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UDP glucuronosyltransferase 2 family, polypeptide A3

Top mentioned proteins: ACID, Glucuronosyltransferase, UDP-glucuronosyltransferase, UGT, UGT1A1
Papers on UGT2A3
The Human UDP-glucuronosyltransferase UGT2A1 and UGT2A2 enzymes are highly active in bile acid glucuronidation.
Barbier et al., Qu├ębec, Canada. In Drug Metab Dispos, 2013
UGT2A3 exhibited detectable but very low activity with all the tested BA substrates.
Altered UDP-glucuronosyltransferase and sulfotransferase expression and function during progressive stages of human nonalcoholic fatty liver disease.
Cherrington et al., Tucson, United States. In Drug Metab Dispos, 2013
We identified upregulation of UGT1A9, 2B10, and 3A1 and SULT1C4 mRNA in both stages of NASH, whereas UGT2A3, 2B15, and 2B28 and SULT1A1, 2B1, and 4A1 as well as 3'-phosphoadenosine-5'-phosphosulfate synthase 1 were increased in NASH (not fatty/cirrhosis) only.
Importance of UDP-glucuronosyltransferases 2A2 and 2A3 in tobacco carcinogen metabolism.
Lazarus et al., Penn Hills, United States. In Drug Metab Dispos, 2013
The goal of the present study was to investigate the importance of two additional UGT2A enzymes, UGT2A2 and UGT2A3, in tobacco carcinogen metabolism.
MicroRNA processing and binding site polymorphisms are not replicated in the Ovarian Cancer Association Consortium.
Ovarian Cancer Association Consortium (OCAC) et al., Tampa, United States. In Cancer Epidemiol Biomarkers Prev, 2011
In total, 226 SNPs within 15 kb of 4 miRNA biogenesis genes (DDX20, DROSHA, GEMIN4, and XPO5) and 23 SNPs located within putative miRNA binding sites of 6 genes (CAV1, COL18A1, E2F2, IL1R1, KRAS, and UGT2A3) were genotyped or imputed and analyzed in the entire dataset.
Human UDP-glucuronosyltransferase UGT2A2: cDNA construction, expression, and functional characterization in comparison with UGT2A1 and UGT2A3.
Finel et al., Helsinki, Finland. In Pharmacogenet Genomics, 2009
Results show that UGT2A2 not only shares exons 2-6 with UGT2A1, it also shares with it a similar tissue expression pattern; both UGTs are primarily expressed in nasal epithelium. The 3rd member of UGT2A subfamily, UGT2A3 exhibited a different tissue expression pattern, found mainly in liver and small intestine.
Novel polymorphic human UDP-glucuronosyltransferase 2A3: cloning, functional characterization of enzyme variants, comparative tissue expression, and gene induction.
Williams et al., Boston, United States. In Mol Pharmacol, 2008
This is the first report establishing UGT2A3 as a functional enzyme.
Tissue- and gender-specific mRNA expression of UDP-glucuronosyltransferases (UGTs) in mice.
Klaassen et al., Kansas City, United States. In Drug Metab Dispos, 2007
UGTs highly expressed in mouse liver include Ugt1a1, Ugt1a5, Ugt1a6, Ugt1a9, Ugt2a3, Ugt2b1, Ugt2b5/37/38, Ugt2b34, Ugt2b35, and Ugt2b36.
Nomenclature update for the mammalian UDP glycosyltransferase (UGT) gene superfamily.
Nebert et al., Australia. In Pharmacogenet Genomics, 2005
However, UGT2A3 and those of the UGT2B (six exons), UGT3 (seven exons) and UGT8 gene families (five or six exons) do not share exons and most likely were derived by a process of duplication of all exons in the gene.
Morphine regulation of a novel uridine diphosphate glucuronosyl-transferase in guinea pig pups following in utero exposure.
Olsen et al., Portland, United States. In Mol Genet Metab, 1999
Sequence analysis revealed a novel UGT2 (subsequently named UGT2A3),(2) that has a 64% amino acid sequence similarity to a known UGT2.(3)
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