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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Unc-5 homolog D

UNC5D, UNC5H4
Top mentioned proteins: netrin-1, UNC5B, UNC5H1, UNC5C, DCC
Papers on UNC5D
FLRT structure: balancing repulsion and cell adhesion in cortical and vascular development.
Klein et al., Martinsried, Germany. In Neuron, 2014
Mechanistically, radial migration is controlled by repulsive FLRT2-Unc5D interactions, while spatial organization in the tangential axis involves adhesive FLRT-FLRT interactions.
Down-regulation of UNC5D in bladder cancer: UNC5D as a possible mediator of cisplatin induced apoptosis in bladder cancer cells.
Bi et al., Shenyang, China. In J Urol, 2014
Therefore, we investigated whether the novel identified dependence receptor UNC5D acts as a tumor suppressor in bladder malignancies.
Maternal obesity and IL-6 lead to aberrant developmental gene expression and deregulated neurite growth in the fetal arcuate nucleus.
Jasoni et al., Dunedin, New Zealand. In Endocrinology, 2014
In addition, the expression of Dcc and Unc5d, receptors for Netrin-1, were altered in the GD17.5 ARC in obese but not normal weight pregnancies.
Overexpression of the dependence receptor UNC5H4 inhibits cell migration and invasion, and triggers apoptosis in neuroblastoma cell.
Hao et al., Shenyang, China. In Tumour Biol, 2014
UNC5H4 is a newly identified member of the UNC5H receptor family.
Unc5D regulates p53-dependent apoptosis in neuroblastoma cells.
Hao et al., Shenyang, China. In Mol Med Report, 2014
In the present study, a novel p53 target gene, Unc5D, was identified and its possible function in human neuroblastoma cells was investigated.
Detection of chromosomal breakpoints in patients with developmental delay and speech disorders.
Cacheux et al., Singapore, Singapore. In Plos One, 2013
Refinement of these regions by Sanger sequencing resulted in the identification of five disrupted genes in three individuals: guanine nucleotide binding protein, q polypeptide (GNAQ), RNA-binding protein, fox-1 homolog (RBFOX3), unc-5 homolog D (C.elegans) (UNC5D), transmembrane protein 47 (TMEM47), and X-linked inhibitor of apoptosis (XIAP).
Expression of netrin-1 receptors in retina of oxygen-induced retinopathy in mice.
Xia et al., Changsha, China. In Bmc Ophthalmol, 2013
RESULTS: RT-PCR results showed that, except for UNC5A, netrin-1 receptor subtypes UNC5B, UNC5C, UNC5D, DCC, neogenin, and A2b were all expressed in the retinas of OIR mice 17 days after birth.
Prdm8 regulates the morphological transition at multipolar phase during neocortical development.
Mizutani et al., Kyoto, Japan. In Plos One, 2013
Prdm8 expression was almost coincident with Unc5D expression, a marker for the late multipolar phase, although the expression of Unc5D was found to be gradually down-regulated to the point at which mVenus expression was gradually up-regulated.
UNC5H4-induced apoptosis in non-small cell lung cancer is not dependent on p53 status only.
Zhu et al., Shenyang, China. In Oncol Lett, 2013
The aim of the present study was to investigate the expression profile and prognostic significance of uncoordinated 5 homolog 4 (UNC5H4) in patients with lung cancer and to evaluate whether UNC5H4 expression may serve as an index for radiosensitivity.
Dependence receptor UNC5D mediates nerve growth factor depletion-induced neuroblastoma regression.
Nakagawara et al., Chiba, Japan. In J Clin Invest, 2013
Here, we show that UNC5D, a dependence receptor that is directly targeted by p53 family members, is highly expressed in favorable NBs.
The tumor-suppressive function of UNC5D and its repressed expression in renal cell carcinoma.
Zhang et al., Beijing, China. In Clin Cancer Res, 2013
PURPOSE: As a newly added member of the UNC5H receptors, the function of UNC5D/H4 in tumorigenesis remains poorly defined.
Dynamic FoxG1 expression coordinates the integration of multipolar pyramidal neuron precursors into the cortical plate.
Fishell et al., New York City, United States. In Neuron, 2012
By utilizing conditional genetic strategies, we show that the downregulation of FoxG1 at the beginning of the multipolar cell phase induces Unc5D expression, the timing of which ultimately determines the laminar identity of pyramidal neurons.
Netrin-1 simultaneously suppresses corneal inflammation and neovascularization.
Liu et al., Xiamen, China. In Invest Ophthalmol Vis Sci, 2012
METHODS: The expression of netrin-1 and its receptors UNC5A, UNC5B, UNC5C, UNC5D, adenosine 2b receptor (A2BAR), deleted in colorectal cancer (DCC), and neogenin in normal and alkali-burned rat cornea were determined by RT-PCR and/or Western blot analysis, or immunostaining.
Genome-wide association and fine mapping of genetic loci predisposing to colon carcinogenesis in mice.
You et al., Milwaukee, United States. In Mol Cancer Res, 2012
Major candidates in these loci are Sema5a, Fmn2, Grem2, Fap, Gsg1l, Xpo6, Rabep2, Eif3c, Unc5d, and Gpr65.
Laminar and areal expression of unc5d and its role in cortical cell survival.
GeneRIF
Yamamoto et al., Suita, Japan. In Cereb Cortex, 2011
Unc5d is primarily expressed by layer 4 cells in the primary sensory areas of the developing neocortex and may mediate the effect of netrin-4 on cortical cell survival in a lamina-specific manner.
The cortical subventricular zone-specific molecule Svet1 is part of the nuclear RNA coded by the putative netrin receptor gene Unc5d and is expressed in multipolar migrating cells.
GeneRIF
Nakajima et al., Tokyo, Japan. In Mol Cell Neurosci, 2008
UNC5D protein and nuclear RNA is localized in the multipolar cells of the subventricular zone throughout cortical development.
A newly identified dependence receptor UNC5H4 is induced during DNA damage-mediated apoptosis and transcriptional target of tumor suppressor p53.
GeneRIF
Nakagawara et al., Chiba, Japan. In Biochem Biophys Res Commun, 2008
UNC5H4 amplifies p53-dependent apoptotic response.
Netrin-1 mediates neuronal survival through PIKE-L interaction with the dependence receptor UNC5B.
Impact
Ye et al., Atlanta, United States. In Nat Cell Biol, 2008
Both UNC5 (that is, UNC5A, UNC5B, UNC5C or UNC5D) and DCC are transmembrane receptors for netrin-1 (Refs 8, 9).
Cloning of three mouse Unc5 genes and their expression patterns at mid-gestation.
GeneRIF
Engelkamp, Frankfurt am Main, Germany. In Mech Dev, 2002
Unc5h4 was cloned; its expression is in the developing limb and mammary gland in developing mouse
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