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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Plasminogen activator, urokinase

This gene encodes a serine protease involved in degradation of the extracellular matrix and possibly tumor cell migration and proliferation. A specific polymorphism in this gene may be associated with late-onset Alzheimer's disease and also with decreased affinity for fibrin-binding. This protein converts plasminogen to plasmin by specific cleavage of an Arg-Val bond in plasminogen. Plasmin in turn cleaves this protein at a Lys-Ile bond to form a two-chain derivative in which a single disulfide bond connects the amino-terminal A-chain to the catalytically active, carboxy-terminal B-chain. This two-chain derivative is also called HMW-uPA (high molecular weight uPA). HMW-uPA can be further processed into LMW-uPA (low molecular weight uPA) by cleavage of chain A into a short chain A (A1) and an amino-terminal fragment. LMW-uPA is proteolytically active but does not bind to the uPA receptor. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2009] (from NCBI)
Top mentioned proteins: Plasminogen, PAI-1, CAN, V1a, MMP-9
Papers using uPA antibodies
Surface-associated plasminogen binding of Cryptococcus neoformans promotes extracellular matrix invasion.
Bruggemann Holger, In PLoS ONE, 2008
... Human complement C3b (product # 204860) and uPA (product # 672112) were purchased from Calbiochem, and rabbit anti-human C3c polyclonal antibody (product # A0062) was from Dako.
uPAR induces epithelial–mesenchymal transition in hypoxic breast cancer cells
Gonias Steven L. et al., In The Journal of Cell Biology, 2005
... uPAR-specific antibodies 399R and 3932 and uPA-specific antibody 3471 were obtained from American Diagnostica, Inc ...
Regulation of α5β1 integrin conformation and function by urokinase receptor binding
Chapman Harold A. et al., In The Journal of Cell Biology, 2002
... Active human uPA and uPAR mAbs were purchased from American Diagnostica.
Urokinase type plasminogen activator receptors associate with beta1 and beta3 integrins of fibrosarcoma cells: dependence on extracellular matrix components
Redmond H P et al., In British Journal of Cancer, 1996
... Monoclonal anti-u-PA and anti-u-PAR Abs were obtained from Santa Cruz Biotechnology (Santa Cruz, CA, USA) ...
Prognostic factors for relapse in stage I testicular seminoma treated with surveillance
D'Armiento Massimino et al., In BMC Cancer, 1996
... Monoclonal antibodies against urokinase plasminogen activator B-chain (uPA) and its receptor (uPAR) were purchased from the American Diagnostica Inc ...
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Papers on uPA
1,25-Dihydroxyvitamin D3 alleviates salivary adenoid cystic carcinoma progression by suppressing GPX1 expression through the NF-κB pathway.
Shen et al., Guangzhou, China. In Int J Oncol, Feb 2016
Downregulating GPX1 expression inhibited SACC cell proliferation, chemoresistance, motility, and uPA secretion, but promoted apoptosis via the NF-κB pathway.
A prospective, open-label, multicenter study to assess the pharmacodynamics and safety of repeated use of 30mg ulipristal acetate.
Brache et al., Paris, France. In Contraception, Feb 2016
OBJECTIVE: Ulipristal acetate (UPA) 30mg is safe and effective for emergency contraception (EC).
Identification of pancreatic tumors in vivo with ligand-targeted, pH responsive mesoporous silica nanoparticles by multispectral optoacoustic tomography.
McNally et al., Louisville, United States. In J Control Release, Feb 2016
The tumor specificity of the MSN particle was improved with the addition of both chitosan, targeting acidic pH, and urokinase plasminogen activator (UPA), targeting UPAR.
SALO, a novel classical pathway complement inhibitor from saliva of the sand fly Lutzomyia longipalpis.
Valenzuela et al., Belo Horizonte, Brazil. In Sci Rep, Dec 2015
Both rSALO and SGH inhibited C4b deposition and cleavage of C4. rSALO, however, did not inhibit the protease activity of C1s nor the enzymatic activity of factor Xa, uPA, thrombin, kallikrein, trypsin and plasmin.
Ulipristal acetate for uterine fibroid-related symptoms.
Koskas et al., Paris, France. In Drugs Today (barc), Nov 2015
Ulipristal acetate (UPA) is an orally active synthetic selective progesterone receptor modulator (SPRM) characterized by a tissue-specific progesterone antagonist effect that reduces the proliferation of leiomyoma cells and induces apoptosis.
Pharmacological modulation of fibrinolytic response - In vivo and in vitro studies.
Buczko et al., Białystok, Poland. In Pharmacol Rep, Aug 2015
Fibrinolysis is an action of converting plasminogen by its activators, like tissue- or urokinase-type plasminogen activators (t-PA, u-PA), to plasmin, which in turn cleaves fibrin, thereby causing clot dissolution and restoration of blood flow.
Components of the Plasminogen-Plasmin System as Biologic Markers for Cancer.
Kwaan et al., Chicago, United States. In Adv Exp Med Biol, 2014
In particular, uPA, its receptor (uPAR) and its inhibitor PAI-1 play an important role in cell migration, cell proliferation and tissue remodeling.
Biomarkers in Breast Cancer: Where Are We and Where Are We Going?
