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Uncoupling protein 1

UCP1, UCP, uncoupling protein 1
Mitochondrial uncoupling proteins (UCP) are members of the family of mitochondrial anion carrier proteins (MACP). UCPs separate oxidative phosphorylation from ATP synthesis with energy dissipated as heat, also referred to as the mitochondrial proton leak. UCPs facilitate the transfer of anions from the inner to the outer mitochondrial membrane and the return transfer of protons from the outer to the inner mitochondrial membrane. They also reduce the mitochondrial membrane potential in mammalian cells. Tissue specificity occurs for the different UCPs and the exact methods of how UCPs transfer H+/OH- are not known. UCPs contain the three homologous protein domains of MACPs. This gene is expressed only in brown adipose tissue, a specialized tissue which functions to produce heat. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: BAT, Insulin, CAN, ACID, HAD
Papers using UCP1 antibodies
AMP-activated protein kinase activation as a strategy for protecting vascular endothelial function.
Xu Aimin, In PLoS ONE, 2007
... Protein A/G-agarose, AMPKα siRNA, and UCP-2 siRNA were obtained from Santa Cruz Biotechnology, Inc ...
Evolving gene/transcript definitions significantly alter the interpretation of GeneChip data
Lodish Harvey F. et al., In Nature cell biology, 2004
... Reduction of dietary obesity in aP2-Ucp transgenic mice: mechanism and adipose ...
Superoxide activates mitochondrial uncoupling protein 2 from the matrix side. Studies using targeted antioxidants.
Xu Aimin, In PLoS ONE, 2001
... Antibodies against uncoupling protein (UCP) 2 were obtained from Fitzgerald Industries International, Inc ...
Papers on UCP1
Intermedin/Adrenomedullin 2 polypeptide promotes adipose tissue browning and reduces high-fat diet-induced obesity and insulin resistance in mice.
Wang et al., Beijing, China. In Int J Obes (lond), Feb 2016
These effects may be due to increased AMP-activated protein kinase (AMPK) phosphorylation and reduced peroxisome proliferator-activated receptor gamma co-activator 1α (PGC1α) acetylation, which result in interactions between PGC1α and PR domain containing 16 (PRDM16) and then promote uncoupling protein 1 (UCP1) expression in adipocytes.
Effects of dietary phosphate on glucose and lipid metabolism.
Taketani et al., Tokushima, Japan. In Am J Physiol Endocrinol Metab, Feb 2016
On the other hand, uncoupling protein 1 (UCP1) and peroxisome proliferator-activated receptor gamma coactivator alpha (PGC1α) expression were significantly increased in the brown adipose tissue (BAT) of HP group.
A Low-Protein, High-Carbohydrate Diet Stimulates Thermogenesis in the Brown Adipose Tissue of Rats via ATF-2.
Kawashita et al., Cuiabá, Brazil. In Lipids, Feb 2016
The expression levels of uncoupling protein 1 (UCP1) and other proteins involved in the regulation of UCP1 expression were determined by Western blot (Student's t test, P ≤ 0.05).
Direct action of capsaicin in brown adipogenesis and activation of brown adipocytes.
Funaba et al., Kyoto, Japan. In Cell Biochem Funct, Feb 2016
UNASSIGNED: The ingestion of capsaicin, the principle pungent component of red and chili peppers, induces thermogenesis, in part, through the activation of brown adipocytes expressing genes related to mitochondrial biogenesis and uncoupling such as peroxisome proliferator-activated receptor (Ppar) γ coactivator-1α (Pgc-1α) and uncoupling protein 1 (Ucp1).
Interruptin B induces brown adipocyte differentiation and glucose consumption in adipose-derived stem cells.
Sung et al., Thailand. In Mol Med Report, Feb 2016
In addition, interruptin B efficiently increased the number and the membrane potential of mitochondria and upregulated the mRNA expression levels of uncoupling protein (UCP)‑1 and cyclooxygenase (COX)‑2, which are all predominantly expressed in brown adipocytes.
Breaking BAT: can browning create a better white?
Mittag et al., Lübeck, Germany. In J Endocrinol, Jan 2016
Recently, it has been demonstrated that certain populations of white adipocytes can be 'browned', i.e., recruited to a more brown-like adipocyte, capable of thermogenesis through increased expression of uncoupling protein 1.
A Creatine-Driven Substrate Cycle Enhances Energy Expenditure and Thermogenesis in Beige Fat.
