gopubmed logo
find other proteinsAll proteins
GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

UDP glucuronosyltransferase 2 family, polypeptide B10

Top mentioned proteins: UGT, UDP-glucuronosyltransferase, Glucuronosyltransferase, UGT2B7, UGT2B4
Papers on UGT2B10
Human UDP-glucuronosyltransferase (UGT) 2B10: Validation of cotinine as a selective probe substrate, inhibition by UGT enzyme selective inhibitors and antidepressant and antipsychotic drugs, and structural determinants of enzyme inhibition.
Miners et al., In Drug Metab Dispos, Jan 2016
UNASSIGNED: Although there is evidence for an important role of UGT2B10 in the N-glucuronidation of drugs and other xenobiotics, the inhibitor selectivity of this enzyme is poorly understood.
Stereospecific Metabolism of the Tobacco-Specific Nitrosamine, NNAL.
Lazarus et al., Spokane, United States. In Chem Res Toxicol, Dec 2015
Comparison of NNAL glucuronides (NNAL-Glucs) formed in reactions of UGT2B7-, UGT2B17-, UGT1A9-, and UGT2B10-overexpressing cell microsomes with pure NNAL enantiomers showed large differences in kinetics for (S)- versus (R)-NNAL, indicating varying levels of enantiomeric preference for each enzyme.
Further Characterization of the Metabolism of Desloratadine and Its Cytochrome P450 and UDP-glucuronosyltransferase Inhibition Potential: Identification of Desloratadine as a Relatively Selective UGT2B10 Inhibitor.
Parkinson et al., Shawnee, United States. In Drug Metab Dispos, Sep 2015
Previously we reported that the formation of 3-hydroxydesloratadine, the major human metabolite of desloratadine, involves three sequential reactions, namely N-glucuronidation by UGT2B10 followed by 3-hydroxylation by CYP2C8 followed by deconjugation (rapid, nonenzymatic hydrolysis of the N-glucuronide).
Inhibition screening method of microsomal UGTs using the cocktail approach.
Rudaz et al., Genève, Switzerland. In Eur J Pharm Sci, May 2015
Specific substrates were first selected for each UGT: etoposide for UGT1A1, chenodeoxycholic acid for UGT1A3, trifluoperazine for UGT1A4, serotonin for UGT 1A6, isoferulic acid for UGT1A9, codeine for UGT2B4, azidothymidine for UGT2B7, levomedetomidine for UGT2B10, 4-hydroxy-3-methoxymethamphetamine for UGT2B15 and testosterone for UGT2B17.
A long-standing mystery solved: the formation of 3-hydroxydesloratadine is catalyzed by CYP2C8 but prior glucuronidation of desloratadine by UDP-glucuronosyltransferase 2B10 is an obligatory requirement.
Parkinson et al., Falkland Islands. In Drug Metab Dispos, Apr 2015
Detailed mechanistic studies with sonicated or saponin-treated CHHs, human liver microsomes, and S9 fractions showed that both NADPH and UDP-glucuronic acid are required for 3-hydroxydesloratadine formation, and studies with recombinant UDP-glucuronosyltransferase (UGT) and P450 enzymes implicated the specific involvement of UGT2B10 in addition to CYP2C8.
A UGT2B10 splicing polymorphism common in african populations may greatly increase drug exposure.
Iglesias et al., Helsinki, Finland. In J Pharmacol Exp Ther, Feb 2015
Additional in vitro studies with recombinant UGTs showed that the contribution of UGT2B10 to RO5263397 glucuronidation is much higher than UGT1A4 at clinically relevant concentrations.
The contribution of common genetic variation to nicotine and cotinine glucuronidation in multiple ethnic/racial populations.
Murphy et al., Minneapolis, United States. In Cancer Epidemiol Biomarkers Prev, 2015
The vast majority were within chromosomal region 4q13, near UGT2B10.
UGT1A and UGT2B genetic variation alters nicotine and nitrosamine glucuronidation in european and african american smokers.
Tyndale et al., Toronto, Canada. In Cancer Epidemiol Biomarkers Prev, 2015
METHODS: Within UGT1A1, UGT1A4, UGT1A9, UGT2B7, UGT2B10, and UGT2B17, 47 variants were genotyped, including UGT2B10*2 and UGT2B17*2.
Human induced hepatic lineage-oriented stem cells: autonomous specification of human iPS cells toward hepatocyte-like cells without any exogenous differentiation factors.
Ochiya et al., Tokyo, Japan. In Plos One, 2014
After 12 days of this culture, the differentiated cells significantly enhanced gene expression of serum hepatic proteins (ALB, SERPINA1, TTR, TF, FABP1, FGG, AGT, RBP4, and AHSG), conjugating enzymes (UGT2B4, UGT2B7, UGT2B10, GSTA2, and GSTA5), transporters (SULT2A1, SLC13A5, and SLCO2B1), and urea cycle-related enzymes (ARG1 and CPS1).