Crown et al., Dublin, Ireland. In Adv Clin Chem, 2014
Following a diagnosis of breast cancer, measurement of multi-analyte profiles such as uPA/PAI-1 or Oncotype DX may be used for determining prognosis and identifying lymph node-negative patients who may be spared from having to receive adjuvant chemotherapy.
Endothelial Progenitor Cells in Sprouting Angiogenesis: Proteases Pave the Way.
Chillà et al., Florence, Italy. In Curr Mol Med, 2014
The pivotal protease systems here described, involved in vascular patterning in sprouting angiogenesis, are the matrix-metalloproteinases (MMPs), the serineproteinases urokinase-type plasminogen activator (uPA) associated with its receptor (uPAR) and receptorassociated plasminogen/plasmin, the neutrophil elastase and the cathepsins.
ER stress cooperates with hypernutrition to trigger TNF-dependent spontaneous HCC development.
Karin et al., San Diego, United States. In Cancer Cell, 2014
To determine whether and how ER stress contributes to obesity-driven hepatic tumorigenesis we fed wild-type (WT) and MUP-uPA mice, in which hepatocyte ER stress is induced by plasminogen activator expression, with high-fat diet.
PAI-1 mediates the antiangiogenic and profibrinolytic effects of 16K prolactin.
Struman et al., Liège, Belgium. In Nat Med, 2014
PAI-1 bound the ternary complex PAI-1-urokinase-type plasminogen activator (uPA)-uPA receptor (uPAR), thereby exerting antiangiogenic effects.
Lycopene inhibits angiogenesis both in vitro and in vivo by inhibiting MMP-2/uPA system through VEGFR2-mediated PI3K-Akt and ERK/p38 signaling pathways.
Hu et al., T'ai-chung-shih, Taiwan. In Mol Nutr Food Res, 2012
Data suggest that lycopene, a dietary component, inhibits angiogenesis; lycopene appears to down-regulate signal transduction by inhibition of uPA and MMP2 (matrix metallopeptidase 2) via vascular endothelial growth factor receptor 2 signaling.
Over-expression of uPA increases risk of liver injury in pAAV-HBV transfected mice.
Zhou et al., Beijing, China. In World J Gastroenterol, 2012
Over-expression of uPA plays a synergistic role in the development of liver injury, inflammation and regeneration during acute HBV infection
Gene expression profiles in genetically different mice infected with Toxoplasma gondii: ALDH1A2, BEX2, EGR2, CCL3 and PLAU.
Song et al., Taejŏn, South Korea. In Korean J Parasitol, 2012
Expression of ALDH1A2, BEX2, EGR2, CCL3 and PLAU are upregulated in Toxoplasma gondiisusceptible C57BL/6 mice.
Expression of urokinase-type plasminogen activator (uPA), its receptor (uPAR), and inhibitor (PAI-1) in human breast carcinomas and their clinical relevance.
Wittliff et al., Louisville, United States. In J Clin Lab Anal, 2012
uPA, uPAR, and PAI-1 were quantified by enzyme-linked immunosorbent assay (ELISA) in extracts of 226 breast tumor biopsies.
Degradation of internalized αvβ5 integrin is controlled by uPAR bound uPA: effect on β1 integrin activity and α-SMA stress fiber assembly.
Bernstein et al., New York City, United States. In Plos One, 2011
The downregulation of uPA/uPAR results in increased integrin alphavbeta5 cell-surface protein levels that regulate the activity of beta1 integrins, promoting characteristics of the persistent Myofibroblasts.
Regulation of cell signalling by uPAR.
Marshall et al., Montréal, Canada. In Nat Rev Mol Cell Biol, 2010
uPAR regulates proteolysis by binding the extracellular protease urokinase-type plasminogen activator (uPA; also known as urokinase) and also activates many intracellular signalling pathways.
Structural basis for EGFR ligand sequestration by Argos.
Lemmon et al., Philadelphia, United States. In Nature, 2008
The three-domain clamp of Argos also resembles the urokinase-type plasminogen activator (uPA) receptor, which uses a similar mechanism to engulf the EGF-like module of uPA.
Prevention of hepatitis B virus infection in vivo by entry inhibitors derived from the large envelope protein.
Urban et al., Hamburg, Germany. In Nat Biotechnol, 2008
Expanding on our demonstration that acylated peptides derived from the large HBV envelope protein block virus entry in vitro, we show their applicability to prevent HBV or woolly monkey hepatitis B virus infection in vivo, using immunodeficient urokinase-type plasminogen activator (uPA) mice repopulated with primary human or Tupaia belangeri hepatocytes.
More papers using uPA antibodies
Requirement of receptor-bound urokinase-type plasminogen activator for integrin αvβ5-directed cell migration
Gonias Steven L. et al., In The Journal of Cell Biology, 1995
... the enzymatic activity of tcuPA was abolished, as determined by the hydrolysis rate of the uPA-specific chromogenic substrate, l-pyroglutamyl-glycyl-arginine-p-nitroanilide HCl (Bachem).
Focal adhesion kinase (p125Fak): a point of convergence in the action of neuropeptides, integrins and oncogenes
Stoppelli M. Patrizia et al., In The Journal of Cell Biology, 1991
... for plasmin (H-D-Nle-HHT-Lys-pNA.2AcOH), uPA Elisa kit, #399 anti-uPAR polyclonal antibody, and the amino-terminal fragment of uPA (aa 1-135) were from American Diagnostica (Greenwich, CT) ...
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