[An immunological approach to acute myeloid leukaemia].
Madrid, Spain. In An Pediatr (barc), Dec 2015
The mean fluorescence intensities of HLA-I, MICA/B and ULBP1-4, ligands for NK cell receptors, were also analysed in ten new diagnosed leukaemia cases, five myeloid and five lymphoid.
Comparative genomics of the NKG2D ligand gene family.
Sapporo, Japan. In Immunol Rev, Sep 2015
In mammals, two families of NKG2DL genes have been identified: the MIC gene family encoded in the MHC region and the ULBP gene family encoded outside the MHC region in most species.
NKG2D Receptor and Its Ligands in Host Defense.
San Francisco, United States. In Cancer Immunol Res, Jun 2015
Although NKG2D is encoded by a highly conserved gene (KLRK1) with limited polymorphism, the receptor recognizes an extensive repertoire of ligands, encoded by at least eight genes in humans (MICA, MICB, RAET1E, RAET1G, RAET1H, RAET1I, RAET1L, and RAET1N), some with extensive allelic polymorphism.
Regulation of ligands for the NKG2D activating receptor.
Berkeley, United States. In Annu Rev Immunol, 2012
We review the numerous pathways that have been implicated in the regulation of NKG2D ligands, discuss the pathologic states in which those pathways are likely to act, and attempt to synthesize the findings into general schemes of NKG2D ligand regulation in NK cell responses to cancer and infection.