Blocking Cancer Growth with Less POMP or Proteasomes.
Boston, United States. In Mol Cell, Aug 2015
In this issue, Zhang et al. (2015) report that miR-101 suppresses the expression of chaperone POMP and 20S assembly, and certain cancers raise proteasome content by losing miR-101.
Identification of Saccharomyces cerevisiae Genes Whose Deletion Causes Synthetic Effects in Cells with Reduced Levels of the Nuclear Pif1 DNA Helicase.
Princeton, United States. In G3 (bethesda), 2014
This study identified eleven genes that were synthetic lethal (APM1, ARG80, CDH1, GCR1, GTO3, PRK1, RAD10, SKT5, SOP4, UMP1, and YCK1) and three genes that were synthetic sick (DEF1, YIP4, and HOM3) with pif1-m2.
Proteasome activation as a novel anti-aging strategy.
Greece. In Free Radic Biol Med, 2014
Stable over-expression of catalytic subunits or POMP resulted in enhanced proteasome assembly and activities and increased cell survival following treatments with various oxidants.
20S proteasome biogenesis.
Berlin, Germany. In Biochimie, 2001
The complex biogenesis is tightly regulated which requires additional components such as the maturation factor Ump1/POMP, an ubiquitous protein in eukaryotic cells.