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Ubiquitin specific peptidase 4

Unp, USP4, Unph
The protein encoded by this gene is a protease that deubiquitinates target proteins such as ADORA2A and TRIM21. The encoded protein shuttles between the nucleus and cytoplasm and is involved in maintaining operational fidelity in the endoplasmic reticulum. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011] (from NCBI)
Top mentioned proteins: Ubiquitin, CAN, USP15, ACID, HAUSP
Papers on Unp
Ubiquitin-Specific Protease 4-Mediated Deubiquitination and Stabilization of PRL-3 Is Required for Potentiating Colorectal Oncogenesis.
Li et al., Guangzhou, China. In Cancer Res, Feb 2016
Ubiquitin specific protease 4 (USP4) is a deubiquitinating enzyme with key roles in the regulation of p53 and TGFβ signaling, suggesting its importance in tumorigenesis.
Fear Potentiated Startle Increases Phospholipase D (PLD) Expression/Activity and PLD-Linked Metabotropic Glutamate Receptor Mediated Post-Tetanic Potentiation in Rat Amygdala.
Shinnick-Gallagher et al., Galveston, United States. In Neurobiol Learn Mem, Jan 2016
In the unpaired group (UNP), blocking the PLD-mGluR increased while activating the receptor decreased transmitter release probability, consistent with decreased synaptic potentials during tetanic stimulation.
An in vitro-in vivo correlation study for nifedipine immediate release capsules administered with water, alcoholic and non-alcoholic beverages: Impact of in vitro dissolution media and hydrodynamics.
Fotaki et al., Graz, Austria. In Int J Pharm, Jan 2016
UNASSIGNED: The impact of hydrodynamics and media composition on nifedipine dissolution profile from IR (immediate release) soft capsules was investigated using dissolution apparatus USP1, USP2, USP3 and USP4 (United State Pharmacopoeia).
USP4 Auto-Deubiquitylation Promotes Homologous Recombination.
Jackson et al., Cambridge, United Kingdom. In Mol Cell, Dec 2015
Here, we establish that the deubiquitylating enzyme USP4 promotes DNA-end resection and DNA repair by homologous recombination.
The Deubiquitylating Enzyme USP4 Cooperates with CtIP in DNA Double-Strand Break End Resection.
Pei et al., Beijing, China. In Cell Rep, Nov 2015
Here, we find that the deubiquitylating enzyme USP4 directly participates in DSB resection and homologous recombination (HR).
USP4 inhibits p53 and NF-κB through deubiquitinating and stabilizing HDAC2.
Chen et al., Xiamen, China. In Oncogene, Oct 2015
In this study, we show that ubiquitin-specific peptidase 4 (USP4) interacts directly with and deubiquitinates HDAC2, leading to the stabilization of HDAC2.
The Relationship Between the Evolution of an Internal Structure and Drug Dissolution from Controlled-Release Matrix Tablets.
Dorożyński et al., Kraków, Poland. In Aaps Pharmscitech, Oct 2015
Commercial, hydroxypropylmethyl cellulose-based quetiapine fumarate controlled-release matrix tablets were studied using the following two methods: (i) MRI inside the USP4 apparatus with subsequent machine learning-based image segmentation and (ii) dissolution testing with piecewise dissolution modeling.
[Research progress on ubiquitin-specific protease in antiviral immunity].
Wei-Lin et al., Hangzhou, China. In Zhejiang Da Xue Xue Bao Yi Xue Ban, Jun 2015
USP2b, USP3, USP18, USP25, UL36USP and HAUSP play a role of antivirus; while USP4, USP13, USP15 and USP17 negatively regulate antiviral immune response.
Evolution of the highly networked deubiquitinating enzymes USP4, USP15, and USP11.
Gray et al., Ottawa, Canada. In Bmc Evol Biol, 2014
BACKGROUND: USP4, USP15 and USP11 are paralogous deubiquitinating enzymes as evidenced by structural organization and sequence similarity.
Ubiquitin removal in the TGF-β pathway.
Massagué et al., New York City, United States. In Nat Cell Biol, 2012
Both ubiquitin-specific peptidase-4 (USP4) and -15 (USP15) extend the life of activated receptors against the negative pressure of receptor-ubiquitinating complexes, but through distinct modes of action.
USP4 is regulated by AKT phosphorylation and directly deubiquitylates TGF-β type I receptor.
ten Dijke et al., Leiden, Netherlands. In Nat Cell Biol, 2012
Results uncover USP4 as an important determinant for crosstalk between TGF-beta/TGF-beta type I receptor and AKT signalling pathways.
The role of UBL domains in ubiquitin-specific proteases.
Sixma et al., Amsterdam, Netherlands. In Biochem Soc Trans, 2012
In contrast, a UBL domain in USP4 binds to the catalytic domain and competes with ubiquitin binding.
Ubiquitin-specific protease 4 mitigates Toll-like/interleukin-1 receptor signaling and regulates innate immune activation.
Zhang et al., Chongqing, China. In J Biol Chem, 2012
USP4 plays an essential role in negative regulation of the TLR/IL-1R signaling-mediated innate immune response
Ubiquitin-specific protease 4 (USP4) targets TRAF2 and TRAF6 for deubiquitination and inhibits TNFα-induced cancer cell migration.
Wang et al., Shanghai, China. In Biochem J, 2012
USP4 deubiquitinates both TRAF2 and TRAF6 in vivo and in vitro in a deubiquitinase activity-dependent manner and inhibits TNFalpha-induced cancer cell migration.
Ubiquitin-specific protease 4 inhibits mono-ubiquitination of the master growth factor signaling kinase PDK1.
Nijman et al., Vienna, Austria. In Plos One, 2011
identify the Ubiquitin-Specific Protease 4 (USP4) as an enzyme that removes ubiquitin from PDK1 in vivo and in vitro and co-localizes with PDK1 at the plasma membrane when the two proteins are overexpressed, indicating direct deubiquitination
From cradle to twilight: the carboxyl terminus directs the fate of the A(2A)-adenosine receptor.
Freissmuth et al., Vienna, Austria. In Biochim Biophys Acta, 2011
The list includes the deubiquinating enzyme USP4, α-actinin, the guanine nucleotide exchange factor for ARF6 ARNO, translin-X-associated protein, calmodulin, the neuronal calcium binding protein NECAB2 and the synapse associated protein SAP102.
Genetic evidence supporting the association of protease and protease inhibitor genes with inflammatory bowel disease: a systematic review.
Lottaz et al., Leuven, Belgium. In Plos One, 2010
Studies indicate that the cylindromatosis/turban tumor syndrome gene (CYLD) ranked highest, followed by acylaminoacyl-peptidase (APEH), dystroglycan (DAG1), macrophage-stimulating protein (MST1) and ubiquitin-specific peptidase 4 (USP4).
The A(2A)-adenosine receptor: a GPCR with unique features?
Freissmuth et al., Vienna, Austria. In Br J Pharmacol, 2008
Established interaction partners include alpha-actinin, ARNO, USP4 and translin-associated protein-X.
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