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UBX domain protein 4

UBXD2, Erasin
UBXD2 is an integral membrane protein of the endoplasmic reticulum (ER) that binds valosin-containing protein (VCP; MIM 601023) and promotes ER-associated protein degradation (ERAD) (Liang et al., 2006 [PubMed 16968747]).[supplied by OMIM, Mar 2008] (from NCBI)
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Papers on UBXD2
Ubiquilin and p97/VCP bind erasin, forming a complex involved in ERAD.
GeneRIF
Monteiro et al., Baltimore, United States. In J Cell Biol, 2009
Knockdown of erasin, a platform for p97/VCP and ubiquilin binding, or knockdown of ubiquilin in human cells slowed degradation of two classical endoplasmic reticulum-associated protein degradation substrates.
Characterization of erasin (UBXD2): a new ER protein that promotes ER-associated protein degradation.
GeneRIF
Monteiro et al., Baltimore, United States. In J Cell Sci, 2006
Erasin/UBXD2 may be involved in endoplasmic-reticulum-associated protein degradation and in Alzheimer's disease.
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