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Unc-5 homolog C

This gene product belongs to the UNC-5 family of netrin receptors. Netrins are secreted proteins that direct axon extension and cell migration during neural development. They are bifunctional proteins that act as attractants for some cell types and as repellents for others, and these opposite actions are thought to be mediated by two classes of receptors. The UNC-5 family of receptors mediate the repellent response to netrin; they are transmembrane proteins containing 2 immunoglobulin (Ig)-like domains and 2 type I thrombospondin motifs in the extracellular region. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: netrin-1, DCC, UNC5B, UNC5H1, CAN
Papers on UNC5C
Whole-exome sequencing of muscle-invasive bladder cancer identifies recurrent mutations of UNC5C and prognostic importance of DNA repair gene mutations on survival.
Nakamura et al., Morioka, Japan. In Clin Cancer Res, 15 Jan 2015
RESULTS: We identified recurrent novel somatic mutations in the gene UNC5C (9.9%), in addition to TP53 (40.7%),
An ancient autoproteolytic domain found in GAIN, ZU5 and Nucleoporin98.
Grishin et al., Dallas, United States. In J Mol Biol, 12 Jan 2015
The autoproteolytic site was kept intact in Nup98, p53-induced protein with a death domain and UNC5C-like, deteriorated in many ZU5 domains and changed in GAIN and FIIND.
A rare mutation in UNC5C predisposes to late-onset Alzheimer's disease and increases neuronal cell death.
Graham et al., San Francisco, United States. In Nat Med, Dec 2014
We have identified a rare coding mutation, T835M (rs137875858), in the UNC5C netrin receptor gene that segregated with disease in an autosomal dominant pattern in two families enriched for late-onset Alzheimer's disease and that was associated with disease across four large case-control cohorts (odds ratio = 2.15, Pmeta = 0.0095).
Investigation of TREM2, PLD3, and UNC5C variants in patients with Alzheimer's disease from mainland China.
Shen et al., Changsha, China. In Neurobiol Aging, Oct 2014
Recently, 3 rare coding variants significantly associated with Alzheimer's disease (AD) risk have been identified in western populations using whole exome sequencing method, including p.R47H in TREM2, p.V232M in PLD3, and p.T835M in UNC5C.
Target-dependent expression of the netrin-1 receptor, UNC5C, in projection neurons of the ventral tegmental area.
Flores et al., Montréal, Canada. In Neuroscience, Mar 2014
We have shown previously that the netrin-1 receptor, unc-5 homologue C (UNC5C), is expressed by ventral tegmental area (VTA) dopamine (DA) neurons of rodents, but only from adolescence onwards (Manitt et al., 2010; Auger et al., 2013).
Netrin 1 and Dcc signalling are required for confinement of central axons within the central nervous system.
Wilson et al., Umeå, Sweden. In Development, Feb 2014
We provide evidence that netrin 1 signalling preserves CNS/PNS axonal integrity in three ways: (1) netrin 1/Dcc ventral attraction diverts axons away from potential exit points; (2) a Dcc/Unc5c-dependent netrin 1 chemoinhibitory barrier in the dorsolateral spinal cord prevents interneurons from being close to the dorsal CNS/PNS transition zone; and (3) a netrin 1/Dcc-dependent, Unc5c-independent mechanism that actively prevents exit from the CNS.
Evaluation of the colorectal cancer risk conferred by rare UNC5C alleles.
Bezieau et al., Nantes, France. In World J Gastroenterol, Feb 2014
AIM: To evaluate the risk associated with variants of the UNC5C gene recently suspected to predispose to familial colorectal cancer (CRC).
Expression of unc5 family genes in zebrafish brain during embryonic development.
Gao et al., Shanghai, China. In Gene Expr Patterns, 2013
Here we have determined the temporal and spatial expression patterns of unc5 gene family members (unc5a, unc5b, unc5c, unc5da and unc5db) by RT-PCR and in situ hybridization.
