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Unc-5 homolog C

UNC5C, UNC5H3
This gene product belongs to the UNC-5 family of netrin receptors. Netrins are secreted proteins that direct axon extension and cell migration during neural development. They are bifunctional proteins that act as attractants for some cell types and as repellents for others, and these opposite actions are thought to be mediated by two classes of receptors. The UNC-5 family of receptors mediate the repellent response to netrin; they are transmembrane proteins containing 2 immunoglobulin (Ig)-like domains and 2 type I thrombospondin motifs in the extracellular region. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: netrin-1, DCC, UNC5B, UNC5H1, CAN
Papers on UNC5C
The Impact of UNC5C Genetic Variations on Neuroimaging in Alzheimer's Disease.
New
Alzheimer’s Disease Neuroimaging Initiative et al., Qingdao, China. In Mol Neurobiol, Jan 2016
UNASSIGNED: UNC5C, which is a transmembrane receptor for netrin-1 to trigger the apoptosis, has been confirmed as a new risk factor for Alzheimer's disease (AD) recently.
Synergistic integration of Netrin and ephrin axon guidance signals by spinal motor neurons.
New
Kania et al., New York City, United States. In Elife, Jan 2016
Our investigations of the mechanism of ephrin-B2 and Netrin-1 integration demonstrate that the Netrin receptor Unc5c and the ephrin receptor EphB2 can form a complex in a ligand-dependent manner and that Netrin-ephrin synergistic growth cones responses involve the potentiation of Src family kinase signaling, a common effector of both pathways.
Resilience to amphetamine in mouse models of netrin-1 haploinsufficiency: role of mesocortical dopamine.
New
Flores et al., Montréal, Canada. In Psychopharmacology (berl), Oct 2015
Second, we investigated whether unc5c, another netrin-1 receptor expressed by dopamine neurons, is involved in these effects.
Alzheimer's disease: rare variants with large effect sizes.
Review
New
Cruchaga et al., Saint Louis, United States. In Curr Opin Genet Dev, Aug 2015
Recent advances in sequencing technology and novel genotyping arrays (focused on low-frequency and coding variants) have made it possible to identify novel coding variants with large effect sizes and also novel genes (TREM2, PLD3, UNC5C, and AKAP9) associated with Alzheimer's disease (AD) risk.
R47H Variant of TREM2 Associated With Alzheimer Disease in a Large Late-Onset Family: Clinical, Genetic, and Neuropathological Study.
New
Bird et al., Seattle, United States. In Jama Neurol, Aug 2015
We also found a rare missense variant, D353N, in a nominated AD risk gene, unc-5 homolog C (UNC5C), in 5 affected individuals in the LOAD123 family.
Expression and significance of netrin-1 and its receptor UNC5C in precocious puberty female rat hypothalamus.
New
Shang et al., Tangshan, China. In Asian Pac J Trop Med, Mar 2015
OBJECTIVE: To study expressions of netrin-1 and its receptor UNC5C in female precocious puberty rat hypothalamus, and explore its effect on precocious puberty process.
Whole-exome sequencing of muscle-invasive bladder cancer identifies recurrent mutations of UNC5C and prognostic importance of DNA repair gene mutations on survival.
Nakamura et al., Morioka, Japan. In Clin Cancer Res, 2015
RESULTS: We identified recurrent novel somatic mutations in the gene UNC5C (9.9%), in addition to TP53 (40.7%),
An ancient autoproteolytic domain found in GAIN, ZU5 and Nucleoporin98.
Grishin et al., Dallas, United States. In J Mol Biol, 2015
The autoproteolytic site was kept intact in Nup98, p53-induced protein with a death domain and UNC5C-like, deteriorated in many ZU5 domains and changed in GAIN and FIIND.
An extracellular biochemical screen reveals that FLRTs and Unc5s mediate neuronal subtype recognition in the retina.
Wojtowicz et al., Berkeley, United States. In Elife, 2014
Consistent with a repulsive role in arbor lamination, we observed complementary expression patterns for one interaction pair, FLRT2-Unc5C, in vivo.
