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N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase

UCE, N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase, alpha-N-acetylglucosaminyl phosphodiesterase, phosphodiester alpha-GlcNAcase, lysosomal alpha-N-acetylglucosaminidase, APAA, mannose 6-phosphate-uncovering enzyme
Hydrolases are transported to lysosomes after binding to mannose 6-phosphate receptors in the trans-Golgi network. This gene encodes the enzyme that catalyzes the second step in the formation of the mannose 6-phosphate recognition marker on lysosomal hydrolases. Commonly known as 'uncovering enzyme' or UCE, this enzyme removes N-acetyl-D-glucosamine (GlcNAc) residues from GlcNAc-alpha-P-mannose moieties and thereby produces the recognition marker. This reaction most likely occurs in the trans-Golgi network. This enzyme functions as a homotetramer of two disulfide-linked homodimers. In addition to having an N-terminal signal peptide, the protein's C-terminus contains multiple signals for trafficking it between lysosomes, the plasma membrane, and trans-Golgi network. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: alpha-N-acetylglucosaminidase, ACID, CAN, STEP, HAD
Papers on UCE
Genome-wide ultraconserved elements exhibit higher phylogenetic informativeness than traditional gene markers in percomorph fishes.
Alfaro et al., Los Angeles, United States. In Mol Phylogenet Evol, Nov 2015
Although UCE datasets typically contain a much larger number of loci and sites than more traditional datasets of PCR-amplified, single-copy, protein coding genes, a fraction of UCE sites are expected to be part of a nearly invariant core, and the relative performance of UCE datasets versus protein coding gene datasets is poorly understood.
Asian Elm tree inner bark prevents articular cartilage deterioration in ovariectomized obese rats with monoiodoacetate-induced osteoarthritis.
Park et al., Asan, South Korea. In Menopause, Nov 2015
METHODS: Ovariectomized (OVX) rats were provided a 45% fat diet containing either (1) 0.6% lyophilized water extract of Korean mistletoe (KME) + 1.4% dextrose (KME; n = 10), (2) 2% lyophilized water extract of Ulmi cortex (UCE; n = 10), (3) 30 μg/kg bw 17β-estradiol + 2% dextrose (positive control; n = 10), (4) 2% dextrose (placebo; OVX-control; n = 10), or (5) 2% dextrose (normal-control; n = 10) for 4 weeks.
RNA/DNA co-analysis from human skin and contact traces--results of a sixth collaborative EDNAP exercise.
Ballantyne et al., Zürich, Switzerland. In Forensic Sci Int Genet, May 2015
Two sets of previously described skin-specific markers were used: skin1 pentaplex (LCE1C, LCE1D, LCE2D, IL1F7 and CCL27) and skin2 triplex (LOR, KRT9 and CDSN) in conjunction with a housekeeping gene, HKG, triplex (B2M, UBC and UCE).
Selection of Reliable Reference Genes for Gene Expression Studies of a Promising Oilseed Crop, Plukenetia volubilis, by Real-Time Quantitative PCR.
Xu et al., Hefei, China. In Int J Mol Sci, 2014
The results showed that ubiquitin-conjugating enzyme (UCE), actin (ACT) and phospholipase A22 (PLA) were the most stable genes in Sacha inchi seedlings.
Phylogenomic methods outperform traditional multi-locus approaches in resolving deep evolutionary history: a case study of formicine ants.
Ward et al., Washington, D.C., United States. In Bmc Evol Biol, 2014
Moreover, UCE data on invertebrates, including insects, are sparse.
Kinetics and activation parameters of the reaction of organoarsenic(V) compounds with glutathione.
Schmidt et al., Freiberg, Germany. In J Hazard Mater, 2014
In this work the kinetics of the reaction of glutathione (GSH) with the organoarsenic(V) compounds phenylarsonic acid (PAA), 4-hydroxy-3-nitrophenylarsonic acid (HNPAA), p-aminophenylarsonic acid (p-APAA) and o-aminophenylarsonic acid (o-APAA) as well as monomethylarsonic acid (MMAA) and dimethylarsinic acid (DMAA) is investigated.
Angiogenin stimulates ribosomal RNA transcription by epigenetic activation of the ribosomal DNA promoter.
Hu et al., Hangzhou, China. In J Cell Physiol, 2014
ANG binds at the upstream control element (UCE) of the promoter and enhances promoter occupancy of RNA Pol I as well as the selectivity factor SL1 components TAFI 48 and TAFI 110.
