Guanosine and its modified derivatives are endogenous ligands for TLR7.
Kawaguchi, Japan. In Int Immunol, Nov 2015
To address a role of G analogs in the disease state, we also examined macrophages from Unc93b1 (D34A/D34A) mice, which suffer from TLR7-dependent systemic inflammation, and found that Unc93b1 (D34A/D34A) macrophages showed significantly enhanced response to G alone or 8-OHdG with ORN.
[Multilevel maturation of Toll-like receptor 9].
Panama. In Postepy Hig Med Dosw (online), 2012
TLR9 delivery to the endosomes is mediated by two distinct proteins, UNC93B1 and AP-2, and post-early endosome distribution is determined by AP-3.
Dissecting immunity by germline mutagenesis.
London, United Kingdom. In Immunology, 2012
Mutations in previously uncharacterized genes in the mouse, like Unc93B or Themis, have demonstrated the impartiality of forward genetics and led to the identification of new crucial immunity actors.