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UL16 binding protein 1

ULBP1, NKG2D ligand, UL16-binding protein, NKG2DL
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Top mentioned proteins: NKG2D, MICA, CAN, MHC, CD8
Papers on ULBP1
A short half-life of ULBP1 at the cell surface due to internalization and proteosomal degradation.
New
Valés-Gómez et al., Madrid, Spain. In Immunol Cell Biol, Feb 2016
We now report that the surface stability of the human GPI-anchored ligand ULBP1 (UL16-binding protein) at the plasma membrane is lower than other ULBP molecules.
Increased serum NKG2D-ligands and downregulation of NKG2D in peripheral blood NK cells of patients with major burns.
New
Markel et al., Tel Aviv-Yafo, Israel. In Oncotarget, Jan 2016
MICB and ULBP1 are stress ligands of NKG2D that can be induced by heat stress.
Human cancer cells with stem cell-like phenotype exhibit enhanced sensitivity to the cytotoxicity of IL-2 and IL-15 activated natural killer cells.
New
Wang et al., Chengdu, China. In Cell Immunol, Dec 2015
CD44+CD24- CSCs expressed higher levels of NKG2D ligands ULBP1, ULBP2 and MICA.
[An immunological approach to acute myeloid leukaemia].
New
Pérez-Martínez et al., Madrid, Spain. In An Pediatr (barc), Dec 2015
The mean fluorescence intensities of HLA-I, MICA/B and ULBP1-4, ligands for NK cell receptors, were also analysed in ten new diagnosed leukaemia cases, five myeloid and five lymphoid.
Comparative genomics of the NKG2D ligand gene family.
Review
New
Sutoh et al., Sapporo, Japan. In Immunol Rev, Sep 2015
In mammals, two families of NKG2DL genes have been identified: the MIC gene family encoded in the MHC region and the ULBP gene family encoded outside the MHC region in most species.
NKG2D Receptor and Its Ligands in Host Defense.
Review
New
Lanier, San Francisco, United States. In Cancer Immunol Res, Jun 2015
Although NKG2D is encoded by a highly conserved gene (KLRK1) with limited polymorphism, the receptor recognizes an extensive repertoire of ligands, encoded by at least eight genes in humans (MICA, MICB, RAET1E, RAET1G, RAET1H, RAET1I, RAET1L, and RAET1N), some with extensive allelic polymorphism.
Distinct mechanisms of tumor resistance to NK killing: of mice and men.
New
Impact
Pardoll, Baltimore, United States. In Immunity, May 2015
In a recent issue of Science, Deng et al. (2015) show that, unexpectedly, a soluble NKG2D ligand can enhance anti-tumor NK cell activity.
Antitumor immunity. A shed NKG2D ligand that promotes natural killer cell activation and tumor rejection.
New
Impact
Raulet et al., Berkeley, United States. In Science, May 2015
In contrast, we show that in mice, a shed form of MULT1, a high-affinity NKG2D ligand, causes NK cell activation and tumor rejection.
Matrine increases NKG2D ligand ULBP2 in K562 cells via inhibiting JAK/STAT3 pathway: a potential mechanism underlying the immunotherapy of matrine in leukemia.
Ma et al., Changzhou, China. In Am J Transl Res, 2014
PURPOSE: The study aimed to investigate the role of the JAK/STAT3 pathway in the matrine induced ULBP2 expression on the human chronic myelogenous leukemia K562 cells.
NKG2D CARs as cell therapy for cancer.
Review
Meehan et al., Vanuatu. In Cancer J, 2014
Under certain conditions, NKG2D ligand expression can be found on nontumor tissue, so potential off-tumor toxicity remains.
Secretory pathways generating immunosuppressive NKG2D ligands: New targets for therapeutic intervention.
Review
López-Larrea et al., Oviedo, Spain. In Oncoimmunology, 2013
Natural Killer Group 2 member D (NKG2D) activating receptor, present on the surface of various immune cells, plays an important role in activating the anticancer immune response by their interaction with stress-inducible NKG2D ligands (NKG2DL) on transformed cells.
Molecular Bases for the Regulation of NKG2D Ligands in Cancer.
Review
Gonzalez et al., Oviedo, Spain. In Front Immunol, 2013
In this review, we attempt to integrate the mechanisms and pathways involved in the regulation of NKG2D ligand expression in cancer.
Regulation of ligands for the NKG2D activating receptor.
Review
Impact
Jung et al., Berkeley, United States. In Annu Rev Immunol, 2012
We review the numerous pathways that have been implicated in the regulation of NKG2D ligands, discuss the pathologic states in which those pathways are likely to act, and attempt to synthesize the findings into general schemes of NKG2D ligand regulation in NK cell responses to cancer and infection.
Reduced NKG2D ligand expression in hepatocellular carcinoma correlates with early recurrence.
GeneRIF
Aoyagi et al., Niigata, Japan. In J Hepatol, 2012
recurrence-free survival of patients with ULBP1-negative hepatocellular carcinoma (HCC) was significantly shorter than that of patients with ULBP1-positive HCC
RAE1ε ligand expressed on pancreatic islets recruits NKG2D receptor-expressing cytotoxic T cells independent of T cell receptor recognition.
Impact
Shaw et al., Saint Louis, United States. In Immunity, 2012
With a transgenic mouse expressing the NKG2D ligand retinoic acid early transcript 1ε (RAE1ε) in β-islet cells of the pancreas, we found that RAE1 expression was sufficient to induce the recruitment of adoptively transferred CTLs to islets.
Human NK cells are alerted to induction of p53 in cancer cells by upregulation of the NKG2D ligands ULBP1 and ULBP2.
GeneRIF
Cerwenka et al., Heidelberg, Germany. In Cancer Res, 2011
Findings define the involvement of p53 in the regulation of ULBP1 and ULBP2 which enhance NK cell-mediated target recognition.
Cutting edge: NKG2D-dependent cytotoxicity is controlled by ligand distribution in the target cell membrane.
GeneRIF
Gross et al., Rockville, United States. In J Immunol, 2011
recombinant ULBP1 fused to CD45 caused a reduction in cytotoxicity and degranulation by NK cells, implying a role for receptor ligand distribution in the activation of NK cell responses
Stress-regulated targeting of the NKG2D ligand Mult1 by a membrane-associated RING-CH family E3 ligase.
GeneRIF
Raulet et al., Berkeley, United States. In J Immunol, 2010
These results identify Mult1 as a target for the MARCH family of E3 ligases
Intravital imaging reveals distinct dynamics for natural killer and CD8(+) T cells during tumor regression.
Impact
Bousso et al., Paris, France. In Immunity, 2010
This NKG2D ligand drove NK cell accumulation, activation, and motility within the tumor.
Identification of a panel of ten cell surface protein antigens associated with immunotargeting of leukemias and lymphomas by peripheral blood gammadelta T cells.
GeneRIF
Silva-Santos et al., Lisbon, Portugal. In Haematologica, 2010
Data show that ULBP1, TFR2 and IFITM1 were associated with increased susceptibility to Vgamma9Vdelta2 T-cell cytotoxicity.
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