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Unc-5 homolog C

UNC5C, UNC5H3
This gene product belongs to the UNC-5 family of netrin receptors. Netrins are secreted proteins that direct axon extension and cell migration during neural development. They are bifunctional proteins that act as attractants for some cell types and as repellents for others, and these opposite actions are thought to be mediated by two classes of receptors. The UNC-5 family of receptors mediate the repellent response to netrin; they are transmembrane proteins containing 2 immunoglobulin (Ig)-like domains and 2 type I thrombospondin motifs in the extracellular region. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: netrin-1, DCC, UNC5B, UNC5H1, CAN
Papers on UNC5C
Alzheimer's disease: rare variants with large effect sizes.
New
Cruchaga et al., Saint Louis, United States. In Curr Opin Genet Dev, 22 Sep 2015
UNASSIGNED: Recent advances in sequencing technology and novel genotyping arrays (focused on low-frequency and coding variants) have made it possible to identify novel coding variants with large effect sizes and also novel genes (TREM2, PLD3, UNC5C, and AKAP9) associated with Alzheimer's disease (AD) risk.
Resilience to amphetamine in mouse models of netrin-1 haploinsufficiency: role of mesocortical dopamine.
New
Flores et al., Montréal, Canada. In Psychopharmacology (berl), 12 Sep 2015
Second, we investigated whether unc5c, another netrin-1 receptor expressed by dopamine neurons, is involved in these effects.
R47H Variant of TREM2 Associated With Alzheimer Disease in a Large Late-Onset Family: Clinical, Genetic, and Neuropathological Study.
New
Bird et al., Seattle, United States. In Jama Neurol, 01 Sep 2015
We also found a rare missense variant, D353N, in a nominated AD risk gene, unc-5 homolog C (UNC5C), in 5 affected individuals in the LOAD123 family.
Expression and significance of netrin-1 and its receptor UNC5C in precocious puberty female rat hypothalamus.
New
Shang et al., Tangshan, China. In Asian Pac J Trop Med, Mar 2015
OBJECTIVE: To study expressions of netrin-1 and its receptor UNC5C in female precocious puberty rat hypothalamus, and explore its effect on precocious puberty process.
Whole-exome sequencing of muscle-invasive bladder cancer identifies recurrent mutations of UNC5C and prognostic importance of DNA repair gene mutations on survival.
New
Nakamura et al., Morioka, Japan. In Clin Cancer Res, Jan 2015
RESULTS: We identified recurrent novel somatic mutations in the gene UNC5C (9.9%), in addition to TP53 (40.7%),
An ancient autoproteolytic domain found in GAIN, ZU5 and Nucleoporin98.
New
Grishin et al., Dallas, United States. In J Mol Biol, Jan 2015
The autoproteolytic site was kept intact in Nup98, p53-induced protein with a death domain and UNC5C-like, deteriorated in many ZU5 domains and changed in GAIN and FIIND.
Genetic and epigenetic alterations of netrin-1 receptors in gastric cancer with chromosomal instability.
New
Fujiwara et al., Okayama, Japan. In Clin Epigenetics, Dec 2014
BACKGROUND: The gene expressions of netrin-1 dependence receptors, DCC and UNC5C, are frequently downregulated in many cancers.
Molecular Effects of Polymorphism in the 3'UTR of Unc-5 homolog C Associated with Conception Rate in Holsteins.
New
Sugimoto et al., Fukushima, Japan. In Plos One, Dec 2014
To enhance our understanding of the genes involved in conception rates, we conducted a genome-wide association study (GWAS) using 822 Holsteins and identified a single-nucleotide polymorphism (SNP) associated with conception rate: A+169G in the 3' untranslated region (UTR) of unc-5 homolog C (UNC5C).
A rare mutation in UNC5C predisposes to late-onset Alzheimer's disease and increases neuronal cell death.