Spiegelman et al., Boston, United States. In Cell, Nov 2015
Genes of creatine metabolism are compensatorily induced when UCP1-dependent thermogenesis is ablated, and creatine reduction in Ucp1-deficient mice reduces core body temperature.
Brown and Beige Fat: Physiological Roles beyond Heat Generation.
Seale et al., San Francisco, United States. In Cell Metab, Nov 2015
Since brown adipose tissue (BAT) dissipates energy through UCP1, BAT has garnered attention as a therapeutic intervention for obesity and metabolic diseases including type 2 diabetes.
Browning of Subcutaneous White Adipose Tissue in Humans after Severe Adrenergic Stress.
Herndon et al., Galveston, United States. In Cell Metab, Sep 2015
Browning of sWAT was determined by the presence of multilocular adipocytes, uncoupling protein 1 (UCP1), and increased mitochondrial density and respiratory capacity.
Clonal analyses and gene profiling identify genetic biomarkers of the thermogenic potential of human brown and white preadipocytes.
Tseng et al., Boston, United States. In Nat Med, Jul 2015
We combined an uncoupling protein 1 (UCP1) reporter system and expression profiling to define novel sets of gene signatures in human preadipocytes that could predict the thermogenic potential of the cells once they were maturated.
Pharmacologic Effects of FGF21 Are Independent of the "Browning" of White Adipose Tissue.
Lloyd et al., Thousand Oaks, United States. In Cell Metab, Jun 2015
"Browning," the appearance and activation of brown-in-white (brite) adipose cells within inguinal white adipose tissue (iWAT), and induction of uncoupling protein 1 (UCP1) correlate with fibroblast growth factor-21 (FGF21)-induced weight loss and glucose homeostasis improvements.
Bioengineering Beige Adipose Tissue Therapeutics.
Stahl et al., Berkeley, United States. In Front Endocrinol (lausanne), 2014
Expansion and/or stimulation of uncoupling protein-1 (UCP1)-positive adipose tissues have repeatedly demonstrated physiologically beneficial reductions in circulating glucose and lipids.
The Therapeutic Potential of Brown Adipocytes in Humans.
Sidossis et al., Galveston, United States. In Front Endocrinol (lausanne), 2014
Brown adipose tissue (BAT) is densely populated with mitochondria containing the inner mitochondrial proton carrier uncoupling protein 1 (UCP1).
A New Role for Browning as a Redox and Stress Adaptive Mechanism?
Casteilla et al., Toulouse, France. In Front Endocrinol (lausanne), 2014
The expression of uncoupling protein-1 in brown-like adipocytes changes their function from energy storage to energy dissipation.
[Human brown adipose tissue].
Nuutila et al., In Duodecim, 2014
Brown adipose cells produce heat by means of uncoupler protein 1 (UCP1) from fatty acids and sugar.
Molecular diagnosis of infantile mitochondrial disease with targeted next-generation sequencing.
Mootha et al., Boston, United States. In Sci Transl Med, 2012
Strong candidate gene for mitochondrial disease, based on recessive mutations detected in infantile patients
Supplementation of Korean fermented soy paste doenjang reduces visceral fat in overweight subjects with mutant uncoupling protein-1 allele.
Park et al., Seoul, South Korea. In Nutr Res, 2012
Doenjang supplementation significantly reduced visceral fat and increased the free fatty acid concentrations in subjects with the G allele of the UCP-1 polymorphism.
The absence of polymorphisms in ADRB3, UCP1, PPARγ, and ADIPOQ genes protects morbid obese patients toward insulin resistance.
Pasanisi et al., Campobasso, Italy. In J Endocrinol Invest, 2012
Single nucleotide polymorphisms in UCP1 is associated with insulin resistance in morbid obese patients.
Absence of RIP140 reveals a pathway regulating glut4-dependent glucose uptake in oxidative skeletal muscle through UCP1-mediated activation of AMPK.
Parker et al., London, United Kingdom. In Plos One, 2011
Absence of RIP140 reveals a pathway regulating glut4-dependent glucose uptake in oxidative skeletal muscle through UCP1-mediated activation of AMPK.
Sex-dependent effects of the UCP1 -3826 A/G polymorphism on obesity and blood pressure.
Kapoor et al., Delhi, India. In Ethn Dis, 2011
This study links the GG homozygous form of UCP1 with obesity and blood pressure among females only.
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