Transcriptomic analysis of pancreatic cancer cells in response to metformin and aspirin: an implication of synergy.
United States. In Sci Rep, 2014
Of the top 10 genes (fold-change > 10, P < 10(-10)) regulated by metformin plus aspirin, PCDH18, CCL2, RASL11A, FAM111B and BMP5 were down-regulated ≥ 20-fold, while NGFR, NPTX1, C7orf57, MRPL23AS1 and UNC5B were up-regulated ≥ 10-fold.
Clinical significance of UNC5B expression in colorectal cancer.
Tokyo, Japan. In Int J Oncol, 2012
The mRNA expression analysis using tissue samples revealed that UNC5B mRNA was down-expressed in about 20% of CRC patients, and the patients with low-UNC5B-expression tumors showed a significantly higher recurrence rate after curative surgery.