New
Impact
Graham et al., San Francisco, United States. In Nat Med, Dec 2014
We have identified a rare coding mutation, T835M (rs137875858), in the UNC5C netrin receptor gene that segregated with disease in an autosomal dominant pattern in two families enriched for late-onset Alzheimer's disease and that was associated with disease across four large case-control cohorts (odds ratio = 2.15, Pmeta = 0.0095).
Investigation of TREM2, PLD3, and UNC5C variants in patients with Alzheimer's disease from mainland China.
New
Shen et al., Changsha, China. In Neurobiol Aging, Oct 2014
Recently, 3 rare coding variants significantly associated with Alzheimer's disease (AD) risk have been identified in western populations using whole exome sequencing method, including p.R47H in TREM2, p.V232M in PLD3, and p.T835M in UNC5C.
Unc5C and DCC act downstream of Ctip2 and Satb2 and contribute to corpus callosum formation.
Tarabykin et al., Berlin, Germany. In Nat Commun, 2013
We show that the expression of two Netrin1 receptors- DCC and Unc5C is under direct negative regulation by Satb2 and Ctip2, respectively.
An iteration normalization and test method for differential expression analysis of RNA-seq data.
Zhang et al., Urbana, United States. In Biodata Min, 2013
What's more, we discovered that gene UNC5C is highly associated with kidney cancer and so on.
Expression of netrin-1 receptors in retina of oxygen-induced retinopathy in mice.
Xia et al., Changsha, China. In Bmc Ophthalmol, 2013
RESULTS: RT-PCR results showed that, except for UNC5A, netrin-1 receptor subtypes UNC5B, UNC5C, UNC5D, DCC, neogenin, and A2b were all expressed in the retinas of OIR mice 17 days after birth.
Down syndrome cell adhesion molecule (DSCAM) associates with uncoordinated-5C (UNC5C) in netrin-1-mediated growth cone collapse.
GeneRIF
Liu et al., Toledo, United States. In J Biol Chem, 2012
knockdown of DSCAM inhibits netrin-induced tyrosine phosphorylation of UNC5C and Fyn as well as the interaction of UNC5C with Fyn. The double knockdown of both receptors abolishes the induction of Fyn tyrosine phosphorylation by netrin-1
Variants in the netrin-1 receptor UNC5C prevent apoptosis and increase risk of familial colorectal cancer.
GeneRIF
Mehlen et al., Lyon, France. In Gastroenterology, 2011
Inherited mutations in UNC5C prevent apoptosis and increase risk of colorectal cancer.
Genetic and epigenetic control of UNC5C expression in human renal cell carcinoma.
GeneRIF
Zhang et al., Beijing, China. In Eur J Cancer, 2011
UNC5C acts as a tumour suppressor in RCC and is down-regulated in RCC. Loss of heterozygosity and DNA methylation contribute to the inactivation of UNC5C in renal cell carcinoma.
Changes in UNC5C gene methylation during human gastric carcinogenesis.
GeneRIF
Sanada et al., Yokohama, Japan. In Anticancer Res, 2009
UNC5C methylation was observed in the course of gastric carcinogenesis and disappeared in highly advanced gastric carcinomas.
Role of the netrin system of repellent factors on synovial fibroblasts in rheumatoid arthritis and osteoarthritis.
GeneRIF
Bosserhoff et al., Regensburg, Germany. In Int J Immunopathol Pharmacol, 2009
Stronger expression of UNC5B and UNC5C receptors in synovial fibroblasts might contribute to the disordered phenotype of rheumatoid arthritis and osteoarthritis.
Epigenetic regulation and downstream targets of the Rhox5 homeobox gene.
Review
Wilkinson et al., Houston, United States. In Int J Androl, 2008
One of them is the tumour suppressor UNC5C, a pro-apoptotic molecule previously only known to be involved in brain development.
Netrin-1 mediates neuronal survival through PIKE-L interaction with the dependence receptor UNC5B.
Impact
Ye et al., Atlanta, United States. In Nat Cell Biol, 2008
Both UNC5 (that is, UNC5A, UNC5B, UNC5C or UNC5D) and DCC are transmembrane receptors for netrin-1 (Refs 8, 9).
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