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UPF1 regulator of nonsense transcripts homolog

UPF1, hUpf1, Rent1
This gene encodes a protein that is part of a post-splicing multiprotein complex involved in both mRNA nuclear export and mRNA surveillance. mRNA surveillance detects exported mRNAs with truncated open reading frames and initiates nonsense-mediated mRNA decay (NMD). When translation ends upstream from the last exon-exon junction, this triggers NMD to degrade mRNAs containing premature stop codons. This protein is located only in the cytoplasm. When translation ends, it interacts with the protein that is a functional homolog of yeast Upf2p to trigger mRNA decapping. Use of multiple polyadenylation sites has been noted for this gene. [provided by RefSeq, Jul 2008] (from NCBI)
Papers on UPF1
The human T-lymphotropic virus type 1 tax protein inhibits nonsense-mediated mRNA decay by interacting with INT6/EIF3E and UPF1.
Jalinot et al., Lyon, France. In J Virol, 2012
HTLV-1 Tax binds to UPF1 and causes an increase in the amount of phospho-UPF1. These activities coincidewith an enhanced localization of UPF1 in the P-bodies, in which Tax was also partially detected
The cryo-EM structure of the UPF-EJC complex shows UPF1 poised toward the RNA 3' end.
Llorca et al., Madrid, Spain. In Nat Struct Mol Biol, 2012
The heptameric assembly of the UPF complex is built around UPF2, a scaffold protein with a ring structure that closes around the CH domain of UPF1, keeping the helicase region in an accessible and unwinding-competent state.
Up-frameshift protein 1 (UPF1): multitalented entertainer in RNA decay.
Akimitsu et al., Tokyo, Japan. In Drug Discov Ther, 2012
UPF1 is an important factor for the RNA quality control system and the regulation of physiological gene expression, and contributes to DNA replication, DNA repair, telomere metabolism, and stabilization of HIV-1 genomic RNA.
Arabidopsis plants having defects in nonsense-mediated mRNA decay factors UPF1, UPF2, and UPF3 show photoperiod-dependent phenotypes in development and stress responses.
Wu et al., Jena, Germany. In J Integr Plant Biol, 2012
The involvement of UPF1, UPF2, and UPF3 in development and in response to stresses, wounding and infection by Pseudomonas syringae pv. tomato strain DC3000, were examined.
Cell type-dependent gene regulation by Staufen2 in conjunction with Upf1.
Yoneda et al., Suita, Japan. In Bmc Mol Biol, 2010
Recruitment of Stau2 alone or in combination with Upf1 differentially affects the fate of mRNAs.
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