An iteration normalization and test method for differential expression analysis of RNA-seq data.
Zhang et al., Urbana, United States. In Biodata Min, 2013
What's more, we discovered that gene UNC5C is highly associated with kidney cancer and so on.
Expression of netrin-1 receptors in retina of oxygen-induced retinopathy in mice.
Xia et al., Changsha, China. In Bmc Ophthalmol, 2013
RESULTS: RT-PCR results showed that, except for UNC5A, netrin-1 receptor subtypes UNC5B, UNC5C, UNC5D, DCC, neogenin, and A2b were all expressed in the retinas of OIR mice 17 days after birth.
Over-expression of either MECP2_e1 or MECP2_e2 in neuronally differentiated cells results in different patterns of gene expression.
Vincent et al., Toronto, Canada. In Plos One, 2013
Down-regulation of expression in the presence of MECP2_e1 was seen with UNC5C and RPH3A.
Unc5C and DCC act downstream of Ctip2 and Satb2 and contribute to corpus callosum formation.
Tarabykin et al., Berlin, Germany. In Nat Commun, 2013
We show that the expression of two Netrin1 receptors- DCC and Unc5C is under direct negative regulation by Satb2 and Ctip2, respectively.
Exome sequencing identifies early gastric carcinoma as an early stage of advanced gastric cancer.
Kim et al., Seoul, South Korea. In Plos One, 2012
The DYRK3, GPR116, MCM10, PCDH17, PCDHB1, RDH5 and UNC5C genes are recurrently mutated in EGCs and may be involved in early carcinogenesis.
Down syndrome cell adhesion molecule (DSCAM) associates with uncoordinated-5C (UNC5C) in netrin-1-mediated growth cone collapse.
Liu et al., Toledo, United States. In J Biol Chem, 2012
knockdown of DSCAM inhibits netrin-induced tyrosine phosphorylation of UNC5C and Fyn as well as the interaction of UNC5C with Fyn. The double knockdown of both receptors abolishes the induction of Fyn tyrosine phosphorylation by netrin-1
Variants in the netrin-1 receptor UNC5C prevent apoptosis and increase risk of familial colorectal cancer.
Mehlen et al., Lyon, France. In Gastroenterology, 2011
Inherited mutations in UNC5C prevent apoptosis and increase risk of colorectal cancer.
Genetic and epigenetic control of UNC5C expression in human renal cell carcinoma.
Zhang et al., Beijing, China. In Eur J Cancer, 2011
UNC5C acts as a tumour suppressor in RCC and is down-regulated in RCC. Loss of heterozygosity and DNA methylation contribute to the inactivation of UNC5C in renal cell carcinoma.
Changes in UNC5C gene methylation during human gastric carcinogenesis.
Sanada et al., Yokohama, Japan. In Anticancer Res, 2009
UNC5C methylation was observed in the course of gastric carcinogenesis and disappeared in highly advanced gastric carcinomas.
Role of the netrin system of repellent factors on synovial fibroblasts in rheumatoid arthritis and osteoarthritis.
Bosserhoff et al., Regensburg, Germany. In Int J Immunopathol Pharmacol, 2009
Stronger expression of UNC5B and UNC5C receptors in synovial fibroblasts might contribute to the disordered phenotype of rheumatoid arthritis and osteoarthritis.
Epigenetic regulation and downstream targets of the Rhox5 homeobox gene.
Wilkinson et al., Houston, United States. In Int J Androl, 2008
One of them is the tumour suppressor UNC5C, a pro-apoptotic molecule previously only known to be involved in brain development.
Netrin-1 mediates neuronal survival through PIKE-L interaction with the dependence receptor UNC5B.
Ye et al., Atlanta, United States. In Nat Cell Biol, 2008
Both UNC5 (that is, UNC5A, UNC5B, UNC5C or UNC5D) and DCC are transmembrane receptors for netrin-1 (Refs 8, 9).
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