Nicotine N-glucuronidation relative to N-oxidation and C-oxidation and UGT2B10 genotype in five ethnic/racial groups.
Le Marchand et al., Honolulu, United States. In Carcinogenesis, 2014
We report here on the proportion of nicotine metabolism by cytochrome P450 2A6-catalyzed C-oxidation, UDP-glucuronosyl transferase 2B10 (UGT2B10)-catalyzed N-glucuronidation and flavin monooxygenase 3-catalyzed N-oxidation in five ethnic/racial groups and the role of UGT2B10 genotype on the metabolic patterns observed.
Genetic factors affecting gene transcription and catalytic activity of UDP-glucuronosyltransferases in human liver.
Ratain et al., Chicago, United States. In Hum Mol Genet, 2014
Transcription levels of five major hepatic UGT1A (UGT1A1, UGT1A3, UGT1A4, UGT1A6 and UGT1A9) and five UGT2B (UGT2B4, UGT2B7, UGT2B10, UGT2B15 and UGT2B17) genes were quantified in human liver tissue samples (n = 125) using real-time PCR.
UGT2B gene expression analysis in multiple tobacco carcinogen-targeted tissues.
Lazarus et al., Poland. In Drug Metab Dispos, 2014
UGT2B10 expression was high in both tonsil and tongue.
Pharmacogenetics of olanzapine metabolism.
Dahl et al., Huddinge, Sweden. In Pharmacogenomics, 2013
The formation of the various olanzapine metabolites is influenced by polymorphisms in the genes coding for CYP1A2, CYP1A expression regulator AHR, UGT1A4 and UGT2B10, as well as FMO3.
Glucuronidation of trans-3'-hydroxycotinine by UGT2B17 and UGT2B10.
Lazarus et al., Penn Hills, United States. In Pharmacogenet Genomics, 2012
UGT2B17 and UGT2B10 play key roles in the glucuronidation of 3HC in the human liver and that functional polymorphisms in UGT2B17 and UGT2B10 are associated with significantly reduced glucuronidation activities against 3HC.
N-glucuronidation of drugs and other xenobiotics by human and animal UDP-glucuronosyltransferases.
Koskinen et al., Espoo, Finland. In Xenobiotica, 2011
The N-glucuronidation rates in humans are typically much higher than in animals, largely due to the activity of two enzymes, the extensively studied UGT1A4, and the more recently identified as a main player in N-glucuronidation, UGT2B10.
Glucuronidation genotypes and nicotine metabolic phenotypes: importance of functional UGT2B10 and UGT2B17 polymorphisms.
Lazarus et al., Penn Hills, United States. In Cancer Res, 2010
Data suggest that UGTs 2B10 and 2B17 play important roles in the glucuronidation of nicotine and suggest that the UGT2B10 codon 67 SNP and the UGT2B17 gene deletion reduce overall glucuronidation rates of nicotine and its major metabolites in smokers.
Functions and transcriptional regulation of adult human hepatic UDP-glucuronosyl-transferases (UGTs): mechanisms responsible for interindividual variation of UGT levels.
Bock, Tübingen, Germany. In Biochem Pharmacol, 2010
Surprisingly, UGT2B4 and UGT2B10 mRNA were found to be abundant in human liver suggesting an underestimated role of the liver in detoxification of their major substrates, bile acids and eicosanoids.
UGT2B10 genotype influences nicotine glucuronidation, oxidation, and consumption.
Murphy et al., Minneapolis, United States. In Cancer Epidemiol Biomarkers Prev, 2010
UGT2B10 genotype influences nicotine metabolism and should be taken into account when characterizing the role of nicotine metabolism on smoking.
Expression levels of uridine 5'-diphospho-glucuronosyltransferase genes in breast tissue from healthy women are associated with mammographic density.
Helland et al., Oslo, Norway. In Breast Cancer Res, 2009
Data show that UGT2B10 predicts MD independently of age, hormone therapy and parity.
Identification of a prevalent functional missense polymorphism in the UGT2B10 gene and its association with UGT2B10 inactivation against tobacco-specific nitrosamines.
Lazarus et al., Penn Hills, United States. In Pharmacogenet Genomics, 2008
The UGT2B10(67Tyr) variant corresponding to haplotype C is a functional single nucleotide polymorphism that may be responsible for inter individual variation in NNAL-N-glucuronidation activity and may increase susceptibility to smoking-related cancers.
share on facebooktweetadd +1mail to friends