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UDP glucuronosyltransferase 2 family, polypeptide B17

This gene encodes a member of the uridine diphosphoglucuronosyltransferase protein family. The encoded enzyme catalyzes the transfer of glucuronic acid from uridine diphosphoglucuronic acid to a diverse array of substrates including steroid hormones and lipid-soluble drugs. This process, known as glucuronidation, is an intermediate step in the metabolism of steroids. Copy number variation in this gene is associated with susceptibility to osteoporosis.[provided by RefSeq, Apr 2010] (from NCBI)
Top mentioned proteins: UGT, Glucuronosyltransferase, UDP-glucuronosyltransferase, UGT2B7, UGT1A1
Papers on UGT2B17
Longitudinal monitoring of endogenous steroids in human serum by UHPLC-MS/MS as a tool to detect testosterone abuse in sports.
Nicoli et al., Lausanne, Switzerland. In Anal Bioanal Chem, Jan 2016
As a second step of analysis, the longitudinal monitoring of these biomarkers using intra-individual thresholds showed, in comparison to urine, significant improvements in the detection of testosterone administration, especially for volunteers with del/del genotype for phase II UGT2B17 enzyme, not sensitive to the main urinary marker, T/E ratio.
Characterization of 137 Genomic DNA Reference Materials for 28 Pharmacogenetic Genes: A GeT-RM Collaborative Project.
Kalman et al., Camden, United States. In J Mol Diagn, Jan 2016
To address this need, the Centers for Disease Control and Prevention-based Genetic Testing Reference Material Coordination Program, in collaboration with members of the pharmacogenetic testing community and the Coriell Cell Repositories, has characterized 137 genomic DNA samples for 28 genes commonly genotyped by pharmacogenetic testing assays (CYP1A1, CYP1A2, CYP2A6, CYP2B6, CYP2C8, CYP2C9, CYP2C19, CYP2D6, CYP2E1, CYP3A4, CYP3A5, CYP4F2, DPYD, GSTM1, GSTP1, GSTT1, NAT1, NAT2, SLC15A2, SLC22A2, SLCO1B1, SLCO2B1, TPMT, UGT1A1, UGT2B7, UGT2B15, UGT2B17, and VKORC1).
Low β2-adrenergic receptor level may promote development of castration resistant prostate cancer and altered steroid metabolism.
Taskén et al., Oslo, Norway. In Oncotarget, Jan 2016
Two UDP-glucuronosyltransferases, UGT2B15 and UGT2B17, involved in phase II metabolism of androgens, were strongly downregulated in two LNCaP shADRB2 cell lines.
Impact of UGT2B17 gene deletion on the steroid profile of an athlete.
Fernandez-Pérez et al., Madrid, Spain. In Physiol Rep, Dec 2015
This study examines the frequencies of the different expression forms of the UGT2B17 gene, and assesses their effects on this marker in volunteer subjects.
Impact of UGT2B17 Gene Deletion on the Pharmacokinetics of 17-hydroexemestane in Healthy Volunteers.
Kamdem et al., United States. In J Clin Pharmacol, Dec 2015
17-hydroexemestane, the major and biologically active metabolite of exemestane in humans is eliminated via glucuronidation by the polymorphic UGT2B17 phase II drug metabolizing enzyme.
Osteoblasts promote castration-resistant prostate cancer by altering intratumoral steroidogenesis.
Welén et al., Göteborg, Sweden. In Mol Cell Endocrinol, Dec 2015
Osteoblast-stimulated LNCaP-19 cells displayed an increased expression of genes encoding for steroidogenic enzymes (CYP11A1, HSD3B1, and AKR1C3), estrogen signaling-related genes (CYP19A1, and ESR2), and genes for DHT-inactivating enzymes (UGT2B7, UGT2B15, and UGT2B17).
Polymorphisms of estrogen metabolism-related genes ESR1, UGT2B17, and UGT1A1 are not associated with osteoporosis in surgically menopausal Japanese women.
Aoki et al., Tokyo, Japan. In Prz Menopauzalny, Sep 2015
Polymorphisms of estrogen receptor 1 (ESR1) and UDP-glucuronosyl transferase (UGT) genes UGT2B17 and UGT1A1 were analyzed, and their association with bone mass and osteoporosis was statistically evaluated.
Multiple roles for UDP-glucuronosyltransferase (UGT)2B15 and UGT2B17 enzymes in androgen metabolism and prostate cancer evolution.
