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UDP-glucose pyrophosphorylase 2

UDPG, UTP-Glucose-1-Phosphate Uridylyltransferase, UGPase
The enzyme encoded by this gene is an important intermediary in mammalian carbohydrate interconversions. It transfers a glucose moiety from glucose-1-phosphate to MgUTP and forms UDP-glucose and MgPPi. In liver and muscle tissue, UDP-glucose is a direct precursor of glycogen; in lactating mammary gland it is converted to UDP-galactose which is then converted to lactose. The eukaryotic enzyme has no significant sequence similarity to the prokaryotic enzyme. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: ACID, HAD, CAN, STEP, Phosphoglucomutase
Papers on UDPG
OsERF2 controls rice root growth and hormone responses through tuning expression of key genes involved in hormone signaling and sucrose metabolism.
New
Zhang et al., Changsha, China. In Plant Mol Biol, Feb 2016
In addition, OsERF2 affected the accumulation of sucrose and UDPG by mediating expression of key genes involved in sucrose metabolism.
Silencing UDP-glucose pyrophosphorylase gene in Phaeodactylum tricornutum affects carbon allocation.
New
Pan et al., Qingdao, China. In N Biotechnol, Feb 2016
The effects of the suppression of UDP-glucose pyrophosphorylase (UGPase) on chrysolaminaran biosynthesis and carbon allocation were investigated in Phaeodactylum tricornutum.
Genetic and biochemical characterization of genes involved in hyaluronic acid synthesis in Streptococcus zooepidemicus.
New
Liu et al., Tianjin, China. In Appl Microbiol Biotechnol, Feb 2016
Of the two UDP-glucose pyrophosphorylase (UGPase) paralogues, the operon-encoded hasC1 was responsible for 65 % of the activity, while hasC2 was responsible for the remaining 35 %.
Structural and enzymatic analyses of a glucosyltransferase Alr3699/HepE involved in Anabaena heterocyst envelop polysaccharide biosynthesis.
New
Zhou et al., Hefei, China. In Glycobiology, Jan 2016
Here we report the crystal structures of HepE in the apo-form and three complex forms that bind to UDP-glucose (UDPG), UDP&glucose and UDP, respectively.
Influence of fermentation conditions on polysaccharide production and the activities of enzymes involved in the polysaccharide synthesis of Cordyceps militaris.
New
Zhang et al., Tianjin, China. In Appl Microbiol Biotechnol, Jan 2016
UNASSIGNED: The influence of different fermentation conditions on intracellular polysaccharide (IPS) production and activities of the phosphoglucomutase (PGM), UDPG-pyrophosphorylase (UGP), phosphoglucose isomerase (PGI), UDPG-dehydrogenase (UGD), and glucokinase (GK) implicated in metabolite synthesis in Cordyceps militaris was evaluated.
Characterization of UGPase from Aureobasidium pullulans NRRL Y-12974 and Application in Enhanced Pullulan Production.
New
Huang et al., Hangzhou, China. In Appl Biochem Biotechnol, Dec 2015
UNASSIGNED: UDPG pyrophosphatase (UGPase) plays an important role in carbohydrate metabolism, catalyzing a reversible production of uridine diphosphate glucose (UDPG) and pyrophosphate (PPi) from Glc-1-P and UTP.
Enhancement of UDPG synthetic pathway improves ansamitocin production in Actinosynnem pretiosum.
New
Hua et al., Shanghai, China. In Appl Microbiol Biotechnol, Dec 2015
The biosynthesis of ansamitocins is initialized by the formation of UDP-glucose (UDPG) which is converted from glucose-1-phosphate (G1P).
Design, synthesis, pharmacological characterization of a fluorescent agonist of the P2Y₁₄ receptor.
New
Jacobson et al., Bethesda, United States. In Bioorg Med Chem Lett, Dec 2015
The P2Y14R is a G(i/o)-coupled receptor of the P2Y family of purinergic receptors that is activated by extracellular UDP and UDP-glucose (UDPG).
Indole-3-acetic acid UDP-glucosyltransferase from immature seeds of pea is involved in modification of glycoproteins.
New
Jakubowska et al., Toruń, Poland. In Phytochemistry, Sep 2015
The enzyme UDPG: indole-3-ylacetyl-β-D-glucosyltransferase (IAA glucosyltransferase, IAGlc synthase) catalyzes the reversible reaction: IAA+UDPG↔1-O-IA-glucose+UDP, which is the first step in the biosynthesis of IAA-ester conjugates in monocotyledonous plants.
