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UDP glucuronosyltransferase 1 family, polypeptide A complex locus

UGT, UDP-galactose transporter
This RefSeq represents a complex locus that encodes several UDP-glucuronosyltransferases. The locus includes thirteen unique alternate first exons followed by four common exons. Four of the alternate first exons are considered pseudogenes. Each of the remaining nine 5' exons may be spliced to the four common exons, resulting in nine proteins with different N-termini and identical C-termini. Each first exon encodes the substrate binding site, and is regulated by its own promoter. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: Glucuronosyltransferase, UDP-glucuronosyltransferase, UGT1A1, ACID, UGT2B7
Papers on UGT
Detection of Total UDP-Glucuronosyltransferase (UGT) Activity in Melanoma Cells.
Meyskens et al., Irvine, United States. In Methods Mol Biol, Feb 2016
UGT expression levels and activity can be induced by drug addition to cells and has been proposed as a potential intratumoral drug resistance mechanism.
UGT genotyping in belinostat dosing.
Figg et al., Bethesda, United States. In Pharmacol Res, Feb 2016
UNASSIGNED: Certain genetic polymorphisms of UDP glucuronosyltransferase 1 family, polypeptide A1 (UGT1A1) can reduce gene expression (*28, *60, *93) or activity (*6), thereby altering the pharmacokinetics, pharmacodynamics, and the risk of toxicities of UGT1A1 substrates, of which irinotecan is a widely-described example.
The UDP-glycosyltransferase (UGT) superfamily expressed in humans, insects and plants: Animal-plant arms-race and co-evolution.
Bock, Tübingen, Germany. In Biochem Pharmacol, Feb 2016
Plant-herbivore arms-race has been the major driving force for evolution of large UGT and other enzyme superfamilies.
Effects of Phenobarbital on Expression of UDP-glucuronosyltransferase 1a6 and 1a7 in Rat Brain.
Nadai et al., In Drug Metab Dispos, Jan 2016
UNASSIGNED: UDP-glucuronosyltransferase (UGT), a phase II drug-metabolizing enzyme, is expressed in the brain and can catalyze glucuronidation of endogenous and exogenous substrates in the brain.
Effects of β-Naphthoflavone on Ugt1a6 and Ugt1a7 Expression in Rat Brain.
Nadai et al., In Biol Pharm Bull, Dec 2015
Uridine 5'-diphosphate-glucuronosyltransferase (UGT) catalyzes a major phase II reaction in a drug-metabolizing enzyme system.
Tissue-specific patterns of gene expression in the epithelium and stroma of normal colon in healthy individuals in an aspirin intervention trial.
Potter et al., Seattle, United States. In Genom Data, Dec 2015
UDP-glucuronosyltransferases (UGT) are involved in aspirin metabolism and clearance, and variant alleles in UGT1A6 have been shown to alter salicylic acid metabolism and risk of colon neoplasia.
Clinical Pharmacogenetics Implementation Consortium (CPIC) Guideline for UGT1A1 and Atazanavir Prescribing.
Haas et al., Pullman, United States. In Clin Pharmacol Ther, Oct 2015
UNASSIGNED: The antiretroviral protease inhibitor atazanavir inhibits hepatic uridine diphosphate glucuronosyltransferase (UGT) 1A1, thereby preventing the glucuronidation and elimination of bilirubin.
[UGT1A1 Genotyping for Proper Use of Irinotecan].
Ando et al., In Rinsho Byori, Jul 2015
Irinotecan is metabolized to form active SN-38, which is further conjugated and detoxified by the UDP-glucuronosyltransferase (UGT) 1A1 enzyme.
[Progress in quantitative methods based on liquid chromatography-mass spectrometry for drug metabolizing enzymes in human liver microsomes].
Zhang et al., In Se Pu, Jun 2015
Cytochrome P450 (CYP) enzymes and uridine 5-diphospho-glucuronosyltransferase (UGT) enzymes are critical enzymes for drug metabolism.
In Vitro Metabolic Pathways of the New Anti-Diabetic Drug Evogliptin in Human Liver Preparations.