Barbier et al., Québec, Canada. In J Steroid Biochem Mol Biol, 2015
The formation of these last derivatives through the glucuronidation reaction involves 2 UDP-glucuronosyltransferase (UGT) enzymes, namely UGT2B15 and UGT2B17.
Germline copy number loss of UGT2B28 and gain of PLEC contribute to increased human esophageal squamous cell carcinoma risk in Southwest China.
Yang et al., Chongqing, China. In Am J Cancer Res, 2014
In addition, an association was drawn between germline copy number variations and somatic alterations for PLEC, UGT2B17 and UGT2B28, but not for other candidate loci.
Drug-Drug Interaction Potentials of Tyrosine Kinase Inhibitors via Inhibition of UDP-Glucuronosyltransferases.
Jeong et al., Chicago, United States. In Sci Rep, 2014
Imatinib was found to exhibit broad inhibition on several UGTs, particularly potent competitive inhibition against UGT2B17 with a Ki of 0.4 μM.
UGT2B17 Polymorphism and Risk of Prostate Cancer: A Meta-Analysis.
Sheng et al., Wuhan, China. In Isrn Oncol, 2012
According to our inclusion criteria, studies that observed the association between UGT2B17 polymorphism and PCa risk were included.
UGT2B17 genetic polymorphisms dramatically affect the pharmacokinetics of MK-7246 in healthy subjects in a first-in-human study.
Harrelson et al., United States. In Clin Pharmacol Ther, 2012
Genetic variations in the UGT2B17 gene dramatically affect the pharmacokinetics of MK-7246 in healthy subjects.
Differential expression of the androgen-conjugating UGT2B15 and UGT2B17 enzymes in prostate tumor cells during cancer progression.
Barbier et al., Québec, Canada. In J Clin Endocrinol Metab, 2012
The study revealed that UGT2B15 and UGT2B17 are differentially regulated during prostate cancer progression.
Glucuronidation of trans-3'-hydroxycotinine by UGT2B17 and UGT2B10.
Lazarus et al., Penn Hills, United States. In Pharmacogenet Genomics, 2012
UGT2B17 and UGT2B10 play key roles in the glucuronidation of 3HC in the human liver and that functional polymorphisms in UGT2B17 and UGT2B10 are associated with significantly reduced glucuronidation activities against 3HC.
Prostate cancer with variants in CYP17 and UGT2B17 genes: a meta-analysis.
Chou et al., Shanghai, China. In Protein Pept Lett, 2012
The UGT2B17 Del polymorphism may significantly contribute to prostate cancer susceptibility in men. (Meta-analysis)
Copy number polymorphisms in new HapMap III and Singapore populations.
Salim et al., Singapore, Singapore. In J Hum Genet, 2011
Data show that 698 CNPs loci overlap with known disease-associated or pharmacogenetic-related genes such as CFHR3, CFHR1, GSTTI and UGT2B17.
Genetic polymorphism in metabolism and host defense enzymes: implications for human health risk assessment.
Sonawane et al., Hartford, United States. In Crit Rev Toxicol, 2010
Of the numerous UGT and SULT enzymes, the greatest likelihood for polymorphism effect on conjugation function are for SULT1A1 (*2 polymorphism), UGT1A1 (*6, *7, *28 polymorphisms), UGT1A7 (*3 polymorphism), UGT2B15 (*2 polymorphism), and UGT2B17 (null polymorphism).
Donor-recipient mismatch for common gene deletion polymorphisms in graft-versus-host disease.
Altshuler et al., Boston, United States. In Nat Genet, 2009
when donor and recipient were mismatched for homozygous deletion of UGT2B17, a gene expressed in GVHD-affected tissues and giving rise to multiple histocompatibility antigens.
[Testosterone metabolism and doping test results].
Medraś et al., Wrocław, Poland. In Endokrynol Pol, 2009
Large testosterone excretion is associated with a deletion polymorphism of the UGT2B17 gene. This polymorphism decreases T/E ratio level.
Inactivation of androgens by UDP-glucuronosyltransferases in the human prostate.
Bélanger et al., Québec, Canada. In Best Pract Res Clin Endocrinol Metab, 2008
Identification of the substrates for each member has revealed that three UGT2B enzymes are mainly responsible for DHT, ADT and 3alpha-DIOL glucuronidation: UGT2B7, UGT2B15 and UGT2B17.
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