Synergistic integration of Netrin and ephrin axon guidance signals by spinal motor neurons.
New York City, United States. In Elife, 03 Jan 2016
Our investigations of the mechanism of ephrin-B2 and Netrin-1 integration demonstrate that the Netrin receptor Unc5c and the ephrin receptor EphB2 can form a complex in a ligand-dependent manner and that Netrin-ephrin synergistic growth cones responses involve the potentiation of Src family kinase signaling, a common effector of both pathways.
Alzheimer's disease: rare variants with large effect sizes.
Saint Louis, United States. In Curr Opin Genet Dev, Aug 2015
Recent advances in sequencing technology and novel genotyping arrays (focused on low-frequency and coding variants) have made it possible to identify novel coding variants with large effect sizes and also novel genes (TREM2, PLD3, UNC5C, and AKAP9) associated with Alzheimer's disease (AD) risk.