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Small nuclear ribonucleoprotein polypeptide C

UIC, U1C, mu1C, U1C protein
This gene encodes one of the specific protein components of the U1 small nuclear ribonucleoprotein (snRNP) particle required for the formation of the spliceosome. The encoded protein participates in the processing of nuclear precursor messenger RNA splicing. snRNP particles are attacked by autoantibodies frequently produced by patients with connective tissue diseases. The genome contains several pseudogenes of this functional gene. Alternative splicing results in a non-coding transcript variant.[provided by RefSeq, Oct 2009] (from NCBI)
Top mentioned proteins: U1A, U1RNP, CAN, ACID, CD45
Papers on UIC
Iodine environmental availability and human intake in oceanic islands: Azores as a case-study.
New
Rodrigues et al., Ponta Delgada, Portugal. In Sci Total Environ, Jan 2016
Urinary iodine concentration (UIC) in schoolchildren was assessed by ICP-MS in a randomized cross-sectional survey with 315 participants from S. Miguel (study group) and Sta.
The Central Region of the Drosophila Co-repressor Groucho as a Regulatory Hub.
New
Courey et al., Los Angeles, United States. In J Biol Chem, Jan 2016
The use of RNA-seq to analyze the gene expression profile of cells subjected to knockdown of Gro or snRNP-U1-C (a component of U1 snRNP) showed a significant overlap between genes regulated by these two factors.
Mapping chemical structure-activity information of HAART-drug cocktails over complex networks of AIDS epidemiology and socioeconomic data of U.S. counties.
New
González-Díaz et al., A Coruña, Spain. In Biosystems, Jun 2015
Three scales or levels were employed to group the counties according to the location or population structure codes: state, rural urban continuum code (RUCC) and urban influence code (UIC).
Structure-function analysis and genetic interactions of the Yhc1, SmD3, SmB, and Snp1 subunits of yeast U1 snRNP and genetic interactions of SmD3 with U2 snRNP subunit Lea1.
New
Shuman et al., New York City, United States. In Rna, Jun 2015
Yhc1 and U1-C are essential subunits of the yeast and human U1 snRNP, respectively, that stabilize the duplex formed by U1 snRNA at the pre-mRNA 5' splice site (5'SS).
U1 snRNP is mislocalized in ALS patient fibroblasts bearing NLS mutations in FUS and is required for motor neuron outgrowth in zebrafish.
New
Reed et al., Boston, United States. In Nucleic Acids Res, May 2015
Here, we report that components of the U1 snRNP core particle (Sm proteins and U1 snRNA), but not the mature U1 snRNP-specific proteins (U1-70K, U1A and U1C), co-mislocalize with FUS to the cytoplasm in ALS patient fibroblasts harboring mutations in the FUS nuclear localization signal (NLS).
Crystal structure of human U1 snRNP, a small nuclear ribonucleoprotein particle, reveals the mechanism of 5' splice site recognition.
Nagai et al., Cambridge, United Kingdom. In Elife, 2014
The zinc-finger of U1-C interacts with the duplex between pre-mRNA and the 5'-end of U1 snRNA.
ARTS: automated randomization of multiple traits for study design.
Lussier et al., Lemont, United States. In Bioinformatics, 2014
ARTS is also available in the Galaxy Tool Shed, and can be used at the Galaxy installation hosted by the UIC Center for Research Informatics (CRI) at galaxy.cri.uic.edu.
Genome-wide RNA-binding analysis of the trypanosome U1 snRNP proteins U1C and U1-70K reveals cis/trans-spliceosomal network.
Bindereif et al., Gießen, Germany. In Nucleic Acids Res, 2014
To search for potential new functions of the U1 snRNP in Trypanosoma brucei, we applied genome-wide individual-nucleotide resolution crosslinking-immunoprecipitation (iCLIP), focusing on the U1 snRNP-specific proteins U1C and U1-70K.
U1 small nuclear RNA variants differentially form ribonucleoprotein particles in vitro.
Herrera et al., Durham, United States. In Gene, 2014
U1 snRNAs associate with 5' splice sites in the form of ribonucleoprotein particles (snRNPs) that are comprised of the U1 snRNA and 10 core components, including U1A, U1-70K, U1C and the 'Smith antigen', or Sm, heptamer.
Structure-function analysis of the Yhc1 subunit of yeast U1 snRNP and genetic interactions of Yhc1 with Mud2, Nam8, Mud1, Tgs1, U1 snRNA, SmD3 and Prp28.
Shuman et al., New York City, United States. In Nucleic Acids Res, 2014
Yhc1 and U1C are homologous essential subunits of the yeast and human U1 snRNP, respectively, that are implicated in the establishment and stability of the complex of U1 bound to the pre-mRNA 5' splice site (5'SS).
Na+/I- symporter and type 3 iodothyronine deiodinase gene expression in amniotic membrane and placenta and its relationship to maternal thyroid hormones.
Tazebay et al., Ankara, Turkey. In Biol Trace Elem Res, 2013
Thyroid hormones, urinary iodine concentration (UIC), and selenium levels were measured in 49 healthy term pregnant women.
A novel intra-U1 snRNP cross-regulation mechanism: alternative splicing switch links U1C and U1-70K expression.
Bindereif et al., Gießen, Germany. In Plos Genet, 2012
The U1 small nuclear ribonucleoprotein (snRNP)-specific U1C protein participates in 5' splice site recognition and regulation of pre-mRNA splicing.
A neurochemical basis for an epigenetic vision of psychiatric disorders (1994-2009).
Review
Grayson et al., Chicago, United States. In Pharmacol Res, 2011
As you know, Dr. Costa was an eclectic scientist and in his 15 years of studies at UIC, he touched many other aspects of neuroscience research that are not discussed in this overview.
Crystal structure of human spliceosomal U1 snRNP at 5.5 A resolution.
Impact
Nagai et al., Cambridge, United Kingdom. In Nature, 2009
An electron density map of the functional core of U1 snRNP at 5.5 A resolution has enabled us to build the RNA and, in conjunction with site-specific labelling of individual proteins, to place the seven Sm proteins, U1-C and U1-70K into the map.
The splicing regulator TIA-1 interacts with U1-C to promote U1 snRNP recruitment to 5' splice sites.
GeneRIF
Valcárcel et al., Heidelberg, Germany. In Embo J, 2003
binding of TIA-1 in the vicinity of a 5' ss helps to stabilize U1 snRNP recruitment, at least in part, via a direct interaction with U1-C
The U1 snRNP protein U1C recognizes the 5' splice site in the absence of base pairing.
Impact
Rosbash et al., Waltham, United States. In Nature, 2002
We also show that recombinant yeast U1C protein, a U1 snRNP protein, selects a 5'-splice-site-like sequence in which the first four nucleotides, GUAU, are identical to the first four nucleotides of the yeast 5'-splice-site consensus sequence.
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