Ulipristal acetate for uterine fibroid-related symptoms.
Paris, France. In Drugs Today (barc), Nov 2015
Ulipristal acetate (UPA) is an orally active synthetic selective progesterone receptor modulator (SPRM) characterized by a tissue-specific progesterone antagonist effect that reduces the proliferation of leiomyoma cells and induces apoptosis.
Biomarkers in Breast Cancer: Where Are We and Where Are We Going?
Dublin, Ireland. In Adv Clin Chem, 2014
Following a diagnosis of breast cancer, measurement of multi-analyte profiles such as uPA/PAI-1 or Oncotype DX may be used for determining prognosis and identifying lymph node-negative patients who may be spared from having to receive adjuvant chemotherapy.
Endothelial Progenitor Cells in Sprouting Angiogenesis: Proteases Pave the Way.
Florence, Italy. In Curr Mol Med, 2014
The pivotal protease systems here described, involved in vascular patterning in sprouting angiogenesis, are the matrix-metalloproteinases (MMPs), the serineproteinases urokinase-type plasminogen activator (uPA) associated with its receptor (uPAR) and receptorassociated plasminogen/plasmin, the neutrophil elastase and the cathepsins.
Regulation of cell signalling by uPAR.
More papers using
Montréal, Canada. In Nat Rev Mol Cell Biol, 2010
uPAR regulates proteolysis by binding the extracellular protease urokinase-type plasminogen activator (uPA; also known as urokinase) and also activates many intracellular signalling pathways.