Lee et al., Puch'ŏn, South Korea. In Molecules, 2014
We characterized the cytochrome P450 (CYP) enzymes responsible for evogliptin hydroxylation to 4(S)-hydroxyevogliptin (M2) and 4(R)-hydroxyevogliptin (M3) and the UGT enzymes responsible for glucuronidation of 4(S)-hydroxyevogliptin (M2) to 4(S)-hydroxy-evogliptin glucuronide (M4).
The dual role of pharmacogenetics in HIV treatment: mutations and polymorphisms regulating antiretroviral drug resistance and disposition.
Wainberg et al., Montréal, Canada. In Pharmacol Rev, 2012
Genetic polymorphisms affecting the activity and/or the expression of cytochromes P450 or UGT isozymes and membrane drug transport proteins are highlighted and include such examples as the association of neurotoxicity with efavirenz, nephrotoxicity with tenofovir, hepatotoxicity with nevirapine, and hyperbilirubinemia with indinavir and atazanavir.
Gilbert syndrome redefined: a complex genetic haplotype influences the regulation of glucuronidation.
Strassburg et al., Hannover, Germany. In Hepatology, 2012
a haplotype of multiple genetic variants at the UGT1A gene locus, which is present in a vast majority of Gilbert syndrome (GS) individuals.
Study of a family in the province of Matera presenting with glucose-6-phosphate dehydrogenase deficiency and Gilbert's syndrome.
Malvasi et al., Matera, Italy. In Mol Med Report, 2012
The molecular analysis of the UGT1A1 gene promoter showed that father and mother had the heterozygous mutation, an insertion of a dinucleotide 'TA repeat'[A(TA)6TAA/A(TA)7TAA].
The value of genetic polymorphisms to predict toxicity in metastatic colorectal patients with irinotecan-based regimens.
Barros et al., Santiago de Compostela, Spain. In Cancer Chemother Pharmacol, 2012
UGT1A*60 showed no association with neutropenia
Differences in metabolite burden of di(2-ethylhexyl)phthalate in pregnant and postpartum dams and their offspring in relation to drug-metabolizing enzymes in mice.
Nakajima et al., Nagoya, Japan. In Arch Toxicol, 2012
DEHP exposure did not influence lipase activity, whereas it slightly enhanced UGT activity and exclusively increased CYP4A14 levels in pregnant and/or postpartum dams.
A genome-wide association study of total bilirubin and cholelithiasis risk in sickle cell anemia.
Klings et al., Boston, United States. In Plos One, 2011
UGT1A region is the major regulator of bilirubin metabolism and associated with cholelithiasis in African Americans with sickle cell anemia.
Gilbert's syndrome and hyperbilirubinaemia in ABO-incompatible neonates.
Levy-Lahad et al., In Lancet, 2000
We asked whether UDP glucuronosyltransferase (UGT) gene promoter polymorphism (Gilbert's syndrome) would increase hyperbilirubinaemia in direct Coombs' negative ABO-incompatible neonates, as seen in other combinations with this condition.
Human UDP-glucuronosyltransferases: metabolism, expression, and disease.
Strassburg et al., San Diego, United States. In Annu Rev Pharmacol Toxicol, 1999
This data, coupled with the introduction of sophisticated RNA detection techniques designed to elucidate patterns of gene expression of the UGT superfamily in human liver and extrahepatic tissues of the gastrointestinal tract, has aided in understanding the contribution of glucuronidation toward epithelial first-pass metabolism.
Genetic variation in bilirubin UPD-glucuronosyltransferase gene promoter and Gilbert's syndrome.
Burchell et al., Dundee, United Kingdom. In Lancet, 1996
A reduced hepatic bilirubin UPD- glucuronosyltransferase (UGT) is associated with this syndrome.
Recognition of uridine diphosphate glucuronosyl transferases by LKM-3 antibodies in chronic hepatitis D.
Manns et al., Hannover, Germany. In Lancet, 1994
These antibodies react with several microsomal antigens that have a molecular weight of 55 KDa and an isoelectric point of about 8. We studied the molecular nature of the antigen and, by immunoscreening a human liver cDNA expression library with KM-3 sera, found that uridine diphosphate glucuronosyl transferases (UGT) appeared as candidate antigens.
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