A rare mutation in UNC5C predisposes to late-onset Alzheimer's disease and increases neuronal cell death.
Impact
Graham et al., San Francisco, United States. In Nat Med, 2014
We have identified a rare coding mutation, T835M (rs137875858), in the UNC5C netrin receptor gene that segregated with disease in an autosomal dominant pattern in two families enriched for late-onset Alzheimer's disease and that was associated with disease across four large case-control cohorts (odds ratio = 2.15, Pmeta = 0.0095).
Molecular Effects of Polymorphism in the 3'UTR of Unc-5 homolog C Associated with Conception Rate in Holsteins.
Sugimoto et al., Fukushima, Japan. In Plos One, 2014
To enhance our understanding of the genes involved in conception rates, we conducted a genome-wide association study (GWAS) using 822 Holsteins and identified a single-nucleotide polymorphism (SNP) associated with conception rate: A+169G in the 3' untranslated region (UTR) of unc-5 homolog C (UNC5C).
Genetic and epigenetic alterations of netrin-1 receptors in gastric cancer with chromosomal instability.
Fujiwara et al., Okayama, Japan. In Clin Epigenetics, 2014
BACKGROUND: The gene expressions of netrin-1 dependence receptors, DCC and UNC5C, are frequently downregulated in many cancers.
An iteration normalization and test method for differential expression analysis of RNA-seq data.
Zhang et al., Urbana, United States. In Biodata Min, 2013
What's more, we discovered that gene UNC5C is highly associated with kidney cancer and so on.
Down syndrome cell adhesion molecule (DSCAM) associates with uncoordinated-5C (UNC5C) in netrin-1-mediated growth cone collapse.
GeneRIF
Liu et al., Toledo, United States. In J Biol Chem, 2012
knockdown of DSCAM inhibits netrin-induced tyrosine phosphorylation of UNC5C and Fyn as well as the interaction of UNC5C with Fyn. The double knockdown of both receptors abolishes the induction of Fyn tyrosine phosphorylation by netrin-1
Variants in the netrin-1 receptor UNC5C prevent apoptosis and increase risk of familial colorectal cancer.
GeneRIF
Mehlen et al., Lyon, France. In Gastroenterology, 2011
Inherited mutations in UNC5C prevent apoptosis and increase risk of colorectal cancer.
Genetic and epigenetic control of UNC5C expression in human renal cell carcinoma.
GeneRIF
Zhang et al., Beijing, China. In Eur J Cancer, 2011
UNC5C acts as a tumour suppressor in RCC and is down-regulated in RCC. Loss of heterozygosity and DNA methylation contribute to the inactivation of UNC5C in renal cell carcinoma.
Changes in UNC5C gene methylation during human gastric carcinogenesis.
GeneRIF
Sanada et al., Yokohama, Japan. In Anticancer Res, 2009
UNC5C methylation was observed in the course of gastric carcinogenesis and disappeared in highly advanced gastric carcinomas.
Role of the netrin system of repellent factors on synovial fibroblasts in rheumatoid arthritis and osteoarthritis.
GeneRIF
Bosserhoff et al., Regensburg, Germany. In Int J Immunopathol Pharmacol, 2009
Stronger expression of UNC5B and UNC5C receptors in synovial fibroblasts might contribute to the disordered phenotype of rheumatoid arthritis and osteoarthritis.
Epigenetic regulation and downstream targets of the Rhox5 homeobox gene.
Review
Wilkinson et al., Houston, United States. In Int J Androl, 2008
One of them is the tumour suppressor UNC5C, a pro-apoptotic molecule previously only known to be involved in brain development.
Netrin-1 mediates neuronal survival through PIKE-L interaction with the dependence receptor UNC5B.
Impact
Ye et al., Atlanta, United States. In Nat Cell Biol, 2008
Both UNC5 (that is, UNC5A, UNC5B, UNC5C or UNC5D) and DCC are transmembrane receptors for netrin-1 (Refs 8, 9).
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