Gene expression in prolactinomas: a systematic review.
Los Angeles, United States. In Pituitary, Feb 2016
Of the many genes identified, three upregulated (HMGA2, HST, SNAP25), and three downregulated (UGT2B7, Let7, miR-493) genes were selected for further analysis based on our subjective identification of strong potential targets.
Oral morphine pharmacokinetic in obesity: the role of P-glycoprotein, MRP2, MRP3, UGT2B7 and CYP3A4 jejunal contents and obesity-associated biomarkers.
In Mol Pharm, Feb 2016
OBJECTIVE: To study the influence of the jejunal expression levels of P-gp, MRP2, MRP3, UGT2B7, CYP3A4, the influence of the ABCB1 c.3435C>T polymorphism and of several obesity-associated biomarkers, on oral morphine and glucuronides pharmacokinetics in a population of morbid obese subjects.
Characterization of 137 Genomic DNA Reference Materials for 28 Pharmacogenetic Genes: A GeT-RM Collaborative Project.
Camden, United States. In J Mol Diagn, Jan 2016
To address this need, the Centers for Disease Control and Prevention-based Genetic Testing Reference Material Coordination Program, in collaboration with members of the pharmacogenetic testing community and the Coriell Cell Repositories, has characterized 137 genomic DNA samples for 28 genes commonly genotyped by pharmacogenetic testing assays (CYP1A1, CYP1A2, CYP2A6, CYP2B6, CYP2C8, CYP2C9, CYP2C19, CYP2D6, CYP2E1, CYP3A4, CYP3A5, CYP4F2, DPYD, GSTM1, GSTP1, GSTT1, NAT1, NAT2, SLC15A2, SLC22A2, SLCO1B1, SLCO2B1, TPMT, UGT1A1, UGT2B7, UGT2B15, UGT2B17, and VKORC1).
Genetic basis of drug-induced liver injury: present and future.
Newcastle upon Tyne, United Kingdom. In Semin Liver Dis, 2014
Though the associations with non-HLA genes have been less well replicated than the HLA associations, there is increasing evidence that drug metabolism genes such as NAT2 and UGT2B7 contribute to some forms of DILI.