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Secretoglobin, family 3A, member 2

UGRP1, uteroglobin-related protein 1, SCGB3A2
The protein encoded by this gene is a secreted lung surfactant protein and a downstream target of thyroid transcription factor. A single nucleotide polymorphism in the promoter of this gene results in susceptibility to asthma.[provided by RefSeq, Mar 2010] (from NCBI)
Top mentioned proteins: Uteroglobin, HAD, OUT, CAN, POLYMERASE
Papers on UGRP1
Unique roles of Akt1 and Akt2 in IGF-IR mediated lung tumorigenesis.
Moorehead et al., Guelph, Canada. In Oncotarget, Jan 2016
RNA sequencing revealed a number of genes differentially expressed in lung tumors lacking Akt2 and five of these genes, Actc1, Bpifa1, Mmp2, Ntrk2, and Scgb3a2 have been implicated in human lung cancer.
SCGB3A2 Inhibits Acrolein-Induced Apoptosis through Decreased p53 Phosphorylation.
Kimura et al., Yonezawa, Japan. In Acta Histochem Cytochem, May 2015
In this study, the effect of SCGB3A2 on acrolein-related apoptosis was investigated using the mouse fibroblast cell line MLg as the first step in determining the possible therapeutic value of SCGB3A2 in COPD.
Secretoglobin 3A2 attenuates lipopolysaccharide-induced inflammation through inhibition of ERK and JNK pathways in bronchial epithelial cells.
Munakata et al., Fukushima, Japan. In Inflammation, Apr 2015
Secretoglobin (SCGB) 3A2, previously known as uteroglobin-related protein 1, is a secreted protein highly expressed in the epithelial cells of the airways.
Epigenetic mechanisms of peptidergic regulation of gene expression during aging of human cells.
Vanyushin et al., Moscow, Russia. In Biochemistry (mosc), Mar 2015
The methylation patterns of the PAX4 gene in pancreatic cells as well as those of the FOXA1, SCGB3A2, and SFTPA1 genes in bronchial cells do not change upon aging and are unaffected by peptides, whereas their expression levels change in both cases.
Secretoglobin 3A2 Exhibits Anti-Fibrotic Activity in Bleomycin-Induced Pulmonary Fibrosis Model Mice.
Kimura et al., Bethesda, United States. In Plos One, 2014
The latter activity was demonstrated using exogenously-administered recombinant SCGB3A2 in the bleomycin (BLM)-induced pulmonary fibrosis model.
Transgenically-expressed secretoglobin 3A2 accelerates resolution of bleomycin-induced pulmonary fibrosis in mice.
Kimura et al., Bethesda, United States. In Bmc Pulm Med, 2014
While SCGB3A2 is known to have anti-inflammatory, growth factor, and anti-fibrotic activities, whether SCGB3A2 has any other roles, particularly in lung homeostasis and disease has not been demonstrated in vivo.
Peptide regulation of gene expression and protein synthesis in bronchial epithelium.
Bernadotte et al., Saint Petersburg, Russia. In Lung, 2014
Gene expression of NKX2-1, SCGB1A1, SCGB3A2, FOXA1, FOXA2, MUC4, MUC5AC, and SFTPA1 was measured by real-time polymerase chain reaction.
Regulation of LH/FSH expression by secretoglobin 3A2 in the mouse pituitary gland.
Kurotani et al., Yonezawa, Japan. In Cell Tissue Res, 2014
To demonstrate whether SCGB3A2 plays any role in pituitary hormone production, NKX2-1 and SCGB3A2 expression in the mouse pituitary gland was examined by immunohistochemical analysis and RT-PCR.
The association of SCGB3A2 polymorphisms with the risk of Graves' disease: a meta-analysis.
Song et al., Shanghai, China. In Endocrine, 2014
The aim of this study is to assess the association of the SCGB3A2 -112G>A promoter polymorphism with Graves' disease(GD) using a meta-analysis.
Association between the -112G/A polymorphism of uteroglobulin-related protein 1 gene and asthma risk: A meta-analysis.
