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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 02 Oct 2014.

Unc-5 homolog C

This gene product belongs to the UNC-5 family of netrin receptors. Netrins are secreted proteins that direct axon extension and cell migration during neural development. They are bifunctional proteins that act as attractants for some cell types and as repellents for others, and these opposite actions are thought to be mediated by two classes of receptors. The UNC-5 family of receptors mediate the repellent response to netrin; they are transmembrane proteins containing 2 immunoglobulin (Ig)-like domains and 2 type I thrombospondin motifs in the extracellular region. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: netrin-1, DCC, UNC5B, UNC5H1, CAN
Papers on UNC5C
Target-dependent expression of the netrin-1 receptor, UNC5C, in projection neurons of the ventral tegmental area.
Flores et al., Montréal, Canada. In Neuroscience, Mar 2014
We have shown previously that the netrin-1 receptor, unc-5 homologue C (UNC5C), is expressed by ventral tegmental area (VTA) dopamine (DA) neurons of rodents, but only from adolescence onwards (Manitt et al., 2010; Auger et al., 2013).
Netrin 1 and Dcc signalling are required for confinement of central axons within the central nervous system.
Wilson et al., Umeå, Sweden. In Development, Feb 2014
We provide evidence that netrin 1 signalling preserves CNS/PNS axonal integrity in three ways: (1) netrin 1/Dcc ventral attraction diverts axons away from potential exit points; (2) a Dcc/Unc5c-dependent netrin 1 chemoinhibitory barrier in the dorsolateral spinal cord prevents interneurons from being close to the dorsal CNS/PNS transition zone; and (3) a netrin 1/Dcc-dependent, Unc5c-independent mechanism that actively prevents exit from the CNS.
Evaluation of the colorectal cancer risk conferred by rare UNC5C alleles.
Bezieau et al., Nantes, France. In World J Gastroenterol, Feb 2014
AIM: To evaluate the risk associated with variants of the UNC5C gene recently suspected to predispose to familial colorectal cancer (CRC).
Expression of unc5 family genes in zebrafish brain during embryonic development.
Gao et al., Shanghai, China. In Gene Expr Patterns, Dec 2013
Here we have determined the temporal and spatial expression patterns of unc5 gene family members (unc5a, unc5b, unc5c, unc5da and unc5db) by RT-PCR and in situ hybridization.
unc5c haploinsufficient phenotype: striking similarities with the dcc haploinsufficiency model.
Flores et al., Canada. In Eur J Neurosci, Sep 2013
We show that unc5c haploinsufficiency results in diminished amphetamine-induced locomotion in male and female mice.
Exome sequencing identifies early gastric carcinoma as an early stage of advanced gastric cancer.
Kim et al., Seoul, South Korea. In Plos One, 2012
The DYRK3, GPR116, MCM10, PCDH17, PCDHB1, RDH5 and UNC5C genes are recurrently mutated in EGCs and may be involved in early carcinogenesis.
Methylation of the UNC5C gene is frequently detected in hepatocellular carcinoma.
Sanada et al., Yokohama, Japan. In Hepatogastroenterology, 2012
BACKGROUND/AIMS: Recently, we detected that UNC5C expression was downregulated in colon and gastric cancer.
Down syndrome cell adhesion molecule (DSCAM) associates with uncoordinated-5C (UNC5C) in netrin-1-mediated growth cone collapse.
Liu et al., Toledo, United States. In J Biol Chem, 2012
knockdown of DSCAM inhibits netrin-induced tyrosine phosphorylation of UNC5C and Fyn as well as the interaction of UNC5C with Fyn. The double knockdown of both receptors abolishes the induction of Fyn tyrosine phosphorylation by netrin-1
Novel candidate genes of thyroid tumourigenesis identified in Trk-T1 transgenic mice.
Zitzelsberger et al., München, Germany. In Endocr Relat Cancer, 2012
The genes Twist2, Ptma, Pde6d, Bmpr1b, Pdlim5, Unc5c, Srm, Trp73, Ythdf2, Taf12 and Slitrk5 are located in these chromosomal bands.
Integrated analysis of mRNA and microRNA expression in mature neurons, neural progenitor cells and neuroblastoma cells.
Sharp et al., Sacramento, United States. In Gene, 2012
Integrated mRNA-miRNA functional analyses reveal that: 1) several very highly expressed genes (e.g., Robo1, Nrp1, Epha3, Unc5c, Dcc, Pak3, Limk4) and a few under-expressed miRNAs (e.g., miR-152, miR-146b, miR-339-5p) in MNs are associated with one important cellular process-axon guidance; 2) some very highly expressed mitogenic pathway genes (e.g., Map2k1, Igf1r, Rara, Runx1) and under-expressed miRNAs (e.g., miR-370, miR-9, miR-672) in NBCs are associated with cancer pathways.
Netrin-1 simultaneously suppresses corneal inflammation and neovascularization.
Liu et al., Xiamen, China. In Invest Ophthalmol Vis Sci, 2012
METHODS: The expression of netrin-1 and its receptors UNC5A, UNC5B, UNC5C, UNC5D, adenosine 2b receptor (A2BAR), deleted in colorectal cancer (DCC), and neogenin in normal and alkali-burned rat cornea were determined by RT-PCR and/or Western blot analysis, or immunostaining.
Variants in the netrin-1 receptor UNC5C prevent apoptosis and increase risk of familial colorectal cancer.
Mehlen et al., Lyon, France. In Gastroenterology, 2011
Inherited mutations in UNC5C prevent apoptosis and increase risk of colorectal cancer.
Genetic and epigenetic control of UNC5C expression in human renal cell carcinoma.
Zhang et al., Beijing, China. In Eur J Cancer, 2011
UNC5C acts as a tumour suppressor in RCC and is down-regulated in RCC. Loss of heterozygosity and DNA methylation contribute to the inactivation of UNC5C in renal cell carcinoma.
Chromosome rearrangement associated inactivation of tumour suppressor genes in prostate cancer.
Lu et al., In Am J Cancer Res, 2010
Subsequently, we further investigated the genes associated with the t(4:6) translocation in LNCaP cells and reveal the genomic fusion of SNX9 and putative TSG UNC5C, which led to the reduced expression of both genes.
Changes in UNC5C gene methylation during human gastric carcinogenesis.
Sanada et al., Yokohama, Japan. In Anticancer Res, 2009
UNC5C methylation was observed in the course of gastric carcinogenesis and disappeared in highly advanced gastric carcinomas.
Role of the netrin system of repellent factors on synovial fibroblasts in rheumatoid arthritis and osteoarthritis.
Bosserhoff et al., Regensburg, Germany. In Int J Immunopathol Pharmacol, 2009
Stronger expression of UNC5B and UNC5C receptors in synovial fibroblasts might contribute to the disordered phenotype of rheumatoid arthritis and osteoarthritis.
Epigenetic regulation and downstream targets of the Rhox5 homeobox gene.
Wilkinson et al., Houston, United States. In Int J Androl, 2008
One of them is the tumour suppressor UNC5C, a pro-apoptotic molecule previously only known to be involved in brain development.
Netrin-1 mediates neuronal survival through PIKE-L interaction with the dependence receptor UNC5B.
Ye et al., Atlanta, United States. In Nat Cell Biol, 2008
Both UNC5 (that is, UNC5A, UNC5B, UNC5C or UNC5D) and DCC are transmembrane receptors for netrin-1 (Refs 8, 9).
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