DAPK2 is a novel regulator of mTORC1 activity and autophagy.
Israel. In Cell Death Differ, Mar 2015
At the molecular level, DAPK2 depletion interfered with mTORC1 inhibition caused by these two stresses, as reflected by the phosphorylation status of mTORC1 substrates, ULK1 (unc-51-like kinase 1), p70 ribosomal S6 kinase and eukaryotic initiation factor 4E-binding protein 1.
Mitophagy is required for acute cardioprotection by simvastatin.
San Diego, United States. In Antioxid Redox Signal, 2014
RESULTS: HL-1 cardiomyocytes exposed to simvastatin for 24 h exhibited diminished protein kinase B (Akt)/mammalian target of rapamycin (mTOR) signaling, increased activation of unc-51-like kinase 1, and upregulation of autophagy and mitophagy.
mTORC1 phosphorylates the ULK1-mAtg13-FIP200 autophagy regulatory complex.
Glasgow, United Kingdom. In Sci Signal, 2008
The complementary inhibitory mechanism in which mTORC1 phosphorylates the autophagy regulatory complex containing unc-51-like kinase 1 (ULK1), the mammalian Atg13 protein, and focal adhesion kinase interacting protein of 200 kD (FIP200) has also been elucidated.