Cheng et al., Guangzhou, China. In Exp Ther Med, 2014
The aim of this study was to investigate the correlation between the -112G/A polymorphism of the uteroglobulin-related protein 1 (UGRP1) gene and asthma risk using meta-analysis.
Preclinical evaluation of human secretoglobin 3A2 in mouse models of lung development and fibrosis.
Kimura et al., Bethesda, United States. In Am J Physiol Lung Cell Mol Physiol, 2014
We hypothesize that human SCGB3A2 may exhibit anti-inflammatory, growth factor, and antifibrotic activities and be of clinical utility.
Secretoglobin superfamily protein SCGB3A2 deficiency potentiates ovalbumin-induced allergic pulmonary inflammation.
Kimura et al., Bethesda, United States. In Mediators Inflamm, 2013
In order to understand the physiological role of SCGB3A2, Scgb3a2(-/-) mice were generated and characterized.
Neuroepithelial body microenvironment is a niche for a distinct subset of Clara-like precursors in the developing airways.
Cardoso et al., Boston, United States. In Proc Natl Acad Sci U S A, 2012
Here we identify expression of the secretoglobin Scgb3a2 and Notch activation as early events in a program of secretory cell fate determination in developing murine airways.
Gene expression signatures differentiate adenocarcinoma of lung and breast origin in effusions.
Wang et al., Oslo, Norway. In Hum Pathol, 2012
Genes overexpressed in lung adenocarcinoma included TITF1, SFTPG, MMP7, EVA1, GPR116, HOP, SCGB3A2, and MET.
The genetic basis of graves' disease.
Bednarczuk et al., Warsaw, Poland. In Curr Genomics, 2011
We review recent findings implicating variants of FCRL3 (gene for FC receptor-like-3 protein), SCGB3A2 (gene for secretory uteroglobin-related protein 1- UGRP1) as well as other unverified possible candidate genes for GD selected through their documented association with type 1 diabetes mellitus: Tenr-IL2-IL21, CAPSL (encoding calcyphosine-like protein), IFIH1(gene for interferon-induced helicase C domain 1), AFF3, CD226 and PTPN2.
Secretoglobin 3A2 suppresses bleomycin-induced pulmonary fibrosis by transforming growth factor beta signaling down-regulation.
Kimura et al., Bethesda, United States. In J Biol Chem, 2011
Secretoglobin 3A2 suppresses bleomycin-induced pulmonary fibrosis by transforming growth factor beta signaling down-regulation
The -112G>A polymorphism of the secretoglobin 3A2 (SCGB3A2) gene encoding uteroglobin-related protein 1 (UGRP1) increases risk for the development of Graves' disease in subsets of patients with elevated levels of immunoglobulin E.
Savost'anov et al., Moscow, Russia. In J Appl Genet, 2011
the SCGB3A2 -112G >A polymorphism may be considered as a likely marker linking susceptibility to allergy/asthma and Graves' disease
The cytokine-driven regulation of secretoglobins in normal human upper airway and their expression, particularly that of uteroglobin-related protein 1, in chronic rhinosinusitis.
Liu et al., Wuhan, China. In Respir Res, 2010
Reduced production of UGRP1, which is likely due, at least in part, to a local cytokine environment, may contribute to the hyper-inflammation in chronic rhinosinusitis and correlates with response to surgery.
Variation in Uteroglobin-Related Protein 1 (UGRP1) gene is associated with allergic rhinitis in Singapore Chinese.
Chew et al., Singapore, Singapore. In Bmc Med Genet, 2010
This study documents the association between polymorphisms in UGRP1 and the common cold, suggesting a potential role in its pathogenesis.
Development of a new sensitive ELISA for the determination of uteroglobin-related protein 1, a new potential biomarker.
Bernard et al., Brussels, Belgium. In Biomarkers, 2010
pattern of UGRP-1 concentration resembled that of Clara cell protein, both proteins occurring in high concentrations in amniotic fluid, sputum and BALF and in much lower concentrations in serum and urine
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