 2 (UQCRC2) and cytochrome C1, both of which are components of mitochondrial respiratory complex III, and cytochrome c oxidase subunit 4 isoform 1 (COX IV 1), which is a component of complex IV, in Neuro-2a cells.
Ferulenol specifically inhibits succinate ubiquinone reductase at the level of the ubiquinone cycle.
Morin et al., Algiers, Algeria. In Biochem Biophys Res Commun, 2007
A mechanism by which ferulenol inhibits this enzymeand demonstrates that mitochondrial dysfunction is an important determinant in Ferula plant toxicity.
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