Neuregulin signaling in pieces--evolution of the gene family.
Arlington, United States. In Curr Pharm Des, 2013
First appearance of ancestral NRG, represented in a NRG4-like gene in the lancelet Branchiostoma floridae, appears to have: 1) occurred in the common chordate ancestor prior to the divergence of lancelets (amphioxus), and; 2) antedated the formation of the receptor gene family.
Relationships between progesterone receptor isoforms and the HER/ErbB receptors and ligands network in 299 primary breast cancers.
Lille, France. In Int J Biol Markers, 2012
The PR isoforms positively correlated with the mRNA levels of HER/ErbB receptors and ligands associated with a more differentiated phenotype (HER3, HER4, EGF, AREG, NRG3 and NRG4) while they correlated negatively with those associated with aggressiveness (EGFR, TGFa, HB-EGF, EREG, and NRG2).