UGT genotyping in belinostat dosing.
Bethesda, United States. In Pharmacol Res, Feb 2016
UNASSIGNED: Certain genetic polymorphisms of UDP glucuronosyltransferase 1 family, polypeptide A1 (UGT1A1) can reduce gene expression (*28, *60, *93) or activity (*6), thereby altering the pharmacokinetics, pharmacodynamics, and the risk of toxicities of UGT1A1 substrates, of which irinotecan is a widely-described example.
Human UDP-glucuronosyltransferases: metabolism, expression, and disease.
San Diego, United States. In Annu Rev Pharmacol Toxicol, 1999
This data, coupled with the introduction of sophisticated RNA detection techniques designed to elucidate patterns of gene expression of the UGT superfamily in human liver and extrahepatic tissues of the gastrointestinal tract, has aided in understanding the contribution of glucuronidation toward epithelial first-pass metabolism.