RNA/DNA co-analysis from human menstrual blood and vaginal secretion stains: results of a fourth and fifth collaborative EDNAP exercise.
Ballantyne et al., Zürich, Switzerland. In Forensic Sci Int Genet, 2014
Two novel menstrual blood mRNA multiplexes were used: MMP triplex (MMP7, MMP10, MMP11) and MB triplex (MSX1, LEFTY2, SFRP4) in conjunction with a housekeeping gene triplex (B2M, UBC, UCE).
Allele frequencies of variants in ultra conserved elements identify selective pressure on transcription factor binding.
Voorhoeve et al., Singapore, Singapore. In Plos One, 2013
By combining our data with 1000 Genome Project data, we show in three independent datasets that prevalent UCE variants (MAF>5%) are more often found in relatively less-conserved nucleotides within UCEs, compared to rare variants.
Alternative xeno-free biomaterials derived from human umbilical cord for the self-renewal ex-vivo expansion of mesenchymal stem cells.
Choi et al., South Korea. In Stem Cells Dev, 2013
In this study, we investigated whether human umbilical cord extract (UCE) could serve as a serum replacement and whether collagen purified from umbilical cord (UC-collagen) could act as an extracellular matrix (ECM) for the in vitro culture of MSCs derived from human UC (UC-MSCs).
A DNA-centric protein interaction map of ultraconserved elements reveals contribution of transcription factor binding hubs to conservation.
Mann et al., Martinsried, Germany. In Cell Rep, 2013
Although in vivo studies of UCE sequences have demonstrated regulatory activity, protein interactors at UCEs have not been systematically identified.
Structure and function of the DUF2233 domain in bacteria and in the human mannose 6-phosphate uncovering enzyme.
Wilson et al., Menlo Park, United States. In J Biol Chem, 2013
DUF2233, a domain of unknown function (DUF), is present in many bacterial and several viral proteins and was also identified in the mammalian transmembrane glycoprotein N-acetylglucosamine-1-phosphodiester α-N-acetylglucosaminidase ("uncovering enzyme" (UCE)).
Development of a xeno-free autologous culture system for endothelial progenitor cells derived from human umbilical cord blood.
Chung et al., Seoul, South Korea. In Plos One, 2012
To develop in vitro culture conditions for EPCs derived from human cord blood (hCB-EPCs), we isolated extracts (UCE) and collagen (UC-collagen) from umbilical cord tissue to replace their animal-derived counterparts.
Analysis of mannose 6-phosphate uncovering enzyme mutations associated with persistent stuttering.
Kornfeld et al., Saint Louis, United States. In J Biol Chem, 2011
Analysis of mannose 6-phosphate uncovering enzyme mutations associated with persistent stuttering.
Mutations in the lysosomal enzyme-targeting pathway and persistent stuttering.
Drayna et al., Bethesda, United States. In N Engl J Med, 2010
identified three mutations in the NAGPA gene associated with stuttering
Characterization of the TGN exit signal of the human mannose 6-phosphate uncovering enzyme.
Rohrer et al., Zürich, Switzerland. In J Cell Sci, 2005
The mannose 6-phosphate uncovering enzyme participates in the uncovering of the mannose 6-phosphate recognition tag on lysosomal enzymes, a process that facilitates recognition of those enzymes by mannose 6-phosphate receptors to delivery to lysosomes.
Human mannose 6-phosphate-uncovering enzyme is synthesized as a proenzyme that is activated by the endoprotease furin.
Kornfeld et al., Oklahoma City, United States. In J Biol Chem, 2002
synthesis as a proenzyme that is activated by furin [mannose 6-phosphate-uncovering enzyme]
Functional cooperativity between transcription factors UBF1 and SL1 mediates human ribosomal RNA synthesis.
Tjian et al., Berkeley, United States. In Science, 1988
The human ribosomal RNA promoter contains two distinct control elements (UCE and core) both of which are recognized by the sequence-specific DNA binding protein UBF1, which has now been purified to apparent homogeneity.
Human rRNA transcription is modulated by the coordinate binding of two factors to an upstream control element.
Tjian et al., In Cell, 1986
The human rRNA promoter contains two distinct cis-control sequences, the core and upstream control element (UCE), that serve as the target for binding cellular trans-activating proteins involved in transcription initiation by RNA polymerase I.
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