Efficient use of energy in anoxia-tolerant plants with focus on germinating rice seedlings.
Review
New
Colmer et al., Sydney, Australia. In New Phytol, Apr 2015
In quiescent cells with little polymer synthesis and associated PPi formation, the PPi required by the vacuolar H(+) -PPi ase and UDPG pyrophosphorylase involved in sucrose mobilisation via sucrose synthase might be produced by conversion of ATP to PPi through reversible glycolytic enzymes, presumably pyruvate orthophosphate dikinase.
De novo transcriptome sequence and identification of major bast-related genes involved in cellulose biosynthesis in jute (Corchorus capsularis L.).
Qi et al., Fuzhou, China. In Bmc Genomics, 2014
Moreover, 5 Susy, 3 UGPase, 9 CesA, 18 CSL, 2 Kor (Korrigan), and 12 Cobra unigenes involving in cellulose biosynthesis were identified.
Inhibitory Role of Greatwall-Like Protein Kinase Rim15p in Alcoholic Fermentation via Upregulating the UDP-Glucose Synthesis Pathway in Saccharomyces cerevisiae.
Shimoi et al., Ikoma, Japan. In Appl Environ Microbiol, 2014
Transcriptional induction of PGM2 (phosphoglucomutase) and UGP1 (UDPG pyrophosphorylase) was impaired in Rim15p-deficient cells in the early stage of fermentation.
The crystal structure of human UDP-glucose pyrophosphorylase reveals a latch effect that influences enzymatic activity.
GeneRIF
Zheng et al., Beijing, China. In Biochem J, 2012
The crystal structure was determined and shown to form octamers through end-to-end and side-by-side interactions. Mutagenesis studies showed that both dissociation of octamers and mutations of the latch loop can significantly affect the activity.
UDP-glucose pyrophosphorylase is rate limiting in vegetative and reproductive phases in Arabidopsis thaliana.
GeneRIF
Watanabe et al., Sendai, Japan. In Plant Cell Physiol, 2010
AtUGP1 and AtUGP2 genes are functionally redundant and UGPase activity is essential for both vegetative and reproductive phases in Arabidopsis.
Hypoxia promotes glycogen accumulation through hypoxia inducible factor (HIF)-mediated induction of glycogen synthase 1.
GeneRIF
del Peso et al., Madrid, Spain. In Plos One, 2009
GYS1 regulation by HIF plays a central role in the hypoxic accumulation of glycogen, and hypoxia also upregulates the expression of UTP:glucose-1-phosphate urydylyltransferase (UGP2) and 1,4-alpha glucan branching enzyme (GBE1)
UDP-glucose pyrophosphorylase is not rate limiting, but is essential in Arabidopsis.
GeneRIF
Kleczkowski et al., Umeå, Sweden. In Plant Cell Physiol, 2009
UGP1 and UGP2, are differentially expressed, with UGP1 being predominant. UGP1 is closely co-regulated with carbohydrate metabolism, late embryogenesis and seed loading, while UGP2 with stress response, fertilized flowers and photosynthetic genes. [UGP1]
A chloroplastic UDP-glucose pyrophosphorylase from Arabidopsis is the committed enzyme for the first step of sulfolipid biosynthesis.
GeneRIF
Saito et al., Yokohama, Japan. In Plant Cell, 2009
The identification of a novel gene, UDP-glucose pyrophosphorylase3 (UGP3), required for sulfolipid biosynthesis, is described.
Why is it challenging to predict intestinal drug absorption and oral bioavailability in human using rat model.
Review
Sun et al., Columbus, United States. In Pharm Res, 2006
In addition, the expressions of metabolizing enzymes (CYP3A4/CYP3A9 and UDPG) showed 12 to 193-fold difference between human and rat intestine with distinct regional dependent expression patterns.
What stay-green mutants tell us about nitrogen remobilization in leaf senescence.
Review
Donnison et al., Aberystwyth, United Kingdom. In J Exp Bot, 2002
When the stay-green locus from Festuca pratensis was introgressed into Lolium temulentum, a gene encoding F. pratensis UDPG-pyrophosphorylase was shown to have been transferred on the same chromosome segment.
Mechanisms of blood glucose homeostasis.
Review
Hers, Brussels, Belgium. In J Inherit Metab Dis, 1989
When glycogen synthesis is intense, the concentrations of UDPG and of glucose 6-phosphate in the liver decrease, allowing a net glucose uptake by the liver.
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